1. Prostaglandin A1 and E1 inhibit the plating efficiency and proliferation of murine melanoma cells (Cloudman S-91) in soft agar.
- Author
-
Bregman, M D, Sander, D, and Meyskens, F L, Jr
- Subjects
Agar ,Alprostadil ,Animals ,Cell Adhesion: drug effects ,Cell Division: drug effects ,Cell Line ,Cyclic AMP: metabolism ,Cyclic GMP: metabolism ,Melanocyte-Stimulating Hormones: pharmacology ,Melanoma: metabolism ,Mice ,Prostaglandins A: pharmacology ,Prostaglandins E: pharmacology ,cyclic amp ,cyclic gmp ,intermedin ,melanin ,prostaglandin a1 ,prostaglandin e1 ,prostaglandin f2 alpha ,radioisotope ,theophylline ,agar ,cyclic AMP ,cyclic GMP ,intermedin ,prostaglandin A ,prostaglandin A1 ,prostaglandin E ,prostaglandin E1 ,anchorage independent growth ,animal experiment ,cell proliferation ,drug comparison ,in vitro study ,melanoma ,mouse ,plating efficiency ,tyrosine h 3 ,animal ,article ,cell adhesion ,cell division ,cell line ,drug effect ,melanoma ,metabolism ,Agar ,Alprostadil ,Animal ,Cell Adhesion ,Cell Division ,Cell Line ,Cyclic AMP ,Cyclic GMP ,Melanoma ,Mice ,MSH ,Prostaglandins A ,Prostaglandins E ,Support ,Non-U.S. Gov't ,Support ,U.S. Gov't ,P.H.S. - Abstract
PGA1 and PGE1 reduced the plating efficiency and inhibited proliferation of Cloudman S-91 murine melanoma cells in a dose dependent manner, as assessed by their effects on colony formation in soft agar. PGF2α did not reduce plating efficiency but was as effective as PGA1 in raising cAMP and cGMP levels. This data suggests that the inhibition of Cloudman S-91 murine melanoma cell growth occurs via a non-cyclic nucleotide mechanism. © 1982.
- Published
- 1982