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Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter. - Provides the authority of a team of outstanding scientists in the field - Presents a comprehensive, up-to-date resource, covering both basic and translational aspects of cell biology - Offers high quality content at a competitive market price

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions'role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells.The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks'output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms'development.

This third edition of Epstein's Inborn Errors of Development provides essays on pathways of development and thoughtful reviews of dysmorphic syndromes for which the causative gene has been identified. The authors of the chapters on each disorder have provided in depth analyses of the role of the gene in the relevant developmental pathway and the mechanism by which mutations in the gene cause the developmental pathology.

The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. - Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience - Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more - In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading - A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

The present book provides a state-of-the-art overview of the adrenal gland pathophysiology. It covers both up-to-date basic and clinical notions on adrenal glands. Amidst the molecular aspects, discussed by leading scientists in the field, there are ER stress, microRNA, hormone biosynthesis, and interactions with other organs. Clinical insights for students and physicians are also provided, from the imaging to the therapeutic management of common disorders of the gland, including adrenal failure, hyperaldosteronism, Cushing's syndrome, neurologic disease, and cancer both in adults and pediatric patients. As mentioned above, chapter contributions are made by worldwide renowned experts, scientists and physicians, working in prestigious hospitals and universities including Brown, Oxford, Case Western Reserve University, Cleveland Clinic, Chinese University of Honk Kong, University of Tennessee, Indiana University School of Medicine, Monash Health in Clayton, Australia, University of Calgary, Northern Ontario School of Medicine and Laurentian University, Medical University of Gdańsk, Université Pierre et Marie Curie in Paris, France, University of Minho, Braga, Portugal, St. Vincent's University Hospital in Dublin, Universities of Londrina, Alfenas, Sao Paulo, and Rio de Janeiro, Brazil. Throughout these chapters, the authors spotlight future avenues for research in basic pathophysiology and in therapy/prevention, in addition to thorough overviews of the current literature pertaining to the adrenal gland and its functional roles. The book also includes several color photographs, schemes and diagrams of molecular relationships, and tables that support and complement the text. The comprehensive and systematic overview provided within this book is expected to assist the reader in comprehending the importance of taking into account the functional roles of the adrenal gland and also to address questions and unresolved issues regarding the treatment of its disorders. Finally, the editor would like to express his sincere appreciation to all the contributors for their dedicated collaboration in this project. He would also like to thank Ms. Carra Feagaiga for her patient support. He sincerely hopes this book will enable readers to connect basic research principles with up-to-date clinical knowledge, thereby encouraging future discoveries and developments of new therapeutic strategies to treat disorders of the adrenal gland.

Cellular domains play vital roles in a wide range of cellular functions. Defining cellular domains and understanding the molecular basis of their formation is essential to the study of cell functionality. This authoritative reference provides the most comprehensive analysis available on cellular domains, with emphasis on the definition and molecular composition of the domain as well as the functional implications of domain organization.

This is the companion volume to Daniel Klionsky's Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi. Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article,'Autophagy: from phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors that will publish in Autophagy.Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal'house-cleaning in the cell is called autophagy – literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 in yeast. These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth. - Establishes the functional roles of specific cellular proteins in selective and nonselective autophagy in mammalian cells, which aides researchers in determining why autophagy is shut down in neoplastia (growth of abnormal tissue mass) and turned on during bacterial invasion - Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture, which helps researchers design clinical approaches that can turn on autophagy and halt tumor growth - Covers higher eukaryotes including lifespan in C.elegans to marine organisms and bridging into the clinical aspects, including autophagy in chronic myelogenous leukemia (CML is one of four types of leukemia), lung cancer, prostate cancer, and cardiac cells

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.