1. The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study
- Author
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Shea, MK, Kritchevsky, SB, Hsu, F-C, Nevitt, M, Booth, SL, Kwoh, CK, McAlindon, TE, Vermeer, C, Drummen, N, Harris, TB, Womack, C, Loeser, RF, and Study, Health ABC
- Subjects
Aging ,Arthritis ,Nutrition ,Pain Research ,Osteoarthritis ,Chronic Pain ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Musculoskeletal ,Aged ,Calcium-Binding Proteins ,Cartilage ,Articular ,Cohort Studies ,Cross-Sectional Studies ,Decarboxylation ,Disease Progression ,Extracellular Matrix Proteins ,Female ,Humans ,Incidence ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Menisci ,Tibial ,Odds Ratio ,Osteoarthritis ,Knee ,Osteophyte ,Phosphorylation ,Vitamin K 1 ,Vitamin K Deficiency ,Phylloquinone ,Vitamin K ,Matrix gla protein ,Epidemiology ,Health ABC Study ,Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Abstract
BackgroundVitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.ObjectiveTo clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).MethodsPlasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ± SD age = 74 ± 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.ResultsLongitudinally, participants with very low plasma PK (
- Published
- 2015