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Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

This book offers to reader a sound understating of two-dimensional Transition-Metal Dichalcogenides (2D TMDs) materials, detailing their physio-chemical mechanisms and technological applications in various areas such as nanoelectronics and optoelectronics. Moving from their invention to their modern developments, including theoretical approaches, experimental interpretations and their technical applications, the book explores the basic concepts of 2D TMDs. It will be of interest to undergraduate and postgraduate students, researchers and scientists working in the area of 2D TMDs. A key goal of this book provides a sound or clear idea about two-dimensional Transition-Metal Dichalcogenides (2D TMDs) materials by providing their sound background, fabrication approaches including interpretations of the inside physio-chemical mechanism including technological applications in various significant areas such as nanoelectronics, optoelectronics, topological insulators, biomedical.

The book provides a strong platform for delineating the complex mechanism underlying cancer therapeutics along with the therapies countering drug resistance. It describes tumor angiogenesis and cancer metastasis, oncogenes and oncogenesis. It covers natural phytochemicals and herbal nanomedicines. It includes the recent advances in nanocomposite films and SiRNA-mediated drug delivery. Cancer biology, mechanistic insight and therapeutics. Valuable source about nanomedicine design, nano-based drug delivery systems and approaches for cancer therapy.

A comprehensive, one-stop guide to gynecological health for busy clinicians The 13th edition of this gold standard for the assessment and management of gynecological health is updated with a broad trove of new evidence-based information to promote the highest standards of clinical practice. With contributions from expert practitioner/educators, this edition encompasses key guidelines reflecting the most current best practices, several new or updated chapters, and two features designed to facilitate student learning and enhance primary care---30 case studies with Q&A for 15 chapters and updated education templates for input into electronic health records. Guidelines are organized in concise outline format to promote easy access to commonly occurring gynecologic issues and clinical conditions. In addition to its value for clinicians specializing in the comprehensive care of women and individuals across the lifespan, this resource will be an asset to all graduate nursing programs preparing nurse practitioners in women's and gender-related health. New to the 13th Edition: Extensively revised clinical guidelines and appendices representing the most current evidence-based information from research and national organizations New chapters on care of sexual and gender minority individuals, adolescents, and older women; use of telehealth in gynecologic care; and women-specific pharmacology issues Updated content on substance abuse and misuse and on best practices developed during COVID 19 pandemic Enhanced mental health chapter focusing on pharmacological approaches Updated guidelines for STIs, vaginitis, and vaginosis and prevention and management of HPV-associated cancers with links to ASCCP for ongoing updates Guidelines for addressing vaccine hesitancy Guidelines for care of individuals who have experienced sexual assault Updated information on contraception, hormone therapy, menopause, and osteoporosis Case studies with Q&A to help students/practitioners translate information into practice Updated, customizable education templates for input into electronic health records with lay public-appropriate language Key Features: Evidence-based guidelines empirically proven to boost patient outcomes Outline format ensuring quick and easy access to essential information Online access to appendices presenting updated clinical resources, assessments, and screening tools Online access to case studies and health record education templates to facilitate student learning

This book presents the design, synthesis, characterization, and advanced applications of nanomaterials and nanodevices in biology and medicine. It begins with an introduction to nanobiology, providing readers with insights into the significance of this emerging field. The book covers methods for characterizing nanoparticles, including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and other spectroscopy techniques. It also explores the applications of nanoparticles in optical coherence tomography, biosensors, neuroscience, genetic engineering, and cell biology. It explores various applications of nanoparticles, including spectroscopy, Raman imaging, molecular nanodevices, bioimaging techniques, regenerative medicine, cancer research, bio-molecular analysis, nanofabrication, multi-modal imaging, and microfluidic platforms. Additionally, it addresses important considerations such as nanotoxicology and safety in nanobiology. The book concludes by discussing future perspectives and potential advancements in the field, making it a valuable resource for researchers, students, and professionals exploring the transformative impact of nanobiology on science and medicine.Key Features: Covers fundamental concepts and advanced applications of nanomaterials and nanodevices in the fields of biology and medicine Presents advanced nanoparticle characterization techniques, including FTIR, SEM, TEM, AFM, and XRD Examines various biological applications of nanoparticles in diagnostics, neurobiology, genetic engineering, regenerative medicine, and cancer research Emphasizes the role of nanoparticles in understanding biological processes at the molecular level and developing innovative solutions for biomedical applications Provides insights into the toxicity issues and mechanisms underlying the toxicity of nanoparticles

Childhood Obesity: From Basic Knowledge to Effective Prevention brings together field experts, taking a multifactorial approach to understand the scope and various causes of the issue and offer the latest in treatment and prevention strategies and resources. Beginning with basic concepts and definitions, chapters progress to cover worldwide prevalence and trends, genetic and epigenetic origins, metabolic programming, and neuroendocrine control of appetite and satiety. Further, this book examines social determinants and lifestyle behaviors contributing to risk factors as well as complications associated with childhood obesity. Final chapters discuss multidisciplinary treatment, strategies for prevention, and current worldwide policies aimed to address obesity in children. This fundamental reference is a vital resource for both researchers and practicing clinicians in pediatric medicine. - Provides a comprehensive approach to childhood obesity - Presents a multi-omics description of the early origins of childhood obesity - Includes innovative strategies to treat and prevent obesity in children

This book explores the transdisciplinary approach to general surgery for the frail patient, promoting the use of a geriatric model of care in general surgical settings and thus proposing a “gerosurgery” approach in frail persons beyond chronological age. Aging, frailty, and surgical needs are increasing dramatically worldwide while surgeons are daily facing with the trouble of the trade-off between short-term outcomes and efficacy of surgery in older persons. However, recent studies have clearly shown that age itself is not a prognostic risk factor for complications after elective surgery in older patients, whereas cognitive or functional frailty is. Neither a referring physician nor an assessing surgeon should deny patients surgery purely based on chronological age. Instead, decisions should be based on a CGA (comprehensive geriatric assessment) with a precise picture of the patient considering the cognitive, functional, nutritional, socioeconomic, and affective status. Recent studies examining the use of preparative CGA in surgical patients showed encouraging results on postoperative outcomes in old and/or frail patients. The most compelling current evidence comes from the orthopaedic community, which has embraced the idea of multidisciplinary team care. Preoperative evaluation, postoperative care, pain control, nutritional support, delirium prevention, mobilization, and rehabilitation are necessary also in general surgery. An expert multidisciplinary team, including geriatricians, anaesthesiologists, specialist nurses, physiotherapists, and nutritionists should mandatorily support surgeons.With this book, the reader will have an exhaustive overview and will gain essential, practical knowledge on how best to manage the surgical and frail patient and how to develop clinical systems that do so reliably.

Edited by world-renowned animal scientist Dr Temple Grandin, this book integrates scientific research and industry literature on cattle, pigs, poultry, sheep, goats, deer, and horses, in both the developed and developing world, to provide a practical guide to humane handling and minimizing animal stress. Reviewing the latest research on transport systems, restraint methods and facilities for farms and slaughterhouses, this new edition expands on new developments in the field, as well as covering the integration of and potential welfare benefits and costs of technological advances such as virtual fencing. An important read for animal scientists, animal welfare researchers and practitioners, and veterinarians, this straightforward text is also a valuable resource for stock-people and farmers.

Pediatrics is an evolving field of medicine and with many new advancements in knowledge, scientific research, and technology in recent years. This concise and comprehensive 2nd Edition of the textbook'Update in Pediatrics'provides an update and overview of the latest advances and current literature in Pediatrics, assisting health professionals to review cutting-edge information in the different subspecialties in Pediatrics. This book is structured into chapters based on the various subspecialties in Pediatrics, and includes chapters ranging from traditional disciplines such as Infectious Disease and Cardiology, to more current disciplines such as Adolescent Medicine and Child Maltreatment. The team of authors is made up of experienced and expert clinicians and researchers in their respective fields. The target audience for this book includes any practitioner who cares for children, including pediatricians, family doctors, nurses and nurse practitioners, allied health professionals, residents, medical students, and health researchers providing an indispensable resource for the busy clinician and learner who wishes to stay up-to-date with the latest advances and knowledge in the field.

River Flow 2022 includes the keynote lecture and contributed papers presented at River Flow 2022, the 11th International Conference on Fluvial Hydraulics (8-10 November 2022, Kingston and Ottawa, Canada; held virtually).River Flow 2022 provides an overview of the latest experimental, theoretical and computational findings on fundamental river flow and transport processes, river morphology and morphodynamics, while covering also issues related to the effects of hydraulic structures on flow regime, river morphology and ecology; sustainable river engineering practices (including stream restoration and re-naturalization); and effects of climate change including extreme flood events. The book presents the state-of-the-art in river research and engineering, and is aimed at academics and practitioners in hydraulics, hydrology and environmental engineering.

Can American health insurance survive?In The Transformation of American Health Insurance, Troyen A. Brennan traces the historical evolution of public and private health insurance in the United States from the first Blue Cross plans in the late 1930s to reforms under the Biden administration. In analyzing this evolution, he finds long-term trends that form the basis for his central argument: that employer-sponsored insurance is becoming unsustainably expensive, and Medicare for All will emerge as the sole source of health insurance over the next two decades. After thirty years of leadership in health care and academia, Brennan argues that Medicare for All could act as a single-payer program or become a government-regulated program of competing health plans, like today's Medicare Advantage. The choice between these two options will depend on how private insurers adapt and behave in today's changing health policy environment.This critical evolution in the system of financing health care is important to employers, health insurance executives, government officials, and health care providers who are grappling with difficult strategic choices. It is equally important to all Americans as they face an inscrutable health insurance system and wonder what the future might hold for them regarding affordable coverage.

'Main objective of this book is to create a platform for the healthcare professionals to share their experiences and treatments while handling Corona patients during this deadly pandemic and post pandemic. The Case studies and issues with heart patients and related diseases during such pandemic mentioned in this book will help the people to take precaution well in advance in adverse conditions to save their life'--

The second edition of Mixed Severity Fires: Nature's Phoenix focuses on wildfire as a keystone ecological process that has shaped plant and animal communities for over 400 million years. The book will describe the renewal process that follows wildfires in forests and chaparral ecosystems as'nature's phoenix'by drawing from examples of wildfire effects in several regions of the world.In addition, the book will describe management and policies that have contributed to wildfire problems, including climate change and land-use practices incompatible with nature's phoenix and what must happen to get to coexistence with wildfires that are not going away no matter how much we try to suppress or alter fire behavior. This second edition of Mixed Severity Fires: Nature's Phoenix provides a comprehensive reference for documenting and synthesizing fire's ecological role. - Comprehensive and complete reference on wildfire ecology that includes the latest science and citations - Debunks debates on wildfire management that can be used by conservation groups and decision-makers to shift egregious wildfire policies - Contains a broad synthesis of the ecology of mixed- and high-severity fires, covering such topics as vegetation, birds, mammals, insects, aquatics, and management actions

The two-volume proceedings set LNCS 14762 and 14763 constitutes the refereed proceedings of the 29th International Conference on Applications of Natural Language to Information Systems, NLDB 2024, held in Turin, Italy, in June 25–27, 2024. The 35 full papers, 26 short papers, 3 demo papers and 8 industry track papers included in these books were carefully reviewed and selected from 141 submissions. They focus on advancements and support studies related to languages previously underrepresented, such as Arabic, Romanian, Italian and Japanese languages.

Authored by over 500 internationally acclaimed expert editors and chapter authors from around the world. Completely updated and expanded with almost 40 new chapters. Significantly increased attention to the role of culture in all aspects of evaluation and care. New sections on Digital Mental Health Services and Technologies, Treatment Issues in Specific Populations and Settings, and on Prevention, Systems of Care, and Psychosocial Aspects of Treatment address key advances. This edition is the first comprehensive reference work to cover the entire field of psychiatry in an updateable format, ensuring access to state of the art information. Earlier editions were called “the best current textbook of psychiatry” by the New England Journal of Medicine, and “the gold standard” by the American Journal of Psychiatry. Tasman's Psychiatry, 5th Edition, builds on the initial vision in prior editions of approaching psychiatric evaluation and care from an integrative bio-psycho-social-cultural perspective. It is designed to be an essential and accessible reference for readers at any level of experience. This editorial approach encompasses the importance of the first encounter between patient and clinician, followed by the complex task of beginning to develop a therapeutic relationship and to develop and implement a treatment plan in collaboration with the patient. The importance of increasing attention to the role of culture and social determinants of mental health is reflected both in specific chapters and in components of many chapters throughout the book, especially in those pertaining to clinical evaluation, the therapeutic alliance, and treatment. The global scope of this edition is reflected throughout the book, including the section on psychiatric disorders where evaluation using both ICD 11 and DSM 5-TR is discussed. Most chapters are authored by experts from at least two different countries or continents, adding a critically important dimension which often is missing in major psychiatric textbooks. Tasman's Psychiatry, 5th Edition, is an essential reference for all medical professionals and students who need a trusted reference or learning tool for psychiatry, psychology, clinical research, social work, counseling, therapy, and all others.

Tauchen Sie ein in die verborgene Welt der Pflanzen! Mit „Pflanzenwelten entschlüsselt“ nimmt Esther Hiltbrunner Sie mit auf eine spannende Entdeckungsreise von den unsichtbaren Wurzeln unter der Erde bis zu den prachtvollen Blüten, die die Landschaft prägen. Dieses Buch offenbart die faszinierende Verbindung von Struktur, Funktion und ästhetischer Perfektion, die jede Pflanze einzigartig macht. Erfahren Sie, wie die Evolution Pflanzen zu wahren Überlebenskünstlern geformt hat, welche raffinierten Strategien sie entwickelt haben, um extreme Bedingungen zu meistern, und wie sie in einem engen Wechselspiel mit ihrer Umwelt stehen. Von den ersten Landpflanzen bis zu den komplexen Blütenpflanzen unserer heutigen Welt – die Autorin beleuchtet eindrucksvoll die Schönheit und Vielseitigkeit der Flora. Mit wissenschaftlicher Tiefe, anschaulichen Beispielen und verständlicher Sprache ist dieses Buch ein Muss für alle Naturbegeisterten, Hobbygärtner und Wissensdurstige, die die Wunder der Pflanzenwelt besser verstehen wollen.

Human Sexuality Today presents a holistic examination that encourages reflection on how human sexuality impacts lives today. The text helps you understand the key concepts of the discipline in order to make responsible decisions in your daily lives. Employing a conversational writing style, authors Pamela Regan and Bruce King present relevant information in a warm manner that instills positive feelings about sex and sexuality. The 10th Edition has been updated to reflect the latest research in the field. The authors present new discussions of topics such as sexuality during pregnancy, paraphilic disorders, the sexual behavior of teenagers and more. To ensure that the text remains current, each chapter contains the latest data and research findings, including more than 900 new citations.

The fifth edition of Canadian Parties in Transition continues and enriches the work of earlier editions in bringing together a highly respected group of scholars to offer a comprehensive account of the development of party politics in Canada. The book addresses the origin and the evolution of the Canadian party system and discusses how that system has been impacted by regionalism, brokerage politics, and political marketing. It focuses on the competing ideological currents that occupy the political stage while also paying attention to the role of third parties in federal politics. Contributors address the representation and democracy through an exploration of voting systems, direct democracy, the role occupied by constituencies, gender politics, and the distinct Quebec dynamics in the federal party system. Finally, the book analyses topical issues, such as electoral participation, social movements, right-wing populist parties, political campaigning, and digital party politics. This new edition has been thoroughly revised and updated to reflect ongoing transformations and includes nineteen new contributing authors and coverage of seven new topics. Canadian Parties in Transition presents a multi-faceted image of party dynamics, electoral behaviour, political marketing, and representative democracy.

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases. - Covers basic mechanisms of genome-editing tools and their therapeutic potential - Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases - Includes research on genome-editing tool development, from basic concept to clinical trials

Future Forests: Adaptation to Climate Change provides background on forests as natural and social systems, the current distribution and dynamics based on major biomes that set the stage for their role of forests in global systems, the nature of climate change organized by biomes, and detailed descriptions of mitigation and adaptation strategies. This book forms presents a foundational summary of the feedback between the effect of climate change on forests and the converse effects of forests on climate, leading to conclusions on how forest management needs to be dictated by climate change.The book will be ideal for readers in the fields of climate change science, forest science and conservation biology, helping them develop a thorough understanding on the broad perspective of climate change on forests, the response of forests to these changes, and other climate-forest interaction potentials. - Organizes information on climate change and the effect of/on forests at a general level before presenting biome-related specifics - Discusses the differences among major biomes (tropical, boreal, temperate) and the systems in which forest management (and hence potential mitigation and adaptation) occurs - Goes beyond simply describing problems, elaborating on potential solutions that can be implemented for climate change mitigation

This two-volume set, LNCS 15346 and LNCS 15347, constitutes the proceedings of the 25th International Conference on Intelligent Data Engineering and Automated Learning, IDEAL 2024, held in Valencia, Spain, during November 20–22, 2024. The 86 full papers and 6 short papers presented in this book were carefully reviewed and selected from 130 submissions. IDEAL 2024 is focusing on Big Data Analytics and Privacy, Machine Learning & Deep Learning for Real-World Applications, Data Mining and Pattern Recognition, Information Retrieval and Management, Bio and Neuro-Informatics, and Hybrid Intelligent Systems and Agents.

This book provides a detailed history of meteorology as a natural science, from an understanding of the Earth's early atmosphere to present-day advancements. In three parts, the book synthesizes developments in quantitative meteorology starting from its very early stages and progressively covers the invention of basic meteorology instruments while highlighting the various turning points and key figures who played roles along the way. The first part addresses the treatment of meteorology during early civilization. Part two goes into the early development of meteorology as a science. Part three covers the science's rapid progression and present-day status while addressing the primary technologies and methodologies used in a variety of areas like weather forecasting, remote sensing, and radar instrumentation. The target audience for the book is students and researchers interested in the history of meteorology as a science, and also general enthusiasts of the subject who have some background on the topic.

This open access book explores a new conceptual framework for the sustainable management of the boreal forest in the face of climate change. The boreal forest is the second-largest terrestrial biome on Earth and covers a 14 million km2 belt, representing about 25% of the Earth's forest area. Two-thirds of this forest biome is managed and supplies 37% of global wood production. These forests also provide a range of natural resources and ecosystem services essential to humanity. However, climate change is altering species distributions, natural disturbance regimes, and forest ecosystem structure and functioning. Although sustainable management is the main goal across the boreal biome, a novel framework is required to adapt forest strategies and practices to climate change. This collaborative effort draws upon 148 authors in summarizing the sustainable management of these forests and detailing the most recent experimental and observational results collected from across the boreal biome. It presents the state of sustainable management in boreal forests and highlights the critical importance of this biome in a context of global change because of these forests'key role in a range of natural processes, including carbon sequestration, nutrient cycling, and the maintaining of biodiversity. This book is an essential read for academics, students, and practitioners involved in boreal forest management. It outlines the challenges facing sustainable boreal forest management within the context of climate change and serves as a basis for establishing new research avenues, identifying future research trends, and developing climate-adapted forest management plans.

Now in its Fourth Edition, the acclaimed Oxford Textbook of Psychopathology aims for both depth and breadth, with a focus on adult disorders and special attention given to personality disorders. It provides an unparalleled guide for professionals and students alike. Esteemed editors Robert F. Krueger and Paul H. Blaney selected the most eminent researchers in abnormal psychology to provide thorough coverage and to discuss notable issues in the various pathologies which are their expertise. This fourth edition is fully updated and also reflects alternative, emerging perspectives in the field (e.g., the NIMH's Research Domain Criteria Initiative; RDoC, the Hierarchical Taxonomy of Psychopathology; HiTOP). The book exposes readers to exceptional scholarship, the history and philosophy of psychopathology, the logic of the best approaches to current disorders, and an expert outlook on what researchers and mental health professionals will be facing in the years to come. This volume will be useful for all mental health workers, including clinical psychologists, psychiatrists, and social workers, and as a textbook focused on understanding psychopathology in depth for anyone wishing to be up to date on the latest developments in the field.

The Handbook of Mind/Body Integration in Child and Adolescent Development examines issues relating to the mind/body connection in the development of children and adolescents, addressing problems of adverse life experiences with clinical implications, including somatization, functional or unexplained medical disturbances in various organ systems, psychosomatic conditions, and the effects. It discusses the interactions of emotions, experiences, thoughts in the mind – and their manifestations in the body – of children and youth. The book describes the effects of bodily conditions on the emotional state and mental functioning of children, such as cerebral palsy, major medical conditions, and other chronic health problems. It also explores the effects of chronic stress as well as child neglect and abuse on bodily manifestations.Key areas of coverage include:Developmental issues in the embodiment of self and body image in children and adolescents.Trauma and mind/body consequences in children and adolescents.Munchausen syndrome by proxy.Unexplained medical conditions, somatoform disorders, and conversion disorders during childhood and adolescence, including unexplained conditions in different organ systems (e.g., gastrointestinal, dermatological, neurological).Body/mind conditions in youth with physical and intellectual disabilities and chronic or severe medical conditions, including palliative care.Complementary and alternative treatment approaches to mind/body issues in children and adolescents, supplementing the usual mental health interventions.The Handbook of Mind/Body Integration in Child and Adolescent Psychiatry is an essential resource for researchers, professors, and graduate students as well as clinicians, therapists, and related professionals in developmental psychology, child and adolescent psychiatry, family therapy, social work, pediatrics, and public health.

This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox).The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

The book showcases the newest research on smart nanoplatforms responding to “hypoxia”; an omnipresent pathological feature of many modern-day diseases and its potential applications. The book demonstrates the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings presented in chapters contributed by various experts in the field. The themes in the book touch upon critical facets to address pathological hypoxia such as nanomaterials enhancing oxygenation, hypoxia responsive nanoformulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nanoformulations to counter molecular consequences of hypoxia, and theranostics combining hypoxia detection systems with drug delivery systems. This book disseminates the current implications of smart nanomaterials in disease management that can be exploited by scholars, researchers, and pharma industries to develop, manufacture, and commercialize hypoxia targeted diagnostics and therapeutics.

The extensively revised third edition of this text offers an in-depth practical guide to clinical conditions encountered in pediatric nephrology. Extensively updated disease-specific chapters offer detailed coverage of relevant basic science, diagnostic work-up, laboratory evaluation methods, appropriate management options and potential complications. Topics covered include disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, chronic kidney disease, dialysis, kidney transplantation and hypertension. Information is also provided on important related issues, including the genetic origins of diseases, the role of complement in the pathogenesis of kidney disease, and pharmacological aspects related to the kidney. Pediatric Kidney Disease comprehensively reviews a range of clinical conditions encountered in pediatric nephrology, assisting the reader to develop their skills and improve their clinical decision-making. It is a vital resource for trainees and practicing clinicians alike and a useful reference for those preparing for pediatric nephrology board examinations.

This 2nd edition is a definitive resource on issues pertaining to the full range of topics in scientific and other scholarly research on the quality of life, including health-related quality of life research or also called patient-reported outcomes research. Altogether 500 new and updated entries appear in this new edition. This single, multidimensional reference work connects the most salient and important contributions to the relevant fields from the behavioral and social sciences as well as health and healthcare. New topics in this 2nd edition are on disabilities, religion/spirituality, sex, sports, politics, government, science, literature, performance and visual arts, environmental quality and sustainable development. The 2nd edition of the Encyclopedia of Quality of Life and Well-being Research is an indispensable reference point for future research and writing topics on quality of life.

La médecine sexuelle et la sexologie sont devenues aujourd'hui une vaste et riche discipline qui couvre différents champs de connaissances et de pratiques. Celles-ci ont grandement évolué ces dernières années : nouvelles connaissances sur l'anatomie, évolution des diagnostics cliniques des troubles sexuels, meilleure prise en compte des questions de diversité sexuelle et de genre, programmes mieux adaptés à certaines populations (personnes âgées, malades…) Cette nouvelle édition de Médecine sexuelle, Fondements et pratiques augmentée et réorganisée, est divisée en sept grandes parties portant sur : les fondements anatomophysiologiques et les troubles sexuels masculins et féminins ; les troubles psychosexuels et la sexologie médicolégale ; les populations particulières et leur sexualité ; les chirurgies sexuelles et enfin, les interventions sexothérapeutiques. Ouvrage de référence dans le milieu francophone, à la fois clinique et académique, il s'appuie sur une documentation scientifique de la médecine basée sur les preuves (evidence based medicine), et offre aussi bien une revue des fondements utiles à la pratique sexologique, que des bases diagnostiques, médicales, sexothérapeutiques et chirurgicales de la pratique clinique.

The Youth Athlete: A Practitioner's Guide to Providing Comprehensive Sports Medicine Care includes topics that provide the most comprehensive and holistic understanding of the youth athlete. The foundation of the book focuses on the growth and development of the athlete from child to adolescence, balancing their physical, mental and emotional needs. The middle sections expand on this foundation, concentrating on common injuries and illnesses as well as unique topics (e.g., Female, Athlete Triad, Sports Specialization). Final sections emphasize specific sports (e.g., Soccer, Basketball, eSports), allowing the reader to synthesize the previous information to assist with return to play decision-making. Written from a scientific perspective and incorporating evidence-based medicine into its content, this book is perfect for health care practitioners of varied specialties. The complete and comprehensive structure of the book will clearly distinguish it from all other textbooks on the market. - Covers diverse topics that reflect our current understanding of youth athletes and issues related to their care - Incorporates evidence-based approach, highlighting the latest state-of-the-art information and research - Written by global content experts throughout the sports medicine field

The rapidly increased understanding of the molecular background of complex diseases facilitated the development of highly advanced therapeutic concepts. Such concepts aiming to consider individual signatures of genomic and proteomic biomarkers including pharmacogenomics as well as advanced diagnostic tools have been successfully implemented in clinical practice in various fields leading to significant improvement of treatment successes. This volume gives an up-to-date overview on applications of precision medicine in various clinical entities, on advanced techniques as well as on economic considerations.

Practical and highly organized, the 5-Minute Clinical Consult 2024 provides rapid access to the diagnosis, treatment, medications, follow-up, and associated conditions for more than 500 disease and condition topics to help you make accurate decisions at the point of care. Organized alphabetically by diagnosis, it presents brief, bulleted points in a templated format, and contains more than 100 diagnostic and therapeutic algorithms. This up-to-date, bestselling reference delivers maximum clinical confidence as efficiently as possible, allowing you to focus your valuable time on providing high-quality care to your patients.

Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Protein Chemistry and Structural Biology series - Includes the latest information on Control of Cell Cycle and Cell Proliferation

This open access book presents the main results of the Collaborative Research Center SFB-TRR 75, which spanned the period from 2010 to 2022. Scientists from a variety of disciplines, ranging from thermodynamics, fluid mechanics, and electrical engineering to chemistry, mathematics, computer science, and visualization, worked together toward the overarching goal of SFB-TRR 75, to gain a deep physical understanding of fundamental droplet processes, especially those that occur under extreme ambient conditions. These are, for example, near critical thermodynamic conditions, processes at very low temperatures, under the influence of strong electric fields, or in situations with extreme gradients of boundary conditions. The fundamental understanding is a prerequisite for the prediction and optimisation of engineering systems with droplets and sprays, as well as for the prediction of droplet-related phenomena in nature. The book includes results from experimental investigations aswell as new analytical and numerical descriptions on different spatial and temporal scales. The contents of the book have been organised according to methodological fundamentals, phenomena associated with free single drops, drop clusters and sprays, and drop and spray phenomena involving wall interactions.

The Gulf Stream: A Physical and Dynamical Description (Second Edition) offers a comprehensive exploration of one of the ocean's most iconic and complex phenomena. While the name'Gulf Stream'is widely recognized, this book provides an in-depth examination of its physical structure, dynamics, and the scientific theories that explain its behavior. Designed for a wide audience of physical scientists, it bridges the gap between general familiarity and specialized understanding, presenting the most thorough discussion available on the subject. Complementing foundational texts like The Oceans and Dynamical Oceanography, this volume focuses exclusively on the Gulf Stream, offering detailed insights into its role in global weather systems, oceanic currents, and broader oceanographic studies. This second edition stands as an authoritative resource for those seeking to understand the intricate workings of this grand natural phenomenon. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1965.

Practical and highly organized, The5-Minute Clinical Consult 2023 provides rapid access to the diagnosis, treatment, medications, follow-up, and associated conditions for more than 540 disease and condition topics to help you make accurate decisions at the point of care. Organized alphabetically by diagnosis, it presents brief, bulleted points in a templated format and contains more than 100 diagnostic and therapeutic algorithms. Edited by Frank J. Domino, Robert A. Baldor, Kathleen A. Barry, Jeremy Golding, and Mark B. Stephens, this up-to-date, bestselling reference delivers maximum clinical confidence as efficiently as possible, allowing you to focus your valuable time on providing high-quality care to your patients.

Andrology & Sexual Medicine is a comprehensive source for urologists, andrologists, sexologists and general practitioners. It contains general and up-to-date information about almost all topics within andrology and sexual medicine, and is a unique source that can be used for both exams and general daily practice. Easily accessible to clinicians and researchers and specialists, it tackles the controversial and complex topics of andrology and sexual medicine for urologists.

Over the course of the previous seven editions, Pediatric Nephrology has become the standard reference text for students, trainees, practicing physicians (pediatricians, nephrologists, internists, and urologists), subspecialists, and allied health professionals seeking information about children's kidney diseases. It is global in perspective, reflecting the fact that the international group of editors are all acknowledged world experts. The latest edition of this text is no different, providing a comprehensive, state-of-the-art overview on pediatric nephrology. Much like the previous edition, the latest edition reviews the most critical aspects of the field. Topics covered include developmental physiology and diseases, renal physiology and diagnostic approaches, glomerular disease, kidney involvement in systemic diseases, renal tubular disorders, homeostasis, cystic kidney disease and related disorders, urinary tract disorders, hypertension, acute kidney injury, and chronic kidney failure.Unlike the previous edition, however, the chapters in this edition now combine physiology, clinical management, and pathology for ease of use. The latest edition also includes a new section on the evaluation of different disorders that can have multiple etiologies, setting the stage for the evaluation and management of specific diseases. This book serves as a superb resource and an invaluable asset for practitioners, health professionals, and trainees seeking out information about children's kidney diseases.

Preslaughter handling and slaughter of meat animals'is unique because it covers the entire period of preslaughter period and slaughter, and its effects on the welfare of multiple species destined for meat production. Several chapters describe the current knowledge on all welfare topics from pre-transport preparation at the farm to stunning and slaughter, and the assessment of animal welfare and stress through physiological, behavioural and meat and carcass quality measures. Other chapters cover new and important topics, such as mobile slaughter and preslaughter handling, and slaughter of non-traditional meat species. This unique and comprehensive work is written by internationally renowned experts and accomplished scientists in the field, who are engaged in active research laboratories and who have demonstrated their devotion to animal care and welfare. This work will be of interest and relevance to animal scientists, academics, students, animal welfare and industry associations, policy makers, veterinarians, livestock and poultry chain stakeholders, and all those involved in and who care about the humane handling of meat species.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer's disease, Parkinson's disease, and Huntington's disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. - Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aβ peptide, tau protein, α-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases - Elucidates neurogenetics of gene APP, gene PSEN1,　gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases - Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer's disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial α 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors - Demonstrates the role of caspases and apoptosis in Parkinson's disease covering truncation of α-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, Δtau314, and several other factors - Explains etiopathogenesis of Huntington's disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1α gene, advanced glycation end-products, autophagy, and many other significant topics

Nucleation of Water: From Fundamental Science to Atmospheric and Additional Applications provides a comprehensive accounting of the current state-of-the-art regarding the nucleation of water. It covers vapor-liquid, liquid-vapor, liquid-ice and vapor-ice transitions and describes basic kinetic and thermodynamic concepts in a manner understandable to researchers working on specific applications. The main focus of the book lies in atmospheric phenomena, but it also describes engineering and biological applications. Bubble nucleation, although not of major atmospheric relevance, is included for completeness. This book presents a single, go-to resource that will help readers understand the breadth and depth of nucleation, both in theory and in real-world examples. - Offers a single, comprehensive work on water nucleation, including cutting- edge research on ice, cloud and bubble nucleation - Written primarily for atmospheric scientists, but it also presents the theories in such a way that researchers in other disciplines will find it useful - Written by one of the world's foremost experts on ice nucleation

A comprehensive guide to understanding mental health, Psychopathology and Function, Sixth Edition offers helpful insights and strategies for occupational therapists to understand the approaches of other disciplines, such as medicine, physical therapy, social work, psychology, and nursing, and work effectively in the care team. An essential occupational therapy resource for more than 30 years, Dr. Bette Bonder's Psychopathology and Function, Sixth Edition clearly describes occupational therapy's unique perspectives and contributions to improving the lives of those struggling with emotional and psychological challenges. The Sixth Edition offers an overview of important research and discusses current and emerging issues and knowledge of mental health issues. Readers will gain an appreciation of the centrality of occupation and meaning to mental health and quality of life as they understand how occupational therapy can emphasize and assert its value. New updates in the Sixth Edition include: • Increased emphasis on issues of social justice • Incorporation of material about the impact of the COVID-19 pandemic on mental health issues • A new chapter on gender dysphoria • A new chapter on sociocultural factors in mental disorders • A streamlined and updated pharmacology chapter • A discussion about the DSM-5 and the reactions to it 5 years after its release A great resource for occupational therapy students and practitioners, Psychopathology and Function, Sixth Edition recognizes the importance of interventions focused on quality of life. This text offers background knowledge and strategies that can support efforts to address social and situational issues.

It is generally well-established that the biomedical model is informed on the assumption that the occurrence of the disease is the result of biological molecules inside the body. This is seen in the view of the biopsychosocial model that the biomedical model is excluding the importance of psychological, social, economic, environmental, spiritual, and behavioral dimensions of the illness. It is essential to create better awareness to accelerate the use of the biopsychosocial model—focusing on the individual as a whole rather than the illness alone. Acceleration of the Biopsychosocial Model in Public Health accelerates the inclusion of the biopsychosocial model in the public health sector in order to achieve universal health coverage. It provides a better understanding of the role of various factors, such as psychological, social, emotional, economic, and behavioral, that are responsible for the development of diseases in order to develop comprehensive prevention and intervention measures. Covering topics such as psychological well-being, public health awareness, and system dynamics, this premier reference source is an excellent resource for public health officials, health therapists, health educators, health psychologists, occupational therapists, palliative care providers, community healthcare providers, hospital administrators, health professionals, medical students, medical libraries, researchers, and academicians.

This book presents a comprehensive overview of pelvic and sexual pain disorders in women and equips therapists to treat these issues in a culturally sensitive way, examining the link between unwanted sexual experiences and the development of sexual pain in later life. Drawing on the wealth of recent research acknowledging the increased risk of developing a pelvic/sexual pain disorder in women who have experienced sexual trauma, Heather Lauren Davidson offers a much-needed resource for professionals within the essential context of the #MeToo movement. Chapters address a range of topics including types of sexual pain disorders, disparities in the mental health system that affect women's access to treatment, how to establish treatment goals for individuals and couples, and effective relapse prevention plans. Illustrated throughout by vignettes and case studies, the book addresses a lack of knowledge in assessing and treating the experiences of these women and explores in depth how they face complex difficulties in accessing diagnosis and treatment. Guided by culturally competent assessment and the use of evidence-based treatment techniques, clinicians will learn to effectively navigate the treatment of women presenting with pelvic/sexual pain disorders and sexual trauma.

Conservation of biodiversity including plant genetic resources are fundamental for the future life on Earth. To safe-guard crop wild relatives, locally adapted landraces and varieties, ex situ genebanks were established at the beginning of the 20th century; primarily to store seeds. However, as any other material on Earth, seeds age and lose viability when stored for prolonged periods. The main factors determining deterioration processes are the genotype, the environmental conditions during seed development and the storage conditions including relative humidity, temperature, gas composition and pressure. To understand physiological, biochemical and genetic changes during seed deterioration in genetic resources of wheat, barley and oilseed rape, fundamental processes of germination, dormancy and seed viability loss are discussed in this book based on 13 scientific publications. Here, the loss of seed viability was investigated depending on seed moisture contents (MCs) between 5% and >25%, storage temperatures between 0°C and 45°C and a modified atmosphere with increased O2 concentration (75%) or increased atmospheric pressure (18 MPa). Although, the response to the different conditions varied among species, overall, elevating seed MCs and storage temperatures led to a gradual change of biochemical mechanisms during seed deterioration. Under dry seed storage conditions, glutathione (GSH) and tocochromanols functioned as low-molecular-weight antioxidants and were degraded. Lipids were oxidised or hydrolysed, the pH decreased, whereas organic radicals accumulated over time and correlated negatively with seed viability. At high seed MCs (>13%) and storage temperatures (>40 °C), membrane damages, changes of pH or organic radicals were absent. Furthermore, GSH and GSSG depleted whereas tocochromanols remained stable or increased. Therefore, seeds stored under high MCs and temperatures were exposed to a different environment than seeds exposed to lower MCs and temperatures where water activity and deterioration rate were reduced and the cytoplasm was assumed to be glassy. As a consequence, quantitative trait loci (QTLs) varied between ageing treatments; thus to understand genetic mechanisms of seeds deterioration in seedbanks, studies must be carried out on dry-stored seeds. Overall, our plant genetic resources are safely preserved in genebanks. However, to avoid genetic drift and to prolong the life of the seed, the conditions for pre-storage and storage should be further optimised and improved for each individual species. Die Erhaltung der biologischen Vielfalt, einschließlich der pflanzengenetischen Ressourcen, ist von grundlegender Bedeutung für das künftige Leben auf der Erde. Um verwandte Wildarten von Nutzpflanzen, lokal angepasste Landrassen und Sorten zu schützen, wurden Anfang des 20. Jahrhunderts Ex-situ-Genbanken eingerichtet, die vor allem Saatgut lagern. Wie jedes andere Lebewesen auf der Erde altert auch Saatgut und verliert an Vitalität, wenn es über einen längeren Zeitraum gelagert wird. Die wichtigsten Faktoren, die für den Verlust der Lebensfähigkeit von Saatgut verantwortlich sind, sind der Genotyp, die Umweltbedingungen während der Entwicklung des Saatguts und die Lagerungsbedingungen wie relative Luftfeuchtigkeit, Temperatur, Gaszusammensetzung und atmosphärischer Druck. Um die physiologischen, biochemischen und genetischen Veränderungen während der Saatgutalterung bei den genetischen Ressourcen von Weizen, Gerste und Raps zu verstehen, werden in diesem Buch auf der Basis von 13 wissenschaftlichen Veröffentlichungen die grundlegenden Prozesse der Keimung, der Keimruhe und des Verlustes der Lebensfähigkeit von Saatgut diskutiert. Die Veränderung der Vitalität von Saatgut wurde in Abhängigkeit von verschiedenen Lagerungsbedingungen wie Feuchtigkeitsgehalte zwischen 5% und >25%, Lagertemperaturen zwischen 0°C und 45°C und eine modifizierte Atmosphäre mit erhöhter O2-Konzentration (75%) oder erhöhtem atmosphä

Aesthetic or cosmetic gynecology is a rapidly expanding and much in demand field worldwide. This book covers all aspects of cosmetic gynecology in great details and interdisciplinary fields. It provides information and practical tips on the new evolving and fast growing branch of aesthetic and regenerative gynecology. The book covers basics along with illustrations, practical tips and troubleshooting points. Chapters include anatomy, physiology, pathology and comprehensive management of diseases in relation to cosmetic gynecology. The book explains the basics of techniques and devices used in this field such as several energy based and high tech devices like lasers, Hifu, HIFEM, their safety profile, scope and uses in an easy to understand language supported by illustrations. It also covers complications, controversies and medicolegal issues surrounding this field. The book includes chapters from national and international experts of each technique and helps in systematic evidence based learning.The book serves as a comprehensive book for postgraduates and consultants in gynecology, plastic surgery, dermatology, urogynecology, vascular surgery, general surgery, for cosmetologists and those interested in regenerative sciences.

Featuring contributions by an international team of the world's experts in urology and gynecology, this fifth edition reinforces its status as the classic comprehensive resource on female urology and urogynecology and an essential clinical reference in the field, with new chapters throughout. Each volume is now available separately. •Offers a comprehensive guide to medical aspects •Covers important classic and newer topics •Presents a practical and manageable level of detail

Biomedical Engineering An exploration of materials processing and engineering technology across a wide range of medical applications The field of biomedical engineering has played a vital role in the progression of medical development technology. Biomedical Engineering: Materials, Technology, and Applications covers key aspects of the field—from basic concepts to advanced level research for medical applications. The book stands as a source of inspiration for research on materials as well as their development and practical application within specialized industries. It begins with a discussion of what biomedical engineering is and concludes with a final chapter on the advancements of biomaterials technology in medicine. Offers comprehensive coverage of topics, including biomaterials, tissue engineering, bioreceptor interactions, and various medical applications Discusses applications in critical industries such as biomedical diagnosis, pharmaceutics, drug delivery, cancer detection, and more Serves as a reference for those in scientific, medical, and academic fields Biomedical Engineering takes an interdisciplinary look at how biomedical science and engineering technology are integral to developing novel approaches to major problems, such as those associated with disease diagnosis and drug delivery. By covering a full range of materials processing and technology-related subjects, it shares timely information for biotechnologists, material scientists, biophysicists, chemists, bioengineers, nanotechnologists, and medical researchers.

This third, thoroughly updated edition of a well received book, presents the most complete collection of theories, paradigms and methods utilized by the landscape sciences. With the introduction of new ecosemiotic concepts and innovative managing procedures, it offers a broad list of ecological, ecosemiotical and cultural tools to investigate, interpret and manage the environmental complexity according to a species-specific individual-based approach. Readers will discover the importance of a landscape perspective to create strategic bridges between science and humanities favored by the holistic sight of sensorial (visual, acoustic, olfactory, tactile, and thermal) “scapes”.Distributed in 10 chapters, the content covers many aspects of the landscape sciences ranging from the description of fundamental theories, principles and models originated by ecological approaches like source-sink models, island biogeography, hierarchical theory and scale. The ecosemioticalapproaches like the eco-field model, the ecoscape paradigm, and the general theory of resources are widely described and discussed. A cultural approach to landscape is utilized to focus on the heritage values of territories and their environmental identity. This book, written in an accessible and didactic style, is particularly dedicated to undergraduate and graduate students but also scholars in ecology, agroforestry, urban planning, nature design, conservation and remediation. Land practitioners, farmers and policymakers can use this book as an authoritative guide to better understand the function and role of environmental systems according to a social-economic integrated perspective.