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Der Begriff menschliches Mikrobiom hat sowohl in der Wissenschaft als auch in der Öffentlichkeit in letzter Zeit große Aufmerksamkeit gefunden. Das Buch führt den aktuellen Forschungsstand des gastrointestinalen Mikrobioms und seinen Einfluss auf eine Vielzahl an Erkrankungen zusammen und benennt neue therapeutische Möglichkeiten, die sich aus den Erkenntnissen ergeben. Internisten, Fachärzte anderer Disziplinen und andere interessierte Fachgruppen erhalten einen Überblick neuer wissenschaftlicher Konzepte. Namhafte Experten aus der Mikrobiom-Forschung erläutern diagnostische und therapeutische Ansätze für die Themenfelder der onkologischen Erkrankungen, Adipositas, Infektionserkrankungen, Neurodegenerative Erkrankungen wie auch den gastrointestinalen funktionellen Krankheitsbildern wie Reizdarmsyndrom oder FD. Eine gute Orientierung bietet das Buch bei der wachsenden Zahl von Studien - unter funktionellen Gesichtspunkten und hinsichtlich von Einsatzmöglichkeiten der zunehmenden Erkenntnisse für die Diagnostik, Prophylaxe und Therapie von Erkrankungen. Es werden Zusammenhänge zwischen Gesundheit und Krankheit und mikrobiellen Konsortien sowie Funktions-Zuschreibungen an bakterielle Spezies und ihre metabolischen Charakteristika vorgenommen. Weiterhin wird die Funktion kommensaler bakterieller Gemeinschaften und der Einfluss dysbiotischer Veränderungen auf die Gesundheit erläutert. Auch die Einflüsse des Mikrobioms auf die Wirksamkeit pharmakologischer Interventionen (z.B. Checkpointinhibitoren) werden als neues relevantes Feld der Mikrobiom-Forschung besprochen.

Towards a better understanding of how medicines are used in society Drug Utilization Research (DUR) is a discipline which combines aspects of pharmacotherapy, epidemiology, and health services research into an interdisciplinary set of methods for analyzing and assessing the prescribing, dispensing and consumption of medicines. It combines both qualitative and quantitative approaches to facilitate the safe and effective use of pharmaceuticals. Drug Utilization Research: Methods and Applications provides a comprehensive introduction to this discipline, prepared by an international team of authors with broad experience in numerous fields. Now reorganized and updated to reflect the latest research and global challenges, it is an indispensable resource for understanding the use of pharmaceuticals. Readers of the second edition of Drug Utilization Research will find: New chapters on methods, including more hands-on guidance on how to plan and conduct different types of drug utilizationA section on specific applications in areas such as psychotropics, opioids, cancer drugs, antibacterials, and cardiovascular drugsA new section with case studies illustrating applications of DUR in different continentsDetailed treatment of subjects including DUR and health policy, DUR in specific populations, and many more Drug Utilization Research is ideal for epidemiologists, pharmacists, physicians, nurses and others interested in drug use and its outcomes.

Head and neck patients who undergo treatment with free tissue transfer are patients with some of the most complex perioperative needs. Due to nature of the defects, reconstructive surgery is complex and often is the only available option offering an acceptable quality of life. Therefore, successful recovery of these patients is of paramount importance. Whilst the surgery itself is of utmost importance, insufficient or inappropriate pre-surgical work up and post-operative care may lead to reconstructive failures. Secondary reconstruction offers less optimal functional outcomes and may add to patient morbidity due to additional surgeries being required. This book serves as a comprehensive source of information related to the pre-, intra- and postoperative care of head and neck patients. It fills a critical need for a single source that addresses all aspects of perioperative management of head and neck patients.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. - Summarizes translational research on brain imaging for brain tumors - Discusses limitations of neuroimaging for diagnosis and treatment - Presents advanced imaging technologies, including CT, MRI, and PET - Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist. Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more. Summarizes the neurologic effects of both cancer and cancer treatment Provides scientific and clinical information relevant to research and treatment Identifies neurological complications by tumor type and tumor therapy Covers GI, lung, breast, gynecological, head and neck cancers, and more Includes radiotherapy, chemotherapy, immunotherapy, and new drugs Contains melanoma, lymphoma, sarcoma, myeloma, leukemia, and more

Anatomical localization skills based in physical examination are essential for any clinician caring for patients with neurologic disease processes. Now fully revised and up to date, Localization in Clinical Neurology, 8th Edition, uses easy-to-read descriptions, full-color illustrations and videos to help readers understand and locate the source of a patient's signs and symptoms. This gold standard text now features dozens of clinical videos that help clinicians improve diagnostic accuracy and avoid unnecessary testing.

This book is an evidence-based guide to the prevention and current management of acute and late toxicities of radiation therapy for a wide range of malignancies. Each chapter focuses on a particular anatomic site and provides information on normal sectional anatomy, contouring of target volumes and organs at risk, dose constraints, the pathophysiology of radiation toxicity, and treatment approaches for each potential toxicity. The information provided will assist in the planning and delivery of intensity-modulated radiation therapy, including volumetric modulated arc therapy, stereotactic radiosurgery, and stereotactic body radiotherapy. It will also enable the selection of appropriate, evidence-based management options in individual patients who experience radiation toxicities, taking into account the organ-specific pathophysiology of radiation injury. Written by acknowledged experts and featuring numerous high-quality illustrations, the book will be an ideal reference aid for practicing clinical and radiation oncologists, radiotherapists, fellows, residents, and nurses.

Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.

Praise for the previous edition:“This book is a milestone and must-have for anyone involved in the care of those with cancer.'--American Journal of Physical Medicine and Rehabilitation“This reference provides a comprehensive, pragmatic approach for physical medicine physicians; speech, occupational, and physical therapists; and nurses with cancer survivor responsibilities…[A]ny cancer program with significant rehabilitation services will find this a useful addition to its library.”--JAMA (Journal of the American Medical Association)This completely revised second edition of the gold-standard reference on cancer rehabilitation provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Authored by some of the world's leading cancer rehabilitation experts and oncology specialists, the book opens with primer-level discussions of the various cancer types and their assessment and management, including potential complications, as a foundation for providing safe and effective rehabilitation. Subsequent sections thoroughly explore the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer. Designed to serve the needs of the entire medical team, this singular resource is intended for any clinician working with cancer survivors to improve function and quality of life. With several new chapters on topics such as inpatient cancer rehabilitation, pediatric oncology, research issues, and barriers to accessing cancer rehabilitation and building a cancer rehabilitation program, the book keeps pace with recent advances in the growing field of cancer rehabilitation. This new edition features updates throughout and expansions to major topics, including imaging in cancer and key disorders such as aromatase inhibitor-induced arthralgias. Presenting the most current medical, clinical, and rehabilitation intelligence, this is a mandatory reference for anyone in the field.Key Features:New edition of the only contemporary comprehensive text covering the field of cancer rehabilitationRevised and updated to reflect current knowledge, practice, and emerging topicsCovers essential aspects of oncology and medical complications of cancer to inform rehabilitation decisions and strategiesProvides state-of-the-art reviews on all major topics in cancer rehabilitation, including pain assessment and management, neuromuscular and musculoskeletal dysfunction, neurologic, and general rehabilitation issues13 new chapters and expanded coverage of signature areasKey points are provided for each chapter to reinforce learning

This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Develop and perfect your neurological localization skills with the gold standard text in the field. Anatomical localization skills based in physical examination are essential for any clinician caring for patients with neurologic disease processes. Newly revised and updated, Localization in Clinical Neurology, Seventh Edition, uses detailed, easy-to-read descriptions and full-color illustrations to help you understand and pinpoint the source of a patient's signs and symptoms. Improve your diagnostic accuracy and avoid unnecessary testing with this outstanding roadmap to neurologic diagnosis.

This book addresses the growing problem of multimorbidity in cancer patients and survivors with the focus on how to best integrate the effective cancer care with the care of multiple chronic conditions. As cancer is more prevalent in older individuals, many patients with cancer also suffer from other chronic conditions that impact on the uptake, tolerance and outcomes of cancer treatment and their long term mortality and morbidity. In addition, cancer and its treatment increase the risk of future chronic conditions. Readers will examine the prevalence and predictors of chronic conditions in cancer, impact of chronic conditions on screening and treatment, evidence for preventative strategies that address both cancer and chronic conditions, emerging management and care integration strategies and directions for management of multimorbidity in special cancer populations – the very young, the very old and those at the end of life. Authored by clinicians and researchers from diverse expertise including epidemiology, sociology, hematology, medical oncology, palliative care, pharmacy and representing Australia, New Zealand, US, Canada and the Netherlands, the book brings an international perspective to a problem that affects all cancer settings. The book is going to be of interest to diverse professionals interested in cancer control including epidemiologists, public health researchers, policy makers as well as clinicians dealing with cancer patients within specialist cancer and non-cancer and primary care settings.

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. - Provides a background to translational research and the use of brain imaging for brain tumors - Contains critical discussions on the potential and limitations of neuroimaging as a translational tool for the diagnosis and treatment of brain tumor and neuro-oncology patients - Presents an up-to-date reference on advanced imaging technologies, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), as well as the recent refinements in these techniques

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites – for quick access to information. Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors. Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance). Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases. Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.Disease Site chapters feature updated information on disease management and outcomes.Thirty all-new anatomy drawings increase your visual understanding.Medicine eBook is accessible on a variety of devices.

Healthcare faces unprecedented global challenges. Rapid advances in genomics, computational sciences, and technology -- as well as the new focus on value-based care and an increased trend toward healthcare commercialization -- represent disruptive changes to an already-fragmented delivery system. The healthcare establishment has been slow to adapt, and now faces rising cancer-care costs and lags in outcome improvement and genomically informed interventions. Managing Disruptive Change in Healthcare codifies the US National Cancer Institute's lessons from utilizing a public-private partnership with community hospitals to navigate the change needed to increase patient access to high-quality cancer care, and enhance hospitals'capacity to conduct and support research initiatives. The treatment of complex diseases requires a delivery system capable of translating scientific advances into care that is coordinated across the full continuum; this book offers a blueprint to just such an infrastructure.

The leading textbook in pain management – updated with the latest research and developments'This is an excellent, comprehensive textbook on all aspects of pain and is recommended for physicians in all specialties who deal with pain patients.'-- reviewing earlier edition in Anesthesia & Analgesia. This concise yet comprehensive text is a true one-stop resource for anesthesiologists and specialists in pain medicine. Every aspect of diagnosing and treating specific pain conditions and syndromes are covered, including physiology, physical and laboratory diagnosis, and therapeutic interventions. While thorough and encompassing the entire curriculum of clinical pain management, the book has been carefully edited to be a manageable length and not overwhelming to readers. Reflecting the fact that pain medicine is a true multidisciplinary specialty, a new co-editor who is a pain psychologist at Beth Israel Deaconess has been added. The third edition also features a greater emphasis on risk management and an updated Interventional Pain Section highlighted by an increased number of figures and a stronger clinical focus. Key clinical concepts are summarized at the end of each chapter Numerous tables and figures highlight the most important concepts and procedures

The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of'ALERT – Adverse Late Effects of Cancer Treatment'is to offer a coherent multidisciplinary approach to the care of cancer survivors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables. It is anticipated that this textbook will become the gold standard in providing information on the late effects of cancer treatment and that, in its digitized form, it will be referenced in cancer survivorship guidelines.

Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. Stephen McMahon, Martin Koltzenburg, Irene Tracey, and Dennis C. Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.Benefit from the international, multidisciplinary knowledge and experience of a'who's who'of international authorities in pain medicine, neurology, neurosurgery, neuroscience, psychiatry, psychology, physical medicine and rehabilitation, palliative medicine, and other relevant fields.Translate scientific findings into clinical practice with updates on the genetics of pain, new pharmacologic and treatment information, and much more.Easily visualize important scientific concepts with a high-quality illustration program, now in full color throughout.Choose the safest and most effective management methods with expanded coverage of anesthetic techniques.Stay abreast of the latest global developments regarding opioid induced hyperalgesia, addiction and substance abuse, neuromodulation and pain management, identification of specific targets for molecular pain, and other hot topics.

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. - Covers both hereditary and cryptogenic neurologic disorders - Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology - Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Neurooncology has become a science of such great proportions and indefinite limits as to include branches which widely diverge from one another. Therefore, it is not an easy task to fit it all into the narrow framework of a book, though the collaboration among scientists compensates partly for the varying depths of knowledge and ex­ perience in the individual disciplines. The principal characteristic of this work, how­ ever, is in casting'pathology'as the common nosographic link. Though scientific progress has brought us well past the nosography of brain tu­ of departure, the area of mutual understanding to mors, pathology remains the point which all students of neurooncology refer when laying out diagnostic, therapeutic, and research schedules. Neurologists, neurosurgeons, and neuroradiologists orient themselves only by referring to tumor types. Neurooncology treatises require ever greater numbers of authors in order to cover the different subject areas with uniform authority. Excellent texts are available today for this purpose. The present book is not, and does not wish to be, a treatise but rather aims at presenting different aspects of neurooncology from the perspective of pathology and its biological and clinical correlates. It expresses the author's experi­ ence in the study of brain tumors and their pathology and clinical characteristics. The emphasis dedicated to the subjects relates to the clinicopathological and theore­ tical importance.

Introduction The prevailing model of medical care for patients with cancer emphasizes the curative efforts of medical technology toward the eradication of the disease. Yet the suffering of the patient as a result of both the disease and our efforts to treat it is often overlooked. If we are to improve the survival of patients with cancer, it will be through intensive research into the molecular under­ pinnings of the disease and clinical trials of new therapies. However, it is essen­ tial to recognize and address the suffering of cancer patients as they are being treated. It is the purpose of this book to illuminate and advance the preven­ tion and treatment of suffering as part of the continuum of care for patients with cancer. Fundamental concepts Since the time of Hippocrates in the fifth century B.c., there have been two overall goals for the physician: • Cure of disease • Relief of suffering From our vantage point in the late twentieth century looking back at previ­ ous centuries, it is easy to observe that, aside from surgery, much of the medical care administered to patients with cancer was aimed at relieving the suffering associated with illness. It wasn't until the concept of disease (as opposed to illness) was elucidated and the scientific method was applied to understand­ ing and eradicating cancer that significant strides were made to improve the physician's ability to cure cancer.

Important contributions about the treatment modalities of breast cancer are presented in this book. The risks and limitations of breast conserving therapy of mammary carcinoma are dealt with. Newest findings show that this form of therapy has the same outcome as conservative treatment modalities. The book also considers controversial issues such as the treatment of mastopathy, precancerous, and non-invasive lesions of the breast. New, but not yet approved, regimes for the prevention of mammary carcinoma and open questions concerning adequate operative treatment are discussed. Latest results presented here show that all modern palliative chemotherapy has a certain but limited effect on outcome and that early detection and preventive therapy (surgical and hormonal) will be of great importance for improved chances of survival of breast cancer.

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.

Human Radiation Injury is a concise but thorough presentation of known toxicities of radiation exposure in humans. This unique text is the only single reference available that studies the risks to humans from medical, environmental, and accidental or terrorist-related exposure to radiation. The chapters cover modern understanding of the molecular and cellular events involved in radiation injury, the known dose-effect relationships for human organ systems, and a full discussion of normal tissue toxicity related to therapeutic radiation. Recommended guidelines are outlined and the best available treatments following injury are also detailed. A companion website offers the fully searchable text and an image bank.

Rosai and Ackerman's Surgical Pathology delivers the authoritative guidance you need to overcome virtually any challenge in surgical pathology. Recognized globally for his unmatched expertise, preeminent specialist Juan Rosai, MD brings you state-of-the-art coverage of the latest advancements in immunohistochemistry, genetics, molecular biology, prognostic/predictive markers, and much more - equipping you to effectively and efficiently diagnose the complete range of neoplastic and non-neoplastic entities.Efficiently review the clinical presentation, gross and microscopic features, ultrastructural and immunohistochemical findings, differential diagnosis, therapy, and prognosis for virtually every pathologic entity. Compare your findings to more than 3,300 outstanding illustrations that capture the characteristic presentation of every type of lesion. Avoid diagnostic pitfalls using Dr. Rosai's expert observations on what to look for, what to be careful about, and which presentations can be misleading. Find quick answers on tumor staging, quality control procedures, and the handling of gross specimens through valuable appendices.Make optimal use of all the very latest advances including our increased understanding of the genetic basis of inherited and acquired disease, the newest molecular genetic and immunohistochemical techniques, and the most recent WHO disease classification schemes.

Neuro-oncologic (brain and spine) cancers account for 19,000 new cases and 13,000 deaths per year. The early and proper diagnosis of these virulent cancers is critical to patient outcomes and diagnosis and treatment strategies are continually evolving. The multidisciplinary team that manages these patients involves medical and radiation oncology, neurosurgery, neuroimaging, nurses and therapists. Principles and Practices of Neuro-Oncology establishes a new gold standard in care through a comprehensive, multidisciplinary text covering all aspects of neuro-oncology. Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric cancers. Expert contributors from multiple disciplines provide detailed and in-depth discussions of the entire field of neuro-oncology including histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches. With contributions from over 180 authors, numerous diagrams, illustrations and tables, and a 48 page color section, Principles and Practice of Neuro-Oncology reflects the breadth and depth of this multi-faceted specialty.

Neuro-Oncology—a new title in the Blue Books of Practical Neurology series—is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist. Access comprehensive coverage of treatment for adult and pediatric conditions—including tumors of the spinal cord as well as the brain. Find coverage of recent advances easily thanks to the emphasis on the latest clinical and laboratory findings and their implications for clinical management and treatment. Apply the possibilities and outcomes of neuro-oncologic surgery within the context of neurologic practice. Address the neurologic complications of cancer and its treatment as well as of primary and secondary tumors. Tap into the global perspectives of experts from all around the world for a multi-disciplinary approach to practice.

Es un compendio de los conocimientos más actuales sobre las afecciones de la mama y su tratamiento, incluyendo tambíen sus características clínicas, su biología y su epidemiología. Expertos de primera línea presentan una revisión de los principales estudios clínicos realizados en relación con la detección y el tratamiento precoz del cáncer de mama. Se dedica especial atención a todos aquellos aspectos relacionados con la genética y la biología molecular, que tienen hoy una importancia creciente. Además de las neoplasias malignas, se describen tambíen aquellas afecciones benignas suysceptibles de malignizarse. Características Principales: Capítulos actualizado s y con una mayor orientación a la clínica Catorce capítulos nuevos y actualizados Más de 500 ilustraciones Se adjunta un desplegable de bolsillo sobre Anatomía y enfermedades de la mama de la Anatomical Chart Company

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complicatio

Drs Eduardo D. Bruera and Russell K. Portenoy have completely revised and updated the widely respected Cancer Pain: Assessment and Management for the second edition of this unanimously praised book. This is a comprehensive, clinically oriented review of all aspects of the complex and multidimensional problem of cancer pain. The unique characteristics of cancer pain, including pathophysiology, clinical assessment, diagnosis, and pharmacological and nonpharmacological management are all discussed here in detail. Internationally recognized leaders in cancer pain research have contributed to many new chapters, including neuraxial analgesia, hospice and institution-based palliative care programs, bone pain, and cancer pain and palliative care in the developing world. Cancer Pain continues to be a scholarly but accessible text that is an essential resource for physicians, nurses, and medical students who treat suffering from cancer pain.

Authored by some of the world's leading cancer experts from wide ranging disciplines including oncology, radiation oncology, neurosurgery, orthopedic surgery, and radiology this compact volume provides authoritative state-of-the-art primer level overviews of the various cancer types, their evaluation, and treatment. Every aspect of oncology is covered with clear, up-to-date descriptions of the general principles and concepts fundamental to attaining a clinical appreciation of the foundations of cancer care.Each chapter is concise but highlights the basic tenets health care professionals working with cancer patients need to know to understand the diseases and current treatment options. To facilitate review, Key Points are boxed in each chapter to summarize important clinical information and concepts at a glance. This book represents a synthesis of information from some of the top physicians in oncology that is not as easily accessed anywhere else.Features of Synopsis of Clinical Oncology include:Multi-specialty expert authorshipFocus on therapeutics management of cancerKey Points boxed in each chapter for quick review

Nasopharyngeal Cancer - Multidisciplinary Management provides a comprehensive account of the current state of knowledge on nasopharyngeal cancer and its multidisciplinary management. The first ten chapters document contain essential background information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequently, the various treatment options and combinations in a range of settings are examined in depth. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical treatment, follow-up, treatment of metastatic disease, treatment-related complications, and nasopharyngeal cancer in children. This is an important book that will prove essential reading for the radiation oncology community worldwide and meet the need for substantial improvements in knowledge of modern techniques.

A Doody's Core Title 2012This new comprehensive reference provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Authored by some of the world« leading cancer rehabilitation experts and oncology specialists, the principles section provides primer level discussions of the various cancer types and their assessment and management. The practice section thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer.This groundbreaking volume enables the entire medical team to provide superior care that results in a better quality of life for cancer survivors. Features include: Multi-specialty editorship and authorship from physiatry, oncology, physical therapy, occupational therapy,and related disciplines. Focus on therapeutic management of cancer-related impairments and complications. In-depth treatment of the medical, neurologic, musculoskeletal, and general rehabilitation issues specific to this patient population.

Patients with cancer can suffer from a bewildering variety of neurologic signs and symptoms. The neurologic symptoms are often more disabling than the primary cancer. Symptoms including confusion, seizures, pain and paralysis may be a result of either metastases to the nervous system or one of several nonmetastatic complications of cancer. The physician who promptly recognizes neurologic symptoms occurring in a patient with cancer and makes an early diagnosis may prevent the symptoms from becoming permanently disabling or sometimes lethal. This monograph, an update of the first edition published in 1995, is divided into 3 sections. The first classifies the wide variety of disorders that can cause neurologic symptoms the patient with cancer, discusses the pathophysiology of nervous system metastases, the pathophysiology and treatment of brain edema and the approach to supportive care of common neurologic symptoms such as seizures, pain, and side effects of commonly used supportive care agents. The second section is devoted to nervous system metastases, addressing in turn, brain, spinal cord, meningeal and cranial and peripheral nerve metastases, describing clinical symptoms, approach to diagnosis and current treatment. The third section addresses several nonmetastatic complications of cancer and includes sections on vascular disease, infections, metabolic and nutritional disorders, side chemotherapy, radiation and other diagnostic and therapeutic procedures. The final chapter addresses paraneoplastic syndromes. The book is intended for practicing oncologists, neurologists, neurosurgeons and radiation oncologists as well as internists who treated patients with cancer. Our attempt was to write a book that would assist oncologists in understanding neurologic problems and neurologists in understanding oncologic problems. The book is also intended for physicians training to specialize in any of the above areas. It includes a practical approach to the diagnosis and management of patients with neurologic disease who are with known to have cancer or in whom cancer is suspected.

Neuro-oncology has evolved substantially as a clinical and research discipline over the past few decades. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition provides clinicians from various backgrounds and levels of training with a reference to help focus the differential diagnosis, treatment strategy, and management plan for the cancer patient with neurologic symptoms and findings. The volume begins with an overview of the field of neuro-oncology and a review of the role of neuroimaging in the diagnosis of neuro-oncologic disease. Several chapters on interpretation and management of common neuro-oncologic symptoms follow. Subsequent sections contain chapters on the direct and indirect neurologic complications of cancer as well as complications of therapy. The final section focuses on the spectrum and management of neurologic disease in patients with cancer of specific organs. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition is an important new work that aims to broaden and deepen the familiarity of clinicians with the range and management of neuro-oncologic diseases in order to improve the quality of care for cancer patients.

Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive,'single-source books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

Das Mammakarzinom stellt in den westlichen Industrienationen den häufigsten malignen Tumor der Frau dar, an dem in Deutschland jede neunte Frau erkrankt. Trotz intensiver Bemühungen, die adjuvante bzw. neoadjuvante Therapie zu verbessern, wird im späteren Verlauf der Erkrankung bei etwa 60% der betroffenen Frauen eine Fernmetastasierung diagnostiziert, die dann einer Heilung nicht mehr zugänglich ist. Das vorliegende Buch bietet auch in der 2. Auflage einen breiten Überblick über die aktuellen Möglichkeiten in der Therapie des metastasierten Mammakarzinoms. Die Autoren vertreten die Fachbereiche der internistischen Onkologie, der Gynäkologie sowie der Pathologie und weisen nicht zuletzt durch die Zusammenarbeit in diesem Buch auf die Notwendigkeit der interdisziplinären Behandlung des Mammakarzinoms hin.

This brand-new text provides you with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Inside, you'll find discussions of the latest research and how it has led to a greater understanding of the cause of disease, as well as burgeoning tests and the latest therapeutic agents available. From Alzheimer's disease to vestibular system disorders, you'll find the practical guidance you need to diagnose effectively and provide an appropriate therapeutic approach for each individual case. Plus, a templated, four-color design offers you easy access to pertinent informationIntegrates basic science with clinical neurology to help you better understand neurologic diseases and provide the most accurate diagnosis and best treatment plan for each patient.Discusses the latest research results and offers new information on treatment options.Features the expertise of international authorities, providing a worldwide perspective.Uses a templated, four-color format that makes information accessible and easy to understand-particularly the basic science concepts.

This volume covers the broad spectrum of imaging methods and abnormalities of relevance in the diagnostic workup of the shoulder. In the first part of the book, individual chapters are devoted to radiography, arthrography, computed tomography and CT arthrography, magnetic resonance imaging and MR arthrography, ultrasound and interventional procedures. Controversies regarding the use of the different imaging techniques are explained and discussed. The second part of the book then documents the application of these techniques to each of the clinical problems and diseases encountered in the shoulder. The authors are all experts in their field and include rising stars of musculoskeletal radiology. This well-illustrated book will assist the general and the musculoskeletal radiologist in planning, guiding and interpreting imaging studies. For the clinician it puts into perspective the role of the different imaging methods.

In Cancer Neurology in Clinical Practice, leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how they should be interpreted and evaluated. Organized by both symptom and organ, the book carefully describes each diagnostic neurologic entity-from symptomatology to diagnostic studies to management and prognosis-and presents each major type of cancer in terms of it neurologic problems and how they should be handled. The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem. Multidisciplinary and up-to-date, Cancer Neurology in Clinical Practice explains to the busy physicians treating cancer patients the latest findings in neuro-oncology that will help them to focus their differential diagnosis, diagnostic strategy, and treatment plan for the cancer patient with neurologic symptoms and findings.

Changes in the focus of neurological practice worldwide have led to the need for new standard texts that reflect the current state of this expanding area of clinical expertise. The second edition of the Handbook of Neurological Rehabilitation is a major reference source that fulfils this need, providing an invaluable resource for all professions that work with patients suffering from neurological disorders. It brings restorative neurology to the bedside and shows how a reiterative, goal-oriented, problem-solving training programme can benefit patients, sometimes on a scale not achieved by pharmacological or surgical interventions.The book is divided into three sections all of which have been updated. Section One explores the clinical and biological principles underpinning rehabilitation practice in the context of neurological disablement. Section Two describes the assessment, treatment, and management of the major physical, cognitive and behavioural impairments, and the resulting functional deficits that may follow or accompany neurological disease. The final section explores in more detail these problems and their management in relation to the more common specific disorders of the nervous system.The text emphasises the fact that rehabilitation is an ongoing process involving multidisciplinary problem-solving, goal-setting and education; in which organised care is more effective than unorganised care; and the breakdown of professional barriers within rehabilitation, to facilitate the use of combined treatment techniques, improves outcome. It describes the contribution made by neural reorganisation and compensatory mechanisms to recovery of function, focuses on the avoidance of secondary deficit, and explores the physical, cognitive, affective and behavioural problems that may occur after neurological damage.At a time when new medical technologies threaten to fragment the integrity of medical care at individual and societal levels, it is crucial that all those involved in the management of chronic neurological disease have a working knowledge of the contents of this book. Their perspective on clinical practice will then be truly integrated and holistic and their patients will benefit accordingly.

First book to achieve an integrated medical and surgical approach to tumors of the pediatric nervous system, giving you a broad array of treatment options. You will find full coverage of the newest diagnostic and management techniques, state-of-the-art technologies, molecular biology advances, and the latest trends in the operating theatre. And you will benefit from in-depth discussions of the most commonly seen tumors as well as the rarer and more esoteric ones.Special benefits of Tumors of the Pediatric Nervous System:- Full discussions of medical and surgical treatment protocols, with advantages, disadvantages, complications, and outcomes of each - Coverage of dramatic advances in genetics, molecular biology and surgery (e.g. endoscopic, frameless, stereotaxy) as well as chemotherapy, radiotherapy, and immunotherapy- Dozens of case studies by leaders in the field offering important clinical insights- Numerous algorithms, charts, tables, and management guidelines for at-a-glance summaries of key points- Nearly 130 full-color pathologic slides- Cost/benefit analysis integrated throughoutTake advantage of this comprehensive approach to diagnosis and treatment that is so critical in today's health care environment. Whether you are a surgeon, oncologist, pediatrician or ancillary specialist, you will find a wealth of broad-based information that enhances patient care and leads to improved outcomes. Stay informed and up-to-date.