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This book contains details of neuromodulation therapies including medical management and surgical management. This book will be very helpful for upcoming neurosurgeons, neurologists and neuromodulation specialists for conducting treatment properly and understanding the basic mechanisms of neuromodulation therapies. So far, many books have been published on this topic but this book contains all information on neuromodulation therapies and their approaches for upcoming clinical research and future directions for neurological surgery. This book has a total of 43 chapters which are written by global neuromodulation experts, neurosurgeons, neurologists and neuroscientists. These chapters are based on the authors'expertise and experiences, and the editors of this book are all well-known experts. In one sentence, this book will be the handbook for upcoming doctors in these fields.

Calming the Bipolar Storm:A Guide for Patients and Their Families is for people with bipolar disorder, and anyone who loves or cares for them. This work captures the rapidly advancing research and treatment strategies in the field of bipolar disorders. Discussing causes, presentation, onset, course, and treatments, the book encourages bipolar persons to set a healthy baseline, outlining five areas that promote good overall health in support of their particular circumstances: diet, exercise, sleep, avoiding substance misuse, and finding social support. In this context, Robert G. Fawcett discusses specific medications and their side effects, offering comparisons among them where possible. He describes other biological treatments such as herbs and supplements, transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), bright light treatment, and sleep deprivation. A discussion of psychotherapies for bipolar includes not only some of the evidence-based treatments such as cognitive-behavioral, interpersonal and social rhythm, and family-focused therapies, but also supportive therapy, which is what patients most commonly encounter.Drawing from the author's experience treating patients with bipolar disorder for more than forty years Calming the Bipolar Storm presents an in-depth, engaging overview of bipolar disorder and its treatment, punctuated with case vignettes and interesting glimpses into the history behind today's concept of bipolar disorder and its treatments. Readers, both sufferers and their families, will come away with a better understanding of bipolar disorder and a clearer path to better treatment.

These volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, Bloomington, USA from May 22- May 27, 1994. This was a continuation of meetings held every three years with the idea of bringing clinicians and basic scientists together, which we hope results in cross-fertilization of ideas. Some of the papers presented in this volume represent oral contributions and others are from posters, but we emphasize that both are considered of equal merit. As is obvious from a perusal of the titles of the papers there has been a shift in the focus of this meeting, which reflects a general shift in the area of purine and pyrimidine metabolism. The emphasis has definitely shifted to gene structure and molecular genetics, with the beginnings we hope of gene therapy as an important branch of this area of science. Although many of the inherited diseases discussed in this text can be treated with drugs, the major thrust in the futurewill be in gene therapy, where the gene (or cDNA) will be used to treat the patient with enzyme deficiency, particularly if the patient is young. As can be seen from the Iist of authors there is a remarkable degree of international cooperation in this area across countries and continents. We thank the many participants who have attended these symposia many times, and we welcome the large group of scientists from Eastern Europe who are attending this meeting for the first time.