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In this book recent developments in dehydrogenation reactions catalyzed by 3d-metals are discussed. With continue efforts to develop sustainable chemical production the discovery of new catalysts and catalytic procedures for (de)hydrogenation reactions are a subject of great interest to the chemistry community. Additionally, (de)hydrogenation reactions enable the creation of closed-loop production cycles that support a circular economy. The chapters presented include the synthesis of heterocycles and tandem-multicomponent (three or more) reactions through dehydrogenative strategy, as well as the conversion of ethanol to n-butanol, higher oxidized hydrocarbons like acids, ester, amides from alcohols, α-alkylation of amines, ketones, and amides with alcohols and mechanistic understanding of dehydrogenation reactions with high-valent metals. With contributions from experts in the field, the book is a valuable resource for scholars working in the field of organometallic chemistry,catalysis, medicinal chemistry, as well as researchers in the industry.

This book provides an overview of the new plant natural product skeletons discovered from 1999 to 2021. It categorizes these natural products by providing their names, source distributions, structural types, structure characteristics, and bioactivities. A total of 1373 plant products in 99 families are presented, which cover 36 different structure types within the Hypericaceae family of which the majority are alkaloid structures. In addition, it presents the biological profiling in the last 23 years by summarizing the biological activities and potential disadvantages. The new natural products skeleton presented are unprecedented structural scaffolds and could bring new opportunities for biological/pharmaceutical areas and provide new structure templates for synthetic chemists. This book helps readers gain in-depth insight into the past and recent trends of natural products; it also assists those interested in assessing the potential biological function of the natural products.

Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides Revolutionize your manufacturing processes and more with this groundbreaking introduction Carbohydrates and complex glycosides are important classes of molecules. The ubiquitous glycosides are extremely diverse in structure and functions, and many of them are of pharmacological significance. Purification of a homogeneous glycoside from the nature sources, especially in an appreciable amount, is always difficult. Chemical synthesis provides a feasible access to the homogenous glycosides and their congeners. Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides presents about 10 families of naturally occurring glycoside natural products, including about 150 molecules that organic chemists have devoted a lot of effort toward their synthesis. In each example, the background of each natural glycoside, including its natural resources, its isolation process and its bioactivities have been described; the total synthesis of the natural glycoside is presented with special emphasis on the glycosylation reaction, the strategy on saccharides assembly, the protecting group manipulation, and the method for the synthesis of the rare saccharide units. Readers can clearly see the progress of total synthesis of naturally occurring glycosides, from early to current arts, from simple to complex molecules, and from tedious strategy to highly efficient and economical methodologies in this book. It will highly benefit the further developments in the total synthesis of naturally occurring glycosides and synthetic carbohydrate chemistry. Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides is ideal for Organic Chemists, Biochemists, Pharmaceutical and Medicinal Chemists, Natural Products Chemists, and Pharmaceutical Industry

This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer's disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.

Plant cell walls have been relevant for human survival throughout evolution, from cell walls recognised as an essential ingredient in human and livestock nutrition, to their use in energy generation, construction, tool making, paper and clothing. This plant-generated material is at the centre of a myriad of human activities, and it represents the world's most abundant natural resource for fuel, fibre, food and fodder. Plant Cell Walls: Research Milestones and Conceptual Insights provides an overview of the key discoveries of hundreds of years of plant cell wall research. With chapter contributions from prominent scientists in the cell wall field, this book provides a comprehensive treatment of plant cell wall research, accompanied by a historical overview to illustrate how concepts have evolved, and how progress has been enabled by emerging technological advances.Plant Cell Walls: Research Milestones and Conceptual Insights elaborates on the translation of research to application in biotechnology and agriculture, and highlights its relevance for climate change mitigation and adaptation. It will be a key resource for plant cell biologists, biochemists and geneticists.

Prosopis (Prosopis juliflora) is a xerophyte which, in its native habitats has been a desert plant. As long as it was confined to that habitat, P. juliflora was a great resource, improving the region's micrometeorology, binding its sandy soil, and providing shelter, fuel, feed, food, medicines, and cosmetics to the people of such regions. In particular, for the economically weaker inhabitants, P.juliflora was a lifeline.But when P. juliflora was indiscriminately introduced in other regions of the world in a hope to derive similar benefits from it, things began to go awry. Indeed, among the invasive species of plants which are spreading at an alarming rate in the tropical and sub-tropical regions of the world, P.juliflora is arguably the most hardy and resilient. It is growing so explosively that it even enters roads and homes, driving humans out of their dwellings. The resulting damage to biodiversity is enormous. This book highlights the dual role played so far by P. juliflora and itemizes the facets that make it a blessing in some contexts and a bane in other contexts.Authored by leading experts in the field, Prosopis juliflora: Attributes, Impact, Utilization is the first title of its kind to comprehensively discuss this hardy plant species. It will be an essential read for students, researchers and governmental agencies interested in plant biology, forestry, plant ecology, invasive plant species and environmental science. - Summarizes all the key information available on P. juliflora, from its origin and systematics to its future prospects - Discusses colonization, utilization and eradication - Authored by leading experts in the field with over 40 years of experience

In this book, key experts in the field of total synthesis of natural products in Japan describe the details of their synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments, including those routes that were unsuccessful the book provides the reader with a better understanding of how other researchers devise their strategy and overcome difficulties in their studies. The contributions in the book have focused on highlighting the research from Japan however it is appealing to researchers and students worldwide. This compilation of cutting-edge natural product synthesis provides high-quality expertise, especially to graduate students and young researchers, regarding research on synthetic organic chemistry. It can be utilized as teaching material in university seminars as well as provide guidance to researchers in the area of total synthesis.This is an open access book.

This volume presents three chapters discussing a range of topics. Chapter 1 deals with the development of efficient methods for compound dereplication that have been critical in the re-emergence of research on natural products as a source of new drug leads. It describes the main methods of dereplication, which rely on the combined use of large natural product databases and spectral libraries, alongside the information obtained from chromatographic, UV-Vis, MS, and NMR spectroscopic analyses of the samples of interest. Chapter 2 describes 989 plant natural products and their ecological functions in plant-herbivore, plant-microorganism, and plant-plant interactions. These compounds include alkaloids, phenols, terpenoids, and other structural types. The information presented should provide the basis for in-depth research on these plant natural products and their natural functions, and also for their further development and utilization. Chapter 3 focuses on lichens, with each constituting a symbiotic association composed of a primary mycobiont and one or more photobionts living mutualistically. Covered are lichens and their bionts, taxonomic identification, and their chemical constituents as exemplified by what is found in lichen biomes, especially those endemic to North America. Extraction and isolation procedures, as well as updates on dereplication methods using mass spectrometric GNPS and NMR spectroscopic spin network fingerprint procedures, and marker-based techniques to identify lichens are discussed. The isolation and structure elucidation of secondary metabolites of an endolichenic Penicillium species that produces bioactive compounds is described in detail.

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part Two: Potent Botanicals to Overcome Cancers and their Chemoresistance offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently overcome cancers and their drug resistance. The book identifies and comments on the best cytotoxic African medicinal plants. The book also provides knowledge on ethnomedicinal uses of the identified plants, their pharmacological potency, and their phytochemistry.An overview of the relationship between cancer and other human diseases healed in the traditional health system with the plants documented is also highlighted. The book appears a unique tool for Scientists to have state-of-the-art of the best cytotoxic plants from the African flora. - Provides a unique tool compiling the best of African plants with amazing potential toward various cancer cell lines, including the multidrug-resistant phenotypes - Discusses in highlights the geographic distribution of the best cytotoxic African plants - Compiles the ethnomedicinal, pharmacological, and phytochemistry information of the best antiproliferative African plants

Emergence of lifestyle diseases, e.g., type II diabetes, cancers, obesity, cardiovascular disorders, liver cirrhosis, etc., are exponentially increasing day by day. Modern drifts toward the utilization of herbal medicines in different healthcare aspects necessitate (demand) the replacement of synthetic molecules with phytoconstituents because of their biocompatibility, biodegradability, economic extraction process, and ready availability from the natural source. This book provides a thorough insight into the comprehensive and up-to-date trends of phytomedicines in the management of lifestyle diseases and its mechanisms, modern methods of extraction and purification of phytoconstituents, and chemical characterization as well as standardization of phytoconstituents using modern equipments.

This book is the second edition of the one originally published in 2016, which focused on state-of-the-art microfluidic research in medical and biological applications. Similar to the first edition, beginners in the field —undergraduates, engineers, biologists, medical and pharmaceutical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. In this second edition, significant revisions have been made to chapters covering technologies that have seen major advancements, such as acoustofluidics, protein crystallography, organ-on-a-chip systems, nanopore sensing, and paper-based microfluidics. In addition, the chapters on cancer diagnosis using exosomes and single-cell sequencing using droplet microfluidics, which are attracting attention as new technologies, have been newly added. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.

This book highlights recent research and advances in natural product chemistry written by promising young researchers in this field who have played a central role for recent innovative advancements. The book consists of seventeen chapters covering novel bioactive natural products, uncovering life phenomena with natural products, biosynthesis of natural products, total synthesis of complex natural products by innovative strategies, and drug discovery using natural products. Each chapter begins with a brief and easy-to-understand introduction, then presents the cutting-edge research in each individual specialty. This book is not only a practical and essential reference resource for natural product chemists, medicinal chemists, synthetic organic chemists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries, but is also a useful guide to understanding new and emerging trends in this field.

This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances.There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans.The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book.The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats.Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.

Biosurfactants: Research and Development provides a thorough overview of biosurfactant research and development across a range of settings and industries, highlighting the novel use of enzymes, metabolic and genetic engineering in biosurfactant production and showcasing diverse experimental models and approaches. Sections discuss fundamental characteristics of biosurfactants, their physio-chemical properties, and their differences from chemically synthesize surfactants, different research approaches for the study of known biosurfactants, and the genetic manipulation of microorganisms to increase biosurfactant productivity, or to produce molecules with improved characteristics. Throughout the book, methods and approaches are discussed in easy-to-digest formats, with methods discussed, ranging from in silico approaches to classical biocatalysis omics analysis and metabolic engineering. - Provides a through overview of biosurfactant enzymes and microorganisms used in biosurfactant production - Features instruction in a wide range of research and development approaches, ranging from in silico techniques to classical biocatalysis omics analysis and metabolic engineering - Features chapter contributions from international leaders in the field

This unique volume covers specific aspects of the biological chemistry of terpenoids. It provides extensive information related to classification, general methods of extraction and isolation of terpenoids, synthesis and pharmacological activities of monoterpenoids, synthesis and medicinal uses of diterpenoids, biogenesis of terpenoids, synthesis and medicinal uses of sesqui terpenoids and sesterpenoids. Some terpenes are also classified as diterpene alkaloids. Most of the terpenoids with diverse molecular structures are biologically active and are used for the treatment of various diseases such as cancer, malaria, inflammation, tuberculosis and infection, and this is discussed.Features:Activities and biological relationships of terpenes An accurate assessment of where and what terpenes can lead to Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes Arranged by biological activities and usage Provides information on eukaryotic enzymes that have been shown to be a source of “ethnobotanical” terpenes

Pharmacognosy: Fundamentals, Applications and Strategies, Second Edition represents a comprehensive compilation of the philosophical, scientific and technological aspects of contemporary pharmacognosy. The book examines the impact of the advanced techniques of pharmacognosy on improving the quality, safety and effectiveness of traditional medicines, and how pharmacokinetics and pharmacodynamics have a crucial role to play in discerning the relationships of active metabolites to bioavailability and function at the active sites, as well as the metabolism of plant constituents. Structured in seven parts, the book covers the foundational aspects of Pharmacognosy, the chemistry of plant metabolites, their effects, other sources of metabolites, crude drugs from animals, basic animal anatomy and physiology, technological applications and biotechnology, and the current trends in research. New to this edition is a chapter on plant metabolites and SARS-Cov-2, extensive updates on existing chapters and the development of a Laboratory Guide to support instructors execute practical activities on the laboratory setting. Covers the main sources of natural bioactive substances Contains practice questions and laboratory exercises at the end of every chapter to test learning and retention Describes how pharmacokinetics and pharmacodynamics play a crucial role in discerning the relationships of active metabolites to bioavailability and function at active sites Includes a dedicated chapter on the effect of plant metabolites on SARS-CoV-2

Application of Waste Materials in Lightweight Aggregates presents the current state of knowledge on aggregates production methods, their characteristics, current standards and legal regulations. In addition, the book briefly discusses the issue of the presence of different types of waste in the environment (including municipal, agricultural, energy and mining industries), their characteristics and uses for the production of lightweight aggregates. This book serves as a source of academic information on the course and conditions of using various waste treatment processes for academics, engineers, professionals and students interested in environmental engineering, as well as for companies dealing with recycling and disposal of waste.

The use of different foods, herbs, and spices to treat or prevent disease has been recorded for thousands of years. Egyptian papyrus, hieroglyphics and ancient texts from the Middle East have described the cultivation and preparations of herbs and botanicals to “cure the sick.” There are even older records from China and India. Some ancient scripts describe the use of medicinal plants which have never been seen within European cultures. Indeed, all ancient civilizations have pictorial records of different foods, herbs, and spices being used for medical purposes. However, there are fundamental issues pertaining to the scientific evidence for the use of these agents or their extracts in modern medicine. These issues are explored in Ancient and Traditional Foods, Plants, Herbs and Spices Used in Diabetes. Features· Investigates alternative healthcare paradigms that use traditional dietary foods, plant-derived materials, and extracts to treat diabetes· Describes scientific studies using modern day biomedical techniques· Provides information on diets, specific agents, extracts and resources.· Many chapters focus on plant-derived material, providing a historical background, uses, toxicity, and cautionary notes and summary points.There have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. Diabetes is one of the most common diseases worldwide, with over 400 million people with the illness. With chapter contributions by an international panel of contributors, this book is useful for researchers in the area of functional foods. Diabetologists, nutritionists, endocrinologists, healthcare workers, and pharmacologists will also find this book extremely valuable.

The year 2022 has been declared by the United Nations as the “International Year of Basic Sciences for Sustainable Development”. Sustainable development is focused on the UN's 17 Sustainable Development Goals. These require the use of basic sciences. This edited book (volume 1) is a collection of twelve invited and peer-reviewed contributions from chemistry, materials science, energy applications, and artificial intelligence.

This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP. The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.

This book provides an overview of biosurfactants as biobased compounds, and highlights novel applications in several industries, including biotech, food processing, cosmetic, oil recovery/petroleum, pharmaceutical, detergent and textile. In the past few decades, biosurfactants have emerged as promising alternative surface-active agents to chemical surfactants due to their high biodegradability, low toxicity, multi-functionality under extreme pH and temperature conditions, long-term physicochemical stability, and their production from renewable sources. This book presents the fundamental aspects (classification, structure, genetics, and properties) of biosurfactants and how their features contribute to the global bioeconomy. Chapters from expert contributors discuss the latest screening, purification and characterization methods of new biosurfactants and biosurfactant-producing fungi and bacteria, including extremophiles. Particular attention is given to the role of biosurfactants in the formulation of sustainable agrochemicals, and their application as eco-friendly mosquitocidal agents, and biopesticides. Readers will discover a perspective on the antiviral activity of biosurfactants, in which the latest in vitro and in silico studies are discussed. Readers will also find more about the foremost therapeutic attributes of biosurfactant-mediated nanoparticles as next-generation drug delivery systems. Given its breadth, this book appeals to a wide readership, from students and academic researchers to scientists and professionals from industry, interested in the study and application of microbial surfactants.

The present volume is the third in a trilogy that documents naturally occurring organohalogen compounds, bringing the total number — from fewer than 25 in 1968 — to approximately 8,000 compounds to date. Nearly all of these natural products contain chlorine or bromine, with a few containing iodine and, fewer still, fluorine. Produced by ubiquitous marine (algae, sponges, corals, bryozoa, nudibranchs, fungi, bacteria) and terrestrial organisms (plants, fungi, bacteria, insects, higher animals) and universal abiotic processes (volcanos, forest fires, geothermal events), organohalogens pervade the global ecosystem. Newly identified extraterrestrial sources are also documented. In addition to chemical structures, biological activity, biohalogenation, biodegradation, natural function, and future outlook are presented.

El UNAM, Instituto de Química de la UNAM ha realizado aportaciones continuas a la química de Productos Naturales desde su fundación, en 1941, parte de las cuales han sido reseñadas en el libro Química de la Flora Mexicana. Investigaciones en el UNAM, Instituto de Química de la UNAM (Romo de Vivar, A. (Ed.) 2006, UNAM, Instituto de Química de la UNAM y Sociedad Química de México). Ahora, en ocasión del 75 aniversario de la dependencia universitaria que se celebrará en 2016, en el presente libro se han integrado contribuciones de diversos autores que cultivan este campo de conocimiento en varias instituciones, las cuales ilustran la diversidad de temas de química de productos naturales que se estudian en el país.

Honey A vital understanding of the health effects of this renowned natural food Honey is among the most famous and widely available natural food products in the world, and its flavor profiles are well understood. Despite its use as a natural remedy by many societies, however, there has until recently been no systematic attempt to assess the scientific basis for claims about honey's health benefits. The ubiquity of honey and honey-derived natural remedies make such an assessment highly desirable. Honey: Composition and Health Benefits offers a systematic assessment for the first time, analyzing the substances that make up honey and their health effects, both separately and in combination. Dedicating full chapters to each of honey's constituent materials, this book provides the first full-length and comprehensive treatment of this natural food. It also includes content on other honey products such as royal jelly, propolis, and bee venom. It promises to shed scientific light on centuries of tradition. Honey readers will also find: Detailed treatment of honey's constituent carbohydrates, amino acids, organic acids, and more Closing chapters dealing with contaminants and toxins found in honey A vast and distinguished team of global contributors with decades of expertise Honey promises to be essential for food scientists, nutritionists, and health scientists, both in academic research and in industry.

Water Management and Circular Economy covers the role of water in the mainstream dimensions of society, economy, environment/ecology and technology. Along with the under conceptualization of the Circular Economy (CE), the book covers the role of recycling and reusing the otherwise lost sources of waste, gray or untapped water sources towards a second round of utility. This book bridges the gap between water inflows in nature with the wide spectrum of its potential applications in humanity. Sections cover direct and indirect entities conceptualized as'outflows, including water, energy, products and services to urban, suburban, rural and insular contexts of analysis. As such, this content will be important reading for Water Scientists, Water Managers, and civil engineers. - Includes real-world applications and case studies to show how these policies can be adopted - Presents global coverage, with a diverse list of contributors – all of whom are experts in the field - Showcases a multidisciplinary approach, with editors from environmental and managerial backgrounds, thus helping to cross the bridge between social and science fields

African Flora to Fight Bacterial Resistance, Part Two: The Best Source of Herbal Drugs and Pharmaceuticals, Volume 107 offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle bacterial drug resistance. Chapters cover Phytochemistry and antibacterial potential of the genus Allanblackia, Phytochemistry and antibacterial potential of the genus Beilschmiedia, Phytochemistry and antibacterial potential of the genus Fagara, Phytochemistry and antibacterial potential of the genus Garcinia, Harungana madagascariensis as a source of antibacterial agents, Hypericum roeperianum as a source of antibacterial agents, and much more. - Provides a unique resource and compilation of the best African plants with amazing potential against multidrug-resistant bacteria - Discusses, in detail, the antibacterial potential of the best phytochemicals identified in African plants against multidrug-resistant bacteria - Compiles the ethnomedicinal, pharmacological and phytochemistry information of the best antibacterial African plants and their most potent phytochemicals

Air Quality Monitoring and Advanced Bayesian Modeling introduces recent developments in urban air quality monitoring and forecasting. The book presents concepts, theories, and case studies related to monitoring methods of criteria air pollutants, advanced methods for real-time characterization of chemical composition of PM and VOCs, and emerging strategies for air quality monitoring. The book illustrates concepts and theories through case studies about the development of common statistical air quality forecasting models. Readers will also learn advanced topics such as the Bayesian model class selection, adaptive forecasting model development with Kalman filter, and the Bayesian model averaging of multiple adaptive forecasting models. - Covers fundamental to advanced applications of urban air quality monitoring and forecasting - Includes detailed descriptions and applications of the instruments necessary for the most successful monitoring techniques - Presents case studies throughout to provide real-world context to the research presented in the book

Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. - Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology - Includes full color presentations throughout - Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach - Includes a clinical overview for each major bacterial group - Presents the latest information on vaccine development, molecular technology and diagnostic technology - Provides more than 100 chapters on all major groups of bacteria

The Handbook of Green and Sustainable Nanotechnology presents sustainable and green technologies for the development of products and processes which are environmental friendly, economically sustainable, safe, energy-efficient, decrease waste and diminish greenhouse gas emissions. It provides the overall spectrum of fundamentals, development and applications of sustainable and green technologies. Topics such as legal, health and safety issues are discussed as well. The book elucidates paths to real time utilization of green and sustainable nanotechnology at commercial scale.

Mass Spectrometry for Lipidomics All-in-one guide to successful lipidomic analysis, combining the latest advances and best practices from academia, industry, and clinical research Mass Spectrometry for Lipidomics presents a systematic overview of lipidomic analysis, covering established standards of lipid analysis, available technology, and key lipid classes, as well as applications in basic research, medicine, pharma, and the food industry. Through connecting recent technological advances with key application areas, this unique guide bridges the gap between academia and industry by translating the vast body of knowledge that has been gained in the past decade into much-needed practical advice for novices as well as routine users. Edited by the president and vice-president of the International Lipidomics Society with contributions from the top experts in lipid analysis, Mass Spectrometry for Lipidomics covers a wide range of key topics, including: Aspects of sample preparation, separation methods, different mass spectrometry modes, as well as identification and quantitation, including the use of bioinformatics tools for data analysis Identification, quantitation and profiling of lipids in different types of biological samples Analytical approaches for all major classes of biological lipids, from fatty acids to phospholipids to sterols Novel applications in biological research, clinical diagnostics, as well as food and crop science For analytical chemists, biochemists, clinical chemists, and analytical laboratories and hospitals, Mass Spectrometry for Lipidomics presents a comprehensive and authoritative overview of the subject, with unmatched expertise from practicing professionals actively involved in the latest research.

Oxylipins are an important class of signaling molecules in plants, which play an important role in plant defence and innate immunity. Oxylipins have critical roles in plant growth and plant responses to physical damage caused by herbivores, insects, and pathogenic microbes. Over the last decade, our understanding of oxylipin production, metabolism, and function, particularly jasmonates, has advanced considerably. Jasmonates have provided further mechanistic insights into enzyme function and signalling cascades. Other oxylipins, such as hydroxy fatty acids, have recently been shown to exhibit individual signaling features and crosstalk with other phytohormones.There is scant literature on plant oxylipins and their relevance to our understanding and therefore, understanding oxylipin production, metabolism, and function is pivotal. As a result, researchers, students, professors, and other book readers will have a thorough understanding of plant oxylipin biosynthesis, structure, and function, assisting in the improvement of plant science.Plant oxylipins: metabolism, physiological roles, and profiling techniques address the mechanism, metabolism, and roles of oxylipins in plant resistance to various biotic and abiotic stimuli in detail. This book covers fundamental ideas in oxylipin production, metabolism, structural biochemistry, and signaling pathways. It also discusses cutting-edge methodologies for oxylipin metabolic profiling, with an emphasis on computing applications. This book is an excellent resource for plant scientists, plant biochemists, biotechnologists, botanists, phytochemists, toxicologists, chemical ecologists, taxonomists, and other scholars in those subjects. The book is written by a global team of professionals. Features Presents concrete and extensive information about a basic and applied aspect of plant oxylipins as well as expanded coverage of signaling mechanisms. Highlights the fundamental concepts of the biosynthesis, metabolism, structural biochemistry, and signaling pathway of oxylipins. Details the state-of-the-art methods and techniques in metabolic profiling of oxylipins in plants. Presents insights on computational applications in the evaluation and study of oxylipins in plants.

The primary aim of the book Small Millets and Pseudo Cereals for Nutritional and Health Security is to present comprehensively the significance and critical research carried out worldwide on these climate-resilient crops, including their origin, cultivation techniques, harvesting information, processing, chemical and nutritional composition, physico-chemical characteristics, processing technology, health-promoting attributes, traditional and modern foods, to the scientific community, student body, and the general public. This book will be highly useful to the common consumer in making nutritious food choices. The 20 chapters in this book have been authored by reputable contributors who possess extensive knowledge in their respective fields from government, industry, and academia. This book will serve as an essential reference for researchers, academicians, and students involved in research and development activities, as well as government officials and policy makers to address the issue of malnutrition in rural areas. Furthermore, this book will drive future research in uncharted territories of traditional foods based on nutri-cereals and pseudo-cereals.

Endophytic Association: What, Why, and How focuses on the endophytic association of plants, how they have originated inside the host, their importance, and how they are beneficial for the environment, as well as humans. The book discusses how using endophytic microbes in agricultural fields can be enriched without impacting environment negatively, and how they can be utilized for pharmaceutical purposes, including bioremediation. It includes advanced and up-to-date information, as well as future directions for young researchers and scientists who are working in the field of agriculture, pharmaceuticals, bio nanotechnology and bioremediation of environmental contaminants for environmental protection and sustainable development. - Details the underlying mechanisms of endophyte-host association and their signaling mechanisms - Describes numerous, successful field studies on the different applications of nanoparticles produced by endophytes (bio-nanotechnology) for sustainable development - Presents recent advances and challenges in endophyte-associated bio-remediation research and applications for human health - Provides information on bioactive compounds produced by endophytes for pharmaceutical purposes

This contributory volume is a comprehensive account of recent research on extremophilic fungi. It brings to the readers, latest information on all categories of extremophilic fungi, their isolation, culture, and potential applications. The book aims at providing the audience in-depth and updated theoretical concepts, also application on the field. It will serve as a supplementary reading material in addition to basic mycology textbooks. The book fills the gap in literature and will be useful to the postgraduate students and researchers in the field of mycology, agriculture, biotechnology and Microbiology.

Medicinal plants supply the ever-growing needs of humankind for natural chemicals, such as pharmaceuticals, nutraceuticals, agrochemicals, and chemical additives. These plants contain bioactive secondary metabolites, which possess antimalarial, anthelminthic, anti-inflammatory, analgesic, antimicrobial, antiarthritic, antioxidant, antidiabetic, antihypertensive, anticancer, antifungal, antispasmodic, cardioprotective, antithyroid, and antihistaminic properties. Secondary metabolites play a major role in the adaptation of plants to the changing environment and stress condition as they are affected by both biotic and abiotic stress. Humans rely on medicinal plants for various needs since ancient time, and their population still seems enough for fulfilling our demands. However, in the foreseeable future, we will be forced to think about the accessibility of resources for future generations. For these reasons, we must look for alternative sustainable options of resources which can protect these immensely important medicinal plants from various stresses induced by challenging environment. Evolving eco-friendly methodologies and mechanisms to improve these plants'responses to unfavorable environmental circumstances is important in creating significant tools for better understanding of plant adaptations to various abiotic stresses and sustaining the supply of pharmaceuticals as global climate change intensifies. One of the great challenges in the near future will be the sustainable production of medicinal plants under increasing adverse effects of climate change. A combination of adverse demographic factors and climatological perturbations is expected to impact food and pharmaceutical production globally. Despite the induction of several tolerance mechanisms, medicinal plants often fail to survive under environmental extremes. To ensure their sustainable production under adverse conditions, multidisciplinary approaches are needed, and useful leads are likely toemerge. However, improving plants'performance under restrictive growth conditions requires a deep understanding of the molecular processes that underlie their extraordinary physiological plasticity. This edited volume emphasizes the recent updates about the current research on medicinal plants covering different aspects related to challenges and opportunities in the concerned field. This book is an attempt to bring together global researchers who have been engaged in the area of stress signaling, crosstalk, and mechanisms of medicinal plants. The book will provide a direction towards implementation of programs and practices that will enable sustainable production of medicinal plants resilient to challenging environmental conditions. Moreover, this book will instigate and commence readers to state-of-the-art developments and trends in this field.

Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health. - Includes sections on fatty acid synthesis, lipid storage and hydrocarbon production - Covers biophysics, biochemistry, metabolism and the bioengineering of plant and algae lipids - Provides readers with a comprehensive resource on lipid dynamics and fluxes in plants and algae

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine sheds new light on various applications of microbial metabolites in the biomedical sector. The purpose of this book is to integrate the latest research advancements on the application of microbial metabolites in the medical industry into a single platform. In 10 chapters, the significance of biomedical applications and future therapeutic applications of microbial metabolites in human health are highlighted. Several chapters are dedicated to the role of microbial metabolites in precision medicine like the impact of the activities of microbial metabolites in antitumor and antidiabetic agents and immunosuppressive activities. It also provides a roadmap for drugs discovery based on antimicrobial products and the effect of microbial metabolites on humans'health and the immune system. The book finalizes with a chapter on the use of microbial metabolites in OMICS technology. Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine targets researchers from both academia and industry, professors, and graduate students from microbiology, molecular biology, biotechnology, and immunology. - Highlights various microbial metabolites and their application in the biomedical sector - Illustrates the application of microbial metabolites as potential therapeutic agents - Convenient for buyers and readers to understand the basics with advanced information of microbial metabolites

This book introduces the approach of Machine Learning (ML) based predictive models in the design of composite materials to achieve the required properties for certain applications. ML can learn from existing experimental data obtained from very limited number of experiments and subsequently can be trained to find solutions of the complex non-linear, multi-dimensional functional relationships without any prior assumptions about their nature. In this case the ML models can learn from existing experimental data obtained from (1) composite design based on various properties of the matrix material and fillers/reinforcements (2) material processing during fabrication (3) property relationships. Modelling of these relationships using ML methods significantly reduce the experimental work involved in designing new composites, and therefore offer a new avenue for material design and properties. The book caters to students, academics and researchers who are interested in the field of materialcomposite modelling and design.

This book provides updated information on marine-based biomedical carriers and their therapeutic potential. Marine biomaterials and bio-based carriers show wide application in pharmaceutical and biomedical fields to deliver small and large molecules. Biomaterial-based composites, scaffolds, or matrix systems are sound systems for controlled and prolonged drug release in target sites and control the premature release of drugs or bioactive compounds. This book discusses essential topics such as the therapeutic potential of marine collagen, management of bone disorders, gene delivery, natural marine compounds in immunomodulation, theranostic applications, tissue engineering, and regeneration. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. Marine biomaterial-based systems are popular for tissue engineering and biomedical imaging.This book is ideal for industry experts, students, and researchers in pharmaceutical sciences and pharmacology.

The Alkaloids, Volume 88, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on the Biology of quinoline and quinazoline alkaloids, Synthesis of pyrimidine-containing alkaloids, and much more. - Provides the latest information on the study of alkaloids - Covers alkaloid chemistry, biology, pharmacology and medical applications - Contains more than 80 published volumes in this interesting field of study

Indian mycologists have extensively studied various groups of fungi such as soil fungi, aquatic fungi, marine fungi, endophytic fungi, fungi associated with man and animals. Though several books on various aspects of fungi are published, this is the first account of the history and development in mycology in India. This book is the second volume of the two-volume book'Progress in Mycology: An Indian Perspective'. While volume 1 contains the historical aspects, taxonomy and information about the various groups of fungi, this volume focuses majorly on the biotechnological applications of the different groups of fungi. It discusses topics such as the extremophilic fungi, the history and development in Candida research, progress of mycotoxin research in India etc. It provides a detailed account of the various enzymes and bio-active molecules derived from fungi. India shows a very high biodiversity of fungi, and this book discusses these different group of fungiand their industrial and biotechnological applications. This book is useful to students, teachers and researchers in botany, microbiology, biotechnology and life sciences, agriculture and industries using fungi to produce various valuable products.

The book covers all aspects of endoscopic biopsies of the stomach inclusive of gastritis and gastropathies. It highlights the best way of handling of endoscopic biopsies in the endoscopic room by the gastroenterologist. It elucidates various steps involved in processing of the biopsy, tissue embedding and paraffin sectioning, approach to interpretation, various precautions that require to be taken while interpreting the biopsies, and the essential background knowledge of the interpreter. The book highlights the importance of the little things for a proper reading like matching of the tissue fragments received and the number of tissue present on a slide after the paraffin section.Chapters cover various forms of gastritis, and the easiest approach for daily routine by avoiding the cumbersome classifications and staging formulated for gastritis. It also discusses the utilization of the right nomenclature for acute and chronic gastritis and various other subtypes of gastritis. Chapters include various rarer and infrequently come across conditions of both acute and chronic gastritis, special form of gastritis and infective conditions. It also includes unusual forms of non-neoplastic gastric pathologies such as, a condition, where the gastric mucosa is affected not only by direct exposure to various irritants but may also be affected by many systemic diseases. It also highlights the frequently observed changes in chronic renal and liver failures. The book is targeted to all the practicing pathologists as well as graduate and post graduate students who are keen to learn about non-neoplastic gastric pathology at various levels.

Bioprospecting of nature-based compounds is an important topic of biochemistry, owing to their structural variety and great application prospects. These chemicals, in particular, have been shown to have positive physiological and immunological benefits. Their use has been linked to the prevention of a variety of diseases as well as the promotion of good health. This book mainly intends to highlight high-quality original research and review papers that include innovative bioactive compounds and cutting-edge characterization techniques that contribute significantly to the area of diverse potential applications. The goal of this book is to emphasize the possibilities of utilizing nature-based compounds with favorable health effects in their entirety.

Organic Redox Chemistry Explore the most recent advancements and synthesis applications in redox chemistry Redox chemistry has emerged as a crucial research topic in synthetic method development. In Organic Redox Chemistry: Chemical, Photochemical and Electrochemical Syntheses, some key researchers in this field, including editors Dr. Frédéric W. Patureau and the late Dr. Jun-Ichi Yoshida, deliver an insightful exploration of this rapidly developing topic. This book highlights electron transfer processes in synthesis by using different techniques to initiate them, allowing for a multi-directional perspective in organic redox chemistry. Covering a wide array of the important and recent developments in the field, Organic Redox Chemistry will earn a place in the libraries of chemists seeking a one-stop resource that compares chemical, photochemical, and electrochemical methods in organic synthesis.

Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture. - Highlights the latest developments in stress signaling, cross-talk and PGR mechanisms as applied to agriculture and agronomy - Includes case studies and examples to provide real-world insights - Presents resources for future research and field application

Comprehensive Heterocyclic Chemistry IV provides a first point of entry for scientists interested in heterocyclic ring systems. Given the rapid expansion of publications in this field, this compilation of definitive reviews is especially important and invaluable. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, this book is an invaluable addition to the reference library of anyone working with heterocyclic ring systems. Spanning 14 volumes, over 13,000 pages, and 240 chapters, this new edition builds on, and complements, the material in previous editions. This comprehensive resource is designed to be used both as a standalone resource and in conjunction with earlier works. Comprehensive – CHEC IV offers a comprehensive review of current heterocycles research and critical insight into the future direction of the field with an emphasis on useful and reliable synthesis and reactions, negating the need for individual searches in the primary literature and across various databases Reputation – This 4th edition matches the impressive reputation of the previous editions as the go-to foundational reference in heterocyclic chemistry Clearly structured - Meticulously organized, articles are split into 14 sections on key topics and clearly cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily Interdisciplinary - chapters written by academics and practitioners from various fields and regions ensures that the knowledge within is easily understood by and applicable to a large audience

Plant Extracts in Food Applications is the first book of its kind focusing on the application of plant extracts in the food industry. Topics cover sources, extraction and encapsulation techniques, the chemistry and stability of plant extracts, antimicrobials, preservatives, nutrient enhancers, enzymes, flavoring and coloring agents, packaging aid, health benefits, opportunities and the challenges surrounding the use of plant extracts in food applications. Written by several experts in the field, this book is a valuable resource for students, scientists, and professionals in food science, food chemistry and nutrition. Concerns and potential risks regarding the use of synthetic chemicals have renewed the interests of consumers using natural and safe alternatives. Plant extracts represent an interesting ingredient, mainly due to their natural origin and phytochemical properties, allowing for obtaining active materials to extend shelf-life and add value to the product. - Presents chapters that deal with different sources of plant extracts and their applications in the food industry - Covers the various extraction procedures which are used for plant extracts - Includes the health benefits and stability of plant extracts - Provides the role of plant extracts for shelf life enhancement, packaging aid, and as flavoring and coloring agents

Lignans are aromatic compounds isolated from plants. This handbook presents an authoritative and comprehensive review of lignan chemistry, biochemistry, nomenclature, uses, and occurrence. Lignans are used in a wide variety of industries and this book will appeal to those working in the pulp and paper industries, renewable energy, specialty chemicals, pharmaceuticals, flavors and fragrances, agriculture and forestry, evolution and ecology. Additionally, the book features a comprehensive lignans dictionary section, drawn from the prestigious Dictionary of Natural Products. Other features include: Presents a comprehensive and up-to-date account of this important group of natural products Addresses and resolves problems in current lignan nomenclature Edited by the leaders in the field of lignan chemistry and biochemistry