1. Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes.
- Author
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Kanapka, Lauren, Wadwa, R, Breton, Marc, Ruedy, Katrina, Ekhlaspour, Laya, Forlenza, Gregory, Cengiz, Eda, Schoelwer, Melissa, Jost, Emily, Carria, Lori, Emory, Emma, Hsu, Liana, Weinzimer, Stuart, DeBoer, Mark, Buckingham, Bruce, Oliveri, Mary, Kollman, Craig, Dokken, Betsy, Cherñavvsky, Daniel, and Beck, Roy
- Subjects
Adolescent ,Blood Glucose ,Child ,Diabetes Mellitus ,Type 1 ,Humans ,Hypoglycemia ,Hypoglycemic Agents ,Insulin ,Insulin Infusion Systems - Abstract
OBJECTIVE: To further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes. RESEARCH DESIGN AND METHODS: After a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented pump (SAP) therapy in 101 children 6-13 years old with type 1 diabetes, 22 participants in the SAP group initiated use of the CLC system (referred to as SAP-CLC cohort), and 78 participants in the CLC group continued use of CLC (CLC-CLC cohort) for 12 weeks. RESULTS: In the SAP-CLC cohort, mean percentage of time in range 70-180 mg/dL (TIR) increased from 55 ± 13% using SAP during the RCT to 65 ± 10% using CLC (P < 0.001), with 36% of the cohort achieving TIR >70% plus time
- Published
- 2021