5 results on '"Eggleston, Barry"'
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2. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.
- Author
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Blakely, Martin L, Tyson, Jon E, Lally, Kevin P, Hintz, Susan R, Eggleston, Barry, Stevenson, David K, Besner, Gail E, Das, Abhik, Ohls, Robin K, Truog, William E, Nelin, Leif D, Poindexter, Brenda B, Pedroza, Claudia, Walsh, Michele C, Stoll, Barbara J, Geller, Rachel, Kennedy, Kathleen A, Dimmitt, Reed A, Carlo, Waldemar A, Cotten, C Michael, Laptook, Abbot R, Van Meurs, Krisa P, Calkins, Kara L, Sokol, Gregory M, Sanchez, Pablo J, Wyckoff, Myra H, Patel, Ravi M, Frantz, Ivan D, Shankaran, Seetha, D'Angio, Carl T, Yoder, Bradley A, Bell, Edward F, Watterberg, Kristi L, Martin, Colin A, Harmon, Carroll M, Rice, Henry, Kurkchubasche, Arlet G, Sylvester, Karl, Dunn, James CY, Markel, Troy A, Diesen, Diana L, Bhatia, Amina M, Flake, Alan, Chwals, Walter J, Brown, Rebeccah, Bass, Kathryn D, St Peter, Shawn D, Shanti, Christina M, Pegoli, Walter, Skarda, David, Shilyansky, Joel, Lemon, David G, Mosquera, Ricardo A, Peralta-Carcelen, Myriam, Goldstein, Ricki F, Vohr, Betty R, Purdy, Isabell B, Hines, Abbey C, Maitre, Nathalie L, Heyne, Roy J, DeMauro, Sara B, McGowan, Elisabeth C, Yolton, Kimberly, Kilbride, Howard W, Natarajan, Girija, Yost, Kelley, Winter, Sarah, Colaizy, Tarah T, Laughon, Matthew M, Lakshminrusimha, Satyanarayana, and Higgins, Rosemary D
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Perinatal Period - Conditions Originating in Perinatal Period ,Clinical Research ,Infant Mortality ,Rare Diseases ,Digestive Diseases ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,Drainage ,Enterocolitis ,Necrotizing ,Feasibility Studies ,Female ,Humans ,Infant ,Extremely Low Birth Weight ,Infant ,Newborn ,Infant ,Premature ,Infant ,Premature ,Diseases ,Intestinal Perforation ,Laparotomy ,Male ,Neurodevelopmental Disorders ,Survival Rate ,Treatment Outcome ,isolated intestinal perforation ,neonatal surgery ,premature infant ,randomized clinical trial ,surgical necrotizing enterocolitis ,Eunice Kennedy Shriver National Institute of Child Health ,Human Development Neonatal Research Network ,Medical and Health Sciences ,Surgery - Abstract
ObjectiveThe aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP).Summary background dataThe impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown.MethodsWe conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of death or NDI at 18 to 22 months corrected age, analyzed using prespecified frequentist and Bayesian approaches.ResultsOf 992 eligible infants, 310 were randomized and 96% had primary outcome assessed. Death or NDI occurred in 69% of infants in the laparotomy group versus 70% with drainage [adjusted relative risk (aRR) 1.0; 95% confidence interval (CI): 0.87-1.14]. A preplanned analysis identified an interaction between preoperative diagnosis and treatment group (P = 0.03). With a preoperative diagnosis of NEC, death or NDI occurred in 69% after laparotomy versus 85% with drainage (aRR 0.81; 95% CI: 0.64-1.04). The Bayesian posterior probability that laparotomy was beneficial (risk difference
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- 2021
3. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants
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Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S, DeMauro, Sara B, Van Meurs, Krisa P, Foglia, Elizabeth E, Lakshminrusimha, Satyan, Walsh, Michele C, Watterberg, Kristi L, Wyckoff, Myra H, Das, Abhik, Handley, Sara C, Network, Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Laptook, R, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, St. Pierre, Lucille, Hibbs, Anna Maria, Truog, William E, Pallotto, Eugenia K, Parimi, Prabhu S, Gauldin, Cheri, Holmes, Anne, Knutson, Allison, Gaetano, Lisa, Poindexter, Brenda B, Schibler, Kurt, Merhar, Stephanie L, Grisby, Cathy, Kirker, Kristin, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D, Rhodes-Ryan, Ginger, White, Donna, Carlton, David P, Patel, Ravi M, Loggins, Yvonne, Mackie, Colleen, Bottcher, Diane I, Bremer, Andrew A, Higgins, Rosemary D, Archer, Stephanie Wilson, Sokol, Gregory M, Herron, Dianne E, Tyson, Jon E, Khan, Amir M, Kennedy, Kathleen A, Pedrozza, Claudia, Eason, Elizabeth, Stephens, Emily K, McDavid, Georgia E, Martin, Karen, Hall, Donna, Wright, Sharon L, Sánchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Clark, Erna, Gutentag, Julie, Park, Courtney, Shadd, Julie C, Stein, Melanie, Baugher, Hallie, McCool, Jacqueline, Gantz, Marie G, Bann, Carla M, Wallace, Dennis, Zaterka-Baxter, Kristin M, Gabrio, Jenna, Leblond, David, Auman, Jeanette O'Donnell, Stevenson, David K, Chock, Valerie Y, Ball, M Bethany, Proud, Melinda S, Reichert, Elizabeth N, Williams, R Jordan, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, McNair, Tara, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F, Colaizy, Tarah T, and Ellsbury, Dan L
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Paediatrics ,Biomedical and Clinical Sciences ,Prevention ,Preterm ,Low Birth Weight and Health of the Newborn ,Infant Mortality ,Clinical Research ,Neurosciences ,Cardiovascular ,Clinical Trials and Supportive Activities ,Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Reproductive health and childbirth ,Good Health and Well Being ,Cerebral Intraventricular Hemorrhage ,Constriction ,Female ,Gestational Age ,Hospital Mortality ,Humans ,Infant ,Extremely Premature ,Infant ,Newborn ,Male ,Retrospective Studies ,Umbilical Cord ,Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network ,Neonatal Research Network ,intraventricular hemorrhage ,placental transfusion ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics - Abstract
ObjectiveTo compare in-hospital outcomes after umbilical cord milking vs delayed cord clamping among infants
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- 2021
4. Placental transfusion and short-term outcomes among extremely preterm infants
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Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S, Van Meurs, Krisa P, DeMauro, Sara Bonamo, Foglia, Elizabeth E, Lakshminrusimha, Satyanarayan, Walsh, Michele C, Watterberg, Kristi L, Wyckoff, Myra H, Das, Abhik, and Handley, Sara C
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Paediatrics ,Biomedical and Clinical Sciences ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Clinical Trials and Supportive Activities ,Infant Mortality ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,Reproductive health and childbirth ,Good Health and Well Being ,Blood Transfusion ,Cerebral Intraventricular Hemorrhage ,Constriction ,Female ,Humans ,Hypotension ,Infant ,Infant ,Extremely Premature ,Infant ,Newborn ,Placenta ,Pregnancy ,Retrospective Studies ,Socioeconomic Factors ,Time Factors ,Umbilical Cord ,Generic Database Subcommittee of the NICHD Neonatal Research Network ,undefined ,epidemiology ,mortality ,neonatology ,outcomes research ,procedures ,Paediatrics and Reproductive Medicine ,Pediatrics - Abstract
ObjectiveTo compare short-term outcomes after placental transfusion (delayed cord clamping (DCC) or umbilical cord milking (UCM)) versus immediate cord clamping among extremely preterm infants.DesignRetrospective study.SettingThe Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network registry.PatientsInfants born
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- 2021
5. Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma
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Sullivan, Keith M, Goldmuntz, Ellen A, Keyes-Elstein, Lynette, McSweeney, Peter A, Pinckney, Ashley, Welch, Beverly, Mayes, Maureen D, Nash, Richard A, Crofford, Leslie J, Eggleston, Barry, Castina, Sharon, Griffith, Linda M, Goldstein, Julia S, Wallace, Dennis, Craciunescu, Oana, Khanna, Dinesh, Folz, Rodney J, Goldin, Jonathan, St Clair, E William, Seibold, James R, Phillips, Kristine, Mineishi, Shin, Simms, Robert W, Ballen, Karen, Wener, Mark H, Georges, George E, Heimfeld, Shelly, Hosing, Chitra, Forman, Stephen, Kafaja, Suzanne, Silver, Richard M, Griffing, Leroy, Storek, Jan, LeClercq, Sharon, Brasington, Richard, Csuka, Mary E, Bredeson, Christopher, Keever-Taylor, Carolyn, Domsic, Robyn T, Kahaleh, M Bashar, Medsger, Thomas, and Furst, Daniel E
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Autoimmune Disease ,Transplantation ,Stem Cell Research - Nonembryonic - Human ,Scleroderma ,Clinical Trials and Supportive Activities ,Clinical Research ,Stem Cell Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Inflammatory and immune system ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Cyclophosphamide ,Disease-Free Survival ,Female ,Follow-Up Studies ,Hematopoietic Stem Cell Transplantation ,Humans ,Immunosuppressive Agents ,Infections ,Intention to Treat Analysis ,Kaplan-Meier Estimate ,Male ,Middle Aged ,Scleroderma ,Systemic ,Transplantation Conditioning ,Transplantation ,Autologous ,Young Adult ,SCOT Study Investigators ,Medical and Health Sciences ,General & Internal Medicine - Abstract
BackgroundDespite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patients with scleroderma.MethodsWe randomly assigned adults (18 to 69 years of age) with severe scleroderma to undergo myeloablative autologous stem-cell transplantation (36 participants) or to receive cyclophosphamide (39 participants). The primary end point was a global rank composite score comparing participants with each other on the basis of a hierarchy of disease features assessed at 54 months: death, event-free survival (survival without respiratory, renal, or cardiac failure), forced vital capacity, the score on the Disability Index of the Health Assessment Questionnaire, and the modified Rodnan skin score.ResultsIn the intention-to-treat population, global rank composite scores at 54 months showed the superiority of transplantation (67% of 1404 pairwise comparisons favored transplantation and 33% favored cyclophosphamide, P=0.01). In the per-protocol population (participants who received a transplant or completed ≥9 doses of cyclophosphamide), the rate of event-free survival at 54 months was 79% in the transplantation group and 50% in the cyclophosphamide group (P=0.02). At 72 months, Kaplan-Meier estimates of event-free survival (74% vs. 47%) and overall survival (86% vs. 51%) also favored transplantation (P=0.03 and 0.02, respectively). A total of 9% of the participants in the transplantation group had initiated disease-modifying antirheumatic drugs (DMARDs) by 54 months, as compared with 44% of those in the cyclophosphamide group (P=0.001). Treatment-related mortality in the transplantation group was 3% at 54 months and 6% at 72 months, as compared with 0% in the cyclophosphamide group.ConclusionsMyeloablative autologous hematopoietic stem-cell transplantation achieved long-term benefits in patients with scleroderma, including improved event-free and overall survival, at a cost of increased expected toxicity. Rates of treatment-related death and post-transplantation use of DMARDs were lower than those in previous reports of nonmyeloablative transplantation. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health; ClinicalTrials.gov number, NCT00114530 .).
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- 2018
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