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'It is the Valley of Fear, the Valley of Death. The terror is in the hearts of the people from the dusk to the dawn'Crammed full of adventure, mystery and of course one or two rather brilliant deductions, The Valley Of Fear is Sir Arthur Conan Doyle's thrilling final Sherlock Holmes novel, brought to life in this spectacular new stage adaptation. A mysterious, coded message is received, a warning of imminent danger, drawing Sherlock Holmes and the faithful Dr Watson into a tale of intrigue and murder stretching from 221B Baker Street to an ancient moated manor house to the bleak Pennsylvanian Vermissa Valley. Faced with a trail of bewildering clues, Holmes begins to unearth a darker, wider web of corruption, a secret society and the sinister work of one Professor Moriarty. Following the huge success of Blackeyed Theatre's 2018/19 international tour of The Sign of Four, the great detective is back in another gripping stage adaptation by Nick Lane, combining original live music, stylish theatricality and magical story-telling for an unforgettable theatrical experience. The game is afoot!

Warum ist das Leben so, wie es ist? In den letzten vier Milliarden Jahren haben sich einfache Bakterien ein einziges Mal zu höherem Leben entwickelt. Und alle komplexen Lebewesen teilen sich seitdem eine Reihe merkwürdiger Eigenschaften: von Sex über das Altern bis zum Sterben. Aber wenn das Leben sich auf einem anderen Planeten entwickelt hätte, wäre die Geschichte genauso abgelaufen oder vollkommen anders? Nick Lane liefert eine neue Sicht auf die Entwicklungsgeschichte des Lebens und bietet überzeugende Lösungen für einige der ungelösten Rätsel der Evolution, die Wissenschaftler seit Jahrzehnten beschäftigen. Seine Antwort liegt in der Energie, einer elektrischen Spannung, die die Entwicklung des höheren Lebens anstieß und von der auch heute noch alles Leben zehrt. Seine Erklärungen geben vielen seltsamen Wendungen der Lebensgeschichte einen Sinn und sie liefern die Antworten auf die großen Fragen: Warum sind wir so, wie wir sind und warum sind wir überhaupt hier?

Wie entstand das Leben? Woher stammt die DNS? Warum sterben wir? In den vergangenen Jahrzehnten haben bahnbrechende Forschungen neue Einsichten in die Enstehung und das Wesen des Lebens geliefert. Aufbauend auf den neuesten wissenschaftlichen Erkenntnissen rekonstruiert der Biochemiker Nick Lane die Geschichte des Lebens auf der Erde, indem er die zehn größten Erfindungen der Evolution Revue passieren lässt. Er zeigt, wie jede dieser Erfindungen - von der DNA über die Photosynthese zum Sex, von der Warmblütigkeit über das Bewusstsein bis schließlich zum Tod - das Leben und manchmal unseren gesamten Planeten verändert hat. Verständlich und lebendig legt Lane die Beweise dar und zeigt, welche Faktoren und Mechanismen für die Entwicklung des komplexen Lebens verantwortlich waren.

Why is life the way it is? Bacteria evolved into complex life just once in four billion years of life on earth-and all complex life shares many strange properties, from sex to ageing and death. If life evolved on other planets, would it be the same or completely different? In The Vital Question, Nick Lane radically reframes evolutionary history, putting forward a cogent solution to conundrums that have troubled scientists for decades. The answer, he argues, lies in energy: how all life on Earth lives off a voltage with the strength of a bolt of lightning. In unravelling these scientific enigmas, making sense of life's quirks, Lane's explanation provides a solution to life's vital questions: why are we as we are, and why are we here at all? This is ground-breaking science in an accessible form, in the tradition of Charles Darwin's The Origin of Species, Richard Dawkins'The Selfish Gene, and Jared Diamond's Guns, Germs and Steel.

Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. Oxford Landmark Science books are'must-read'classics of modern science writing which have crystallized big ideas, and shaped the way we think.

While it is barely 50 years since the first reliable reports of the recovery of living cells frozen to cryogenic temperatures, there has been tremendous growth in the use of cryobiology in medicine, agriculture, horticulture, forestry, and the conservation of endangered or economically important species.As the first major text on cryobiolog

Oxygen has had extraordinary effects on life. Three hundred million years ago, in Carboniferous times, dragonflies grew as big as seagulls, with wingspans of nearly a metre. Researchers claim they could have flown only if the air had contained more oxygen than today - probably as much as 35 per cent. Giant spiders, tree-ferns, marine rock formations and fossil charcoals all tell the same story. High oxygen levels may also explain the global firestorm that contributed to the demise of the dinosaurs after the asteroid impact. The strange and profound effects that oxygen has had on the evolution of life pose a riddle, which this book sets out to answer. Oxygen is a toxic gas. Divers breathing pure oxygen at depth suffer from convulsions and lung injury. Fruit flies raised at twice normal atmospheric levels of oxygen live half as long as their siblings. Reactive forms of oxygen, known as free radicals, are thought to cause ageing in people. Yet if atmospheric oxygen reached 35 per cent in the Carboniferous, why did it promote exuberant growth, instead of rapid ageing and death? Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death. The book explains far more than the size of ancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. The result is a captivating vision of contemporary science and a humane synthesis of our place in nature. This remarkable book will redefine the way we think about the world.