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This second volume of the two-volumes work “Antimicrobials in Livestock” offers an in-depth look at the antimicrobials commonly used in veterinary medical care of the major food producing animals pigs, poultry and cattle as well as horses, bringing to readers'attention also pharmacokinetic and pharmacodynamic characteristics of these drugs. The individual chapters also provide a brief description of preventive tools as well as alternatives to conventional treatment options that could help minimise the use of antibiotics and combat the problems caused by increasing antimicrobial resistance. The focus is on Europe, without neglecting the global context. The complete two-volumes provide an extensive review of various aspects related to the use of antimicrobials in veterinary medicine. Volume I explores the use of antimicrobials in animals from the regulatory, practical as well scientific perspective and is targeted on EU policies and regulatory surroundings, providing also information on risks linked to the extensive use of antibiotics in livestock and highlighting importance of methods of laboratory testing for susceptibility and resistance, starting from phenotype tests and moving towards genetic analysis results providing molecular biology aspects. Each chapter confronts the reader with open questions to stimulate further discussions and future research on the topics covered. Volume II more specifically discusses medical aspects necessary for targeted, responsible, and evidence-based use of antimicrobials in cattle, pigs, poultry, and horses, as well as pharmacokinetics and pharmacodynamics as two of the most important factors necessary for proper dosing schedule setting of effective treatment. While the preface of the first volume started with questions, Volume II's preface ends with them, having the intention to provoke more in depth and innovative thinking and might be the start of a new era, which is needed to keep antimicrobials working and available for the future generations both in human and veterinary medicine.

This book presents the most up-to-date information on the effects of nutrition and food on cancer prevention and management. The book will provide clinicians and other healthcare practitioners with an educational source on how to educate cancer patients and their families on nutrition and dietary during cancer treatment. Recent nutritional epidemiology studies have occasionally produced controversial or unexpected results and highlight the need for additional research on diet and cancer risk. Chapters within the book focus among others on the role of natural antioxidants in cancer, the importance of micronutrients in cancer prevention and nutritional genomics and their role in cancer prevention.By familiarizing readers with the latest developments in this complex field, the book offers a valuable resource for scientists, clinicians and students alike.

Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This'sequential'strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the'druggability'of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term'Safety Pharmacology'was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. &nb

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. - Provides up-to-date information on current molecular biomarkers research for cancer - Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient's survivorship - Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas

This book is based on detailed coverage of the role of phytochemicals as a epigenetic modifier to prevent various cancers. It presents the novel features of phytochemicals and their role in preventing cancer by regulating DNA, RNA and protein levels. It also covers the role of various kinds of phytochemicals especially focused on vitamins, flavconoids, polyphenois and phytols in cancer prevention and treatment. It also deals with the discovery of novel biomarkers for cancer treatment that are enabled by phytochemical modulation of epigenetic activity, highlighting its promise as an alternative treatment approach in cancer. The major goal of this project is to summarise what we currently know about natural product active chemicals, including their pharmacologic activity and molecular markers. There are several books available on phytochemicals and cancer, but to date there is no such book reported which compiles the broad spectrum of applications of phytochemicals at epigenetic levels. This project is themed to combine, promote and lift the potentialities of dietary phytochemicals in cancer prevention and treatment and reduce the dependability on synthetic drugs which often cause many negative side effects. Key Features: • Details the role of various kinds of phytochemicals in cancer chemoprevention by specific targeting at the epigenetic level. Covers the role of phytochemicals in natural drug development against cancer. Presents epigenetic regulation, molecular signalling, and cancer development in detail. Unique coverage of phytochemicals based nanomedicine for cancer treatment. Offers coverage of the role of phytochemicals in preventing various molecular cancer pathways.

Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase, Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase, Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Updated release includes the latest information on Steroid Biochemistry

Adequate intake of fruits has been linked with the reduction in the risk of chronic diseases and maintenance of body weight. Fruits and Their Roles in Nutraceuticals and Functional Foods covers recent research related to the bioactive compounds present in a variety of fruits. Novel techniques and methodologies used in the extraction, isolation, and identification of bioactive compounds of functional fruits are discussed in detail. Written by various experts in the field, the book examines a variety of fruit including apple, pear, mango, pomegranate, papaya, watermelon, pineapple, banana, and orange, among others.Key Features Covers all aspects related to the role of fruits in the nutraceutical and functional foods Examines the health elements of bioactive compounds as a treatment for various chronic disorders Provides an insight on the global regulatsory aspects for the utilization of fruits in nutraceuticals and functional foods

This contributed volume explores the ways in which researchers engineer new biomaterials for the challenging problems of the peripheral and central nervous systems. These biomaterials are uniquely positioned for use in creating in vitro models of injury and disease, testing therapeutic treatments, understanding neural development, and mapping the multi-scalar environment of the brain. This book informs readers from biology, chemistry, materials science, engineering, and neuroscience on cutting edge research in engineering technologies, from fundamental material development through pre-clinical studies. The book also highlights target applications in three areas of research: (1) engineering neural models and materials, (2) probing biological underpinnings of neurological function and disease, and (3) designing therapeutic and diagnostic treatments for neurological disease.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Technologies to Recover Polyphenols from AgroFood By-products and Wastes: Applications in Different Fields covers the most used technologies to extract and recover polyphenols from all kinds of by-products and wastes generated by the food industry, restaurant and agricultural sectors. Polyphenols are characterized by different AgroFood by-products and waste sources, hence this book explores the practical applications of these polyphenols in the development of functional foods and pharmaceutical and cosmetic products. Containing definitions, case studies, applications, literature reviews, and coverage of recent developments, this book will be a welcomed resource for food scientists, including those working in sustainability, agriculture and engineering. - Promotes a circular economy by discussing the valorization of these compounds - Features case studies that enable the reader to understand the potential of several polyphenols and the possibilities regarding their incorporation into several matrixes - Presents tools for the development of new lines of research or in support of ongoing investigations with solutions for existing challenges

There has been a worldwide increase in the demand for medicinal plants that aid the immune system, and considerable progress has been made in plant-based drug development. Herbs, Shrubs and Trees of Potential Medicinal Benefits examines how plants are used in the development of drugs preventing and treating cancer, hepatitis, asthma, influenza, HIV, and other diseases by manipulating a variety of bioactive molecules found in these plant parts. The book analyses how plants may strengthen human immunity, improve mood and brain function, enhance blood and oxygen circulation, boost the healing processes, and maintain blood pressure.Though many herbs, shrubs and trees have been identified for developing healthcare products, many of them require further exploration for potential usage. This volume in the Exploring Medicinal Plants series, presents information on herbs, shrubs and trees discussing traditional knowledge, chemical derivatives, and potential benefits of these items.Features:Identifies and highlights some medicinal herbs, shrubs and or trees around the world, presenting overall potential benefits to human health.Explores important medicinal plants for their bioactive constituents and phytochemicals.Discusses medicinal herbs, shrubs, and or trees for their uses in herbal drug preparation.Written by an international panel of plant scientists, this book is an essential resource to students, pharmacists, and chemists. It provides valuable information on fundamental chemical principles, modes of action, and product formulation of bioactive natural products derived from plants for medical applications.

DRUG TRANSPORTERS Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. Reflects the current state of the field and offers perspectives on future directions Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science Provides up-to-date information on drug transporter families, mechanisms, and clinical implications Includes extensive references and numerous figures and tables throughout Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. - Highlights active agents from natural sources for development as novel anti-cancer agents - Features contributions from active researchers and leading experts working in the field - Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.

Wein verlängert das Leben und hält geistig fit! Der genussvolle Gesundheitsratgeber zum Thema Wein von Bestseller-Autor Hans-Ulrich Grimm. Die wissenschaftlichen Beweise sind überwältigend: Wein hilft nicht nur gegen Viren und Bakterien, sondern auch gegen die großen Zivilisationskrankheiten, angefangen von Alzheimer über Herzleiden und Krebs bis hin zu Diabetes, und er hat einen positiven Anti-Aging-Effekt. Der Erfolgsautor Hans-Ulrich Grimm beschreibt die erstaunliche Wirkung, die Wein auf unsere Gesundheit ausübt. Wein war über Tausende von Jahren das wichtigste Medikament, oft sogar das einzige. Womöglich spielt er sogar eine tragende Rolle bei der Entwicklung der menschlichen Zivilisation, weil er die Menschen verbindet, die Kommunikation fördert. Hans-Ulrich Grimm vereint das Wissen um die kulturgeschichtliche Bedeutung des Weines mit neuesten wissenschaftlichen Erkenntnissen und betont auch die genießerische Freude, mit der man etwas für seine Gesundheit tun kann. In einer spannenden Spurensuche vereint der Bestseller-Autor alle bekannten Fakten zu einem genussreichen Lesevergnügen. Mit 20 Fotos und 30 Abbildungen, zweifarbig illustriert.Dr. Hans-Ulrich Grimm ist Journalist und Autor. Seine jahrelangen Recherchen in der Welt der industrialisierten Nahrungsmittel bewegten ihn, sämtliche Erzeugnisse von Nestlé, Knorr & Co aus den Küchenregalen zu verbannen, zugunsten frischer Ware von Märkten und Bauern. Seine Erkenntnis: Genuss und Gesundheit gehören zusammen.Grimms Bücher sind Bestseller. Allein'Die Suppe lügt'ist in einer Gesamtauflage von über 250.000 Exemplaren erschienen und gilt mittlerweile als Klassiker der modernen Nahrungskritik. Zuletzt sind bei Droemer'Echtes Essen. Der Anti-Aging-Kompass'und'Dumm gegessen! Wie uns die Nahrungsindustrie um den Verstand bringt'erschienen. Hans-Ulrich Grimm lebt mit seiner Familie in Stuttgart.

In the context of climate change, pollution and food safety, the current challenge is to enhance legumes production to sustain the growing population needs by 2050. This is a daunting task because abiotic and biotic stresses are threatening the growth, survival and productivity of legumes. For instance, the productivity of legumes is documented to be reduced by 14-88% by abiotic stresses. The co-occurrence of abiotic and biotic stresses under field conditions leads to interactive stress types, thus yielding positive or negative outcomes. Legumes react using antioxidant defense, osmoregulatory adjustments, hormonal regulations and molecular mechanisms to tolerate stress. Hence, improving legume productivity requires knowledge on the sensitivity, mechanisms and approaches of stress tolerance in legumes, in order to design new crops and alternative management systems. This book presents advances on bioactive compounds, applications, effect of various stresses and biotechnology-based stress tolerance mechanisms of legumes. This is our second volume on Legume Agriculture and Biotechnology, published in the series Sustainable Agriculture Reviews.

Oilseeds offer a plethora of opportunities for the food and feed industry, thanks to their high oil and protein content. Their phytonutrients and functional components have attracted the interest of researchers, leading to the development of functional foods. This book gathers the latest scientific information on the nutrients, phytonutrients and health benefits as well as the adverse effects of consuming various conventional and non-conventional oilseeds. In addition, each chapter includes a section comprehensively explaining the use of oilseeds in functional bakery, dairy, and other food products. Given its scope, the book is a valuable resource for students, researchers, nutritionists, food scientists and technologists, and for anyone involved in product development based on oilseed and its components.

Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.

Nature and Nutrition: A New Era of Therapeutic Herbs -A.K. Mohiuddin The book offers learning of alternative medicines having widespread use, acceptance and also the rules and regulations that ensures their best uses as well. The use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide relying on them for some part of primary healthcare. It has become essential, therefore, to furnish the general public including healthcare professionals with adequate information to facilitate better understanding of the risks associated with the use of these products and to ensure that all medicines are safe and of suitable quality. As an author, it is my heartiest believe that the book will adjoin significant apprehension to future research pharmacists and alternative medical practitioners as most of the text portion is created from the recently published books, newsletters and articles of different journals.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Food security and the medicinal needs of billions of people around the world are pressing global issues, and the biodiversity and sustainable utilization of plants is of great significance in this context. Further, ethnobotanical studies are vital in the discovery of new drugs from indigenous medicinal plants, and plants with industrially important metabolites need to be cultivated to meet the growing market demand. In addition, the production of plant metabolites under in vitro conditions also has tremendous possibilities. The totipotency of plant cells plays a valuable role in the sustainable utilization of plant resources through cell, tissue and organ culture. At the same time, production can be enhanced using productive cell lines, treatment with elicitors, changing nutritional parameters and metabolic engineering. This book provides state-of-the-art information on biodiversity, conservation, ethnobotany, various aspects of In vitro secondarymetabolite production, bioprospecting from various plant groups and drug discovery. It also discusses methods of extracting and characterizing drug leads from plant sources.​

Biodiversity and Biomedicine: Our Future provides a new outlook on Earth's animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth's species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world's most bio-rich communities and the molecular diversity of various species. - Presents new developments in documenting and identifying species for biodiversity conservation and ethical considerations for biodiversity research - Examines biodiversity as an irreplaceable resource for biomedical breakthroughs using available species for medical research - Discusses challenges and opportunities for biodiversity protection and research in biosphere reserves

The volume reviews different types of bioactive components associated with food fermentation and their impact on human health. The diversity of microorganism responsible for the production of different types of fermented foods and beverages includes bacteria, yeasts, and fungi. Biotransformation of food constituent by microorganisms occurs during fermentation processes for the production of fermented food and in the gastrointestinal tract by gut microorganisms. This biotransformation results in production of specific bioactive compounds that are responsible for a wide range of health benefits. The bioactive compounds discussed in this book includes polyphenols, bioactive peptides, fibrinolytic enzymes, gama-amino butyric acids (GABA) exopolysaccharides, probiotic, prebiotic, symbiotic and antinutritional factors. These bioactive compounds are responsible for health benefits such as antioxidant, antihypertension, antimicrobial, cholesterol lowering, anticancer, obesity and antithrombotic properties. Advanced research in the field of food fermentation and their health benefits have resulted in commercialization of some of the fermented foods as functional foods. The traditional fermented foods consumed in different parts of the world and their health benefits are discussed in detail and the book concludes with recent advances in microbial transformation during gut fermentation and their impact on human health. There has been increasing interest among researchers on the proposed title in the last decade and the book brings updated information on research and advances in different types of health benefits exhibited by bioactive compounds in a wide range of fermented foods.

The use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide relying on them for some part of primary healthcare. This past decade has obviously witnessed a tremendous surge in acceptance and public interest in natural therapies both in developing and developed countries, with these herbal remedies being available not only in drug stores, but now also in food stores and supermarkets. The use of herbal remedies has also been widely embraced in many developed countries with complementary and alternative medicines (CAMs) now becoming mainstream in the UK and the rest of Europe, as well as in North America and Australia. In the developed countries, the most important among many other reasons for seeking herbal therapy is the belief that it will promote healthier living. Herbal medicines are, therefore, often viewed as a balanced and moderate approach to healing and individuals who use them as home remedies and over-the-counter drugs spend huge amount of money (in excess of billions of dollars) on herbal products. As the global use of herbal medicinal products continues to grow and many more new products are introduced into the market, public health issues, and concerns surrounding their safety are also increasingly recognized. Although some herbal medicines have promising potential and are widely used, many of them remain untested and their use also not monitored. This makes knowledge of their potential adverse effects very limited and identification of the safest and most effective therapies as well as the promotion of their rational use more difficult. It is also common knowledge that the safety of most herbal products is further compromised by lack of suitable quality controls, inadequate labeling, and the absence of appropriate patient information. It has become essential, therefore, to furnish the general public including healthcare professionals with adequate information to facilitate better understanding of the risks associated with the use of these products and to ensure that all medicines are safe and of suitable quality.

Mit Erscheinen des Doppelfaszikels 38/39 ist das Deutsche Theater-Lexikon abgeschlossen.

Keine ausführliche Beschreibung für'Zedler - Zysset'verfügbar.