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Dissemination of knowledge is the best and only strategy capable of improving clinical management in rare and ultra-rare malignancies, including primary adrenal malignancies. It is preliminary to any further healthcare policy such as, for example, the centralization of cases in referral institutions. Adrenal primary malignancies are probably the rarest among rare pathologies. This epidemiological consideration is at the origin of a vicious circle: the lack of preoperative diagnosis leads to inappropriate surgical procedures and to inadequate follow-up and systemic therapy strategies. Furthermore, when malignancy is recognized, the relative role of systemic, surgical, or other local ablative techniques is often misinterpreted. All this produces a negative impact on survival, also in patients who could have been cured with a correct therapeutic strategy. This open access book provides a user-friendly exploration of these rare conditions, using a transversal approach common in modern precision medicine. The text covers various clinical aspects, including epidemiology, genetics, molecular medicine, imaging, and surgery. Guidelines for managing syndromic situations are provided. The book thoroughly addresses all the different surgical issues and emphasizes the importance of pathology in assessing prognosis. The pivotal role of medical oncologists in managing these patients is explored, along with alternative treatments such as nuclear medicine and radiotherapy. Finally, the book highlights the latest preclinical research and its implications for translational medicine.

This revised and expanded second edition provides a comprehensive and up-to-date overview of topics relating to head and neck and endocrine surgery, including: maxillofacial injuries, surgery of the scalp, surgery of the salivary glands, jaw tumors, surgery of the oral cavity (lips, tongue, floor of the mouth, and palate), swellings and ulcers of the face, inflammation in the neck, cervical lymphadenopathy, midline and lateral neck swellings, tumors of the pharynx, and endocrine surgery (thyroid gland, parathyroid glands, suprarenal glands, and neuroendocrine tumors). This second edition also includes additional and detailed chapters on thyroidectomy procedures, thyroid and parathyroid endocrine emergencies, thyroid and parathyroid disease during pregnancy, and thyroid and parathyroid transplantation. The coverage extends beyond surgical indications and procedures to encompass aspects such as anatomy, clinical presentation, and imaging diagnosis. With its clear structure, the book facilitates quick reference and will serve as a valuable tool for practitioners, as well as for upper-level graduate students.

This open access book on thyroid surgery has been authored by an international team of contributors who present a comprehensive understanding of both benign and malignant thyroid disorders. It also outlines an interdisciplinary approach to their surgical management that reflects the latest changes in surgical techniques. The book reviews the most up-to-date literature available on thyroid surgery and presents it in a concise manner for use in clinical practice. For each thyroid disorder, the book covers etiology, clinical manifestations, diagnostic and localization procedures, as well as surgical and non-surgical treatment options. The operating techniques and postoperative management are explained in detail, while the benefits, risks, controversial issues, and cost-effectiveness of each approach are reviewed. To aid in the understanding of complex information, the book features drawings and photographs. Written in an easy-to-understand style, the book includes tablesand diagrams that highlight best practices and current guidelines, as well as self-assessment material at the end of each section. It serves as an ideal resource for all levels of surgical experience, from a practical reference for endocrine surgeons to a perfect companion for students and residents.

'A lucid, persuasive case for overhauling diagnosis regimes to catch cancer early rather than late.'—Kirkus ReviewsCatching cancer early remains the single best way to combat a disease that is the second-leading killer in both the US and worldwide. But the vast majority of resources in the fight against cancer are devoted to relatively ineffective late stage treatments. Early Detection examines this important anomaly in an accessible and expertly researched survey.In a co-authorship that brings together the passion and urgency of someone touched deeply by the experience of cancer with the knowledge of a skilled science writer, Ratner and Bonislawski narrate compelling case studies across a range of screening programs and different forms of cancer. They look at the science underpinning early detection and discuss the organizational and social challenges of widespread screening, a dimension that has been shown to be especially important in the COVID-19 pandemic. And they call for the government and the medical establishment to provide resources for expanding screening, especially in economically disadvantaged communities that have traditionally been underserved.

The book comprehensively discusses the surgical management of thyroid and parathyroid diseases. It includes separate chapters dedicated to preliminary evaluation enabling the reader to understand the decision making process. It discusses details of specific preparation for optimizing the conditions suitable for operation. It provides comprehensive description of the complex anatomy of neck and the variations supported by representative photographs. It includes appropriate flowcharts and videos of procedures for better understanding. The book describes the steps of all surgical procedures of thyroid and parathyroid glands emphasizing practical aspects of surgical techniques, supported by representative photographs. It covers chapters on the management of immediate and late complications, adjuvant treatment as well as treatment of late recurrences. Parathyroid diseases are not common but are known to induce disabling complications. The book also discusses various aspects of presentation and treatment of parathyroid diseases in detail. It stresses upon the role of specialists in different department in the postoperative management of thyroid cancers. The book meets the curriculum requirements of postgraduate students in specialties like general surgery, head and neck surgery, and endocrine surgery. It also serves as a reference for junior surgeons and enables them to prepare and perform proper thyroid surgeries as well provides guidance in the postoperative management of all thyroid diseases especially thyroid cancer.

Schilddrüse interdisziplinär – Neues aus Diagnostik und Therapie so lautete das Thema der 26. Konferenz über die menschliche Schilddrüse, die vom 5.–6. Oktober 2023 in Mannheim stattfand. Ein Schwerpunkt umfasste die Diagnostik und die Therapie von Schilddrüsenknoten, wobei der Fokus auf der bildmorphologischen Diagnostik, der weiterführenden Diagnostik einschließlich der Feinnadelpunktion und möglicher Therapieoptionen der Struma nodosa lag. In einem zweiten Themenkomplex befassten sich die Referenten mit den autoimmunen Schilddrüsenerkrankungen. Dabei wurden nicht nur die Aspekte der Diagnostik einschließlich der Antikörperdiagnostik, sondern auch die Verlaufsbeurteilung und mögliche Therapieoptionen der Autoimmunthyreoiditis und des Morbus Basedow besprochen. Intensiv diskutiert wurden zudem Fragen der Fertilität im Zusammenhang mit Schilddrüsendysfunktionen, dem Thema Schilddrüse und Schwangerschaft sowie potentiellen Nebenwirkungen von Immuncheckpoint-Inhibitoren und deren Auswirkungen auf die Schilddrüse.

The second edition of this important textbook covers all aspects of neuroendocrine tumors (NETs), from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies and immunotherapies. Readers will find individual discussion of each of the various types of NET: gastrointestinal, lung, and pancreatic tumors such as insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, and non-functioning pancreatic NETs, as well as medullary thyroid carcinomas, pheochromocytomas, paragangliomas, etc. In addition to NETs, endocrine tumors such as thyroid tumors and adrenocortical tumors are also covered. The contributing authors are internationally recognized experts who bring a wealth of science and experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists, and pathologists as well as for trainees in these fields.

The book provides a comprehensive overview of the challenges and debates on the diagnosis and treatment of midline neck swellings to clarify some uncertainties, make suggestions for resolving others, and establish strategies for achieving therapeutic success. In addition to information on the surgical anatomy of the neck with particular emphasis on midline cervical regions, and the classification and clinical approach for diagnosis and management of neck swellings, the chapters explore cervical lymphadenopathy, swellings of the submental region, swellings of the hyoid bone region, swellings of the laryngeal/pharyngeal region, swellings of the tracheal region, and swellings of the supra-space of Burns. The last chapter emphasizes the importance of scheduling regular follow-ups as well as patient counselling and education.The volume, enriched with color images and flowcharts, will be a key resource for head and neck surgeons, maxillofacial surgeons, orthopedic surgeons,endocrinologists, oncologists, pediatricians, and clinicians of other specialties as they face the most challenging midline neck swellings and work towards providing each patient with the best possible outcome.

Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1. The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets. - Discusses recently discovered molecular targets for cancer therapy - Brings updated literature of heterocyclic compounds, an important construction motif for the development of new anticancer drugs - Encompasses comprehensive compilation of recently introduced anticancer drugs in the market and their health outcomes and pharmacoeconomics

With a history that likely dates back to the dawn of human civilization more than 10,000 years ago, and a record that includes the domestication and selective breeding of plants and animals, the harnessing of fermentation process for bread, cheese, and brewage production, and the development of vaccines against infectious diseases, biotechnology has acquired a molecular focus during the 20th century, particularly following the resolution of DNA double helix in 1953, and the publication of DNA cloning protocol in 1973, and transformed our concepts and practices in disease diagnosis, treatment and prevention, pharmaceutical and industrial manufacturing, animal and plant industry, and food processing.While molecular biotechnology offers unlimited opportunities for improving human health and well-being, animal welfare, agricultural innovation and environmental conservation, a dearth of high quality books that have the clarity of laboratory manuals without distractive procedural details and the thoroughness of well-conversed textbooks appears to dampen the enthusiasm of aspiring students. In attempt to fill this glaring gap, Handbook of Molecular Biotechnology includes four sections, with the first three presenting in-depth coverage on DNA, RNA and protein technologies, and the fourth highlighting their utility in biotechnology. Recognizing the importance of logical reasoning and experimental verification over direct observation and simple description in biotechnological research and development, the Introduction provides pertinent discussions on key strategies (i.e., be first, be better, and be different), effective thinking (lateral, parallel, causal, reverse, and random), and experimental execution, which have proven invaluable in helping advance research projects, evaluate and prepare research reports, and enhance other scientific endeavors.Key features Presents state-of-the-art reviews on DNA, RNA and protein technologies and their biotechnological applications Discusses key strategies, effective thinking, and experimental execution for scientific research and development Fills the gap left by detailed-ridden laboratory manuals and insight-lacking standard textbooks Includes expert contributions from international scientists at the forefront of molecular biotechnology research and development Written by international scientists at the forefront of molecular biotechnology research and development, chapters in this volume cover the histories, principles, and applications of individual techniques/technologies, and constitute stand-alone, yet interlinked lectures that strive to educate as well as to entertain. Besides providing an informative textbook for tertiary students in molecular biotechnology and related fields, this volume serves as an indispensable roadmap for novice scientists in their efforts to acquire innovative skills and establish solid track records in molecular biotechnology, and offers a contemporary reference for scholars, educators, and policymakers wishing to keep in touch with recent developments in molecular biotechnology.

Tutorials in Clinical Chemistry is designed for trainee pathology residents, clinical chemists, medical students, and clinical laboratory scientists, in addition to those preparing for board and postgraduate examination. It is helpful to those in training as well as a teaching aid for mentors, faculty, and directors. The book is organized into 17 system-based chapters covering essential pathophysiology, biochemical investigation, and technical aspects of relevance to results interpretation. Tutorials in Clinical Chemistry is a must-have, didactic and essential knowledge as well as practical resource for learning and review.? Facilitates easy access to troubleshooting common questions within a daily practice? Provides the landscape for the required knowledge and competency in clinical chemistry? Presents concise, direct, practical material for clinicians and clinical practitioners reaching out to the clinical laboratoryfor advice and interpretation of findings? Covers all aspects of clinical chemistry fellowship curriculum

This book has been conceptualized keeping in mind that the postgraduate trainees not only need a good guide for their examinations, but also they will step out into the real world of medical practice as consultant surgeons. The purpose of the book is not to spoon feed the readers with answers to all questions but to provide clues and information so that the students can perceive the concepts and produce their own answers.

This updated text is a pictorial atlas of endocrine and metabolic disorders. Each chapter focuses on providing multiple illustrations as well as a thorough discussion of the diagnosis and management of a variety of endocrine diseases with their appropriate treatment plans. Using updated guidelines, it provides a comprehensive discussion of the latest therapies, including diabetes technology. Presenting a large number of clinical images, including imaging of thyroid ultrasounds, DXA images, bone scans, and new technologies in diabetes mellitus, this atlas aims to provide the reader with the information needed to make accurate diagnoses, making it an updated source of highly illustrated information for endocrinologists, clinicians, residents, fellows and trainees. With new chapters on transgender medicine and obesity, this textbook is a valuable resource for the contemporary endocrine practitioner. Features new chapters such as transgender medicine and inborn errors of metabolism Aims to be an invaluable aid for endocrinologists, internal medicine specialists, family practice clinicians, residents, fellows, and trainees Explores diabetes technology with updated guidelines

The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.

Das Buch Umfassender Überblick zu Tumorentitäten und Behandlungskonzepten. -Klassifikation, Klinik, Diagnostik -aktuelle, evidenzgesicherte Behandlungskonzepte -Empfehlungen und gängige Therapieschemata -Onkologische Notfälle, Supportivmaßnahmen und Palliativmedizin -Medikamentenübersicht Verfasst von interdisziplinären Autorenteams. Mit evidenzbasierten Handlungsempfehlungen. Für die tägliche Arbeit in Praxis und Klinik - für konzentrierten Überblick und zum Selbststudium. Online-Version Die Online-Version des Taschenbuchs Hämatologie und Onkologie ist unter www.onkologie2024.de zugänglich.

Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling illustrates the current scope of the practice of genetics for healthcare professionals, so they can understand principles applicable to genetic testing and consultation. Written by an authoritative well-balanced team, including experienced clinical geneticists, genetic counselors, and medical subspecialists, this book adopts an accessible, easy-to-follow format. Sections are dedicated to basic genetic principles; clinical genetic and genomic testing; prenatal, clinical and cancer genetic diagnosis and counseling; and ethical and social implications in genomic medicine. Over 100 illustrative cases examine a range of prenatal, pediatric and adult genetic conditions and testing, putting these concepts and approaches into practice. Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling is important for primary care providers, as patient care evolves in the current genomic-influenced world of precision medicine. - Clearly explains central concepts of genetic testing and genomic medicine for non-genetic physicians, healthcare providers, and trainees - Offers clear steps for clinical integration of genetic concepts, genomic technology, and interpretation of genetic test results approachable and relevant to clinical practice - Descriptive, applied case studies illustrate recommended genetic evaluation, counseling and management for a range of conditions throughout the lifetime

Dieses Standardwerk bietet allen Ärztinnen und Ärzten Sicherheit in der Durchführung und Bewertung endokrinologischer Funktionsteste. Es unterstützt bei einer effizienten Diagnostik, verhilft zu verwertbaren Ergebnissen und einer zuverlässigen Bewertung in der Endokrinologie, Diabetologie, Gynäkologie, Urologie, Andrologie, Kinder- und Jugendmedizin, Inneren Medizin. Die Inhalte orientieren sich an den Empfehlungen nationaler und internationaler Fachgesellschaften.Detailliert und praxisrelevant erhalten Sie einen raschen Überblick über Indikationen, Kontraindikationen, Nebenwirkungen, Testvorbereitung, Rahmenbedingungen, konkrete Handlungsanleitungen zur Testdurchführung, sichere Bewertung der Ergebnisse sowie Praxistipps und potenzielle Fallstricke. Die 5. Auflage wurde kompett aktualisiert und erweitert u.a. um folgende Themen: „Trouble shooting“ bei Immuno-Assays, paraneoplastische Syndrome, Screening der Malnutrition, basales und stimuliertes Copeptin, Metyrapon-Test, Macimorelin-Test und digitale Diabetes-Parameter (CGM).Orientierend an Empfehlungen nationaler und internationaler Fachgesellschaften

This book is a comprehensive and desirable resource for the modern and busy learner. This textbook provides a robust review of pediatric otolaryngology tightly packaged into segments of high yield information. Subject matter authorities from prestigious institutions have written up-to-date and succinct material to provide bullet point concepts and practical guidelines. The reader will find both important details and consensus statements on management decisions for common and rare pediatric otolaryngology conditions. This is a textbook ready for daily use as a quick reference, or review material, for anyone managing ear, nose, and throat disorders in the youngest population.

This book provides readers information on optimal decision on surgical management of pheochromocytoma and retroperitoneal raraganglioma. After overviewing clinical features and diagnosis of pheochromocytoma and retroperitoneal raraganglioma, following chapter presents surgical treatment of adrenal pheochromocytoma, abdominal paraganglioma, paragangliomas in the bladder and scrotum with selected cases. Treatment options and complications from perspective of urologists, endocrinologists, and thoracic surgeons are highlighted to provide a multidisciplinary approach to treatment of patients. This book is suitable for the urologists, endocrinologists and surgeons in oncology, as well as practitioners who are interested in this field.

This book serves as a concise surgical manual that quickly references the latest information essential for determining the policies of surgical patient care and pre-and post-operative treatment. It is a necessary guide not only for surgical residents and medical students but also for practicing surgeons.Features of this book:1. Provides information on surgical care through a systematic approach to surgery-related topics.2. Reflects the latest research findings and recommendations on the rapid development and evolution of the surgical field.3. Covers a wide range of topics and areas in surgical surgery, including patient management before and after surgery, basic techniques and procedures, management of complications, fluids, and nutrition.4. Offers practical guidance that can help in real surgical situations and practice.5. Available in a pocket size that can be easily referred to at any time.6. An English edition that can be referenced by medical professionals both in the Korea and abroad.Table of contentsContributors Preface to the 5th edition of SNU Manual of Surgical Preface to the 1st edition Preface to the 2nd edition Preface to the 3rd edition Preface to the 4th edition I. Basic Considerations 01 Surgical Infections and Antibiotics 02 Fluids and Nutrition 03 Critical Care Medicine 04 Surgical Complications 05 Preoperative Evaluation and Management for Medical Disease 06 Basic Surgical Skills 07 Symptomatic Surgical Management II. Specific Considerations 01 Liver 02 Bile Duct and Pancreas 03 Gastrointestinal Tract 04 Small Intestines 05 Colon, Rectum and Anus 06 Breast 07 Endocrine 08 Vascular 49109 Kidney and Pancreas Transplantation 10 Pediatric Surgery 11 Trauma 12 Liver Transplantation Index

CANCER CONSULT New edition covering the specialties of hematology, oncology and cellular therapy, now in two volumes Cancer Consult: Expertise in Clinical Practice, Volume 1: Solid Tumors & Supportive Care, Second Edition includes hundreds of answers to practice-based questions covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of cancer. This textbook series also provides expert guidance in the areas of cancer-related uncertainties and controversies, including experience-based discussions. The book's smaller size allows for easy access during medical rounds. This volume also includes: Up-to-date, clinically relevant information on the very latest topics such as molecular techniques, targeted therapies, immunotherapy, cellular therapy and translational cancer research Sections on head, neck, thoracic, breast, GI, genitourinary, skin, gynecological and hereditary cancers, amongst other topics Streamlined, engaging content to make finding information easier and less time consuming for the reader Concise and practical expert perspectives that reference key studies References to the latest NCCN, ESMO, ASCO, and other national guidelines With its powerful focus on pragmatic clinical diagnostic, therapeutic and prognostic approaches, Cancer Consult: Expertise in Clinical Practice, Volume 1: Solid Tumors & Supportive Care, Second Edition will help keep hematology, oncology and cellular therapy practitioners up-to-date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base. It also offers clinicians, trainees, and fellows an excellent opportunity to enhance their preparation for the ABIM, hematology and oncology fellowship and recertification exams.

The idea for the book emanated from the experience of one of the editors, Dr. Hana Ajouz, who encountered many general surgery residents who were seeking a good ABSITE review book from which to study, and none was found to be truly comprehensive and up-to-date. There is an immense need for a comprehensive yet concise and easy-to-use book that has a clear structure and one that reflects new findings, methods and references that current surgical residents will find to be applicable. The intentional structure of the book is simply this - capture the most pertinent information for each specialty that is on the SCORE® curriculum and frequently asked on the ABSITE exam and present it to the reader in a capsulized, simplified format of charts or tables. Hence, in addition to its study-friendly structure, this review book comprehensively mirrors most contemporary general surgery curricula. It also encompasses key operative steps of wider general surgery procedures, which most review books lack. Moreover, while most ABSITE review books are written by one or a few authors, each chapter in this book is reviewed/authored by someone with expertise in their specialty. This compiles the experience of many authorities into one resource helping general surgery residents stay up-to-date with the most recent and important concepts in the field.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. - Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases - Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more - Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others - Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies—by the investigator who discovered it - Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens - Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue - Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more - Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care - Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis - Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

The book covers all aspects of thyroid and parathyroid surgery, including history and examination, pre-operative workup, and how ancillary specialties like pathology, radiology, radiotherapy, and nuclear medicine impact the outcome of thyroid and parathyroid patients. It offers a step-by-step approach to help the readers manage their cases in their practice. It includes numerous color photographs, anatomical and operative line diagrams for easy understanding. Chapters include flow charts explaining the case management and the decision-making process. The book serves as a valuable resource to endocrine surgeons, general surgeons, endocrinologists, and internists. It also serves as reference material for the exit examination of masters of surgery and the super specialty entrance and exit exam for endocrine surgery. Additionally, it helps consultants and postgraduate students of radiology, pathology, nuclear medicine, and radiotherapy.

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

The 2nd edition of the successful book also summarises the factual knowledge of visceral surgery in a condensed, keyword-like form. It is suitable for preparation for the specialist examination as well as for quick reference in everyday clinical practice.All articles have been written by renowned experts. The focus is on detailed recommendations on the diagnostic procedure, the indication and the implementation of therapy; for the most important interventions, the steps of the surgical procedure are also presented. Brief overviews facilitate the targeted memorisation of the most important facts.

This open access book provides basic concepts on Integrated Diagnostics and Theranostics with special emphasis on different human thyroid diseases. Thyroid diseases are increasingly detected (incidentally in many cases) but are clinically negligible in a significant proportion of patients. Accordingly, it is urgent to move from the simple disease detection to a reliable disease characterization in order to concentrate efforts on patients in need of tailored disease management. The current scenario of in vitro and in vivo diagnostics, is fastly moving toward the Integrated Diagnostics (i.e. convergence of imaging, pathology and laboratory tests with advanced information technology). Furthermore, the integration of different information will aid clinicians to properly select treatments and stratify patients'prognosis over time. Theranostics is a perfect paradigm of such integrated approach and radioiodine, indicated for benign and malignant thyroid disease management, was the first and is still the mostly used theranostic agent in medicine. Featuring basics concepts and clinical cases discussions the Atlas will be an invaluable tool for clinicians, laboratory specialists, imaging physicians and biomedical technologists involved in diagnosis and therapy of thyroid diseases.

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in an easy-to-access format. Chapters cover the key topics of greatest and most frequent concern to clinicians treating newborns, delivering current, data-driven management and treatment advice in a single source relevant to the seasoned practitioner, fellow, or trainee. - A highly templated format makes it easy to find exactly the information you need. - Lavishly illustrated with photos, radiographs, drawings, and charts and graphs that clarify key concepts in a helpful and accessible way. - Evidence-based focus ensures that only the most reliable treatment protocols and clear-cut, data-driven guidance are included. - Coverage of all relevant topics in the NICU: skin lesions, congenital anomalies, architecture/development of neonatal intensive care units, pain control, anesthesia for newborn infants, and much more. - Ideal for every member of the NICU team: neonatologists, neonatology fellows, residents, and neonatal nurses, as well as all other clinicians working in the NICU, including PAs, occupational therapists, respiratory therapists, and others.

This comprehensive atlas covers various common and uncommon cases of parathyroid disorders encountered in the day to day radiological practice. It serves as an illustrative database with numerous state of the art images of the diverse imaging features of parathyroid nodules and their correlation with various other imaging modalities. The book includes videos as well. It covers the typical and atypical ultrasound features of parathyroid nodules, their color Doppler findings and Sestamibi correlation. Size of the nodules detected range from small sub-centimeter nodules measuring between 6-15 mm, where often the sestamibi scan is negative, and diagnostic ultrasound scan is quite vital in management of these cases. The larger nodules range in size to be even larger than the thyroid gland and completely compressing and displacing the thyroid gland, which often leads to a missed diagnosis on initial imaging.Chapters cover tips and tricks in scanning along with various pitfalls. Additionally, it covers parathyroid nodules diagnosed on ultrasound in Sestamibi negative cases, localization of additional parathyroid nodules and parathyroid carcinoma. It covers correlation with surgical findings and includes histopathology images where relevant. The book serves as a teaching tool for radiologists, ENT surgeons, head and neck surgeons, general surgeons, endocrinologists, nephrologists, gastroenterologists, medical oncologists and radiation oncologists involved in the management of parathyroid disorders.

The book is written and edited by an individual fortunate to see and work through the evolution of precision medicine in the last three decades. The book begins with an introduction to genomics and precision medicine, followed by a chapter on pediatric genomic sequencing and nine chapters focused on the pathologic diagnosis required for precision therapies in cancer. Tumors of the central nervous system (the brain and spinal cord) and the thyroid and salivary glands are described, including the most up-to-date World Health Organization (WHO) diagnostic pathologic classifications. The importance of the WHO classification of cancer in precision medicine is discussed. For hematolymphoid neoplasms, a detailed historical background for leukemia and lymphoma classifications precedes the comparison of the 5th edition WHO 2022 classification with the International Consensus Classification. Novel techniques in flow cytometry and measurable residual disease detection in hematolymphoid neoplasms by flow cytometry are described with ample illustrations. Other chapters include liquid biopsies in blood cancer, precision diagnosis in the lung, colorectal, ovarian, and prostate cancers, novel immunotherapies in cancer, including essential concepts underlying pathologic testing in cancer, and digital pathology and artificial intelligence as necessary tools for advancing precision medicine.

The central nervous system can be affected in many hereditary tumor syndromes, also sometimes referred to as familiar tumor syndromes, genetic tumor syndromes or cancer predisposition syndromes. Although a few of these have been recognized for a long period of time and have been well delineated with regard to clinical presentations and genetic abnormalities, some have been only recently defined. These disorders are highly complex and patients are best cared for in specialized centers which have broad interdisciplinary expertise to handle the wide array of phenotypic manifestations of these disorders. This book contains a collection of chapters which focus on a subset of these syndromes. The focal of the chapters in this text is on the neuropathologic features associated with the various syndromes that are highlighted.

The book provides a comprehensive overview of the challenges and debates on the diagnosis and treatment of lateral neck swellings to clarify some uncertainties, make suggestions for resolving others, and establish strategies for achieving therapeutic success. In addition to information on the surgical anatomy of the neck, and the classification and clinical approach for diagnosis and management of neck swellings, the chapters explore solid swellings and cystic swellings of the anterior and posterior triangles. The last chapter emphasizes the importance of scheduling regular follow-ups as well as patient counselling and education.The volume, enriched with colour images and flowcharts, will be an indispensable resource for head and neck surgeons, maxillofacial surgeons, endocrinologists, oncologists, pediatricians, and clinicians in other specialties as they face the most challenging lateral neck swellings and work towards providing each patient with the best possible outcome.

Now in its 3rd edition, Tumor Board Review: Evidence-Based Case Reviews and Questions is the most comprehensive clinical case review book in the field. With hands-on input from current fellows and oncologists, this new edition has been enhanced and reformatted for greater efficiency and practicality. The review covers all disease-site areas in oncology and features a wide variety of board-style questions pivotal in helping fellows and oncologists prepare for both the ABIM medical oncology board exam and maintenance of certification (MOC) assessments. Evidence-based discussions of difficult patient cases offer an in-depth and accurate depiction of what is discussed at tumor boards and foster critical thinking essential for clinical practice. Patient cases also highlight impactful treatment decisions that include newly approved immunotherapies and targeted therapies. Each chapter contains digestible essentials for each case, including a summary of diagnosis, molecular and genomic testing, treatment options, toxicity considerations, follow-up, and survivorship. Each chapter ends with high-yield multiple-choice questions including answers and detailed rationales ensuring readers are well-equipped with the knowledge they need to make well-informed, individualized treatment decisions. Tumor Board Review: Evidence-Based Case Review and Questions is an essential case-based reference for anyone working in oncology. Key Features: Describes more than 120 patient cases, including locally advanced and metastatic cases for each major disease site Contains 300 board-style questions and answers related to case reviews Includes new advances in diagnosis and therapy, with a greater emphasis on immunotherapies, cancer genomics, and precision-based targeted therapies Provides essentials for toxicity considerations, follow-up, and survivorship considerations

General surgery is the common ancestor of all surgical specialties. Within general surgery, many subspecialty areas of practice have evolved. This book is the first manual recognizing the growing role General Surgeons play in Head & Neck Surgery. From benign to malignant conditions and form ablative to reconstructive challenges, the renowned comprehensive capability of the General Surgeon is well suited to demands of this discipline. Each chapter details relevant anatomical considerations to enable understanding of this complex regional specialty and the full range of head and neck pathologies with requisite assessment, investigation, surgical and relevant reconstructive techniques. Written by a multidisciplinary, international team of recognized experts, this textbook is a practical but comprehensive guide for both candidates preparing for final surgery examinations as well as general surgeons requiring an up-to-date source of definitive advice on topics of this regional specialty.

Ace your board exams with almost 4000 practice questions and enhance your pathology practice with compentency-based training tools Prepare for licensing exams offered by the American Board of Pathology and the Royal College of Physicians and Surgeons of Canada.The most comprehensive review guide on the market will ensure you're confident and ready when you sit down to write your certification exam. With protocols from the College of American Pathologists for examining and reporting tumors, and “competency by design” principles from the Royal College of Physicians and Surgeons of Canada, this guide is also a powerful tool for improving your practice as a pathologist. Pathology Review and Practice Guide is an essential resource both before and after your exam. Here's what you'll find in the new and revised third edition of this bestselling guide: 3900 multiple choice and short answer questions—almost 800 new questions for the third edition 1900 color images 10 new sets of mock exam questions available online for self-evaluation 10 specimen grossing videos available online that support the book's content A comprehensive image index Question formats that present case scenarios, differential diagnoses, diagnostic procedures, classification of tumors, hallmark features of pathological entities, and pathogenesis Tumor staging information from the 8th edition of the American Joint Committee on Cancer staging manual Comprehensive answers that build your knowledge while you study Tips for maximizing your success, both on the exam and in your practice New “must know, must see, must do” sections that incorporate Canadian Royal College's “competency by design” principles into each chapter

This book is composed of 13 informative chapters written by world-renowned healthcare providers and researchers in the fields of endocrinology, pharmacy, radiology, infertility, pediatrics, internal medicine, psychology and genetics. From topics covering psychosocial impacts to pharmacokinetic and homecare resources, the intent of this book is to provide guiding principles for a safe and informative transition of care for pediatric and adolescent patients with various familial endocrine cancer syndromes that are transitioning from pediatric to adult health care. It provides an in-depth exploration of the diagnostic and therapeutic strategies, survivorship navigation intervention, patient, caregiver and primary care provider challenges, and multidisciplinary care plans for conditions such as MEN1, MEN2 and other familial and genetic endocrine neoplasias.Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients is a much-needed resource, as the literature currently lacks a comprehensive publication to facilitate pediatric patients'transition to adult clinics and resources following endocrine cancer diagnosis and treatment.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. - Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes—more than 150 diagnoses in all - Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care - Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others - Meticulously edited by Dr. Vania Nosé with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered - Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis - Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification - Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care - Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Now with additional review content and a larger page size, The MD Anderson Surgical Oncology Manual, Seventh Edition, focuses on multidisciplinary, cooperative management approaches to issues confronting today's surgical oncologist. Lead editor Dr. Barry W. Feig is joined by recently graduated surgical oncology fellows Michael G. White, Cameron E. Gaskill, Anai N. Kothari, and Sandra R. DiBrito to bring you comprehensive yet concise information on the complete range of oncologic considerations needed to effectively understand cancer and all aspects of its treatment.

Key Clinical Topics in Paediatric Surgery is an indispensable and practical guide for clinical practice and examination revision. Edited by experienced surgeons and with contributions from specialists who have recognised expertise in their field, this book provides an authoritative and up-to-date guide to common paediatric surgical conditions. Presented in a concise format that enables rapid access to core information, Key Clinical Topics in Paediatric Surgery delivers the essential clinical knowledge and practical skills for paediatric surgeons in training.

This is the third edition of a well-received book that recapitulates the thyroid fine-needle aspiration (FNA) cytology. It covers the basics and critical principles of thyroid cytopathology, addresses technical aspects, and presents the latest breakthrough events in the field, including the new editions of the WHO classification of thyroid tumors and the Bethesda system for reporting thyroid cytopathology.Thyroid FNA Cytology, The Third Edition is a practical handbook for cytopathologists, pathologists, cytotechnologists, endocrinologists, thyroid surgeons, radiologists, thyroid cancer patients, and their families. This edition covers more topics than the previous editions and invites authors from 20 countries from Asia, Europe, and America. It should serve as an individualized guide to readers practicing in various geographic areas with different medical settings and social resources. The book provides multiple chapters on differential diagnosis and pitfalls to show the unique approaches in many countries. The book will broaden their perspectives and serve as a foundation for further advancement in this field.

Since the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available “quick reference” for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

Identifying tumor-specific molecular aberrations via molecular profiling is vital for the use of targeted therapies. Understanding a patient's unique tumor genetics provides predictive and prognostic information that enables a personalized care plan to be put in place, improving outcomes and minimizing ineffective treatments.'Fast Facts: Molecular Profiling in Solid Tumors'provides a firm knowledge foundation of somatic molecular profiling methodologies, key information to help with the use of molecular profiling in daily practice and advice on communicating with patients about molecular testing and results. Table of Contents: • Molecular profiling: the basics • Rationale for testing • Sample collection • Test selection and process • Interpreting the report • Talking to patients • Challenges and opportunities

The only textbook for PA students by PA educators that covers everything you need to know for your clinical medicine courses. This groundbreaking clinical textbook designed specifically for physician assistant students was developed by PA educators to ensure that you have the exact information you need to succeed in your challenging clinical medicine courses. Designed with the unique PA curriculum in mind, Clinical Medicine for Physician Assistants addresses current ARC-PA standards, providing you with a single go-to resource for all the topics you'll need to master. Organized by body system, this text provides the in-depth, head-to-toe foundation you'll need as you prepare to move into clinical practice. Not only does it cover hundreds of clinical conditions, but it also provides important insights on how to manage the most common chief complaints, system by system, with useful algorithms to guide you through patient visits. Chapters include a digestible and methodical review of conditions, including pathophysiology, etiology, history, signs and symptoms, physical exam, and diagnosis details for each. Also included are treatment options, patient education, and special considerations for various patient populations. Additionally, you'll find key points at the end of each chapter, along with knowledge checks to help you synthesize and apply what you learned. Key Features: The first clinical medicine textbook developed for PAs by PAs specifically for the PA curriculum Designed to reflect current ARC-PA competencies and standards for clinical medicine courses Covers all the clinical topics on the current NCCPA PANCE blueprint and more Includes chapters on surgery, abuse, care of the LGBTQ+ patient population, and preventive medicine More than 300 four-color illustrations, dozens of algorithms, and 600 useful tables and boxes to facilitate learning Key points and knowledge checks to reinforce learning Useful guidance for navigating common chief complaints Robust instructor resources, including an instructor manual, PowerPoint lectures, case studies, and a test bank with more than 1,000 questions

The book is divided into nine sections arranging closely related subjects into clusters. There are a total of 38 chapters. Section 1 commences with introduction to thyroid disorders, Section 2 discusses the diagnostic approaches, Section 3 highlights all aspects of hypothyroidism, Section 4 encompasses disorders of thyroid hormone excess, Section 5 elaborates the entire spectrum of goiter, thyroid nodules and thyroid cancer, Section 6 focuses on thyroid disorders in women, Section 7 is exclusively devoted to thyroid disorders in children while Sections 8 and 9 address thyroid disorders in special situations and miscellaneous thyroid topics.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners and trainees at all levels of experience and training. Covering all aspects of cytology, including gynecologic, nongynecologic exfoliative, fine-needle aspiration, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cytopathology is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Covers all areas of cytopathology, including clinical, radiologic, and immunohistochemical as well as cytopathologic features and molecular correlates where applicable Contains new chapters on ancillary molecular tests specific to thyroid, prognostic/therapy-related immunomarkers in cell blocks, and small biopsies Provides new immunohistochemical and molecular coverage, including new immunostains and genomic targets Incorporates new reporting terminology (such as serous fluid and effusions) and updates to existing reporting terminologies Reflects the expanded use of fine-needle aspiration for small biopsies (FNA-B) with many more images added and updated throughout Keeps you up-to-date with current and emerging reporting systems on pancreaticobiliary, salivary, breast, and soft tissue cytology Features more than 3,000 print and online images, including carefully annotated histology and gross pathology photos, full-color illustrations, clinical photographs, and radiologic images to help practicing and in-training pathologists reach a confident diagnosis Includes new videos on such topics as the cytoprepratory process, cell transfer cell block and smears, collodion bag cell block, and more Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert cytopathology reference at the point of care

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. - Provides up-to-date information on current molecular biomarkers research for cancer - Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient's survivorship - Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas

In bringing out this edition, our authors have done an extensive revision of all individual chapters by omitting few ‘behind the time'texts, incorporating recent management concepts, discussing new treatment modalities and adding new diagrams and figures. Our section editors, all of whom are experts in their own right in their respective subspecialities, have done an excellent job. They further refined editing of the chapters in their sections keeping in view the current clinical practice and need of medical students. The chapter on ‘Nasopharynx'has been shifted from Head and Neck section to the Rhinology section, where it better belongs, particularly keeping in mind the rapid developments in the field of endoscopic surgery of the sinuses, skull base and surrounding areas. Recent concepts in ever-changing management of head and neck cancers—particularly thyroid cancers, cochlear implantation/middle ear implants, allergic rhinitis/rhinosinusitis and sleep related breathing disorders have been incorporated.

The team of this edition includes specialists of their own subspeciality (Urology, Nephrology, Neurosurgery, Radiology, Surgical Oncology, Gastrointestinal Surgery, Anesthesiology, Plastic Surgery and Breast and Endocrine Surgery) and hence, the content is coming directly from the specialists to the young doctors. The second important change is the inclusion of a lot of case-based scenarios, image library as well as multiple choice questions and key topics on the perioperative journey of a patient, transplant journey of a patient, bariatric surgery, more detailed discussion of concepts of portal hypertension, fluid and electrolyte abnormalities and many more. All the updated guidelines of 2020–2023 have been summarized including the new definitions of shock, the new ATLS guidelines, compartment syndromes, urological cancers and sepsis amongst others. Topics like renal failure, coagulation and anticoagulation, acid-base balance, cardiac and respiratory risk assessment as well as management are very important in surgical workup and management of the patient and are highlighted here. All of us have also tried to increase the number of algorithms, figures, and tables and flowcharts and minimize the theory part.