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Since its emergence in late 2019, COVID-19 has sparked global catastrophe, taking the lives of millions around the world. This pandemic has deeply challenged the global community across sectors, including health and economics. Constantly evolving information led to millions of publications related to the disease in less than two years, a ground-breaking magnitude in the world of academic. This book “Critical Care and COVID-19” summarizes what we know about COVID-19 as it pertains to epidemiology, pathology, therapeutics, and effects on different organ systems. It also dives into the mental health challenges as a result of COVID-19, the nursing and respiratory therapist journey, and lessons learned from the frontline. This 25-chapter book covers the COVID-19 spectrum and benefits clinicians, nurses, respiratory therapists, pharmacists, and regulators.

The encyclopedia consists 13 subareas as follows:1: Synthesis and Characterisation of Ionic Liquids (Section Editors: Prof. Fu-Wei Li and Prof. Zhen Li)2: Physicochemical Properties of Ionic Liquids (Section Editors: Asso. Prof. Qing Zhou, Prof. Xingmei Lu and Prof. Xiaoyan Ji)3: Computational and Theoretical Modeling of Ionic Liquids (Section Editors: Prof. Guang Feng and Prof. Peter T. Cummings)4: Toxicology and Biodegradation of Ionic Liquids (Section Editors: Prof. Chunxi Li and Prof. Stefan Stolte)5: Ionic Liquids in Electrochemistry (Section Editors: Prof. Yingying Lu, Prof. Houlong Zhuang and Prof. Chuan Zhao)6. Ionic Liquids in Organic Reaction (Section Editors: Prof. Liang-Nian He and Prof. Bhalchandra M. Bhanage)7. Ionic Liquids in Separation (Section Editors: Prof. Huabin Xing)8. Ionic Liquids in Biomass and Biomolecules (Section Editors: Prof. Toshiyuki Itoh and Prof. Jian Sun)9. Ionic Liquids in Materials Science (Section Editors: Prof. Sheng Dai and Prof. Tao Wang)10. Ionic Liquids in Polymer Science (Section Editors: Asso. Prof. Jinming Zhang and Prof. Jun Zhang)11. Ionic Liquids in Environmental Science (Section Editors: Prof. Tiancheng Mu, Prof. Arunprakash T. Karunanithi and Prof. Yingxiong Wang)12. Ionic Liquids in Green Chemistry (Section Editors: Prof.Buxing Han and Prof. Peter Licence)13. Emerging Applications of Ionic Liquids (Pharmacology, Food Science, Agriculture, Nuclear Science Technology, Optics) (Section Editors: Prof. Zhonghao Li and Prof. Maya Guncheva)This encyclopedia is systematic and comprehensive, with detailed descriptions about theory, technology, and industrial applications. This encyclopedia is valuable for students, researchers and industrial players, giving them a quick understanding and overview of ionic liquids in various aspects.

This book discusses different approaches for successful pest-management through biotechnological interventions. Pest management is directly associated with the agricultural productivity. The book introduces the reader to various kinds of biopesticides that have been developed and are being developed for field application. Chemical pesticides have been widely used to control pests, and these induce pesticide resistance as well as other environmental problems. This book discusses the necessity to develop alternate pest control strategies, especially environment-friendly and target-specific biopesticides against destructive pests. The book describes important aspects such as microbial biopesticides, plant-based biopesticides, natural products that act against pests and the various other biotechnological advances and limitations of these biopesticides. It provides an in-depth knowledge of the latest research and development in the area of biopesticides. This informative book is meant for students and researchers in the fields of biotechnology, agriculture and applied microbiology.

This book provides an up-to-date overview on the biology of microsporidia, focusing on areas where significant progress has been made in recent years. In particular, our understanding of the evolutionary position and the role of genome reduction in the biology of these enigmatic intracellular pathogens is discussed. This book also offers important updates on the mechanisms used by these organisms to modify the host cell biology of mammals, insects, nematodes, and aquatic animals, as well as the mechanisms controlling infection and host specificity. Readers gain a detailed overview of the structure and function of the polar tube, the unique invasion apparatus of microsporidia, as well as the physics and dynamics of spore firing. Particular attention is given to chronic infections in mammals caused by microsporidia, as well as common immune responses.Written by an international team of authors representing the main research groups working on microsporidianbiology, this book is a valuable resource for health management professionals, experienced microbiologists, and early career scientist alike who want to learn more about these fascinating parasites. The ideas and latest finding covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being. Chapter “Impact of Genome Reduction in Microsporidia“ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.

The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function. In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.

In many countries, the development of railway science is of great significance to both the economy and society, and transdisciplinary studies involving railways and other fields has also become more important in recent years. This book presents the proceedings of the 7th International Symposium on Innovation & Sustainability of Modern Railway (ISMR 2020), held in Nanchang, China from 23 - 25 October 2020. The symposium has been held biennially since 2008 and is principally aimed at expanding the scientific partnership between Russian and Chinese transport universities in the field of railway transportation. It is organized in a collaboration between the Federal Railway Transport Agency, Irkutsk State Transport University (IrGUPS) and East China Jiaotong University, and enables scientists from Russia, China and Mongolia to come together to discuss breakthrough technologies, as well as the problems of innovation in the secure operation of modern railways. Despite the disruption caused by the global pandemic, 89 submissions were received for the 2020 edition, 38 of which were selected after review for presentation and publication here. These comprise 12 papers dealing with railways and mechanics, 20 covering railways and computer sciences, and 6 related to railways and management, together with the 2 contributions of the invited keynote speakers (professor Xiaoyan Lei, principle of East China Jiaotong University, and professor Erol Guler from George Mason University). The book provides an insight into new ideas and developments in the industry, and will be of interest to all railway practitioners.

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. - Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine - Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery - Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series

Nanomaterials in Chromatography: Current Trends in Chromatographic Research Technology and Techniques provides recent advancements in the wide variety of chromatographic techniques applied to nanotechnology. As nanomaterials'unique properties can improve detection sensitivity and miniaturize the devices used in analytical procedures, they can substantially affect the evaluation and analysis ability of scientists and researchers and foster exciting developments in separation science. The book includes chapters on such crucial topics as the use of nanomaterials in sample preparation and the legalization of nanomaterials, along with a section on reducing the cost of the analysis process, both in terms of chemicals and time consumption. - Presents several techniques for nanomaterials in chromatography, including well-known materials like carbon nanomaterials and functionalized nanomaterials - Includes suggested readings at the end of each chapter for those who need further information or specific details, from standard handbooks, to journal articles - Covers not only applications of nanomaterials in chromatography, but also their environmental impact in terms of toxicity and economic effects

Algae Based Polymers, Blends, and Composites: Chemistry, Biotechnology and Material Sciences offers considerable detail on the origin of algae, extraction of useful metabolites and major compounds from algal bio-mass, and the production and future prospects of sustainable polymers derived from algae, blends of algae, and algae based composites. Characterization methods and processing techniques for algae-based polymers and composites are discussed in detail, enabling researchers to apply the latest techniques to their own work. The conversion of bio-mass into high value chemicals, energy, and materials has ample financial and ecological importance, particularly in the era of declining petroleum reserves and global warming. Algae are an important source of biomass since they flourish rapidly and can be cultivated almost everywhere. At present the majority of naturally produced algal biomass is an unused resource and normally is left to decompose. Similarly, the use of this enormous underexploited biomass is mainly limited to food consumption and as bio-fertilizer. However, there is an opportunity here for materials scientists to explore its potential as a feedstock for the production of sustainable materials. - Provides detailed information on the extraction of useful compounds from algal biomass - Highlights the development of a range of polymers, blends, and composites - Includes coverage of characterization and processing techniques, enabling research scientists and engineers to apply the information to their own research and development - Discusses potential applications and future prospects of algae-based biopolymers, giving the latest insight into the future of these sustainable materials

The proceedings of the 2014 International Conference on Logistics, Informatics and Services Sciences (LISS'2014) gather 259 papers on the latest fundamental advances in the state of the art and practice of logistics, informatics, service operations and service science. The books is divided into four main sections focusing on different aspects: Service Management, Logistics Management, Information Management, and Engineering Management. It also covers ten special sessions: Advanced Management Decision Making Techniques and Application; Freight Transportation and Information Technology; Free Trade Zone (FTZ) and Supply Chain Management; Innovation in Service Science; Comprehensive Service; International Trade and Investment of Service Industries Theories and Practices, Trends and Strategies; Supply Chain Management, Industrial Economy and Urban Logistics; Management Process Optimization Modeling & Data Analysis; Logistics Management & IOT Technology Application; and Digital Publishing & Media. The papers in each section describe state-of-art research works that are often oriented towards real-world applications and highlight the benefits of related methods and techniques for developing the emerging field of service science, logistics and informatics.

This book is an up-to-date text covering topics in utilizing hydrogen bonding for constructing functional architectures and supramolecular materials. The first chapter addresses the control of photo-induced electron and energy transfer. The second chapter summarizes the formation of nano-porous materials. The following two chapters introduce self-assembled gels, many of which exhibit unique functions. Other chapters cover the advances in supramolecular liquid crystals and the versatility of hydrogen bonding in tuning/improving the properties and performance of materials.This book is designed to bring together in a single volume the most important and active fields of hydrogen bonding strategy for designing supramolecular materials. The book will be a valuable resource for graduates and researchers working in the fields of supramolecular chemistry and materials sciences.Zhan-Ting Li, PhD, is a Professor of Organic Chemistry at the Department of Chemistry, Fudan University, ChinaLi-Zhu Wu, PhD, is a Professor of Organic Chemistry at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China

The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.

Nanomaterials attract tremendous attention in recent researches. Although extensive research has been done in this field it still lacks a comprehensive reference work that presents data on properties of different Nanomaterials. This Handbook of Nanomaterials Properties will be the first single reference work that brings together the various properties with wide breadth and scope.

QCM-D Studies on Polymer Behavior at Interfaces reviews the applications of quartz crystal microbalance with dissipation (QCM-D) in polymer research, including the conformational change of grafted polymer chains, the grafting kinetics of polymer chains, the growth mechanism of polyelectrolyte multilayers, and the interactions between polymers and phospholipid membranes. It focuses on how QCM-D can be applied to the study of polymer behavior at various solid-liquid interfaces. Moreover, it clearly reveals the physical significance of the changes in frequency and dissipation associated with the different polymer behaviors at the interfaces.

Molecularly Imprinted Polymers, by Karsten Haupt, Ana V. Linares, Marc Bompart und Bernadette Tse Sum Bui.- Physical Forms of MIPs, by Andrea Biffis, Gita Dvorakova und Aude Falcimaigne-Cordin.- Micro and Nanofabrication of Molecularly Imprinted Polymers, by Marc Bompart, Karsten Haupt und Cédric Ayela.- Immuno-Like Assays and Biomimetic Microchips, by M. C. Moreno-Bondi, M. E. Benito-Peña, J. L. Urraca und G. Orellana.- Chemosensors Based on Molecularly Imprinted Polymers, by Subramanian Suriyanarayanan, Piotr J. Cywinski, Artur J. Moro, Gerhard J. Mohr und Wlodzimierz Kutner.- Chromatography, Solid-Phase Extraction, and Capillary Electrochromatography with MIPs, by Blanka Tóth und George Horvai.- Microgels and Nanogels with Catalytic Activity, by M. Resmini, K. Flavin und D. Carboni.

The anticipation of biological and clinical utility of biomarkers has attracted important interest. Significant molecular biomarkers for cancers have applications for establishing disease predisposition, early detection, cancer staging, therapy selection, identifying whether or not a cancer is metastatic, therapy monitoring, assessing prognosis, and advances in the adjuvant setting. This book presents current research data from across the globe in the study of cancer biomarkers, including oral cancer biomarkers through a cell cycle perspective; molecular markers of infectious agents to detect cancer; protein isoforms; bioinformatics analysis of gene networks involved in genomic stability and cancer; comet assay in human biomonitoring; metabolomics; and immunoelectrophoresis to detect immunoglobins of myeloma patients.

From the Introduction: Nanotechnology and its underpinning sciences are progressing with unprecedented rapidity. With technical advances in a variety of nanoscale fabrication and manipulation technologies, the whole topical area is maturing into a vibrant field that is generating new scientific research and a burgeoning range of commercial applications, with an annual market already at the trillion dollar threshold. The means of fabricating and controlling matter on the nanoscale afford striking and unprecedented opportunities to exploit a variety of exotic phenomena such as quantum, nanophotonic and nanoelectromechanical effects. Moreover, researchers are elucidating new perspectives on the electronic and optical properties of matter because of the way that nanoscale materials bridge the disparate theories describing molecules and bulk matter. Surface phenomena also gain a greatly increased significance; even the well-known link between chemical reactivity and surface-to-volume ratio becomes a major determinant of physical properties, when it operates over nanoscale dimensions. Against this background, this comprehensive work is designed to address the need for a dynamic, authoritative and readily accessible source of information, capturing the full breadth of the subject. Its six volumes, covering a broad spectrum of disciplines including material sciences, chemistry, physics and life sciences, have been written and edited by an outstanding team of international experts. Addressing an extensive, cross-disciplinary audience, each chapter aims to cover key developments in a scholarly, readable and critical style, providing an indispensible first point of entry to the literature for scientists and technologists from interdisciplinary fields. The work focuses on the major classes of nanomaterials in terms of their synthesis, structure and applications, reviewing nanomaterials and their respective technologies in well-structured and comprehensive articles with extensive cross-references. It has been a constant surprise and delight to have found, amongst the rapidly escalating number who work in nanoscience and technology, so many highly esteemed authors willing to contribute. Sharing our anticipation of a major addition to the literature, they have also captured the excitement of the field itself in each carefully crafted chapter. Along with our painstaking and meticulous volume editors, full credit for the success of this enterprise must go to these individuals, together with our thanks for (largely) adhering to the given deadlines. Lastly, we record our sincere thanks and appreciation for the skills and professionalism of the numerous Elsevier staff who have been involved in this project, notably Fiona Geraghty, Megan Palmer and Greg Harris, and especially Donna De Weerd-Wilson who has steered it through from its inception. We have greatly enjoyed working with them all, as we have with each other.

Ron Howard: From Mayberry to the Moon… and Beyond, the first full-length biography of Ron Howard, takes an in-depth look at the Oklahoma boy who gained national fame as a child star, then grew up to be one of Hollywood's most admired directors. Although many show biz kids founder as they approach adulthood, Ron Howard had the advantage of brains, common sense, and two down-to-earth parents who kept him from having an inflated view of his own accomplishments. He also had a longstanding goal: to trade the glare of the spotlight for a quieter but equally creative life behind the camera. This biography tracks his career from 1960, when he debuted as six-year-old Opie Taylor on The Andy Griffith Show through 2002, when he accepted his Academy Award® as Best Director for A Beautiful Mind.Author Beverly Gray, an entertainment industry veteran, has spoken to teachers, friends, and professional colleagues from all phases of Howard's career. She has also combed the archives to gain further insight into this very private man whose accomplishments have brought pleasure to so many.