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Plants of willow genus are rich in various flavonoids. In 60-e years of the XX century the works of V. A. Kompantsev showed that leaves of willow triandra, growing in the North Caucasus, contain up to 5% of rutin. The method, which required long sample preparation (extraction of the raw material with TLC, chromatographic layer extraction with methanol, removal of the solvent, dissolution in ethanol, optical density measurements) was used. Currently available and simple methods for the determination of rutin in plant material are described. Given that leaves of Salix triandra contain significant amounts of rutin and can be a potential raw material for the creation of medicines on their basis, it is essential to determine the amount of flavonoids in the leaves of Salix triandra and its branches.The purpose of this study is determination of the amount of flavonoids in the willow triandra, growing in the North Caucasus, depending on the place and time of collection.Methods. TLC and the method of differential spectrophotometry were used to study chemical reactions. Results. The presence of flavonoids in various vegetative plant organs was established using qualitative reactions (cyanidin test; boric-citric reaction; the reaction with solution of lead acetate and solution of ammonia). Rutin and quercetin flavonoids in the presence of standard samples were identified using TLC. the method of differential spectrophotometry, based on the reaction of flavonoids with aluminum chloride was used for the quantitative determination of the amount of flavonoids. It is shown that the greatest quantity of flavonoids amount accumulated in the leaves (up to 3.76%), its value in branches is slightly smaller (up to 3.26%). The branches without leaves have almost 10 times less flavonoids. It was established experimentally that the accumulation of flavonoids in raw material of Salix triandra is dependent on the place and time of raw materials gathering.Conclusion. The results confirmed the previously obtained information about the fact that Salix triandra mainly contains rutin. The method of differential spectrophotometry allows determining the amount of flavonoids with a relative error not exceeding 2.5%.

The review systematizes data about chemical composition of bark, leaves, inflorescences, and sprouts of different species of Salix L. The closest attention is payed to investigations of Salix, which has been recently carried out in our country and abroad. For every group of biologically active substances described in Salix there are data about suppressed types of pharmacological activity.

The article is devoted to basic life milestones of Professor, Doctor of Pharmaceutical Science, Honored Scientist of Russia V.G. Belikov, who made a great contribution to the development of domestic pharmaceutical education and science, more than 30 years headed the leading pharmaceutical institution of the country.

Under review is Salix babylonica L., which is widely cultivated in Russia as an ornamental plant. The purpose of the review is to summarize the literature on the chemical composition and pharmacological activity of the Babylonian willow. In Russia, only the qualitative composition of the studied species studied, pharmacologi-cal studies have not been conducted. Abroad, there is a positive experience of Salix babylonica in folk medicine, and obtained results that indicate a high content of biologically active compounds. Shown in the survey data suggest the prospect of studying the Babylonian willows growing in the southern regions of Russia for use in medicine and pharmacy.

Qualitative and quantitative composition of phenolcarbonic acids in one year tendrils of Salix triandra L. was determined. Identification in quantitative determination of certain phenolcarbonic acids was carried out using high-performance liquid chromatography. Six individual substances were discovered. The total content of the sum of phenolcarbonic acids was determined with extractionphotometric method, based on a selective extraction from acidulous solution into ethyl acetate. The highest content of phenolcarbonic acids (about 0.47%) was detected in the leaves of Salix triandra L., the lowest content was detected in the tendrils without leaves (about 0.40%). Phenolcarbonic acids discovered in the tendrils of Salix triandra L. may significantly contribute to the total pharmacological effect.

Article is devoted to basic life milestones of Professor, Doctor of Pharmacy, Honored Scientist of Russia V. G. Belikov, who made a great contribution to the development of domestic pharmaceutical education and science, more than 30 years headed the leading pharmaceutical institution of the country.