1. Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial
- Author
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Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Mankara, Alio K, Harouna, Abdoul N, Cook, Catherine, Hinterwirth, Armin, Worden, Lee, Zhong, Lina, Chen, Cindi, Ruder, Kevin, Zhou, Zhaoxia, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Le, Victoria, Arnold, Benjamin F, Porco, Travis, Keenan, Jeremy D, Lietman, Thomas M, and Doan, Thuy
- Subjects
Clinical Trials and Supportive Activities ,Pediatric ,Antimicrobial Resistance ,Clinical Research ,Anti-Bacterial Agents ,Azithromycin ,Child ,Preschool ,Drug Resistance ,Bacterial ,Humans ,Macrolides ,Mass Drug Administration ,azithromycin ,antibiotic resistance ,gut resistome ,mass drug distribution ,Niger ,preschool children ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.Clinical trials registrationNCT02047981.
- Published
- 2021