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2 results on '"Zekan, Šime"'

1. Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: a cohort analysis of time patterns, sex, and other risk factors.

Author

Perović Mihanović, Marta, Haque, Najm S, Rutherford, George W, Zekan, Šime, and Begovac, Josip

Subjects
Humans, HIV Infections, Anti-HIV Agents, Treatment Outcome, Drug Therapy, Combination, Multivariate Analysis, Risk Factors, Cohort Studies, Sex Characteristics, Time Factors, Adult, Middle Aged, Female, Male, HIV-infected patients, HIV-infection, toxicity, adverse events, virologic failure, antiretroviral therapy, Drug Therapy, Combination, Medical and Health Sciences, General Clinical Medicine
Abstract

BackgroundModifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects. We investigated the frequency of and reasons for antiretroviral drug modifications (ADM) during the first 3 years after initiation of CART, in a closed cohort of CART-naïve adult patients who started treatment in the period 1998-2007 in Croatia.Material and methodsWe calculated differential toxicity rates by the Poisson method. In multivariable analysis, we used a discrete-time regression model for repeated events for the outcome of modification due to drug toxicity.ResultsOf 321 patients who started CART, median age was 40 years, 19% were women, baseline CD4 was

Published
2013

2. Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: A cohort analysis of time patterns, sex, and other risk factors

Author

Mihanović, Marta Perović, Haque, Najm S, Rutherford, George W, Zekan, Šime, and Begovac, Josip

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, HIV/AIDS, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adult, Anti-HIV Agents, Cohort Studies, Drug Therapy, Combination, Female, HIV Infections, Humans, Male, Middle Aged, Multivariate Analysis, Risk Factors, Sex Characteristics, Time Factors, Treatment Outcome, HIV-infected patients, HIV-infection, toxicity, adverse events, virologic failure, antiretroviral therapy, Medical and Health Sciences, General Clinical Medicine, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundModifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects. We investigated the frequency of and reasons for antiretroviral drug modifications (ADM) during the first 3 years after initiation of CART, in a closed cohort of CART-naïve adult patients who started treatment in the period 1998-2007 in Croatia.Material and methodsWe calculated differential toxicity rates by the Poisson method. In multivariable analysis, we used a discrete-time regression model for repeated events for the outcome of modification due to drug toxicity.ResultsOf 321 patients who started CART, median age was 40 years, 19% were women, baseline CD4 was

Published
2013

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