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This book is a systematic collection and critical analysis of current information on rejuvenation, starting from the evolutionary aspects of the origin of life, immortality, and aging. Models, mechanisms, and types of rejuvenation are the key subjects of the book. Processes like cellular reprogramming, resetting of the aging clock, immortal unicellulars and cell cultures are explored through the lens of rejuvenation. Recent discoveries in this field offer a nuanced view of rejuvenation that has fascinated mankind since early history. There is evidence, though still controversial, indicating that biological time could be reversible. Indeed, under specific experimental conditions, cells can be moved back and forth along the age axis. Differentiation status and replicative age of cells can be modified not only by defined transcription factors, but also by ‘cocktails'of small molecules originating from natural substances or well-known longevity-promoting drugs. Still in its infancy, such findings open up the perspective of in vivo rejuvenation trials. Special attention is given to the quasi-immortal and extremely long-lived multicellular animal species as well as to the role of rejuvenation in treatment of pathology and healthy aging. Rejuvenation is experiencing a significant growth in recent years. There is ample debate in the scientific and near-scientific community about the ethics of rejuvenation and radical life span extension. This book aims to take a balanced and scientific approach to the mirage of immortality and ever-lasting youth and serves as a valuable resource for parties on both sides of the coin.

This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases.The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems.The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability ofthe genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

In this sweeping chronicle of guarana—a glossy-leaved Amazonian vine packed with more caffeine than any other plant—Seth Garfield develops a wide-ranging approach to the history of Brazil itself. The story begins with guarana as the pre-Columbian cultivar of the Satere-Mawe people in the Lower Amazon region, where it figured centrally in the Indigenous nation's origin stories, dietary regimes, and communal ceremonies. During subsequent centuries of Portuguese colonialism and Brazilian rule, guarana was reformulated by settlers, scientists, folklorists, food technologists, and marketers. Whether in search of pleasure, profits, professional distinction, or patriotic markers, promoters imparted new meanings to guarana and found new uses for it. Today, it is the namesake ingredient of a multibillion-dollar soft drink industry and a beloved national symbol.Guarana's journey elucidates human impacts on Amazonian ecosystems; the circulation of knowledge, goods, and power; and the promise of modernity in Latin America's largest nation. For Garfield, the beverage's history reveals not only the structuring of inequalities in Brazil but also the mythmaking and ordering of social practices that constitute so-called traditional and modern societies.

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.​

Não é nenhum segredo que o amor atormenta a família Owens há séculos. Mas onde começa a história dessa família? Com Maria, no ano de 1664, quando ela é abandonada ainda bebê, num campo nevado do interior da Inglaterra, e é adotada por Hannah Owens. A mãe adotiva reconhece que Maria tem talento para a magia e ensina a menina a praticar a'Arte Sem Nome'. Ela herda o Grimório de Hannah – um livro mágico de encantamentos que inclui receitas para curar doenças, ingredientes para um fazer um sabão que devolve a juventude e feitiços que podem fazer uma pessoa arder de paixão. Ela aprende também sua primeira e principal lição: sempre ame alguém que possa retribuir esse amor. Quando Maria é abandonada com a filha pelo homem que lhe declarou seu amor, ela o segue numa viagem até Salem, em Massachusetts, e acaba sendo acusada de bruxaria. Ali invoca a maldição que acompanhará sua família por séculos.

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Molecular Players in iPSC Technology, Volume 12 addresses the molecular players underlying induced pluripotent stem cell (iPSC) generation, maintenance, expansion, and differentiation. The discovery of iPSCs revolutionized biomedical research. iPSC technology involves multiple molecular mechanisms. This volume covers exosomal microRNAs, auxiliary pluripotency-associated genes, inducible caspase-9 suicide gene, cell cycle proteins, ion channels, Notch signaling, kinase signaling, SOCS3/JAK2/STAT3 pathway, NANOG, Krüppel-like factors, H1FOO, and much more in iPSCs. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of iPSC technology, regenerative medicine, and therapeutics - Covers the different key molecular players involved in iPSC formation, maintenance, expansion, and differentiation - Is contributed by world-renowned experts in the field

O Novo Dicionário Bíblico Champlin foi idealizado para fornecer um panorama abrangente de personagens, termos, palavras mais comuns utilizadas tanto no Antigo como no Novo Testamento, oferecendo um breve, mas necessário pano de fundo de cada livro da Bíblia, com especial atenção ao AT. Por esta ferramenta única no mercado, também foram incluídos termos filosóficos e antropológicos e outros que possam contribuir à pesquisa e enriquecimento cultural do leitor. O NDBC não é apenas uma coletânea de palavras, mas sim uma coletânea de conhecimentos, sendo fundamental à toda biblioteca de quem deseja uma compressão mais profunda das Escrituras. Características: - Cerca de 1500 verbetes. - Mais de 300 verbetes novos e imagens. - Evangélico e ecumênico na sua perspectiva. - Elaborado pelo Dr. Russell N. Champlin autor de Antigo e Novo Testamentos Interpretados versículo por versículo e da Enciclopédia de Bíblia Teologia e Filosofia.

This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.

Para melhor explicitar o que significa a Eucaristia para a vida do dia a dia, este livro aborda a questão a partir de uma perspectiva que difere de muitas outras fontes disponíveis atualmente. Ele apresenta uma mistagogia da Eucaristia que é um portal de travessia reflexivo. Coloca duas perguntas simples sobre a Eucaristia: O que devemos fazer? E o que significa isso? Para isso, o livro toma as ações rituais da Eucaristia como seu ponto de partida. Depois ele lança mão dos símbolos litúrgicos, dos textos de preces e comentário reflexivo para analisar qual o significado que essas ações rituais podem ter para a vida cristã.

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

A coming-of-age story set in Angola in the period leading up to the colony's independence, Saudade focuses on a Goan immigrant family caught between complicity in Portuguese rule, and their dependence on the Angolans who are their servants. The title (saudade means ‘melancholy'in Portuguese) speaks to the longing for homeland that haunts its characters, and especially the young girl who is the book's protagonist and narrator. Suneeta Peres da Costa's novella captures with intense lyricism the difficult relationship between the daughter and her mother, and the ways in which their intimate world opens up questions about domestic violence, the legacies of Portuguese slavery, and the end of empire. The young woman's intellectual awakening unfolds into a growing awareness of the lies of colonialism, and the violent political ruptures that ultimately lead to her father's death, and their exile.‘[Her] voice is unique: neither childlike nor grownup, but instead by turns gravely articulate, wildly poetic, and hilariously original…a haunting and magical vision of childhood.'Austin Chronicle

Esta obra originalmente era parte do conjunto de seis volumes chamado O Tesouro de Spurgeon, posteriormente publicado em 3 volumes nos EUA, Milagres e parábolas de nosso Senhor está agora disponível em um volume para o público de língua portuguesa. O mestre e expositor Charles Spurgeon lança luz sobre a obra terrena e ensino de Jesus com 173 sermões dele preservados nesta bela obra. Uma peça essencial da biblioteca de qualquer pastor ou estudioso de bíblia e teologia.

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners.This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research.Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

Guerreiras de oração: Guia de estudo é uma ferramenta indispensável para você fazer uso proveitoso e eficaz do livro Guerreiras de oração: o caminho para uma vida de vitória, de Stormie Omartian. Este guia irá conduzir você a se preparar para a grande batalha espiritual que atinge toda a humanidade: a guerra entre o Bem e o Mal. É um combate que atinge todos e provoca problemas que vão de acidentes, enfermidades e divórcios a dificuldades relacionais, profissionais e financeiras. Você já está recrutada por Deus para fazer parte do seu poderoso exército e a entrar nesta batalha para lutar como uma vitoriosa guerreira de oração. Por meio de perguntas perspicazes, bem elaboradas e direcionadas, Guerreiras de oração: Guia de estudo vai ajudar você a manejar com maestria as armas que Deus pôs à sua disposição para entrar nessa grande batalha espiritual.

Slavoj Žižek conseguiu firmar-se como referência maior da tentativa contemporânea em renovar o pensamento da esquerda. Neste livro, publicado simultaneamente na Alemanha e na Inglaterra como Die gnadenlose Liebe (O amor impiedoso) e como On belief (Sobre a crença), Žižek mostra sua capacidade de partir de premissas aparentemente não problemáticas, disposições arraigadas de conduta, assim como mitos intelectuais que não são vistos como tais, a fim de mostrar como a estrutura da crença é muito mais arraigada do que gostaríamos de imaginar. Dessa forma, essa ampliação da crença não funciona como um convite à simples defesa de sua racionalidade, mas à consciência clara dos desafios que um pensamento realmente crítico deve saber superar.

In the fall of 2009, Amy Lutz and her husband, Andy, struggled with one of the worst decisions parents could possibly face: whether they could safely keep their autistic ten-year-old son, Jonah, at home any longer. Multiple medication trials, a long procession of behavior modification strategies, and even an almost year-long hospitalization had all failed to control his violent rages. Desperate to stop the attacks that endangered family members, caregivers, and even Jonah himself, Amy and Andy decided to try the controversial procedure of electroconvulsive therapy or ECT. Over the last three years, Jonah has received 136 treatments. His aggression has greatly diminished, and for the first time Jonah, now fourteen, is moving to a less restricted school. Each Day I Like It Better recounts the journeys of Jonah and seven other children and their families (interviewed by the author) in their quests for appropriate educational placements and therapeutic interventions. The author describes their varied, but mostly successful, experiences with ECT. A survey of research on pediatric ECT is incorporated into the narrative, and a foreword by child psychiatrist Dirk Dhossche and ECT researcher and practitioner Charles Kellner explains how ECT works, the side effects patients may experience, and its current use in the treatment of autism, catatonia, and violent behavior in children.

Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.

Dans ce livre, l'auteure trace un cadre interrogatif, mobile, inquiet et en même temps admiratif, d'un monde urbain éclaté. Elle propose de penser autrement la ville et ses mutations actuelles, observant ses mouvements d'ouverture et de fermeture. Le concept de'devenir-village'ici utilisé permet d'établir une zone d'intersection entre la pensée philosophique filmique et urbanistique, comme le font le film de Lars von Trier Dogville et la philosophie de Deleuze et Guattari.

Autor w 1979 roku założył na Uniwersytecie w Lizbonie pierwszy w dziejach Portugalii lektorat języka i kultury polskiej. Zainteresowany kulturą i historią tego odległego kraju przygotował książkę, w której oprócz dziennika, jaki prowadził w czasie pierwszych miesięcy pobytu w Lizbonie, znalazły się: reportaże z podróży po Portugalii, które odbył w 1980 roku, trzy studia naukowe o związkach polsko-portugalskich, a przede wszystkim fascynująca opowieść o tragicznej historii miłości królewicza portugalskiego Pedra i Ines de Castro, w Polsce właściwie nieznana, o której w przeszłości pisało wieku znakomitych autorów portugalskich, hiszpańskich, francuskich, niemieckich czy angielskich. Książka jest pierwszym ogniwem przygotowywanego przez Autora'tryptyku europejskiego'. Część druga Mój Paryż ukazała się w 2008 roku, a ostatnia, trzecia pt. Moja Prowansja ukaże się niebawem.'Proponując czytelnikowi Moją Portugalię pragnę nade wszystko pokazać, jak bardzo interesujący jest to kraj, jak bogatą posiada on historię, jak trwałe nici wiążą jego kulturę z naszą. Pragnę zarazem pokazać, że mój dziewięciomiesięczny pobyt w Lizbonie nie poszedł na marne. Jak miałem okazję stwierdzić to wiosną 2007 roku, dziś nadal na Uniwersytecie Lizbońskim działa założony przeze mnie lektorat języka i kultury polskiej, nadal corocznie przyciąga on grupę kilkudziesięciu słuchaczy pragnących poznać nasz język i naszą kulturę.'- z przedmowy autora

For years lipids have fascinated cell biologists and biochemists due to their profound effects on cell function.'Cellular Lipid Metabolism'highlights new concepts and recent findings, but also reviews important discoveries made in the past. Outstanding international experts contribute 13 chapters on the genetics, molecular and cell biology of lipids. Presenting analyses at the molecular level they reveal the principles by which cellular lipid metabolism functions. Further, numerous intriguing observations that cannot yet be explained are identified, stimulating the readers to future studies. This book provides an invaluable source of information for biomedical researchers in energy metabolism, vascular biology, endocrinology and lipidology.

NOWHERE TO RUN. NOWHERE TO HIDE. Fleeing her dark past, Tasya Flynn desperately breaks into a mansion -- and is caught red-handed by its owner, legendary millionaire and cat burglar Ian MacPherson. Fiercely intelligent and strangely attractive, he has been a recluse ever since his partner-in-crime betrayed him, but he is still a man to be reckoned with. Tasya expects him to call the police; instead he offers to mold her into a world-class jewel thief. After all, she needs a refuge and he needs someone to help him retrieve the priceless stone his former partner double-crossed him to obtain. But when the heist goes awry, Tasya discovers the mystery of the stone and embarks upon a perilous and passionate journey. For Ian is on a deadly quest for revenge, and it's up to Tasya to save him from a tragic fate...if she can.