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This volume comprises the proceedings of the International Workshop, ShapeMI 2023, which took place alongside MICCAI 2023 on October 8, 2023, in Vancouver, British Columbia, Canada.The 23 selected full papers deal with all aspects of leading methods and applications for advanced shape analysis and geometric learning in medical imaging.

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. - Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes - Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes - Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Life expectancy in Japan, South Korea, and much of urban China has now outpaced that of the United States and other high-income countries. With this triumph of longevity, however, comes a rise in the burden of noncommunicable diseases (NCDs) like diabetes and hypertension, reducing healthy life years for individuals in these aging populations, as well as challenging the healthcare systems they rely on for appropriate care. The challenges and disparities are even more pressing in low- and middle-income economies, such as rural China and India. Moreover, the COVID-19 pandemic has underscored the vulnerability to newly emerging pathogens of older adults suffering from NCDs, and the importance of building long-term, resilient health systems. What strategies have been tried to prevent NCDs—the primary cause of morbidity and mortality — as well as to screen for early detection, raise the quality of care, improve medication adherence, reduce unnecessary hospitalizations and increase'value for money'in health spending? Fourteen concise chapters cover multiple aspects of policy initiatives for healthy aging and economic research on chronic disease control in diverse health systems — from cities such as Singapore and Hong Kong to large economies such as Japan, India, and China.

Biomedical Composites, Second Edition, provides revised, expanded, and updated content suitable for those active in the biomaterials and bioengineering field. Three new chapters cover modeling of biocomposites, 3D printing of customized scaffolds, and constructs and regulatory issues. Chapters from the first edition have been revised in order to provide up-to-date, comprehensive coverage of developments in the field. Part One discusses the fundamentals of biocomposites, with Part Two detailing a wide range of applications of biocomposites. Chapters in Part Three discuss the biocompatibility, mechanical behavior, and failure of biocomposites, while the final section looks at the future for biocomposites. Professor Luigi Ambrosio is the Director of the Institute for Composite and Biomedical Materials, Italy. He is a renowned scientist with expertise in biomedical composites and has published over 150 papers in international scientific journals and books, 16 patents, and over 250 presentations at international and national conferences. - Led by an expert editor with many years of experience in academia and widely recognized as an international expert on biomedical composites - Features an overview of biocomposites for a wide range of biomedical applications - Provides revised, expanded, and updated coverage, including three new chapters

The book, “Basic science of spinal diseases”, is categorized into different sections. Section I describes the anatomy and physiology of the intervertebral disc. In this section, anatomy, biomechanics, imaging and vascular anatomy of intervertebral disc are described. Also, various animal models for disc degeneration, back pain & sciatica and spinal deformity are discussed. Section II explains pathophysiology of the intervertebral disc that includes pathophysiology, genetics and the role of inflammation in disc degeneration. Also, pain pathways and various strategies to regenerate the disc are described. Section III, which is the science of spinal instrumentation, includes implant properties and biomechanics of spinal instrumentation. Biomechanics of cervical spine instrumentation, thoracolumbar, lumbar interbody fusion, motion-preserving implants, interspinous process devices and cement augmentation is discussed. Implant testing, patent and regulatory pathways are described. Section IV describes the science of spinal interventions that includes pain management, use of epidural injections and stem cells in spine. Spinal fusion and graft extenders are also discussed.