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This book presents outstanding contributions in an exciting, new and multidisciplinary research area: the application of formal, automated reasoning techniques to analyse complex models in systems biology and systems medicine. Automated reasoning is a field of computer science devoted to the development of algorithms that yield trustworthy answers, providing a basis of sound logical reasoning. For example, in the semiconductor industry formal verification is instrumental to ensuring that chip designs are free of defects (or “bugs”). Over the past 15 years, systems biology and systems medicine have been introduced in an attempt to understand the enormous complexity of life from a computational point of view. This has generated a wealth of new knowledge in the form of computational models, whose staggering complexity makes manual analysis methods infeasible. Sound, trusted, and automated means of analysing the models are thus required in order to be able to trust their conclusions. Above all, this is crucial to engineering safe biomedical devices and to reducing our reliance on wet-lab experiments and clinical trials, which will in turn produce lower economic and societal costs. Some examples of the questions addressed here include: Can we automatically adjust medications for patients with multiple chronic conditions? Can we verify that an artificial pancreas system delivers insulin in a way that ensures Type 1 diabetic patients never suffer from hyperglycaemia or hypoglycaemia? And lastly, can we predict what kind of mutations a cancer cell is likely to undergo? This book brings together leading researchers from a number of highly interdisciplinary areas, including: · Parameter inference from time series · Model selection · Network structure identification · Machine learning · Systems medicine · Hypothesis generation from experimental data · Systems biology, systems medicine, and digital pathology · Verification of biomedical devices “This book presents a comprehensive spectrum of model-focused analysis techniques for biological systems...an essential resource for tracking the developments of a fast moving field that promises to revolutionize biology and medicine by the automated analysis of models and data.”Prof Luca Cardelli FRS, University of Oxford

This book highlights cutting-edge research in the field of network science, offering scientists, researchers, students and practitioners a unique update on the latest advances in theory, together with a wealth of applications. It presents the peer-reviewed proceedings of the VII International Conference on Complex Networks and their Applications (COMPLEX NETWORKS 2018), which was held in Cambridge on December 11–13, 2018. The carefully selected papers cover a wide range of theoretical topics such as network models and measures; community structure and network dynamics; diffusion, epidemics and spreading processes; and resilience and control; as well as all the main network applications, including social and political networks; networks in finance and economics; biological and neuroscience networks; and technological networks.

This book highlights cutting-edge research in the field of network science, offering scientists, researchers, students and practitioners a unique update on the latest advances in theory, together with a wealth of applications. It presents the peer-reviewed proceedings of the VII International Conference on Complex Networks and their Applications (COMPLEX NETWORKS 2018), which was held in Cambridge on December 11–13, 2018. The carefully selected papers cover a wide range of theoretical topics such as network models and measures; community structure and network dynamics; diffusion, epidemics and spreading processes; and resilience and control; as well as all the main network applications, including social and political networks; networks in finance and economics; biological and neuroscience networks; and technological networks.

This book constitutes the refereed proceedings of the 14th International Conference on Computational Methods in Systems Biology, CMSB 2016, held in Cambridge, UK, in September 2016. The 20 full papers, 3 tool papers and 9 posters presented were carefully reviewed and selected from 37 regular paper submissions. The topics include formalisms for modeling biological processes; models and their biological applications; frameworks for model verification, validation, analysis, and simulation of biological systems; high-performance computational systems biology and parallel implementations; model inference from experimental data; model integration from biological databases; multi-scale modeling and analysis methods; and computational approaches for synthetic biology.

This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2014, held in Cambridge, UK, in June 2014.The 25 revised full papers presented were carefully reviewed and selected from 44 submissions. The papers focus problems concerning computational techniques in bioinformatics, systems biology, medical informatics and biostatistics.

This book constitutes the refereed proceedings of the 11th International Conference on Artificial Immune Systems, ICARIS 2012, held in Taormia, Italy, in August 2012. The 19 revised selected papers presented were carefully reviewed and selected for inclusion in this book. In addition 4 papers of the workshop on bio and immune inspired algorithms and models for multi-level complex systems are included in this volume. Artificial immune systems (AIS) is a diverse and maturing area of research that bridges the disciplines of immunology, biology, medical science, computer science, physics, mathematics and engineering. The scope of AIS ranges from modelling and simulation of the immune system through to immune-inspired algorithms and in silico, in vitro and in vivo solutions.

This book constitutes the refereed proceedings of the 10th International Conference on Artificial Immune Systems, ICARIS 2011, held in Cambridge, UK, in July 2011. The 37 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on immunoinformatics and computational immunology; theory of immunological computation; and applied immunological computation.

This volume contains the papers from BIOWIRE 2007, the first in a series of wo- shops on the bio-inspired design of networks, and additional papers contributed from the research area of bio-inspired computing and communication. The workshop took place at the University of Cambridge during April 2–5, 2007 with sponsorship from the US/UK International Technology Alliance in Network and Information Sciences. Its objective was to present, discuss and explore the recent developments in the field of bio-inspired design of networks, with particular regard to wireless networks and the self-organizing properties of biological networks. The workshop was organized by Jon Crowcroft (University of Cambridge), Don Towsley (University of Massachusetts), Dinesh Verma (IBM T. J. Watson Research Center), Vasilis Pappas (IBM T. J. Watson Research Center), Ananthram Swami (ARL), Tom McCutcheon (DSTL) and Pietro Liò (University of Cambridge). The program for BIOWIRE 2007 included 54 speakers covering a diverse range of topics, categorized as follows: 1. Self-organized communication networks in insects 2. Neuronal communications 3. Bio-computing 4. Epidemiology 5. Network theory 6. Wireless and sensorial networks 7. Brain: models of sensorial integration The BIOWIRE workshop focuses on achieving a common ground for knowledge sharing among scientists with expertise in investigating the application domain (e. g., biological, wireless, data communication and transportation networks) and scientists with relevant expertise in the methodology domain (e. g., mathematics and statistical physics of networks).