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Semiconductor heterojunctions are ubiquitous components of modern electronics. Their properties depend crucially on the band alignment at the interface, which may exhibit straddling gap (type-I), staggered gap (type-II) or broken gap (type-III). The distinct characteristics and applications associated with each alignment make it highly desirable to switch between them within a single material. Here we demonstrate an electrically tunable transition between type-I and type-II band alignments in MoSe2/WS2 heterobilayers by investigating their luminescence and photocurrent characteristics. In their intrinsic state, these heterobilayers exhibit a type-I band alignment, resulting in the dominant intralayer exciton luminescence from MoSe2. However, the application of a strong interlayer electric field induces a transition to a type-II band alignment, leading to pronounced interlayer exciton luminescence. Furthermore, the formation of the interlayer exciton state traps free carriers at the interface, leading to the suppression of interlayer photocurrent and highly nonlinear photocurrent-voltage characteristics. This breakthrough in electrical band alignment control, interlayer exciton manipulation, and carrier trapping heralds a new era of versatile optical and (opto)electronic devices composed of van der Waals heterostructures.

Proprioception is critical to motor control and functional status but has received limited study early after stroke. Patients admitted to an inpatient rehabilitation facility for stroke (n = 18, mean(±SD) 12.5 ± 6.6 days from stroke) and older healthy controls (n = 19) completed the Wrist Position Sense Test (WPST), a validated, quantitative measure of wrist proprioception, as well as motor and cognitive testing. Patients were serially tested when available (n = 12, mean 11 days between assessments). In controls, mean(±SD) WPST error was 9.7 ± 3.5° in the dominant wrist and 8.8 ± 3.8° in the nondominant wrist (p = 0.31). In patients with stroke, WPST error was 18.6 ± 9° in the more-affected wrist, with abnormal values present in 88.2%; and 11.5 ± 5.6° in the less-affected wrist, with abnormal values present in 72.2%. Error in the more-affected wrist was higher than in the less-affected wrist (p = 0.003) or in the dominant (p = 0.001) and nondominant (p < 0.001) wrist of controls. Age and BBT performance correlated with dominant hand WPST error in controls. WPST error in either wrist after stroke was not related to age, BBT, MoCA, or Fugl-Meyer scores. WPST error did not significantly change in retested patients. Wrist proprioception deficits are common, bilateral, and persistent in subacute stroke and not explained by cognitive or motor deficits.

X-ray radiolytic labeling uses broadband X-rays for in situ hydroxyl radical labeling to map protein interactions and conformation. High flux density beams are essential to overcome radical scavengers. However, conventional sample delivery environments, such as capillary flow, limit the use of a fully unattenuated focused broadband beam. An alternative is to use a liquid jet, and we have previously demonstrated that use of this form of sample delivery can increase labeling by tenfold at an unfocused X-ray source. Here we report the first use of a liquid jet for automated inline quantitative fluorescence dosage characterization and sample exposure at a high flux density microfocused synchrotron beamline. Our approach enables exposure times in single-digit microseconds while retaining a high level of side-chain labeling. This development significantly boosts the method's overall effectiveness and efficiency, generates high-quality data, and opens up the arena for high throughput and ultrafast time-resolved in situ hydroxyl radical labeling.

Pancreatic islet transplantation to restore insulin production in Type 1 Diabetes Mellitus patients is commonly performed by infusion of islets into the hepatic portal system. However, the risk of portal vein thrombosis or elevation of portal pressure after transplantation introduces challenges to this procedure. Thus, alternative sites have been investigated, among which the omentum represents an ideal candidate. The surgical site is easily accessible, and the tissue is highly vascularized with a large surface area for metabolic exchange. Furthermore, the ability of the omentum to host large volumes of islets represents an intriguing if not ideal site for encapsulated islet transplantation. Research on the safety and efficacy of the omentum as a transplant site focuses on the utilization of biologic scaffolds or encapsulation of islets in a biocompatible semi-permeable membrane. Currently, more clinical trials are required to better characterize the safety and efficacy of islet transplantation into the omentum.

Pancreatic islet transplantation to restore insulin production in Type 1 Diabetes Mellitus patients is commonly performed by infusion of islets into the hepatic portal system. However, the risk of portal vein thrombosis or elevation of portal pressure after transplantation introduces challenges to this procedure. Thus, alternative sites have been investigated, among which the omentum represents an ideal candidate. The surgical site is easily accessible, and the tissue is highly vascularized with a large surface area for metabolic exchange. Furthermore, the ability of the omentum to host large volumes of islets represents an intriguing if not ideal site for encapsulated islet transplantation. Research on the safety and efficacy of the omentum as a transplant site focuses on the utilization of biologic scaffolds or encapsulation of islets in a biocompatible semi-permeable membrane. Currently, more clinical trials are required to better characterize the safety and efficacy of islet transplantation into the omentum.

Tuberous Sclerosis (TS) is a genetic disorder that affects multiple organ systems and is associated with growth of non-malignant hamartomas throughout the body. The disease is highly associated with seizures, cognitive impairments, and behavioral or social deficits such as ASD or ADHD.There have been various studies examining the association between TS and intellectual and behavioral outcomes for young patients using event related potentials (ERPs) obtained on EEG. This includes the Mismatch Negativity (MMN) ERP. The measurement of these potentials is a reliable, non-invasive method to compare brain activity patterns across subjects. Following from previous study data, we want to explore specific, altered patterns of electrical activity in TS patients with ASD that are distinct from those found in TS patients without ASD.

Radiant cooling and heating systems provide an opportunity to achieve significant energy savings, peak demand reduction, load shifting, and thermal comfort improvements compared to conventional all-air systems. As a result, application of these systems has increased in recent years, particularly in zero-net-energy (ZNE) and other advanced low-energy buildings. Despite this growth, completed installations to date have demonstrated that controls and operation of radiant systems can be challenging due to a lack of familiarity within the heating, ventilation, and air-conditioning (HVAC) design and operations professions, often involving new concepts (particularly related to the slow response in high thermal mass radiant systems). To achieve the significant reductions in building energy use proposed by California Public Utilities Commission’s (CPUC’s) Energy Efficiency Strategic Plan that all new non-residential buildings be ZNE by 2030, it is critical that new technologies that will play a major role in reaching this goal be applied in an effective manner. This final report describes the results of a comprehensive multi-faceted research project that was undertaken to address these needed enhancements to radiant technology by developing the following: (1) sizing and operation tools (currently unavailable on the market) to provide reliable methods to take full advantage of the radiant systems to provide improved energy performance while maintaining comfortable conditions, (2) energy, cost, and occupant comfort data to provide real world examples of energy efficient, affordable, and comfortable buildings using radiant systems, and (3) Title-24 and ASHRAE Standards advancements to enhance the building industry’s ability to achieve significant energy efficiency goals in California with radiant systems. The research team used a combination of full-scale fundamental laboratory experiments, whole-building energy simulations and simplified tool development, and detailed field studies and control demonstrations to assemble the new information, guidance and tools necessary to help the building industry achieve significant energy efficiency goals for radiant systems in California.

Radiant cooling and heating have the potential for improved energy efficiency, demand response, comfort, indoor environmental quality, and architectural design. Many radiant buildings have demonstrated outstanding performance in these regards. However, there are no well-established best practices for design of radiant buildings and their control systems, and most industry professionals are unfamiliar with radiant systems. This study summarizes interviews with eleven professionals with substantial experience with design and operation of radiant buildings in North America. Interviews focused specifically on high thermal mass radiant buildings, referred to as thermally active building systems (TABS). Interviews revealed a diverse range of approaches for design and control of TABS buildings. While interviewees expressed many similar approaches, they also have manyunique preferences. Examples of consistent themes include the use of dedicated outdoor air systems for ventilation and for supplemental cooling, and the use of a relatively simple control schemes that target a constant slab temperature for all times of the day and night. However, interviewees described unique preferences for space types where TABS should be applied, design and types of valves or pumps used for radiant zone control, the control of changeover between slab heating to slab cooling, and many other design considerations. Preferences appear to be driven by project constraints and by personal experience. Interviewees report that their design preferences are effective, but there is no industry consensus about how alternatives compare for energy performance. This paper outlines opportunities for further research, improvement radiant design and control, and the development of best practices.

BackgroundImmunomodulatory therapies, including CTLA-4 and PD-1 inhibitors, provide a directed attack against cancer cells by preventing T cell deactivation. However, these drugs also prevent the downregulation of auto-reactive T cells, resulting in immune-related adverse events (IRAEs). Reports show a varied incidence of endocrine IRAEs, ranging from 0% to 63%.ObjectiveTo describe the frequency and clinical characteristics of endocrine IRAEs in patients taking cancer immunomodulatory therapies.DesignRetrospective cohort study.PatientsA total of 388 patients aged ≥18 years who were prescribed ipilimumab, nivolumab and/or pembrolizumab between 2009 and 2016 at our institution.MeasurementsBiochemical criteria were used to define endocrine IRAEs, including thyroid, pituitary, pancreas and adrenal dysfunction, following use of immunomodulatory therapies.ResultsFifty endocrine IRAEs occurred in our cohort, corresponding to a rate of 12.9%. The most common endocrine IRAEs were thyroid dysfunction (11.1%), with a lower incidence of pituitary dysfunction (1.8% of patients).ConclusionsOver 12% of patients receiving ipilimumab, nivolumab and/or pembrolizumab in our study sample developed an endocrine IRAE. Patients who undergo treatment with immunomodulatory therapies should be monitored for the development of endocrine IRAEs.

Radiant cooling and heating has the potential for improved energy efficiency, demand response, comfort, indoor environmental quality, and architectural design. Many radiant buildings have demonstrated outstanding performance in these regards, and application of the technology in commercial buildings is expanding. However, there are no well-established best practices for design of radiant buildings and their control systems, and most professionals in the building industry are unfamiliar with radiant systems.In this study, TRC Energy Services and the UC Berkeley Center for the Built Environment interviewed eleven prominent professionals who have substantial experience with design, construction, and operation of radiant buildings in North America, having collectively designed more than 330 radiant cooled buildings. The objective of the study was to document the variety of design and control approaches currently used for radiant cooled buildings, highlight themes of common practice and variations in common practice, and identify areas where research could be of service to practitioner needs.

Osteochondroma is a benign cartilaginous neoplasm and the most common benign tumor of bone. Osteochondromas occur primarily in the axial skeleton with a predilection for the distal femur, and relatively few cases occur in the head and neck region. The majority of cases of osteochondromas in the head and neck region affect the mandibular condyle, with fewer cases reported in the skull base and the neck. To our knowledge, there is no reported case of osteochondroma of the hyoid bone documented in the English literature. We thus report the first case of a hyoid bone osteochondroma, presenting as an asymptomatic mass in a young woman.

Each year, droughts cause significant economic and agricultural losses across the world. The early warning and onset detection of drought is of particular importance for effective agriculture and water resource management. Previous studies show that the Standard Precipitation Index (SPI), a measure of precipitation deficit, detects drought onset earlier than other indicators. Here we show that satellite-based near surface air relative humidity data can further improve drought onset detection and early warning. This paper introduces the Standardized Relative Humidity Index (SRHI) based on the NASA Atmospheric Infrared Sounder (AIRS) observations. The results indicate that the SRHI typically detects the drought onset earlier than the SPI. While the AIRS mission was not originally designed for drought monitoring, we show that its relative humidity data offers a new and unique avenue for drought monitoring and early warning. We conclude that the early warning aspects of SRHI may have merit for integration into current drought monitoring systems.

Each year, droughts cause significant economic and agricultural losses across the world. The early warning and onset detection of drought is of particular importance for effective agriculture and water resource management. Previous studies show that the Standard Precipitation Index (SPI), a measure of precipitation deficit, detects drought onset earlier than other indicators. Here we show that satellite-based near surface air relative humidity data can further improve drought onset detection and early warning. This paper introduces the Standardized Relative Humidity Index (SRHI) based on the NASA Atmospheric Infrared Sounder (AIRS) observations. The results indicate that the SRHI typically detects the drought onset earlier than the SPI. While the AIRS mission was not originally designed for drought monitoring, we show that its relative humidity data offers a new and unique avenue for drought monitoring and early warning. We conclude that the early warning aspects of SRHI may have merit for integration into current drought monitoring systems.