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Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Covers radical SAN enzymes in detail

In Cellular Cancer Markers leading pathologists and physicians review today's most promising cellular cancer markers, an important emerging class of prognostic markers that can be used in the clinical evaluation of cancer patients. The markers reviewed have been chosen because they are biologically relevant to the growth of cells and possess an accurate and reproducible assay for detection. They also are predictors of tumor behavior, are useful in making clinical decisions, and are cost effective. Cellular Cancer Markers provides a status report for markers of tumor cell activation, proliferation, and longevity that makes possible an informed judgment regarding the value of many newly proposed tumor markers. It also offers insight into the latest approaches to diagnosing cancer and an appreciation of how these marker-based tests can clarify the prognosis of cancer.

An increased understanding of the environmental and human health impacts of engineered nanoparticles is essential for the responsible development of nanotechnology and appropriate evidence-based policy and guidelines for risk assessment. Presenting the latest advances in the field from a variety of scientific disciplines, this book offers a comprehensive overview of this challenging, inter-disciplinary research area. Topics covered include: The properties, preparation and applications of nanomaterials Characterization and analysis of manufactured nanoparticles The fate and behaviour of nanomaterials in aquatic, terrestrial and atmospheric environments Ecotoxicology and human toxicology of manufactured nanoparticles Occupational health and exposure of nanomaterials Risk assessment and global regulatory and policy responses Understanding the behaviour and impacts of nanotechnology in the environment and in human health is a daunting task and many questions remain to be answered. Environmental and Human Health Impacts of Nanotechnology will serve as a valuable resource for academic researchers in nanoscience and nanotechnology, environmental science, materials science and biology, as well as for scientists in industry, regulators and policy makers.

Milk is a vital nutritional source for offspring of all mammals, including humans. In addition to its nutritional value it is a rich source of proteins, of which lactoferrin (Lf) is one. Lf is truly a multifunctional molecule which has been studied extensively over the past decades. It is best known for its ability to bind iron, which initially leads to the discovery of its antibacterial activity. In addition, Lf has demonstrated potent antiviral, antifungal and antiparasitic activity, towards a spectrum of strains. Additionally, it has been evaluated as an important host defense molecule during infant development. Extensive work has been done to characterize the active domains in Lf, testing numerous Lf-derived peptides and related peptide libraries for activity towards different microbes. The peptides structural requirements for antimicrobial activity has been addressed, and compared to other cationic host defense peptides which related chemical and biological characteristics, in an attempt to understand different antimicrobial modes of action. The antimicrobial activity of Lf and one N-terminal peptide fragment of Lf (lactoferricin) are the main topics of this book, with particular focus on antiviral activities. Antibacterial, –fungal and –parasitic activities are discussed, in addition to the selective activity demonstrated by Lf and lactoferricin, towards tumor cell membranes. It has also become increasingly recognized that several antimicrobial protein and peptides possesses immunomodulatory activity, thus these properties are discussed in brief detail.

DNA Repair, Part A provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. - A laboratory standard for more than 40 years - Over 400 volumes strong - Also available on ScienceDirect - Part A of a 2-part series

DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.Selected Contents: - Base Excision Repair - Eukaryotic DNA Mismatch Repair - Double Strand Break Repair - Functions of DNA Polymerases - Somatic Hypermutation: A Mutational Panacea

Here is the most comprehensive and up-to-date treatment of one of the hottest areas of chemical research. The treatment of fundamental kinetics and photochemistry will be highly useful to chemistry students and their instructors at the graduate level, as well as postdoctoral fellows entering this new, exciting, and well-funded field with a Ph.D. in a related discipline (e.g., analytical, organic, or physical chemistry, chemical physics, etc.). Chemistry of the Upper and Lower Atmosphere provides postgraduate researchers and teachers with a uniquely detailed, comprehensive, and authoritative resource. The text bridges the'gap'between the fundamental chemistry of the earth's atmosphere and'real world'examples of its application to the development of sound scientific risk assessments and associated risk management control strategies for both tropospheric and stratospheric pollutants. - Serves as a graduate textbook and'must have'reference for all atmospheric scientists - Provides more than 5000 references to the literature through the end of 1998 - Presents tables of new actinic flux data for the troposphere and stratospher (0-40km) - Summarizes kinetic and photochemical date for the troposphere and stratosphere - Features problems at the end of most chapters to enhance the book's use in teaching - Includes applications of the OZIPR box model with comprehensive chemistry for student use

As a textbook, Molecular Biology and Biotechnology has always been immensely popular. Now in its fourth edition, it has been completely revised and updated to provide a comprehensive overview and to reflect all the latest developments in this rapidly expanding area. Written by recognised experts, the book aims to identify the impact that molecular biology has had on the development of biotechnology, with each of the nineteen chapters describing a specific subject area relevant to the subject. The impressive breadth of coverage includes areas such as plant biotechnology; food technology; vaccine development; the production of transgenic plants and animals; and the addition of an appropriate and timely new chapter devoted to bioinformatics. Presenting information in an easily assimilated form, Molecular Biology and Biotechnology makes an ideal undergraduate text. It will be of particular interest to students of biology and chemistry, as well as to scientists from outside the field requiring a rapid introduction to the subject.