Search

Leukaemia Diagnosis Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as: The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.

Litt's Drug Eruption & Reaction Manual is a succinct reference to give clinicians the essential information for an informed decision about patient management. The full database from which it is derived — Litt's Drug Eruption & Reaction database: www.drugeruptiondata.com — currently holds over 1800 drug profiles with over 73,000 documented drug reactions, as evidenced by well over 156,000 references on PubMed, and is internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions. As a special offer for this 30th edition, a 12-month free access to the database is offered to buyers of a new print copy of this edition in 2024.This edition: Provides documentation of adverse reactions to the 1500 most consulted drug and herbal profiles Gives clinicians managing patients with many different medications a route to making an informed decision about problematic reactions Offers clinicians a one-stop reference for the essential information about a drug CONTENTS: A to Z listing of the 1500 most consulted drug and herbal profiles (including supplements, vaccines, and botanicals), including generic name and trade names; pharmaceutical company; indications; half-life; and pregnancy category Descriptions of important reactions List of drugs that cause important adverse reactions List of main classes of drugs 28 tables showing reactions of members of a class of drugs (such as statins or monoclonal antibodies), enabling clinicians to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—information that is critical for an informed decision to change drugs within the same class 2 tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions A concordance of synonyms and trade names for ease of cross-reference

Our aim in compiling this book is to provide the healthcare professionals; researchers; students; and anyone interested in hematology with a comprehensive resource that reflects the current state of the field. This book has been divided into various sections; each dedicated to a specific aspect of hematology; from the basic science underpinning blood cell formation to the clinical management of hematologic disorders. In the following pages; you will find contributions from experts in the field; sharing their insights; research findings; and clinical experiences. Topics covered include the molecular basis of blood disorders; cutting-edge diagnostic techniques; therapeutic advancements; and emerging trends in hematology research.

Litt's Drug Eruption & Reaction Manual is intended as a succinct reference to give clinicians the essential information for an informed decision about patient management. The full database from which it is derived — Litt's Drug Eruption & Reaction database: www.drugeruptiondata.com — currently holds over 1800 drug profiles with over 72,000 documented drug reactions, as evidenced by well over 153,000 references on PubMed and is internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions. This 29th edition of the manual has been comprehensively updated for 2023 to give a quick precis of the essential information a clinician needs for an informed decision.This edition:✓ Provides documentation of adverse reactions to the 1500 most consulted drug and herbal profiles✓ Gives clinicians managing patients with many different medications a route to making an informed decision about problematic reactions✓ Offers clinicians a one-stop reference for the essential information about a drug✓ We allow you to search the profiles of thousands of generic and trade name drugs, while also providing over 60,000 references that link directly to PubMed, enabling you to better diagnose and treat your patientsCONTENTS:✓ A to Z listing of the 1500 most consulted drug and herbal profiles (including supplements, vaccines, and botanicals), including generic name and trade names; pharmaceutical company; indications; half-life; and pregnancy category✓ Descriptions of important reactions✓ List of drugs that cause severe adverse reactions✓ List of main classes of drugs✓ 28 tables showing reactions of members of a class of drugs (such as statins or monoclonal antibodies), enabling clinicians to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—information that is critical for an informed decision to change drugs within the same class✓ 2 tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions✓ A concordance of synonyms and trade names for ease of cross-reference

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.

Litt's Drug Eruption & Reaction Manual is a succinct clinical reference derived from Litt's Drug Eruption & Reaction Database (www.drugeruptiondata.com), which currently holds over 1800 drug profiles with over 70,000 documented drug reactions, as evidenced by well over 150,500 references on PubMed. Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, this 28th edition has been comprehensively updated with the essential information for an informed clinical decision. A one-year access to the associated database is now included on proof of purchase in 2022 of a new copy of the 2022 print edition. • Provides documentation of adverse reactions to the 1500 most consulted drug and herbal profiles • Gives clinicians managing patients with many different medications a route to making an informed decision about problematic reactions • Offers clinicians a one-stop reference for the essential information about a drug

Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community. - Describe the short and long impact of COVID-19 on autoimmunity - Provides understanding to the acute and chronic impact of the SARS-CoV-2 - Gives insights into the long-term effects of COVID-19 on recovered patients - Provides conclusions on the novel terms'chronic post-COVID-19 syndrome','post-acute COVID-19 syndrome', and'long COVID-19'

This volume includes nine chapters that detail treatment options for health problems associated with pregnancy and childbirth. Chapter One gives an overview of the various technologies and techniques that can be used for prenatal diagnosis. Chapter Two collects the latest evidence on treatment for tubal ectopic pregnancy and highlights the impact that drugs and surgical techniques used for this purpose may have. Chapter Three discusses the problem of human childbirth and the rise of caesarean sections from the viewpoint of evolutionary anthropology. Chapter Four collects the latest evidence on treatment for non-tubal ectopic pregnancy. Chapter Five proposes a risk score model for venous thromboembolism prophylaxis for caesarean sections that balances clinical risks and cost-effectiveness. Chapter Six establishes a differential protocol for placenta praevia based on a model of risk factors to enable food outcomes in caesarean section. Chapter Seven provides a detailed analysis of the various therapeutic options available for ectopic tubal and non-tubal pregnancy, and their indications, contraindications and special considerations during the COVID-19 pandemic and patients affected with this disease. Chapter Eight addresses the impact of ectopic pregnancy and the effects of treatments on patients'fertility. Finally, Chapter Nine addresses the course of ectopic pregnancy from diagnosis to treatment.

This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.

This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.

Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt's Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient care. This 27th edition is a comprehensively revised and updated quick reference, and each entry includes:• Quantitative summaries of reports and incidence for reactions• Drug–drug interactions• Categories of adverse drug reactions, eruptions, and cutaneous reaction patterns• Essential reference information on prescription and over-the-counter drugs as well as herbals and supplements The book contains... • A to Z listing of the 1500 most consulted drug and herbal profiles, including generic name and trade names; pharmaceutical company; indications; half-life; and pregnancy category• Over 31,000 adverse reactions and drug-eruption listings • Includes supplements, vaccines, and botanicals• Clinical definitions of common and severe adverse reactions• List of drugs that cause severe adverse reactions• List of main classes of drugs as a quick clinical reference guide• 27 tables of members of a class of drugs (such as statins or monoclonal antibodies), enabling clinicians to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—information that is critical for an informed decision to change drugs within the same class• 2 extensive tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions• A concordance of synonyms and trade names for ease of cross-reference Markets: Dermatologists, Neurologists, Oncologists, Psychiatrists, Pharmacists, Family Physicians, and those caring for patients on multiple medications, such as Geriatricians and Hospital Generalist Physicians. Litt's Drug Eruption & Reaction Manual is a succinct clinical reference derived from Litt's Drug Eruption & Reaction Database, located at www.drugeruptiondata.com, which currently holds over 1750 drug profiles with almost 70,000 documented drug reactions, as evidenced by well over 145,000 references on PubMed. Quick and easy access via the Litt app provides real time access to the most up-to-date drug safety information to a busy practitioner on-the-go. Subscribers to the database benefit from:• Easy access via the Litt app, ideal for working across a number of work-places• Full drug profiles with a wealth of information including category, half-life, indications, drug-drug interactions, and known adverse reactions• Links to PubMed abstracts • Searching a class of drugs for a specific reaction• Searching by adverse reaction pattern• Searching by indication for a drug• Searching by drug name (generic name/brand name) as well as by pharmaceutical company or drug class• Searching herbal medicines and supplements• Diagnosing the cause of reactions in patients on multiple drugs by selecting the adverse reaction(s) experienced and the drug(s) the patient is taking• Comparing reaction profiles for up to four drugs in a customized chart that can be saved for future reference• Descriptions of reaction patterns• Photographs of adverse reactions• Access via a computer, tablet, or smartphone• Regular updates To learn more, and to subscribe to the database, visit www.drugeruptiondata.com.

This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.​

In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men's and women's groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19).

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. - Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic - Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways - Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt's Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient care. This 26th edition has been comprehensively revised and updated throughout to act as a quick reference, and each entry includes:• Summaries of numbers of reports and incidence for reactions• Clinically important and potentially hazardous drug–drug interactions• Categories of adverse drug reactions, eruptions, and cutaneous reaction patterns• Essential reference information on prescription and over-the-counter drugs as well as biologics and supplements The book contains... • A to Z listing of the 1500 most consulted generic drug and herbal drug profiles, including generic and trade names; pharmaceutical company; indications; half-life; interactions; pregnancy category; and categories of adverse reactions/eruptions, with summaries of number of reports or level of incidence of reaction• Over 31,000 adverse reactions and drug-eruption listings • Supplements, vaccines, and other biologics• Descriptions of important reactions• List of drugs that cause important reactions• List of main classes of drugs as a quick clinical reference guide• 26 tables showing the reaction profile for members of a class of drugs (such as ACE inhibitors or statins), enabling a clinician to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—this information can be used as the basis for an informed decision to change drugs inside the same class• 2 tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions• A concordance of synonyms and trade names for ease of cross-reference

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. - Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer - Discusses treatment options available currently and prospective options for the future - Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, this is a succinct clinical reference and essential drug-safety tool for patient care. The new edition features further tables of reactions known to be caused by classes of drugs, with additional genetic data.

The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients'style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.

Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach that could improve care while reducing cost- but has it and can it? Integrated Diabetes Care- A Multidisciplinary Approach collates evidence of worldwide approaches to both horizontal integration (across disciplines) and vertical integration (across organizations) in diabetes care and describe what was done, what worked and what appeared to be the barriers to achieving the goals of the programmes. Evidence is sought from groups who have developed different approaches to integrating diabetes care in different health systems (eg insurance vs tax payer funded, single vs multiple organization, published vs unpublished). A final chapter brings the evidence together for a final discussion about what seems to work and what does not.

•Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists.'This is a well written text and should be a good reference book for those who see patients with HCC..'- Practical Gastroenterology'...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC.'- Digestive and Liver Disease

This comprehensive resource covers the current thoughts and trends on narcolepsy, as well as cutting-edge evidence-based research. Updates from the previous edition include advances in diagnostic guidelines, treatments, protocols and clinical and psychosocial considerations. Aspects of narcolepsy relating to sleep medicine, neurology, psychiatry and public health are featured throughout the text. Narcolepsy, 2nd Edition provides clinicians and allied health professionals with patient management modalities, clinical and quality of life issues and best practices for health care delivery.

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. - Enhanced encyclopedic format with drug monographs now organized alphabetically - Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions - Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing - Extensive bibliography with over 40,000 references - A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Seit dem 19. Jahrhundert wird der Begriff der'Eucharistie'für das Abendmahl in lutherischen Kirchen immer wichtiger. Gleichzeitig wurde in die Abendmahlsfeier ein'eucharistisches Hochgebet'eingeführt. Dieses Buch untersucht verschiedene Positionen in Deutschland und den Vereinigten Staaten unter der Fragestellung, ob ein derartiger Wechsel in Kontinuität oder im Kontrast zur Theologie Luthers steht. Aus dem Inhalt: Lehre und Feier des Herrenmahls bei Luther Theologie und Feier des Herrenmahles in den Bekenntnisschriften Julius Muethel und die Diskussion um die Herrenmahlsliturgie Peter Brunners Theologie des eucharistischen Hochgebetes Die Theologie des Eucharistischen Hochgebetes bei Hans-Christoph Schmidt-Lauber Theologie der Repräsentation Das Eucharistische Hochgebet in den lutherischen Kirchen in den USA Das Neue Testament und das eucharistische Hochgebet Eucharistiegebet und Kirchengeschichte An investigation of the rise of the concept of'eucharist'and its systematic implications for the Lord's Supper in Lutheranism since the 19th century. Der Autor wurde 2011 an der Eberhard-Karls-Universität Tübingen mit dieser Untersuchung promoviert.

Die gesamte Onkologie – verlässliches Wissen für Ihre Kompetenz!'Die Onkologie'stellt sich der Herausforderung, das ständig wachsende Wissen über Tumorerkrankungen in seiner Gesamtheit zu vermitteln. Sowohl inhaltlich als auch didaktisch auf höchstem Niveau: Fundiertes Grundlagenwissen zum umfassenden Nachschlagen Praxisrelevantes Know-how für Diagnostik und Therapie Systematischer Aufbau für das Verständnis der komplexen Zusammenhänge Angesehene Experten aus Klinik, Forschung und Praxis liefern Ihnen in Teil1 Klinisches Grundlagenwissen zu den Grundprinzipien der Therapie, Epidemiologie, Ätiologie und Pathogenese, sowie zu Komplikationen des malignen Wachstums. Teil 2 enthält umsetzbare und aktuelle Empfehlungen zu Diagnostik und Therapie aller relevanten soliden Tumoren und malignen Systemerkrankungen. Zum Nachschlagen und Anwenden: Finden Sie alle Optionen - auch für Ihren schwierigsten Fall. Der übersichtliche Aufbau und die exzellenten Abbildungen erleichtern Ihnen das schnelle Auffinden und Verständnis der gesuchten Informationen. Für den Alltag onkologisch tätiger Ärzte ist Die Onkologie ein unentbehrlicher Meilenstein.

Water-soluble gums are beneficial in many fields, including food, agricul­ ture, adhesives, biotechnology, ceramics, cosmetics, explosives, paper, tex­ tiles and texturization, among many others. It is almost impossible to spend a day without directly or indirectly enjoying their qualities. This book on hydrocolloid applications is divided into two major portions. The first is devoted to a few important gelling and non-gelling gums, their sources, the raw materials from which they are manufactured, their structures, functions and properties, followed by their food applica­ tions. The second part of the book details gums'industrial, non-food uses in a unique way: it assumes the reader's unfamiliarity with the many fields in which gums can be useful. It, therefore, provides a broad introduction to the development, technology and many aspects of gums'major non-food uses, as well as giving detailed explanations of where, when and how gums are incorporated into products in these industries. The text is also accom­ panied by a detailed index, designed to help the reader locate information easily. I wish to thank the publishers for giving me the opportunity to write this book. Their patience is very much appreciated. I wish to thank my editor Camille Vainstein for working shoulder-to-shoulder with me when time was getting short and Dr Zippora Gershon for supporting me with references and good advice over the years.

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of non-traditional agents. The chapters that follow next address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and post traumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy is thoroughly reviewed in Chapter 8 and provides a synthesis of the scientific literature in the area, one that is noted for contradictory and controversial findings, as well as guidelines for prescribing. The next chapter then provides an overview of the treatment of depression in the pediatric population, highlighting clinical concerns such as suicide risk. The book concludes with two chapters at the interface of medicine and psychiatry in the treatment of mood disorders: managing depression in primary care settings and depression associated with medical illnesses. The outstanding clinician-scientists who have contributed to this volume are all leaders in their fields and represent a broad spectrum of renowned institutions. A timely contribution to the literature, The Pharmacotherapy of Depression, Second Edition, offers busy clinicians from many disciplines a strong scientific foundation that seamlessly transitions into practical recommendations for clinicalpractice. The result is another gold-standard guide to the safe and effective use of the latest antidepressant medications.

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de

Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. Endocrine and metabolic diseases are common, includes diseases such as diabetes, thyroid disease, and obesity. Endocrinologists, including diabetes professionals, internal medicine and primary care practitioners, obstetricians and gynecologists, and others will find this book useful when treating endocrine or metabolic diseases.The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler's Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.This volume is critical for any health professional involved in the administration of endocrine and metabolics mediations. - - Surpasses the Physician's Desk Reference © by including clinical case studies and independent expert analysis - Complete index of drug names - Most complete cross referencing of drug-drug interactions available - Extensive references to primary and secondary literature - Also includes information on adverse effects in pregnancy The book is divided into eight sections: - Corticosteroids and related drugs - Prostaglandins - Sex hormones and related drugs - Iodine and drugs that affect thyroid function - Insulin and other hypoglycemic drugs - Other hormones and related drugs - Lipid-regulated drugs - Endocrine and metabolic adverse effects of non-hormonal and non-metabolic drugs

SARS caused more fear and social disruption than any other diseases of our time. While it killed a relatively small number of people, it nevertheless buckled economies, crippled international trade and travel, and emptied the streets of some of the world's most prosperous cities. Where did this frightening disease come from? How did it spread? And will the world be any better prepared if it returns? For the first time, these and other questions are answered in this remarkable inside account of what really took place in those fateful months of 2003 when severe acute respiratory syndrome threatened to engulf the world. Written largely by the public health experts and scientists who were at the centre of the battle, this book tracks the ways in which the virus spread, how close it came to bringing public health systems to their knees and how, in the end, an unprecedented global coalition stopped it in its tracks. For health specialists, this book will serve as an indispensable guide to the science of SARS, providing a detailed account of the clinical symptoms associated with the disease, the unravelling of the genetic secrets of the SARS coronavirus and the development of vaccines and diagnostics. This book is published by the World Health Organization s Regional Office for the Western Pacific, where 95% of the more than 8,000 global cases took place and where 12 countries or areas were hit, some with devastating force.

Volume 28 in the series of Side Effects of Drugs Annuals (http://www.elsevier.com/locate/series/seda) continues to serve its primary goal: to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has reviewed new data and trends by selecting from the year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is unproven or misleading. The use of the book is enhanced by separate indexes, allowing the reader to access the text via drug name, adverse effect, or drug interaction. The current annual includes an essay by the editor, Dr Jeffrey Aronson, entitled'Classifying Drug Adverse Reactions in the 21st Century.'In it he describes how the modern approach to classifying adverse drug reactions takes into account the dose that causes the reaction, the time-course of the reaction, and the susceptibility factors that increase the individual patient's risk, and shows how this analysis can facilitate regulatory decision making. - Provides a critical yearly survey of new data and trends - Includes an essay that describes the modern approach to classifying adverse drug reactions - Special reviews in this Annual include, among other topics: Antipsychotic drugs and now-onset diabetes mellitus, Treating asthma during pregnancy, and MMR vaccine and autism

The assessment of cancer risk is a complex process that requires the examination of etiological agents, real-world environments, and individual rates of exposure. This reference offers practical approaches to determine cancer risk in individuals, groups of exposed persons, and the general public in relation to individual genetic and acquired suscep

Severe acute respiratory syndrome (SARS) is a devastating disease and although the virus would appear to have been contained, it is clear that the impact it has had around the world, and could have again in the future, is immense. Hong Kong has been significantly impacted in the recent SARS outbreak, and clinicians and researchers alike have gained a lot of experience in dealing with the disease at short notice. This new book aims to be a state-of-the art update on SARS, with particular reference to imaging, which plays a crucial role in the diagnosis, management and follow-up of patients with the disease (it is widely accepted that SARS patients cannot be managed without imaging and it is included in the WHO's own list of diagnostic criteria for the disease). The book will also provide a perspective on the treatment and experience of the disease outside Hong Kong.

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.• Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells• Examines the role of genetic recombination in cancer including cancer invasion and metastasis• Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Extensively revised since the third edition in 1995, this comprehensive text covers all common and rare malignant blood cancers and is an essential reference for hematologists and oncologists. The sixty-two chapters are divided into sections on Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, Lymphomas, and Supportive Care.