1. Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines
- Author
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Tate, David F, Dennis, Emily L, Adams, John T, Adamson, Maheen M, Belanger, Heather G, Bigler, Erin D, Bouchard, Heather C, Clark, Alexandra L, Delano-Wood, Lisa M, Disner, Seth G, Eapen, Blessen C, Franz, Carol E, Geuze, Elbert, Goodrich-Hunsaker, Naomi J, Han, Kihwan, Hayes, Jasmeet P, Hinds, Sidney R, Hodges, Cooper B, Hovenden, Elizabeth S, Irimia, Andrei, Kenney, Kimbra, Koerte, Inga K, Kremen, William S, Levin, Harvey S, Lindsey, Hannah M, Morey, Rajendra A, Newsome, Mary R, Ollinger, John, Pugh, Mary Jo, Scheibel, Randall S, Shenton, Martha E, Sullivan, Danielle R, Taylor, Brian A, Troyanskaya, Maya, Velez, Carmen, Wade, Benjamin SC, Wang, Xin, Ware, Ashley L, Zafonte, Ross, Thompson, Paul M, and Wilde, Elisabeth A
- Subjects
Allied Health and Rehabilitation Science ,Health Sciences ,Neurosciences ,Traumatic Brain Injury (TBI) ,Brain Disorders ,Biomedical Imaging ,Traumatic Head and Spine Injury ,Physical Injury - Accidents and Adverse Effects ,4.2 Evaluation of markers and technologies ,Mental health ,Neurological ,Brain Injuries ,Traumatic ,Humans ,Magnetic Resonance Imaging ,Military Personnel ,Stress Disorders ,Post-Traumatic ,Veterans ,Biological Psychology ,Clinical and Health Psychology ,Psychology ,Applied and Developmental Psychology ,Aging ,Rehabilitation ,Clinical Research ,Behavioral and Social Science ,Activities of Daily Living ,Aged ,Aged ,80 and over ,Executive Function ,Female ,Independent Living ,Male ,Middle Aged ,Neuropsychological Tests ,ROC Curve ,Regression Analysis ,Reproducibility of Results ,TBI ,traumatic brain injury ,military ,veteran ,blast injury ,ENIGMA ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology ,Biomedical and clinical sciences ,Health sciences - Abstract
Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal, diffuse or combination of injury to the brain. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in this patient population. The purpose of this manuscript is to describe both the challenges and opportunities when conducting military-relevant TBI research and introduce the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Military Brain Injury working group. ENIGMA is a worldwide consortium focused on improving replicability and analytical power through data sharing and collaboration. In this paper, we discuss challenges affecting efforts to aggregate data in this patient group. In addition, we highlight how "big data" approaches might be used to understand better the role that each of these variables might play in the imaging and functional phenotypes of TBI in Service member and Veteran populations, and how data may be used to examine important military specific issues such as return to duty, the late effects of combat-related injury, and alteration of the natural aging processes.
- Published
- 2021