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1. Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Author

Renslo, Adam, Arkin, Michelle, Heise, CE, Murray, J, Augustyn, KE, Bravo, B, Chugha, P, Cohen, F, Giannetti, AM, Gibbons, P, Hannoush, RN, and Hearn, BR

Abstract

Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 tha

Published
2012

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