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Dissemination of knowledge is the best and only strategy capable of improving clinical management in rare and ultra-rare malignancies, including primary adrenal malignancies. It is preliminary to any further healthcare policy such as, for example, the centralization of cases in referral institutions. Adrenal primary malignancies are probably the rarest among rare pathologies. This epidemiological consideration is at the origin of a vicious circle: the lack of preoperative diagnosis leads to inappropriate surgical procedures and to inadequate follow-up and systemic therapy strategies. Furthermore, when malignancy is recognized, the relative role of systemic, surgical, or other local ablative techniques is often misinterpreted. All this produces a negative impact on survival, also in patients who could have been cured with a correct therapeutic strategy. This open access book provides a user-friendly exploration of these rare conditions, using a transversal approach common in modern precision medicine. The text covers various clinical aspects, including epidemiology, genetics, molecular medicine, imaging, and surgery. Guidelines for managing syndromic situations are provided. The book thoroughly addresses all the different surgical issues and emphasizes the importance of pathology in assessing prognosis. The pivotal role of medical oncologists in managing these patients is explored, along with alternative treatments such as nuclear medicine and radiotherapy. Finally, the book highlights the latest preclinical research and its implications for translational medicine.

This book discusses the most recent evidence-based approach to hematological diagnosis and management in ICU. It elaborates on the hematological problems in critical care setup, from hematological malignancies to post-operative management of bone marrow transplants. The book also covers the interpretation of laboratory abnormalities, administration of various chemotherapeutic agents, and critical care management of various primary and secondary hematological issues. It explains how to handle different complications in the intensive care unit. Various coagulation tests and their interpretations, particularly point-of-care tests such as thromboelastography and ROTEM are also focused on. Critical Care Hematology will benefit practitioners and trainees in hematology and critical care medicine. The book's comprehensive coverage will provide readers with a holistic view of the appropriate approaches to hematology in the ICU. Also, the chapters provide a systematic approach to diagnosing and flowcharts to assist medical practitioners in making timely decisions amid their hectic duties.

This book delves into the various aspects of the renin-angiotensin-aldosterone system (RAAS) and its role in cardiovascular disorders. It explores the use of anti-hypertensive agents, with a focus on (ACE) angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs). The chapters cover topics such as the preferred use of ACE inhibitors over ARBs in high-risk patients, the impact of these agents on insulin resistance, their role in acute heart failure and peripheral artery disease, and their immunomodulatory activity in hypertensive patients. Additionally, the book examines the role of ACE inhibitors and ARBs in COVID-19 patients and provides insights into recent trends in managing hypertension through RAAS inhibition. It serves as a valuable resource for researchers, clinicians, and healthcare professionals involved in the field of cardiovascular medicine.

O livro Regulação da Temperatura Corporal: Exercício Físico, Desempenho e Saúde aborda um tema central e atual no campo da fisiologia e da prescrição de exercícios físicos. Esta é a primeira obra no Brasil dedicada inteiramente ao estudo de como o corpo humano responde durante a prática de exercícios físicos em diferentes ambientes térmicos, principalmente nos ambientes quentes. Este tema é de extrema importância no cenário atual de aquecimento global, em que as pessoas irão conviver e se exercitar em ambientes cada vez mais quentes. Assim, este livro se propõe a ser uma obra de consulta fundamental aos professores, estudantes e profissionais envolvidos com as ciências do esporte, atletas de rendimentos e amadores, bem como ao público praticante de atividades físicas em geral. Além disso, temas importantes como os efeitos do treinamento aeróbio e de força, hidratação, crianças, envelhecimento, deficiências, hipertensão arterial, diabetes, obesidade, avaliação do estresse térmico ambiental, fadiga durante o exercício físico, cronobiologia, termografia, inflamação sistêmica, efeitos termogênicos dos alimentos, dentre outros, são abordados. O leitor encontrará também uma profunda revisão das bases termorregulatórias. Cabe ressaltar que todo o conteúdo do livro foi pensado numa linguagem clara e de fácil entendimento.

This insightful book explores the impact of internet-based technologies on second language acquisition, focusing on informal learning. It traces the evolution of informal learning, emphasizing the crucial role of input, interaction, and output in acquiring English as a second language. The book analyzes diverse out-of-school practices, such as watching TV, gaming, and social media engagement, and their impact on L2 development. Additionally, it delves into various intervening variables—age, gender, proficiency, engagement, and affective variables—highlighting the personalized nature of L2 acquisition. It also addresses the challenges encountered by L2 teachers, advocating innovative teaching methods to bridge the gap between classroom teaching and the real world. This book is an invaluable resource for enthusiasts interested in the intersection of language acquisition, teaching methodologies, and modern technologies.

Medical Ethics: Accounts of Ground-Breaking Cases provides an in-depth study of Bioethics through the fascinating lens of the cases that have changed the rules. Authored by a pioneer in the field, the critically-important and thought-provoking content is organized clearly, providing a framework for students'own self-reflection and critical analysis. It includes discussions of famous cases, guiding students through detailed consideration of the issues raised. Pence integrates descriptions of the cases and their issues with historical overviews, following cases over decades to tell readers what did, and often what did not, happen. Medical Ethics'single, engaging authorial voice guides students through this exciting, complex, and ever-expanding field.

In the articles included in this collection, Professor Daniel argues that Abbot Joachim of Fiore was a disciple of Bernard of Clairvaux whose tertius status was reformist, not millenialist. Like the other reformists, Gerhoch of Reichersberg and Hildegard of Bingen, Joachim looked forward to the coming of a thoroughly reformed, holy church to be achieved in the near future by reform of the episcopate and the clergy. The status of the Holy Spirit was the culmination of the preceding status, not a radically new beginning. Apocalypticism in both its reformist and in its imperialist versions was part of the mainstream, despite the efforts of the schoolmen to suppress it. The author also sheds significant new light on apocalyptic thinking in the mid-fourteenth century with a thorough analysis of Henry of Kirkstede's vade mecum, Cambridge Corpus Christi 404 and his first edition of Henry's De antichristo et de fine mundi. This study, and three others, are published here for the first time.

As the first text to present, in one place, a comprehensive and systematic overview of Spanish language acquisition research, The Acquisition of Spanish: A Research Overview in Multilingual Learning Contexts discusses a range of theoretical perspectives that outline issues surrounding language learning and the gaps in its research and teaching. Drawing on classic and current empirical studies on learner cohorts at different proficiency stages all over the world, the authors aim to bring bi-/multilingualism to the forefront to provide readers with a deeper conceptual understanding of the challenges faced by different groups of Spanish learners in various learning contexts.Eve Zyzik and Melissa A. Bowles expertly synthesize and analyze a range of linguistic features and factors that affect learning, connecting these insights from Spanish to key theoretical and applied questions in SLA research more broadly. The text concludes with observations about research methodology, indicating the gaps in the literature and setting an agenda for future work in Spanish second language acquisition (SLA) to move the field forward.This unique, cohesive volume will be an invaluable foundational resource to advanced students and researchers in SLA, bilingualism/multilingualism, Hispanic and Romance studies, applied linguistics, education, and related areas, who are interested in LOTEs (languages other than English) and Spanish SLA in particular. It will also be useful to those studying to become Spanish second language educators.

O presente Tratado de Coloproctologia, Segunda Edição, reúne a grande experiência de mais de 300 membros da Sociedade Brasileira de Coloproctologia (SBCP) e de alguns colaborado_x0002_res internacionais de renome, atualizando os temas mais importantes desta especialidade. Honrando o passado de uma obra ganhadora do Prêmio Jabuti no Brasil, esta nova edição será importante fonte de estudo e atualização, indispensável tanto para jovens quanto para experientes especialistas em coloproctologia, cirurgia geral e aparelho digestivo.

Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.

This book covers contemporary essays by opinion leaders on crucial topics in dermatology that are not readily available in other textbooks and journals. The essays are written in an unconventional style compared to other textbook styles. Each chapter is authored by a globally renowned expert in that field.The book focuses on artificial intelligence in dermatology, placebo and nocebo in dermatology, mind and skin diseases, unconventional/holistic views on skin aging, evidence-informed dermatology, procedural dermatology, investigative dermatology, lasers and light sources in dermatology, skin in rheumatologic diseases, immunology of the skin, live imaging techniques in dermatology, and so on. The book will help specialists look at the subject from an entirely different perspective and understand how dermatology is evolving in the 21st century. A wide range of dermatology topics is covered, providing a snapshot of contemporary dermatology and the dermatology of the future. It promises to be a delightful journey from basic science to translational science to clinical science. This book will be Intellectually stimulating for dermatology trainees, practitioners, and academicians.

This book provides the reader with the latest research on vibrational circular dichroism (VCD) spectroscopy including its useful features and applications to many fields. The book starts from an unresolved question in gel chemistry of how component molecules are organized in the flexible fibrils of gels. VCD spectroscopy was successful in giving a clear answer to this mystery. The book also describes a key aspect of this technique lay in the fact that VCD signals were remarkably enhanced when chiral molecules formed a stereoregular molecular array over a few hundred nanometers. VCD spectroscopy was also applied to other topics involving chiral molecules such as the chiral discrimination mechanism in heterogeneous asymmetric catalysis and the build-up of supramolecular chirality in molecular crystals. Furthermore, the book covers the recent instrument developments leading to multi-dimensional VCD measurements with the coordinates of wavenumber, space and time. This progress has opened up new biological and medical applications such as the heterogenous distributions of protein domains in insect wings and the quality control of chiral drugs. The last part of the book presents the possibility of medical diagnosis of Alzheimer's disease through multi-dimensional VCD analyses. This book appeals not only to researchers and students who study spectroscopy but also to ones in catalysis, biology and medicine as users of the VCD methods.

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

Comprehensive Chirality, Second Edition is the definitive ten-volume reference, offering a thorough exploration of chiral research and application. This extensively updated edition features 121 new chapters and 70 revised ones, focusing on the latest advancements in chiral research across synthesis, catalysis, analytical chemistry, and bioactive compound synthesis. Edited by a world-class editorial board, with contributions from leading experts, Comprehensive Chirality, Second Edition bridges theoretical principles with practical applications, making it an invaluable resource for advanced students, researchers, and professionals. Key highlights include:- Innovative Reactions and Methods: advanced diastereo- and enantioselective techniques for controlling stereogenic centers in complex natural products and pharmaceuticals.- Chiral Auxiliaries and Modern Reagents: transformative uses of chiral auxiliaries and cutting-edge reagents such as hypervalent iodide.- Catalytic Methodologies: comprehensive coverage of C-C bond formation, emphasizing transition metals, biocatalysis, and multicatalysis.- Asymmetric Photochemistry: light-induced asymmetric transformations.- Olefin Functionalization and Cycloaddition: asymmetric oxidation and reduction methods.- Biocatalysis and Enzyme Engineering: in-depth analysis of enzyme design and engineering as powerful synthesis catalysts.- Industrial Applications: practical insights into asymmetric synthesis for industrial applications, illustrated through recent case studies.- Spectroscopic Techniques: updated spectroscopic methods for separating and analyzing enantiomers. - Unites different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts - Includes different areas of research and deep foundational reviews - Helps users apply context to diverse journal literature, aiding them in identifying areas for further research and/or for solving problems - Serves as a valuable, critical tool for instructors, practicing experimentalists, and students of the field, as well as those curious to gain appreciation of the chirality landscape and its vast expanse

Il recente libro di Lorenzo Tomasin, Europa Romanza (2021), ha avuto il merito rinnovare gli studi sul contatto linguistico, privilegiando testi di consumo e scritti di carattere privato (realizzati tra Medioevo e Rinascimento) in cui si faceva prova di un più o meno consapevole plurilinguismo. Tomasin ha contribuito a «inquadrare il multilinguismo della società e il plurilinguismo degli individui come caratteri fondanti della cultura europea nel suo insieme». Convergenze plurilingui ha raccolto da Europa Romanza l'invito a riflettere su una «costituzione della coscienza linguistica attraverso il confronto e l'incrocio delle esperienze culturali». I lavori di questo volume continuano infatti, idealmente, le sette storie raccontate da Tomasin, tentando di contribuire alla definizione del fenomeno plurilingue. Il plurilinguismo, inteso come intersezione tra diversi volgari o diverse varianti di una stessa lingua, si rivela essere il segno di una funzione culturale e, in alcuni casi, anche una marca di genere testuale. Questo volume è dunque destinato ai linguisti interessati tanto alla formazione delle lingue in contesto europeo quanto al plurilinguismo in chiave storica.

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe. - Provides comprehensive coverage and is basically a'one-stop'resource across all disciplines contributing to precision medicine - Authoritative guide edited by distinguished authorities who are shaping the advancement of precision medicine - Thematically organized, allowing for easy exploration across interconnecting disciplines - Digitally innovative resource with multimedia features that complement the text and provide additional learning and teaching resources

Encyclopedia of the Human Brain, Second Edition, Seven Volume Set builds on the success of the first edition, providing neuroscience researchers with the ideal'one-stop'resource on all topics related to human brain understanding. Given the length of time since the first edition published, EHB2 is thoroughly revised, with substantial updates on many new and exciting topics, including areas such as human neuroimaging, non-invasive brain stimulation, molecular biology (including genetics and epigenetics), and the clinical diagnoses of brain disorders, along with chapters exploring the introduction of new theoretical and methodological ideas in areas ranging from cognitive neuroscience to evolution of the human brain. In total, there are 440 articles – a vast increase from 224 previously - thus reflecting the huge explosion in neuroscience research during the last 20 years. EHB2 provides a brand new generation of neuroscientists with the perfect tool with which to learn and master the fundamentals of how and why the human brain operates as it does. - Provides a comprehensive and up-to-date resource for exploring the human brain - Includes timely, key topics, providing an excellent overview of the field in a thematically structured one-stop shop location - Moves from an alphabetical structure to a systems/topic approach that is more fruitful for specialized readers and allows easier serendipity to less expert readers

This book stems from the urgent necessity to address neurodegenerative diseases, which are among the most severe health challenges currently confronting society. Neurodegenerative diseases have become a major threat to public health in recent years, impacting millions of people globally and creating a substantial strain on healthcare systems and society as a whole. Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis are examples of these diseases. This book offers a thorough survey of the latest developments in this rapidly growing field. This book is targeted towards a wide range of readers, including academics, researchers, medical professionals, students, policy makers, and anybody else who is interested in the convergence of neuroscience, nanotechnology, and healthcare. Irrespective of one's familiarity with the subject, this book provides motivation and insightful information to bolster our group's endeavors in combating these debilitating diseases.

This open access book gathers the latest advances and innovations in the field of architectural education, as presented at the 2023 annual conference of the European Association for Architectural Education (EAAE AC), “School of Architecture(s)”, held in Turin, Italy, on August 30–September 1, 2023.

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.

This book highlights recent research on intelligent systems and machine learning based solutions. It presents 46 selected papers focused on Industrial Applications from the 23rd International Conference on Intelligent Systems Design and Applications (ISDA 2023), which was held in 5 different cities namely Olten, Switzerland; Porto, Portugal; Kaunas, Lithuania; Greater Noida, India; Kochi, India, and in online mode. The ISDA is a premier conference in the field of artificial intelligence, and the latest installment brought together researchers, engineers, and practitioners whose work involves intelligent systems and their applications in industry. ISDA 2023 had contributions by authors from 64 countries. This book offers a valuable reference guide for all industrial specialists, scientists, academicians, researchers, students, and practitioners in the field of artificial intelligence and industrial applications.

The World Today Series: East & Southeast Asia provides historical background on the evolution of Modern East & Southeast Asia to help readers gain a thorough understanding of contemporary developments in this vital region. Broad introductory regional chapters are followed by sections on each country in the region. The combination of factual accuracy and up-to-date detail make this an outstanding resource for researchers, practitioners in international development, media professionals, government officials, potential investors, and students to understand the immediate background of contemporary developments.

VETERINARY ANESTHESIA AND ANALGESIA A thoroughly updated new edition of the foundational reference on veterinary anesthesia and analgesia Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones is a fully updated revision to this comprehensive, authoritative reference to all aspects of veterinary anesthesia and pain management. Encompassing both scientific principles and clinical applications, the new edition adds new knowledge, techniques, and discussion of emerging issues throughout. Fourteen new chapters significantly expand the coverage of patient monitoring modalities and nociception and pain, while presenting new information on safety culture, infection prevention and control, biomedical engineering, and point-of-care ultrasound. Logically organized into sections, information on basic principles, pharmacology, specific body systems, and specific species is easy to access. Comparative anesthetic considerations for dogs and cats, horses, ruminants, swine, laboratory animals, free-ranging terrestrial mammals, marine mammals, reptiles, amphibians, fish, and birds are discussed. Chapters are devoted to anesthesia and pain management of common domestic species and patient populations, including updated chapters on local and regional anesthetic and analgesic techniques. A companion website offers video clips of point-of-care ultrasound techniques and pain assessment and scoring. Readers of Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones will also find: Significantly expanded coverage of patient monitoring, including new chapters devoted to anesthetic depth and electroencephalography, electrocardiography, blood pressure, ventilation, oxygenation, and anesthetic gas monitoring. More in-depth coverage of respiratory physiology and pathophysiology, with new sections covering oxygen therapy, mechanical ventilation, anesthetic management considerations for bronchoscopy, intrathoracic procedures, including one-lung ventilation, and patients with respiratory disease. Expanded coverage of pain physiology and pathophysiology, recognition and quantification of pain, and clinical pain management, including both pharmacologic and nonpharmacologic modalities. A companion website incorporating video clips and example pain scoring sheets to complement the more than 500 images in the text itself. With its unparalleled multidisciplinary approach, Veterinary Anesthesia and Analgesia is a must-own volume for veterinary anesthesia specialists and researchers; specialists in other disciplines, including both small and large animal surgeons; practitioners; and students.

The most common form of severe dementia, Alzheimer's disease (AD), is a cumulative neurological disorder because of the degradation and death of nerve cells in the brain tissue, intelligence steadily declines and most of its activities are compromised in AD. Before diving into the level of AD diagnosis, it is essential to highlight the fundamental differences between conventional machine learning (ML) and deep learning (DL). This work covers a number of photo-preprocessing approaches that aid in learning because image processing is essential for the diagnosis of AD. The most crucial kind of neural network for computer vision used in medical image processing is called a Convolutional Neural Network (CNN). The proposed study will consider facial characteristics, including expressions and eye movements using the diffusion model, as part of CNN's meticulous approach to Alzheimer's diagnosis. Convolutional neural networks were used in an effort to sense Alzheimer's disease in its early stages using a big collection of pictures of facial expressions.

The book showcases how the technologies are transforming entertainment, education, and professional training, offering readers real-world examples of their applications.'Innovative Technologies for Enhancing Experiences and Engagement'is an enlightening guide that reveals how emerging technologies are shaping our world, offering insights into the evolving digital landscape and inspiring a future of more personalized, immersive, and engaging experiences.

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery. Many advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF/ADAMTS13 as risk factors of thrombosis. Edited by a team of experts in VWD and an international team of contributors, Textbook of von Willebrand Disease covers sample topics such as: VWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance Clinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD Pediatric aspects of VWD and of women with VWD Management of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates Acquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease Providing complete and accessible coverage of the subject, Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition is a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding/clotting disorders.

This book proposes an innovative pedagogical approach, Usage-Based Second Language Instruction, which continues the tradition of challenges to existing paradigms such as Steven Krashen's Natural Approach, and Michael Lewis'Lexical Approach. It begins by analysing historical teaching methods to make the case for change. The author argues that Communicative Language Teaching lacks a theory of learning and overemphasises spoken production as a result. The book then examines theories of first language acquisition to establish a theoretical basis for change. It finds that usage-based theories offer a highly plausible account of language learning. The author sets out six principles to guide the application of usage-based theory to second language learning. The book will be of particular interest to students and researchers of Applied Linguistics and Language Education.

This is an open access book. The 2nd International Conference of Science Technology of Elementary Education (ICSTEE) 2023 was held on 9th of November 2023 by virtual. This conference is organized by Elementary Teacher Education Faculty of Education State University of Makassar (Jurusan PGSD FIP Universitas Negeri Makassar). The ICSTEE is the 2nd international conference dedicated to the advancement of the theory and practices in elementary education.The aims of the 2nd ICSTEE is to provide an opportunity for researchers, academicians, teachers, practices and university students and all the people who care the development of elementary education quality and education in general to promote research.

Die umfassendste antike Darstellung der Rhetorik findet sich ohne Zweifel in der Institutio oratoria von Quintilian. Obwohl schon viele Wissenschaftlerinnen und Wissenschaftler ihre Forschungen der antiken Rhetorik gewidmet haben, gab es bisher keinen umfangreichen und tiefgehenden Kommentar des 7. Buches von Quintilians Institutio oratoria. Die vorliegende Arbeit schließt diese Forschungslücke. Sie ermöglicht dem/der Leser/-in eine erkenntnisreiche Lektüre, indem ausführliche Informationen zu sprachlichen, textkritischen und inhaltlichen Problemen geboten werden. Die Untersuchung ist in drei Hauptteile gegliedert: (1.) Die Einleitung bietet Erklärungen zu den Hauptthemen der divisio (systematische Gliederung mithilfe von Fragen) sowie der Statuslehre (Einteilung dieser Fragen in Kategorien). (2.) Die Neuedition des Textes stellt die Grundlage für (3.) den Kommentar dar. Jeder, der sich für antike Rhetorik, ihre Argumentationsstruktur, die Welt der Deklamationen und die Kultur der frühen Kaiserzeit interessiert, bekommt mit diesem Buch einen kritischen Begleiter zum Verständnis des von der Forschung eher oberflächlich rezipierten 7. Buches der Institutio oratoria.

The study of “usage” has constituted a major line of second language learning research for decades now. The concept of usage, however, can be defined and studied in many different ways.In this comprehensive, forward-looking text, international scholars from a variety of perspectives review and critically examine current conceptualizations of usage, learning, and their connections in the field of second language acquisition (SLA). Bringing these diverse perspectives into conversation, Kevin McManus synthesizes the state of the art to set the agenda for new directions in theory-building and empirical SLA research.This text will be an invaluable resource to students and researchers in SLA, applied linguistics, psychology and cognitive science, education, and related areas.

Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more. - Includes contributions from a world-renowned editorial board and expert contributors with wide-ranging backgrounds in toxicology - Thoroughly updated with the latest advances in the science - Contains concise and accessible content, providing an authoritative reference resource for non-specialists and readers from undergraduate level upwards, as well as advanced healthcare providers - Covers new topics such as computational toxicology, alternatives to animal testing, pharmaceutical ingredients, artificial intelligence models of toxicological exposure and effects, wildfires and effects of their smoke, vaping, high throughput transcriptomics, and the effect of environmental chemicals on the microbiome

This book explores a platform for insightful discussions and scientific discourse on various aspects of landslides and their risk management, with insights focused on the Himalayan states at a sub-regional level. A fundamental reference is thus provided for further research not only in landslides but also in associated natural hazards. The book is divided into four major parts, starting from conceptual models in approaching landslide risk, followed by evaluation of risk, management of landslide risk, end-to-end solutions for landslide risk assessment, and a synopsis. Included are topics such as the nature of landslide hazard impact, scale dependency in landslide hazard and risk analysis, and systematic procedures of landslide hazard mapping for risk assessment using spatial prediction models. The book also covers such important aspects as the response of the insurance industry to landslide risk and the role of administrative bodies in landslide risk assessment and sustainable management. Readers gain ample knowledge through case studies regarding the types of landslides in the Himalayan region, which will help them in their future research hypotheses.

This book offers a comprehensive perspective of herbal medicine phytochemistry and explores the application of plant extracts as bioactive compounds in disease prevention and treatment in modern or traditional medicine. The book starts with an introduction to the history and value of herbal medicine, followed by 3 parts covering the main phytochemical components and metabolites in herbal medicine, different uses and practices in herbal medicine, including a region-wise analysis of methods and practices and an overview of regulations and policies for herbal medicinal practitioners, and the advances and challenges in quality assessment of herbal medicine. Plants generally have the tendency to bioaccumulate trace metals from the environment and they are easily contaminated by microorganisms from water sources and poor hygiene practices of the herbalist. Quality assessment and assurance is, thus, a pertinent challenge in herbal medicine practice (i.e., in remedy formulation and application), and this book offers an authoritative perspective on this topic, covering aspects such as quality control strategies, preparation techniques, chemical quantification in phytomedicine, and the efficacy and safety of herbal remedies. Moreover, in this book, readers will find valuable insights into the latest trends and developments in the field, and a critical review of the application of medicinal plants to treat cardiovascular, digestive, respiratory neurological and reproductive diseases. Particular attention is given to the advances and trends in the field, and readers will learn about the latest biotechnological approaches, the use of nanotechnology in herbal medicine, metabolomic analysis of medicinal plants, big data application in herbal medicine, and the value of herbal medicine towards sustainability. Given its breadth, this book is aimed at researchers, academics, practitioners and professionals working in the fields of natural, life, health, clinical, and biomedical sciences, and interested in herbal remedies, pharmacology, pharmacognosy, human nutrition and dietetics, plant biology, and biotechnology/microbiology.

Colorectal surgery has been evolving rapidly over recent years and the COVID pandemic has necessitated a critical approach to all aspects of care. This book offers an up-to-date appraisal of the increasingly used neoadjuvant therapy. In many situations a multidisciplinary approach is taken to achieve high quality and successful outcomes. In addition, topics such as the management of the open abdomen, complex abdominal wall reconstruction, artificial intelligence and modern management of inflammatory bowel disease are covered. Written by experts in their field, this book is of interest to both trainees and practicing surgeons in coloproctology.

Essentially a bio-bibliography of the Bonn prototypographer Laurenz van der Mülen. With bibliography 1541-1553.

This state-of-the-science handbook offers a comprehensive discussion of input processing in second language acquisition. The volume assesses past and current research on input processing and engages the reader in critical reflection about the current state of the field and what lies ahead for future research, theory-building, and implications for language instruction.The handbook considers multiple theoretical perspectives, pivotal research findings, issues in research methodology, and instructional implications that underscore the centrality of input processing in second language acquisition. Whereas to date most research in this area has focused on input processing as it relates to the acquisition of morphosyntax and lexis, the present volume also attends to more recent theoretical advances regarding other linguistic subsystems, such as phonology and pragmatics, as well as processing resource allocation during multilevel input processing.Thorough and forward-looking, this volume is an indispensable resource to scholars and advanced students of second language acquisition, bilingualism, applied linguistics, cognitive science, psychology, and education.

The second edition of The Chemistry of Clay-Organic Reactions book provides a comprehensive and fully updated summary of the literature on the interactions of clay minerals with organic molecules, including reaction mechanisms and bonding modes together with their practical and industrial applications. The reader will gain an insight into the formation and properties of complexes between clay minerals and a variety of organic compounds and the use of such complexes as sorbents and carriers of organic pollutants, pesticides, dyes, and pharmaceuticals.KEY FEATURES An authoritative resource providing a detailed synthesis of published data on clay-organic complexes and reactions. Authored by a globally recognized expert in the field. Describes developments in the interactions of organic compounds with fibrous and short-range order clay minerals. This book is written for environmental and industrial chemists, organic geochemists, and soil scientists, and it will appeal to academics, researchers, industry professionals, and graduate students.

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

This comprehensive book explores both the fundamental and practical aspects of microbial genetics, shedding light on viroids, viruses, phytoplasma, bacteria, fungi, and protozoa. Unveiling a fresh perspective, the book tackles traditional taxonomical debates by embracing DNA-based taxonomy, offering a novel approach to understanding phylogeny within this microbe realm. Furthermore, it delves into the exciting realm of metagenomics, revolutionizing the identification and classification of unculturable microorganisms. Written by leading experts, this essential reading material caters to students and researchers in Microbiology, Genetics, and Biotechnology.

HIV-Associated Neurocognitive Disorders: Molecular and Cellular Mechanisms and Clinical Manifestations is a comprehensive volume on the field of HIV-Associated Neurocognitive Disorders (HAND) as well as its associated comorbidities. Covering clinical manifestations as well as molecular and cellular mechanisms, this book discusses available macaque and rodent animal models of HAND, epigenetic regulation, and signaling pathways underlying symptoms. Chapters also cover prevention and therapeutic strategies, as well as diagnosis and biomarkers associated with disease outcomes. This volume is appropriate for basic research and clinical investigators working in the area of HIV-1 infection. - Provides an in-depth exploration of the clinical manifestations of HAND and its comorbidities - Includes detailed assessments of the molecular and cellular mechanisms underlying HAND symptoms - Examines animal models for studying HAND, including macaque and rodent models - Presents insights into epigenetic regulation and signaling pathways implicated in HAND - Covers prevention, therapeutic strategies, and diagnostic approaches

Praise for previous editions:'The evidence-based protocols are designed as a primary reference and are useful, substantive, and timely....The broader contributions of useful format and succinct review of the evidence make it likely that this text will continue to be the leading resource in nursing education and practice.'--The Gerontologist'As a gerontological clinical educator/research nurse, I will often use this as a reference. The format and the content are good, and the explanations of how to best use the evidence simplify the process of sifting through mountains of information to figure the best practice.'Score: 97 --Doodys The result of a collaboration between expert practitioners and educators in geriatric nursing, the seventh edition of this acclaimed reference has been updated and revised with new information on chronic conditions and emerging models of care presented in 10 completely new chapters. It provides the most current, evidence-based protocols for improving both quality of care and patient outcomes when caring for older adults in multiple disciplines and settings. As in past editions, the seventh edition is distinguished by its use of a rigorous systematic method (AGREE: Appraisal of Guidelines for Research and Evaluation) to improve the validity of the book's evidence-based content. Chapters provide assessment and management principles, clinical interventions, and information on specialty practice and models of care. Included in most chapters are protocols developed for each clinical condition by experts in that specific area. Evidence is current and derived from all settings of care, including community, primary, acute, and long-term care. Protocols include an overview and evidence-based assessment and intervention strategies. Illustrative case studies with discussion are presented in most chapters, along with chapter objectives and references with evidence ratings. Instructor's resources include an AACN Mapping Grid, Course Cartridge, Transition Guide, PowerPoints, and Test Bank. New to the Seventh Edition: Updated to encompass the latest trends in older adult care, chronic conditions, and emerging models of care New chapters on care and management of diabetes and respiratory care New chapters on issues surrounding nutrition and dementia, and mental illness New chapter on care and comfort at the end of life New chapters on adopting principles of diversity, equity, and inclusion and an age-friendly health system into practice New chapters on models of care in long-term, community-based, and primary care Key Features: Delivers easy-to-follow geriatric protocols for best practices Updates evidence regularly to reflect current practice standards Encompasses a broad scope of content including detailed information rarely covered in professional literature Offers case studies and discussions to illustrate application of protocol to practice Written by renowned leaders in geriatric nursing education and practice Use of AGREE (Appraisal of Guidelines for Research and Evaluation) to improve the validity of evidence throughout the text

The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.

This book highlights the usefulness of magnetic resonance imaging (MRI) for the evaluation of lung and thoracic tumors. MRI will become a standard examination for lung cancer, pulmonary nodules/masses, and thoracic neoplasms. This is due to it being economical and providing no radiation exposure to patients. Compared to computerized tomography (CT), MRI allows for qualitative analysis of benign or malignant disease, not just morphology. Compared to positron emission tomography–computed tomography (PET-CT), MRI enables early assessment of therapeutic effects, is inexpensive, and does not require radioactive isotopes. This book is useful for the assessment of lung and thoracic neoplasms and should be recommended reading for doctors dealing with thoracic diseases. Those who will find this book most useful are physicians, respiratory physicians, radiologists and thoracic surgeons who are interested in MRI examinations, as well as MRI companies, general hospitals and publishers of radiology.

Der Klassiker der Intensivmedizin in 13. Auflage!In diesem großen Standardwerk für die Intensivmedizin finden Sie alle Themen der modernen, interdisziplinären Intensivmedizin zusammengetragen. Es bietet höchsten Standard für die ärztliche Weiterbildung und ist gleichzeitig ein wertvolles Nachschlagewerk im klinischen Alltag für Ärztinnen und Ärzte auf Intensivstationen aller Fachrichtungen, u.a. aus Anästhesiologie, Innere Medizin, Chirurgie und Neurologie. Dargestellt werden u.a. moderne Diagnostik, Monitoring - und Therapieverfahren, intensivmedizinisch relevante Krankheitsbilder und Notfälle, Intensivtherapie nach neurochirurgischen, herzchirurgischen, thoraxchirurgischen und abdominalchirurgischen Eingriffen sowie ethische, psychosoziale und pflegerische Aspekte. Weitere Themen sind: Teleintensivmedizin, Weiterbildung und Kompetenzvermittlung in der Intensivmedizin, Langzeitfolgen nach Intensivtherapie, Akut- und Frührehabilitation, Palliativmedizin in der Intensivmedizin, Risikomanagement und Fehlerkultur. Die 13. Auflage erscheint komplett überarbeitet und aktualisiert.

There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the “Interdisciplinary Cancer Research” series, entitled “Breast Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast cancer treatment are explained. Promising hormone immunotherapy combination as well as targeted therapies for breast cancer is also discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers and oncologists who wish to extend their knowledge on breast cancer treatment.

This book analyzes the role of social networks during electoral campaigns around the world, taking into account the non‑technological particularities (political, electoral, social, economic, cultural) of the media configurations of different countries.Political parties all over the world engage in real virtual battles to appear at the cutting edge of technology. Providing in‑depth case studies from across Europe, North America, Latin America, Asia, and Africa, this book emphasizes the need to study how institutions, culture, and politics shape the processes of technology diffusion in each context. It asks: what are the uses of social networks in election campaigns in different countries? and what are the factors that lead to social networks playing an important role in the elections of a given country? International and comparative in focus, this book brings together work on the uses of social networks (Facebook, X (formerly Twitter), WhatsApp, TikTok, Instagram, Telegram, and more) in the context of an election campaign by different actors (such as parties, companies, journalists, and voters). This book explores the different methodological and theoretical approaches developed for the study of the uses of social networks in an electoral context. The contributors focus on the identification of the “online ecosystem” of electoral actors in each country, studying their strategies and logic. They also analyze the scaremongering rhetoric about the possible effect of social media on elections as an object of study. While taking seriously the issues of polarization, disinformation, or negative campaigning, this book provides understanding of how these work and how their discourses are constructed.This book will be of great interest to upper‑level students and scholars of Political Science, Media, and Communications Studies.

The Neuropsychology of Anxiety first appeared in 1982 as the first volume in the Oxford Psychology Series, and it quickly established itself as a classic work in the psychology and neuroscience literature. It presented an innovative, and at times controversial, theory of anxiety and the brain systems, especially the septo-hippocampal system, that subserve it. This completely updated and revised third edition provides a further updated theory of septo hippocampal function combined with an improved understanding of anxiety. The book includes a new chapter on prefrontal cortex integrating frontal and hippocampal views of anxiety, as well as an extensively modified chapter on personality providing a new basis for further developments of Reinforcement Sensitivity Theory. In addition, numerous figures have been fully updated and converted to colour to support the text. This book is essential for postgraduate students and researchers in experimental psychology and neuroscience, as well as for all clinical psychologists and psychiatrists.