1. Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
- Author
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Wang, Jun, Conti, David V, Epeldegui, Marta, Ollikainen, Miina, Tyndale, Rachel F, Hwang, Amie Eunah, Magpantay, Larry, Mack, Thomas McCulloch, Martinez-Maza, Otoniel, Kaprio, Jaakko, and Cozen, Wendy
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Hematology ,Clinical Research ,Tobacco ,Rare Diseases ,Lymphoma ,Cancer ,Prevention ,Tobacco Smoke and Health ,TARC/CCL17 ,BAFF ,MCP1 ,spg130 ,smoking ,Hodgkin lymphoma ,follicular lymphoma ,twins ,chemokines ,cytokines ,biomarkers ,Oncology and carcinogenesis - Abstract
Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (Ptrend < 0.05). The strongest association was observed for CCL17/TARC (Ptrend = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas.
- Published
- 2021