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This richly illustrated book, now in an updated and extended third edition, systematically covers the use of diffusion-weighted (DW) MR imaging in all major areas of neuroradiology, including imaging of the head and neck and the spine as well as the brain. The authors guide the reader from the basic principles of DW imaging through to the use of cutting-edge diffusion sequences such as diffusion tensor (DTI) and kurtosis (DKI), fiber tractography, high b value, intravoxel incoherent motion (IVIM), neurite orientation dispersion and density imaging (NODDI), and oscillating gradient spin echo (OGSE). Pathology, pathophysiology, and patient management and treatment are all thoroughly discussed. Since the early descriptions by LeBihan and colleagues of the ability to image and measure the micromovement of water molecules in the brain, diffusion imaging and its derivatives have contributed ever more significantly to the evaluation of multiple disease processes. In comprehensivelydescribing the state of the art in the field, this book will be of high value not only for those who deal routinely with neuro-MR imaging but also for readers who wish to establish a sound basis for understanding diffusion images in the hope of extending these principles into more exotic areas of neuroimaging.

Few advances in MR imaging have had the impact degenerative neurologic disorders, white matter d- that dif usion-weighted (DW) imaging has had in the eases, toxic/metabolic disorders, and tumors. As one evaluation of brain. From the time of the early de- can easily see from the table of contents, the authors scriptions by LeBihan and colleagues of the ability have systematically covered all major areas of neu- to image and measure the micromovement of water radiology. T is will allow cross-referencing to pr- molecules in the brain to the present time, dif usion lematic cases which one may encounter. Additionally, imaging and its derivatives have made an impact in knowledge of what represents a normal adult brain the evaluation of multiple disease processes, primar- and a normal developing brain along with an exp- ily in ischemia, but also in other conditions of the nation of artifacts seen in DW imaging makes this a brain. In most medical centers dif usion imaging is valuable book. It is noteworthy that the authors have no longer considered a sequence to be used in spe- chosen to abundantly illustrate the clinical material, cial circumstances, but rather it is employed as part drawing on pathologic correlations in a number of of routine MR imaging of the brain. Because the in- areas.