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1. A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

Author

Kogan, Scott, Bagley, BN, Keane, TM, Maklakova, VI, Marshall, JG, Lester, RA, Cancel, MM, Paulsen, AR, Bendzick, LE, and Been, RA

Abstract

Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous fo

Published
2012

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