1. A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score
- Author
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da Hora Passos, Rogério, Ramos, João Gabriel Rosa, Mendonça, Evandro Jose Bulhoes, Miranda, Eva Alves, Dutra, Fábio Ricardo Dantas, Coelho, Maria Fernanda R, Pedroza, Andrea C, Correia, Luis Claudio L, Batista, Paulo Benigno Pena, Macedo, Etienne, and Dutra, Margarida MD
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Liver Disease ,Kidney Disease ,Digestive Diseases ,Sepsis ,Hematology ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Female ,Humans ,Male ,Prospective Studies ,Renal Replacement Therapy ,Risk Factors ,Severity of Illness Index ,Septic acute kidney injury ,Risk score ,7-day mortality ,Hemodiafiltration ,Medical Physiology ,Anesthesiology ,Clinical sciences - Abstract
BackgroundThis study aimed to identify predictors of early (7-day) mortality in patients with septic acute kidney injury (AKI) who required continuous renal replacement therapy (CRRT).MethodsProspective cohort of 186 septic AKI patients undergoing CRRT at a tertiary hospital, from October 2005 to November 2010.ResultsAfter multivariate adjustment, five variables were associated to early mortality: norepinephrine utilization, liver failure, medical condition, lactate level, and pre-dialysis creatinine level. These variables were combined in a score, which demonstrated good discrimination, with a C-statistic of 0.82 (95% CI = 0.76-0.88), and good calibration (χ 2 = 4.3; p = 0.83). SAPS 3, APACHE II and SOFA scores demonstrated poor performance in this population.ConclusionsThe HEpatic failure, LactatE, NorepInephrine, medical Condition, and Creatinine (HELENICC) score outperformed tested generic models. Future studies should further validate this score in different cohorts.
- Published
- 2017