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This is a concise, informed and practical manual detailing the cause, prevention and interventional treatment of oral cancer – the deadliest of oral diseases. In the 21st century, oral cancer remains a lethal and deforming disease exhibiting rising incidence of epidemic proportions, particularly in younger patients, and is of global significance with over 300,000 new cases presenting each year. Despite advances in diagnosis and management, half of all patients die within five years. Even following successful initial treatment, long-term prognosis is compromised by the presentation of advanced tumours and development of widespread, multi-focal disease throughout the mouth and upper aero-digestive tract. The transformation of normal mouth lining into ‘potentially malignant'and subsequently malignant tissue is a complex, multistep and multifactorial process in which accumulated genetic alterations, often instigated by overuse of tobacco and alcohol, disrupt the normal functioning of oral epithelial cells. Unfortunately, there is considerable public ignorance regarding oral cancer, and it is imperative for disease prevention to raise awareness of the causes and symptoms of the disease, especially in those populations most ‘at-risk'of cancer. This book provides pragmatic strategies to improve both prevention and treatment intervention. Spanning nearly 40 years of clinical investigation, it reviews the biological basis of oral cancer, outlines primary, secondary and tertiary preventive strategies and describe a pragmatic treatment intervention protocol that specifically utilizes the ‘potentially malignant window'to identify malignant disease at the earliest possible stage and intervention to ‘stop the oral cancer clock'and halt the progression of this deadliest of oral diseases.

This book examines the impact of the digital deluge on employees and organizations and sets out the leadership actions needed to create a corporate culture fit for the digital age.In the digital world executives are presented with exponentially more information than their predecessors were a generation ago – and yet we're not exponentially more productive. Why? Because we're using twenty-first century technology with a twentieth century mindset. Excessive working hours, email overload and invasion of private life are all symptoms of a working culture that has used technology to simply amplify old management processes rather than enable and refine newer, more productive ones.Instead of liberating us, technology has created a digital overload, accentuating the problems of presenteeism, unreasonable deadlines and management demands. Organizations need to stop using technology to turn up the volume and start using it to change the channel. Written by aunique team of experts, this edited collection covers leadership, corporate culture, technology, wellness and workplace design. It argues that digital overload is a problem of corporate culture and a failure of leadership. As such it takes leadership to fix it. Leaders who have the courage to explore alternative ways of working with technology, the enlightenment to give employees more freedom and control over their own lives, and the humility to live and demonstrate the new culture personally. Those who do this have the power to transform their organizations so they can ride the digital wave rather than be swamped by it.

Originally published in 1971. Nineteenth-century theatre in England has been greatly neglected, although serious study would reveal that the roots of much modern drama are to be found in the experiments and extravagancies of the nineteenth-century stage. The essays collected here cover a range of topics within the world of Victorian theatre, from particular actors to particular theatres; from farce to Byron's tragedies, plus a separate section about Shakespearean productions.

Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oralcancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer: Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.

Siberia's Lake Baikal is one of nature's most magnificent creations, the largest and deepest body of fresh water in the world. And yet it is nearly unknown outside of Russia. In Sacred Sea--the first major journalistic examination of Baikal in English--veteran environmental writer Peter Thomson and his younger brother undertake a kind of pilgrimage, journeying 25,000 miles by land and sea to reach this extraordinary lake. At Baikal they find a place of sublime beauty, deep history, and immense natural power. But they also find ominous signs that this perfect eco-system--containing one-fifth of earth's fresh water and said to possess a mythical ability to cleanse itself--could yet succumb to the even more powerful forces of human hubris, carelessness, and ignorance. Ultimately, they help us see that despite its isolation, Baikal is connected to everything else on Earth, and that it will need the love and devotion of people around the world to protect it.

This book constitutes the refereed proceedings of the Third International Conference on Evolvable Systems: From Biology to Hardware, ICES 2000, held in Edinburgh, Scotland, UK, in April 2000.The 27 revised full papers presented were carefully reviewed and selected for inclusion in the proceedings. Among the topics covered are evaluation of digital systems, evolution of analog systems, embryonic electronics, bio-inspired systems, artificial neural networks, adaptive robotics, adaptive hardware platforms, molecular computing, reconfigurable systems, immune systems, and self-repair.

Reviews of the First Edition`...valuable and enjoyable reading for all studying Shakespeare's plays.'Following in the patternestablished by John Russell Brown for the excellent series (Theatre and Production Studies), he provides first an account of Shakespeare's company, then a study of three individual plays Twelfth Night, Hamlet and Macbeth as performed by the company. Peter Thomson writes in a crisp, sharp, enlivening style.'TLS'`...the best analysis yet of Elizabethan acting practices, excavated form the texts themselves rather than reconstructed on basis of one monolithic theory, and an essay on Hamlet that is a model of Critical intelligence and theatrical invention.'Yearbook of English Studies`Synthesizes the important facts and summarizes projects with a vigorous prose style, and expertly applies his experience in both practical drama and academic teaching to his discussion.'Review of English Studies

The eighteenth century produced more inventive actors than fine dramatists, and it displayed its actors to increasing advantage as theatre management became more expert, and stage design more ambitious. First published in 1972, the eleven papers collected in The Eighteenth-Century English Stage, originally read at a Manchester University Symposium in July 1971, follow this historical emphasis. Two papers are centred on dramatists, four on actors, three on managers, and two on designers.Malcolm Kelsall analyses Steele's debt to Terence, using his classical scholarship as illuminatingly as Edgar Roberts uses his musical scholarship in writing about the songs in Fielding's plays. George Taylor compares and evaluates a number of theories of acting, and speculates on the likely relevance of the best-known books on rhetoric, whilst Kathleen Barker, Arnold Hare, and David Rostron consider the work of individual actors – Powell, Cooke, and John Kemble. Theatre managers are represented by John Rich in Paul Sawyer's sympathetic account, Thomas Harris, who is given new life in the recent researches of Cecil Price, and Stephen Kemble, fixed by Kenneth Robinson in canny control of the Newcastle theatre circuit. Finally, Graham Barlow reaches some controversial conclusions about the dimensions of the Theatre Royal, Drury Lane, by subjecting Thornhill's sketches to a practising designer's statistical examination, and Sybil Rosenfeld carries a stage further her pioneering work on eighteenth-century scene-painting and design. The two last are attractively illustrated by 8 pages of plates.This book's particular value lies in its bringing together several simply presented but deeply informed explorations of often neglected aspects of the eighteenth-century theatre. The papers, with their general sense of enthusiasm and concern for their subject, will interest all students of the eighteenth century, and theatre enthusiasts in particular.