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Backgrounds and Aim: Cardiovascular diseases, especially atherosclerosis, are among the main causes of mortality in developing countries of Asia and West Asia. The purpose of this study was to investigate the effect of eight weeks of aerobic training on serum lipid profile and fibrinogen in middle-aged men with heart failure. Materials and Methods: Twenty men with aged 50 to 60 years, with heart failure grade 1 to 3, and heart power of less than 45% were selected and then randomly divided into experimental and control groups. Aerobic exercise was included of eight weeks of aerobic training with intensity of 35-65% of maximal heart rate with a three-session frequency per week. Fasting blood samples were collected from participants before and after of eight weeks. Data were analyzed by Paired sample t-test and Independent sample t-test. Results: The results showed that after eight weeks of intervention, mean changes of HDL, TC / HDL ratio and fibrinogen were statistically significant (P0.05). Conclusion: The results of this study indicate that performing aerobic exercises along with drug therapy can be useful as a good way to prevent cardiovascular disease in people with heart failure