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Introduction: knee osteoarthritis is one of the most important causes of pain and disability in society. The aim of this study was to investigate the level of pain and the quality of life in patients with knee osteoarthritis treated with Nigella Sativa capsules and drug therapy. Materials and Methods: This case-control study was conducted on patients who referred to the Baqiyatallah clinic with complaints of knee osteoarthritis in 2022. A total of 120 patients were randomly divided into two groups, namely, standard treatment (physiotherapy, exercise to strengthen muscles and nutritional recommendations), and the group receiving Nigella Sativa capsules (650 mg, orally and twice a day). Then 36-item Quality of Life Questionnaire, Functional Questionnaire, Western Ontario and Mcmaster Universities Index (WOMAC), and Visual Pain Scale (VAS) were completed for patients in both case and control groups. All the collected data were entered into SPSS software and analyzed using Chi Squared and Student's t-test. In all analyses, the significance limit of the results was p value=0.05. Results: No significant difference was found between the quality of life score of the patients in the case and control groups (p>0.05). However, a significant difference was observed in the visual pain intensity score between the case and control groups (p0.05). Conclusion: The result of our study showed that Nigella Sativa capsules reduces pain, improves dry joints, and reduces visual pain, however it did not have any significant effect on the quality of life.