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The second edition of this important textbook covers all aspects of neuroendocrine tumors (NETs), from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies and immunotherapies. Readers will find individual discussion of each of the various types of NET: gastrointestinal, lung, and pancreatic tumors such as insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, and non-functioning pancreatic NETs, as well as medullary thyroid carcinomas, pheochromocytomas, paragangliomas, etc. In addition to NETs, endocrine tumors such as thyroid tumors and adrenocortical tumors are also covered. The contributing authors are internationally recognized experts who bring a wealth of science and experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists, and pathologists as well as for trainees in these fields.

This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

The second edition of this book focuses on the synthesis, design, and application of semiconducting metal oxides as gas sensing materials, including the gas sensing mechanism, and modification methods for sensing materials, while also providing a comprehensive introduction to semiconductor gas sensing devices. As an essential part of IoT (Internet of things), gas sensors have shown great significance and promising prospects. Therefore, studies on functional mesoporous metal oxides, one of the most important gas sensing materials based on their unique Knudsen diffusion behavior and tailored pore structure, have increasingly attracted attention from various disciplines. The book offers a valuable reference guide to metal oxide gas sensing materials for undergraduate and graduate students alike. It will also benefit all researchers who are involved in synthesis and gas sensing of metal oxides nanomaterials with relevant frontier theories and concepts. Engineers working on research and development of semiconductor gas sensors will also find some new ideas for sensor design.

This book supplies all the information that the young orthopaedic surgeon needs to know when preparing to perform total or partial knee replacement for the first time and also provides more experienced surgeons with a comprehensive general update on the basics. After an opening section on anatomy and kinematics of the knee, patient management during the pre-, peri-, and postoperative phases is covered in detail with the aid of numerous illustrations. The final section considers postoperative patient evaluation, outcome measurements, and the value of registries. Readers will gain a sound understanding of the scientific basis underlying management decisions, of component design philosophies, and of the rationale for preferences such as mechanical alignment and ligament balancing. The pros and cons of a variety of management choices are explained, and guidance provided on patient selection. Surgical techniques are presented on high-quality videos and many tips and tricks are highlighted to help the inexperienced to cope with challenging situations.

The book covers all aspects of endoscopic biopsies of the stomach inclusive of gastritis and gastropathies. It highlights the best way of handling of endoscopic biopsies in the endoscopic room by the gastroenterologist. It elucidates various steps involved in processing of the biopsy, tissue embedding and paraffin sectioning, approach to interpretation, various precautions that require to be taken while interpreting the biopsies, and the essential background knowledge of the interpreter. The book highlights the importance of the little things for a proper reading like matching of the tissue fragments received and the number of tissue present on a slide after the paraffin section.Chapters cover various forms of gastritis, and the easiest approach for daily routine by avoiding the cumbersome classifications and staging formulated for gastritis. It also discusses the utilization of the right nomenclature for acute and chronic gastritis and various other subtypes of gastritis. Chapters include various rarer and infrequently come across conditions of both acute and chronic gastritis, special form of gastritis and infective conditions. It also includes unusual forms of non-neoplastic gastric pathologies such as, a condition, where the gastric mucosa is affected not only by direct exposure to various irritants but may also be affected by many systemic diseases. It also highlights the frequently observed changes in chronic renal and liver failures. The book is targeted to all the practicing pathologists as well as graduate and post graduate students who are keen to learn about non-neoplastic gastric pathology at various levels.

The essential multidisciplinary guide for the prevention and management of vascular injury from master skull base surgeonsVascular injury is the most significant source of morbidity or mortality during skull base surgery, regardless of the surgical approach. While skull base approaches always placed arteries and veins at risk, newer endoscopic endonasal approaches have introduced new challenges for the prevention and management of vascular injury. Greater anatomic knowledge, additional surgical options, improved instrumentation, advances in interventional neuroradiology, and enhanced training all contribute to successful outcomes. Vascular Challenges in Skull Base Surgery by renowned skull base experts Paul Gardner, Carl Snyderman, Brian Jankowitz, and distinguished contributors, fills a gap in the literature, with invaluable guidance on managing rare but potentially catastrophic surgical complications.The full range of surgical approaches to the anterior, middle, and posterior cranial fossae are covered in 22 chapters. Diverse topics encompass open and endoscopic endonasal surgical approaches, endovascular techniques including balloon test occlusion and embolization, and standard and alternative bypass procedures. The last three chapters discuss venous considerations, neurophysiologic monitoring, and the role of training and simulation in vascular injury prevention. Key learning points, illustrated discussion of relevant anatomy, and tips and tricks are targeted at helping skull base surgeons leverage practical strategies to improve patient outcomes.Key HighlightsAn impressive group of expert, highly-experienced surgeons share firsthand knowledgeInsightful analyses of root causes and clinical pearls provide indispensable prevention tacticsHigh-quality images and videos enhance visual understanding of surgical anatomy and techniquesTrainees and practicing skull base surgeons will greatly benefit from the collective knowledge and evidence-based injury avoidance strategies shared by authors who have learned to master the art of skull base surgery.

This book includes selected papers presented at International Conference on Computational Intelligence, Data Science,, and Cloud Computing (IEM-ICDC 2021), organized by the Department of Information Technology Institute of Engineering and Management, Kolkata, India, during December 22 – 24, 2021. It covers substantial new findings about AI and robotics, image processing and NLP, cloud computing and big data analytics as well as in cyber-security, blockchain and IoT, and various allied fields. The book serves as a reference resource for researchers and practitioners in academia and industry.

In Revalidatie voor volwassenen worden diagnostiek, prognostiek, behandeling en evaluatie zoveel mogelijk behandeld aan de hand van het ICF-model (International Classification of Functioning, Disability and Health). In het ICF-model worden het menselijk functioneren en de daarop van invloed zijnde factoren benaderd vanuit de wisselwerking tussen de verschillende aspecten van de algemene gezondheidstoestand naast de beïnvloedende externe en de persoonlijke factoren. Dit betreft de tweede, volledig herziene editie. De bestaande hoofdstukken zijn geactualiseerd en er zijn een aantal nieuwe hoofdstukken toegevoegd. Zo is er nu aandacht voor het Post Intensive Care Syndroom, inclusief informatie ten aanzien van de revalidatie van COVID-19 patiënten. Daarnaast bevat het boek nu ook hoofdstukken omtrent arbeidsrevalidatie en patiëntenparticipatie. Het boek bestaat uit drie delen: •In deel 1 staat het ICF-model centraal en wordt ingegaan op de sturing van houding en beweging. •Deel 2 behandelt de voor de revalidatiegeneeskunde relevante diagnosegroepen met daarin de algemene, medische en revalidatieaspecten. In de meeste hoofdstukken is er daarbij aandacht voor de zaken als “functional outcome”, prognose, en relevante klinimetrie, naast maatschappelijke, psychologische en seksuele aspecten. •In deel 3 worden overstijgende thema's behandeld, zoals instrumentele ganganalyse, sport, seksualiteit, spasticiteit en revalidatiehulpmiddelen. De diverse bijdragen zijn geschreven door Nederlandse en Vlaamse auteurs, waardoor er sprake is van synergie tussen beide landelijke benaderingswijzen van de beschreven revalidatieproblematiek. Revalidatie voor volwassenen biedt de ‘state of the art'van de revalidatiegeneeskunde aan alle professionals uit het vakgebied, aan hen die daarvoor in opleiding zijn en aan de specialismen en beroepen die aan revalidatiegeneeskunde verwant zijn. Een standaardwerk dus dat dankzij de modulaire opbouw ook zeer geschikt is voor onderwijsdoeleinden. Dit boek is tot stand gekomen onder redactie van: Prof. dr. J.H.B. Geertzen, hoogleraar Revalidatiegeneeskunde, Afdeling Revalidatiegeneeskunde van het Centrum voor Revalidatie van het Universitair Medisch Centrum Groningen; Prof. dr. J.S. Rietman, hoogleraar Revalidatiegeneeskunde en Technologie, verbonden aan Roessingh Research and Development, Universiteit Twente in Enschede; Prof.dr.G. G. Vanderstraeten, prodecaan Faculteit Geneeskunde en Gezondheidswetenschappen, voormalig diensthoofd Fysische Geneeskunde en Revalidatie, Universitair Ziekenhuis Gent; Dr. R. Berdusek, chef de policlinique bij het Centrum voor Revalidatie van het Universitair Medisch Centrum Groningen; Prof. dr. K. Oostra, klinisch professor Fysische Geneeskunde en Revalidatie, Universitair Ziekenhuis Gent; Dr. B. Fard, revalidatiearts bij Roessingh Centrum voor Revalidatie en lid van de Werkgroep Amputatie en Prothesiologie (WAP) van de VRA.

This book, now in an extensively revised and updated second edition, provides a comprehensive overview of both machine learning and deep learning and their role in oncology, medical physics, and radiology. Readers will find thorough coverage of basic theory, methods, and demonstrative applications in these fields. An introductory section explains machine and deep learning, reviews learning methods, discusses performance evaluation, and examines software tools and data protection. Detailed individual sections are then devoted to the use of machine and deep learning for medical image analysis, treatment planning and delivery, and outcomes modeling and decision support. Resources for varying applications are provided in each chapter, and software code is embedded as appropriate for illustrative purposes. The book will be invaluable for students and residents in medical physics, radiology, and oncology and will also appeal to more experienced practitioners and researchers and members ofapplied machine learning communities.

In medicine, endocrinology is perhaps the domain that encompasses the most molecular imaging using radioactive agents, also called radiopharmaceuticals. This is due to the diversity of molecular targets, including hormone synthesis pathways expressed uniquely by endocrine tumors and the growing knowledge in their pathophysiology and genetics. Those radiopharmaceuticals not only serve as diagnostic agents, but can also serve as a platform for characterizing endocrine disorders and treat patients and be used to monitor intracellular events that are induced by various therapies. Finally, they may be able to predict the aggressiveness and metastatic potential of endocrine tumors. This book provides comprehensive and up-to-date insights into the diagnostic, therapeutic, and future approaches of nuclear medicine to endocrine tumors in a new spirit of precision medicine. It will be of interest to practicing physicians, including nuclear medicine specialists, radiologists, endocrinologists, and oncologists, as well as fellows in training, students, and other health care professionals.

This book covers relevant concepts in nuclear cardiology, combining imaging techniques and clinical data to do so. Today, nuclear cardiology is a worldwide discipline connected to the broader field of cardiovascular imaging. The combination of clinical aspects (symptoms, medications, previous cardiac procedures), ancillary exams and nuclear images is key to decision-making in clinical practice. Thus, a book on this topic is essential to provide better outcomes for cardiology patients. The chapters cover a comprehensive range of topics in current cardiology practice, such as ambulatory patients, patients in emergency settings, patients after complex cardiac procedures, and patients during and after the use of cancer therapies that are potentially toxic for the heart (cardio-oncology). As such, multiple clinical scenarios are also presented: patients with suspected coronary disease, patients with heart failure of unknown origin, patients with acute chest pain in the emergencydepartment, patients with suspected pulmonary embolism, patients with complications of the left ventricular assist device, etc. Furthermore, the book describes nuclear cardiology procedures and techniques, discusses the main clinical indications and scenarios for each procedure, presents new technological advances in the field (machine learning and artificial intelligence tools), and mentions the coronavirus disease 2019 (COVID-19) pandemic. Given its scope, the book offers a valuable guide and videos for various medical professionals, especially cardiologists and nuclear physicians.

This book offers a comprehensive review of the state of the art in Ultrasonography (USG) dentomaxillofacial imaging to help radiologists and dentists in their training and daily practice.The book examines the relationship between clinical features, diagnosis, and choice of minimally invasive technique for a range of dentomaxillofacial disorders and provides information on post-treatment therapy. Accurate interpretation of indications for treatment is the cornerstone of success in medicine, and as such, the book explains how the selection of imaging technique is closely linked to clinical and diagnostic aspects and how recognition of this relationship forms the foundation for optimal outcomes. In addition to examining the various modalities, the book highlights the role of the latest USG imaging techniques. Further, it discusses in detail the pathology, treatment, and prognosis of common and rare diseases, as well as congenital/developmental malformations in the dentomaxillofacial, an area that is often underestimated and largely ignored by dentists.Featuring updated high-resolution images created with state-of-the-art equipment, the book introduces readers to current imaging modalities. It also includes pathological descriptions of radiologic diagnoses to help clarify the pathophysiology of the disease, while the pearls and pitfalls of image interpretation provide a quick reference guide for practitioners.Written by leading international experts, this outstanding book is a valuable resource for both radiologists, dentists and students seeking a more in-depth appreciation of the subject and its contribution to the scientific radiology community.

Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. - Presents recent advances in the field of breath analysis - Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design - Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments - Acts as both a primer for beginners and a reference for seasoned researchers

Breath Analysis presents state-of-the-art research in this specialized field, also offering guidance on how best to design the technology and conduct analysis. The book primarily focuses on the diagnosis of lung cancer, asthma and Chronic Obstructive Pulmonary Diseases. The reliability, consistency and utility of the results from breath analysis depends on exhaled breath sampling procedures and tools, gas sensor array technology (sensing material and transducer), and finally, medical pertinence and interpretation. The book gives step-by-step procedures and discusses best practice solutions for problems in sample collection, sensor technology, clinical assessment, medical interpretation and data analysis. The book's primary audience would include biomedical engineers and medical doctors, but it is also useful for hospital technicians, hospital and biomedical SME leading figures, and those in PhD level Engineering and Medicine. - Presents an overview of existing breath analysis technology, along with their pros and cons - Provides a tool for mapping, bridging and translating different approaches and available devices - Covers best practices and procedures for exhaled breath collection

This book focuses on the use of semiconducting metal oxides as gas sensing materials, including the sensing mechanism and sensing materials modification approach, while also providing a comprehensive introduction to semiconductor gas sensing devices. As an essential part of IoT (Internet of things), gas sensors have shown great significance and promising prospects. Therefore, studies on semiconducting metal oxides, one of the most important gas sensing materials, have increasingly attracted attention from various disciplines. The book offers a valuable reference guide to metal oxide gas sensing materials for undergraduate and graduate students alike. It will also benefit all researchers who investigate metal oxides nanomaterials synthesis and gas sensing with relevant frontier theories and concepts. Engineers working on research and development for semiconductor gas sensors will also find new ideas in sensor design.

Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes. - Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom - Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color - Includes coverage of diseases involving post translational modifications

Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today's clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide. - Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease. - Includes access to a new video library with demonstrations of key procedures. - Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation. - Covers today's key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma. - Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource. The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike. - Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome - Focuses on the proposed physiological or pathological conditions - Presents an up-to-date, useful reference

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

This extensively updated edition provides a comprehensive review of hypertrophic cardiomyopathy, the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level. The disease produces abnormal and oftentimes focal hypertrophy on a macroscopic level that further impairs cardiac performance and may lead to life-threatening arrhythmias. This edition provides a practical approach, establishing evidence-based best practice for all scenarios.Hypertrophic Cardiomyopathy provides readers with key points and critical clinical pearls to assist them in managing patients. New chapters have been included on managing hypertension, sleep apnea, coronary artery disease, structural and congenital disease, nutrition and pharmacotherapies. All aspects of treatment are covered – medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) – in addition to genetics, family screening, lifestyle concerns, and athletic screening. The practical approach has been reinforced with an expanded emphasis on creating a Center of Excellence, how to facilitate the multi-disciplinary approach, and on case-based reviews and discussions, with each chapter ending with a post-test.This book is an essential text for cardiology professionals from trainee to board-certified physician, and includes important information for interventional cardiologists, cardiac surgeons, cardiac imagers, critical care physicians, sports medicine physicians, genetic counsellors, and electrophysiologists.

This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients'symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.

This book describes breath signal processing technologies and their applications in medical sample classification and diagnosis. First, it provides a comprehensive introduction to breath signal acquisition methods, based on different kinds of chemical sensors, together with the optimized selection and fusion acquisition scheme. It then presents preprocessing techniques, such as drift removing and feature extraction methods, and uses case studies to explore the classification methods. Lastly it discusses promising research directions and potential medical applications of computerized breath diagnosis. It is a valuable interdisciplinary resource for researchers, professionals and postgraduate students working in various fields, including breath diagnosis, signal processing, pattern recognition, and biometrics.

Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, and MEN1- and MEN2-related tumors. Following a chapter on radiopharmaceuticals in neuroendocrine imaging, it turns to the physics and technology of current and cutting-edge radiology, including SPECT/CT and PET/CT and PET/MR. Discussing of radionuclide imaging covers the tumors mentioned above, as well as pulmonary and thymic neuroendocrine tumors and medullary thyroid carcinoma. A presentation of radionuclide therapies follows, including 131I-MIBG therapy, somatostatin receptor-based therapy, andalpha radionuclide therapy, as well as the role of nanoparticles.Comprehensive and up-to-date, Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors will assist and guide physicians who encounter patients with these conditions, either from a diagnostic or therapeutic standpoint, and particularly emphasizes the current and emerging medical devices and imaging and therapeutic options.

This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.

Vascular surgery has seen a remarkable evolution. A discipline focused on the natural history and treatment of vascular disease by open operation is now primarily a minimally invasive specialty. Mastery of the basic pathophysiology has been retained while the transformation by improved imaging and endovascular intervention has been integrated into practice.This fourth edition of Vascular Surgery: Principles and Practice has incorporated these advances building on the specialty's past assets. Knowledge of natural history and open surgery will always have an essential role in optimal care of patients with vascular diseases. The authors'exposition of the old and the new will make this edition a valuable resource for vascular surgeons and all others dedicated to the care of vascular patients.

Featuring new co-editor Piyush Patel, MD, the updated edition of Cottrell and Patel's Neuroanesthesia continues to serve as the definitive reference on this important field of medicine. Clinically oriented chapters are clearly organized and cover key clinical points, case presentations, and discussions, delivering the complete and authoritative guidance you need to ensure optimal perioperative safety for neurosurgical patients. - Integrates current scientific principles with the newest clinical applications. - Explains what to do under any set of circumstances, the logic behind why it should be done, and how to avoid complications. - Clear conceptual illustrations make complex concepts easier to understand at a glance. - Comprehensive and broad coverage of all important aspects of neuroanesthesia enables you to find reliable answers to any clinical question. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. - Access brand-new information to keep you current! All chapters have been thoroughly updated to reflect the latest developments in neurosurgical anesthesia. - A completely reorganized TOC offers easier access to information. - Covers the latest advances in neuromodality monitoring — brain tissue oxygenation oximetry; microdialysis; and depth of anesthesia. - Includes a brand-new chapter on end-of-life care and the diagnosis and management of brain death, as well as a new chapter on minimally invasive techniques. - New information on Parkinson's disease has been added to the chapter on Awake Craniotomy.

This book presents a concise, evidence-based review of extracorporeal life support (ECLS) for adult diseases. It describes the use of ECLS with patients who are experiencing severe hypoxemic respiratory failure (ARDS and pneumonia), ventilatory failure (status asthmaticus and COPD), cardiogenic shock and circulatory or gas exchange failure following complications in cardiothoracic surgery, as well as its use as a bridge to lung transplant. Historically, clinicians have used ECLS as a last resort; however, this text details the technological improvements, evidence of improved outcomes and adverse consequences of alternative treatments that are causing this modality to be more commonly adopted. Topics include a description of the complex physiology and technology underlying ECLS; the evidence base for its use in specific clinical conditions; vascular access techniques; daily management of the circuit and patient; guidance regarding the weaning and decannulation process and recommendations for crisis management and rehabilitation related to ECLS. Extracorporeal Life Support for Adults is ideal reading for practicing physicians, nurses, perfusion specialists, therapists and critical care trainees who are considering whether to refer their patients for ECLS or are already providing ECLS and are seeking a practical reference to best practices and updated information.

Consult the leading text in the field that delivers the information you need to diagnose and treat pediatric gastrointestinal and liver diseases effectively. In one convenient and comprehensive volume, Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay provide all the latest details on the most effective new therapies, new drugs, and new techniques in the specialty. In addition, the new two-color design throughout helps you find what you need quickly and easily. Full-color endoscopy images to help improve your visual recognition Definitive guidance from renowned international contributors who share their knowledge and expertise in this complex field Detailed diagrams that accurately illustrate complex concepts and provide at-a-glance recognition of disease processes More than 400 board review-style questions, answers, and rationales New therapies for hepatitis B and C, new drugs for the treatment of inflammatory bowel disease, and an expanded discussion of the newest endoscopic and motility techniques available for pediatric patients The most current information on diagnosing and treating abnormalities of protein, fat, and carbohydrate metabolism New chapters on pancreatic transplantation and liver pathology The latest surgical techniques for children with gastrointestinal conditions

This book brings together personal narratives from critical care medicine specialists around the world. Most of these physicians started in critical care at or before the exponential increase in technological modalities to reverse or sustain organ function, have seen patient care both ways, and have worked as many as 30 years or more at the bedside. The narratives are organized around such themes as : how and why these physicians entered the discipline of critical care; what was critical care like in the beginning; how they have experienced the flood of innovations in critical care; why they decided to retire (or not); and what their retirement options have been (or not).Composed by influential critical care medicine specialists, The Intensivist's Challenge: Aging and Career Growth in a High-Stress Medical Specialty is a valuable resource bringing together a discussion of the nature and problems of aging as they apply to physicians in a high-stress occupation, while assessing the value of clinical experience at the bedside in a world increasingly full of soulless technology.

Obra de referencia en Cardiología que pretende seguir siendo un recurso fundamental en todos los aspectos de la Cardiología contemporánea proporcionando a clínicos, médicos en formació y estudiantes de todos los niveles las herramientas críticas para mantenerse al día en las bases científicas y los avances clínicos de la medicina cardiovascular. Ayuda al lector a aplicar los conocimientos más actuales en biología molecular y genética, imagen, farmacología, cardiología intervencional y electrofisiología entre otras cuestiones. Del total de los 89 capítulos que constituyen esta nueva edición, 27 son nuevos. Igualmente colaboran en esta nueva edición 53 nuevos autores, todos ellos reconocidos expertos internacionales en sus respectivas disciplinas. Todos los capítulos han sido revisados y actualizados en profundidad para recoger todas las novedades registradas en el área de la medicina cardiovascular. La nueva edición de esta obra de referencia incluye un total de 2.600 figuras, 600 tablas y 240 vídeos. Algunas de las novedades que incorpora esta nueva edición hacen referencia a imagen molecular, ultrasonido intravascular, regeneración cardiovascular e ingeniería de tejidos, terapias avanzadas para fallo cardiaco, manejo de la fibrilación atrial, enfermedad cardiaca estructural, cuestiones éticas en Medicina cardiovascular, cuestiones relacionadas con ensayos clínicos y otras cuestiones de interés. La nueva edición de este tratado de Cardiología presenta un acceso on line a través de www.ExpertConsult.com en el que los usuarios podrán acceder a la videoteca completa, actualizaciones en línea, lecturas adicionales y audios. Obra de referencia en Cardiología que proporciona respuestas definitivas y actuales sobre todos los aspectos de la medicina cardiovascular contemporánea. Del total de los 89 capítulos, 27 son nuevos y aprenda de los grandes expertos internacionales, incluidos los 53 autores nuevos que participan en esta edición. Manténgase al tanto de las más novedosas técnicas y modalidades diagnósticas y de imagen, como ecocardiografía tridimensional, técnica de rastreo de puntos, Doppler tisular, tomografía computarizada y resonancia magnética cardíaca. La versión en línea se actualiza periódicamente e incluye los más novedosos estudios clínicos, reseñas de nuevas y destacadas publicaciones y lo más reciente de la práctica clínica de los primeros expertos de la disciplina.

Understanding the key components of the diagnosis, assessment and management of inflammatory arthritis patients is essential to improving patient care. This book aims to cover these areas. It places inflammatory arthritis into a historical context; deals with the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients and provides a comprehensive overview of currently available treatment options. It provides insight into stratified medicine, an area of emerging importance in the management of heterogeneous diseases like RA. Finally, it provides an overview of what treatments strategies are in development.

This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytomas, paragangliomas and non-functioning pancreatic NETs. The contributing authors are internationally recognized experts who bring a wealth of experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists and pathologists and also trainees.

This book is a rich source of information on point-of-care (POC) tests for the diagnosis and treatment of severe hemorrhage, including thromboelastography, thromboelastometry, heparin monitoring systems, and platelet function analyzers (Multiplate, PFA-100, VerifyNow, etc.). The opening chapters focus on the pathophysiology of coagulation and the general characteristics of POC devices. The relevance of POC tests in specific scenarios is then carefully explained, with guidance on their use in contexts including trauma, cardiovascular surgery, ECMO, liver surgery, postpartum hemorrhage, and disorders of hemostasis in the critically ill. An individual chapter is devoted to practical issues when applying POC tests, and the book closes by presenting a set of informative clinical cases. As POC devices gain increasing popularity as bedside diagnostic tools in different clinical settings, it is important for practitioners to understand their role and value. Point-of-Care Tests for Severe Hemorrhage will be a useful and reliable source of information for anesthesiologists, intensivists, cardiologists, and hematologists.

This book focuses on the current clinical practice, outcome and the future development of Total Knee Arthroplasty (TKA) in surgical settings. A major objective of this work is to address “What is the optimal design and fixation of the implants we use for knee arthroplasty reconstruction? What are the gold standards? and, Can we do better?”. In an attempt to throw light on these questions, the authors evaluate data from clinical studies and assess various factors which may influence the long term outcome of TKA. Many variables such as age, severity, implant design and surgical techniques for appropriate component placement and soft tissue balancing are explored in great detail by expert surgeons in the field. Total Knee Arthroplasty: Long Term Outcomes will be a useful resource for recently qualified surgeons in search of an introduction to this topic and for more experienced surgeons seeking an in-depth critical review of current practices in TKA.

Effectively apply the latest techniques and approaches with complete updates throughout including 4 new sections (Abdominal Imaging, The Spine, Oncological Imaging, and Interventional Radiology) and 28 brand new chapters. Gain the fresh perspective of two new editors—Jonathan Gillard and Cornelia Schaefer-Prokop -- eight new section editors -- Michael Maher, Andrew Grainger, Philip O'Connor, Rolf Jager, Vicky Goh, Catherine Owens, Anna Maria Belli, Michael Lee -- and 135 new contributors. Stay current with the latest developments in imaging techniques such as CT, MR, ultrasound, and coverage of hot topics such as: Image guided biopsy and ablation techniques and Functional and molecular imaging. Solve even your toughest diagnostic challenges with guidance from nearly 4,000 outstanding illustrations. Quickly grasp the fundamentals you need to know through a more concise, streamlined format.

Helicobacter pylori is a universally distributed bacterium which affects more than half of the world population. The infection is associated with the development of various diseases of the upper gastrointestinal tract, besides extradigestive diseases. This book is a comprehensive overview of contributors on H. pylori infection in several areas. Its chapters were divided into sections concerning general aspects of H. pylori infection, immunopathology and genetic diversity, questions regarding possible routes of bacterium transmission, the importance of the strains characteristics in the development of gastric cancer and the possibilities of prevention, H. pylori infection in children, the possible association between its infection and extradigestive diseases, and the principal therapeutic regimens of bacterium eradication, considering the antimicrobial resistance.

Revalidatiegeneeskunde houdt zich bezig met het voorkomen of, wanneer dat niet mogelijk blijkt, verminderen van gevolgen van ziekten en aandoeningen. Een Nederlandstalig standaardwerk over kinderrevalidatie is er al jaren, maar met deze uitgave is het standaardwerk voor revalidatie voor volwassenen ook een feit. In Revalidatie voor volwassenen worden diagnostiek, prognostiek, behandeling en evaluatie behandeld aan de hand van de International Classification of Functioning, Disability and Health (ICF). In dit model wordt menselijk functioneren en de daarop van invloed zijnde factoren benaderd vanuit de wisselwerking tussen de verschillende aspecten van de gezondheidstoestand, de externe en de persoonlijke factoren. In Deel 1 staat het ICF-model centraal, en wordt ingegaan op de sturing van houding en beweging. Deel 2 behandelt de relevante diagnosegroepen met daarin algemene, medische en revalidatieaspecten. In de meeste hoofdstukken is er daarbij aandacht voor de zaken als functional outcome, prognostiek, relevante klinimetrie en maatschappelijke, psychologische en seksuele aspecten. In Deel 3 worden overstijgende thema's behandeld als instrumentele ganganalyse, sport, seksualiteit, spasticiteit en evalidatiehulpmiddelen. De diverse bijdragen zijn geschreven door Nederlandse en Vlaamse auteurs, waardoor er sprake is van synergie tussen de beide expertisegebieden. Revalidatie voor volwassenen biedt de'state of the art'van de Revalidatiegeneeskunde aan alle professionals uit het vakgebied, aan hen die daarvoor in opleiding zijn en aan de specialismen en beroepen die aan Revalidatiegeneeskunde verwant zijn. Een standaardwerk dus dat dankzij de modulaire opbouw ook zeer geschikt is voor onderwijsdoeleinden. Prof. dr. J.H.B. Geertzen is als hoogleraar Revalidatiegeneeskunde verbonden aan de Afdeling Revalidatiegeneeskunde van het Centrum voor Revalidatie van het Universitair Medisch Centrum Groningen. Prof. dr. J.S. Rietman is als hoogleraar Revalidatiegeneeskunde en Technologie verbonden aan Roessingh Research and Development, van de Universiteit Twente in Enschede. Prof. dr. G.G. Vanderstraeten is decaan van de Faculteit Geneeskunde en Gezondheidswetenschappen en diensthoofd Fysische Geneeskunde en Revalidatie van het Universitair Ziekenhuis Gent.

Completely revised, this fifth edition of Bailey's Head and Neck Surgery – Otolaryngology offers the most current and useful evidence-based information available for the practicing otolaryngologist and otolaryngology resident. Written to increase the reader's understanding, retention, and ability to successfully apply the information learned, this easy-to-read text contains concise, practical content on all areas of head and neck surgery in Otolaryngology. With 207concise chapters, over 3,000 four-color illustrations, and helpful summary tables everything about this two-volume reference is designed to enhance the learning experience.

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. Understanding why and how plaque develops and ruptures requires a multi-disciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, pathological and histological imaging. Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment presents a new dimension of understanding Atherosclerosis in 2D and 3D. This book presents work on plaque stress analysis in order to provide a general framework of computational modeling with atherosclerosis plaques. New algorithms based on 3D and 4D Ultrasound are presented to assess the atherosclerotic disease as well as very recent advances in plaque multimodality image fusion analysis.The goal of Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment is to fuse information obtained from different 3D medical image modalities, such as 3D US, CT and MRI, providing the medical doctor with some sort of augmented reality information about the atherosclerotic plaque in order to improve the accuracy of the diagnosis. Analysis of the plaque dynamics along the cardiac cycle is also a valuable indicator for plaque instability assessment and therefore for risk stratification. 4D Ultrasound, a sequence of 3D reconstructions of the region of interest along the time, can be used for this dynamic analysis. Multimodality Image Fusion is a very appealing approach because it puts together the best characteristics of each modality, such as, the high temporal resolution of US and the high spatial resolutions of MRI and CT.

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. - Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis - Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds - Includes case presentations documenting applications in multiple areas of human health and safety

Computer-assisted surgery is a growing sub-discipline of orthopaedic surgery. This book offers a comprehensive presentation of scientific work and clinical experience including new technologies like individual templating in unicompartmental and total knee arthoplasty based on computer-assisted design technology. Computer-assisted surgery involves not only total knee and total hip arthroplasty, but also trauma, sports and revision surgery. In this edition we have added sections on 3D fluoroscopy-based spinal surgery as well as 3D fluoroscopy-based trauma surgery. Even in total hip surgery, navigation systems offer exciting new aspects, and the clinical benefit of navigation in total knee arthroplasties has now been demonstrated. We believe that this textbook will be of interest to those new to this specific field, while also providing an update for experienced users. An added benefit is the international character of this textbook, including experiences from Switzerland, Israel, the United States and the German-speaking countries.

The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potential associated artifacts and pitfalls; the second part addresses clinical applications and novel applications of each method. With a strong focus on the clinical application of each modality or technique in CNS radiology, this book provides in-depth chapter coverage of: • Ultrasound Vascular Imaging (UVI) • Computed Tomography Angiography (CTA) • Magnetic Resonance Vascular imaging (MRV) • Digital subtraction angiography (DSA) • Brain perfusion techniques: CT and MRI • Plaque imaging • Intravascular imaging • Pediatric vascular imaging Along with numerous illustrations and case studies, Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications, and Emerging Techniques is an important book for those faced with choosing from the wide range of choices available for clinical practice.

Un humain sur sept vit avec un handicap. Comment peut-on faciliter la communication des personnes en situation de handicap? Une trentaine de chercheurs spécialistes des sciences de l'information et de la communication, du design, de la psychologie cognitive, de la sémiotique et de la sociologie du handicap présentent leurs travaux sur les nouvelles formes de communication et les pratiques inclusives du handicap dans toutes ces formes. (Des articles en français et en anglais).

Obra que se ha establecido como la líder indiscutible en Cardiología, un campo cada vez más competitivo. La novena edición incluye una revisión completa de todos los capítulos existentes y de los protocolos de actuación, y cuenta con ocho nuevos capítulos sobre imagen molecular, ecografía intravascular, regeneración e ingeniería tisular, terapia con dispositivos para la insuficiencia cardíaca avanzada, manejo de la fibrilación auricular, cardiopatía estructural, entre otros. Incorpora 25 nuevos colaboradores, que sintetizan todos los avances que están revolucionando la práctica: nuevos hallazgos en biología molecular y genética, técnicas de imagen más recientes o tratamientos farmacológicos.Diseño a todo color con 2.460 ilustraciones (1.835 a todo color), muchas de ellas nuevas.Incorpora una página web con una colección de vídeos de imágenes cardiacas, biblioteca de audio de sonidos de corazón y todas las imágenes del libro. Obra que se ha establecido como la líder indiscutible en Cardiología, un campo cada vez más competitivo. La novena edición incluye una revisión completa de todos los capítulos existentes y de los protocolos de actuación, y cuenta con ocho nuevos capítulos sobre imagen molecular, ecografía intravascular, regeneración e ingeniería tisular, terapia con dispositivos para la insuficiencia cardíaca avanzada, manejo de la fibrilación auricular, cardiopatía estructural, entre otros. Cuenta con cerca de 25 nuevos colaboradores, que sintetizan todos los avances que están revolucionando la práctica: nuevos hallazgos en biología molecular y genética, técnicas de imagen más recientes o tratamientos farmacológicos.Diseño a todo color con 2.460 ilustraciones (1.835 a todo color), muchas de ellas nuevas.Incorpora una página web con una colección de vídeos de imágenes cardiacas, biblioteca de audio de sonidos de corazón y todas las imágenes del libro.

–Comprehensive, multi-disciplinary text addressing all aspects of head and neck cancer and crosses a wide spectrum of specialists, including surgical, radiation and medical oncologists, dentists, pathologists, radiologists, and nurses. –8 new chapters – 9 with new authors –Revisions highlight new techniques and imaging –New imaging emphasizes diagnostics, image guided therapies, follow-up imaging, and novel imaging approaches –Less basic science and more clinical diagnostics and management –25% new illustrations, along with more color images to assist in diagnostics and therapeutics

This book covers the entire spectrum of cerebellopontine angle lesions, from the most common to the rarest. All aspects are considered, including biological and radiological characteristics, neurological presentation, diagnosis, treatment options and follow-up care. The main focus, however, is on surgical management, which is presented in detail with the aid of numerous figures and images documenting technical particularities. Emphasis is placed on an individualized approach tailored to the particular tumor type and extension pattern. Both novice and experienced surgeons will find the book to be an invaluable source of information and guidance. It will enable neurosurgeons in the initial years of training to understand and become familiar with the main steps in surgical management while simultaneously providing their senior colleagues with details and technical tips that will help to improve treatment results.

Representing the pinnacle of skull base surgery, paraganglioma management requires the advanced surgical skills and expertise that are presented by Dr. Mario Sanna and his team in this comprehensive reference. It incorporates extensive surgical and radiological data compiled over 20 years at the preeminent Gruppo Otologica Clinic in Piacenza, Italy, and features the exquisite intraoperative photographs and schematic diagrams that are a hallmark of the highly regarded Sanna texts. All head and neck and skull base surgeons will find their knowledge, technical proficiency, and ability to manage these challenging tumors vastly increased by this informative resource.Special Features:Step-by-step descriptions of the full range of head and neck paraganglioma procedures, including the infratemporal fossa approach type A, the extreme lateral approach, and the transcervical approach, plus guidance on managing complex tympanojugular paragangliomas More than 1,800 clearly labeled, high-quality intraoperative photographs correlated to full-color schematic drawings for an in-depth understanding of techniques Detailed discussion of managing the internal carotid artery during procedures, including the neuroradiological use of stents Pathology-oriented structure that allows the reader to identify a lesion at a particular stage and then follow the critical thinking, assessment, pre-operative management, and intra-operative course taken by the surgeon Comprehensive sections on pathology, physiology, anatomy, epidemiology, and new genetic breakthroughs that lay the groundwork for the surgical chapters Tips, hints, and pitfalls at the end of each chapter that offer valuable insights for managing different clinical scenarios Demonstrating the complex decision-making process in many actual cases and offering practical advice for handling complications, this book puts the reader into the operating room with the surgeon. It is indispensable for all head and neck and skull base surgeons who manage paragangliomas and related pathologies, as well as for otolaryngologists, neurosurgeons, maxillofacial surgeons, radiologists, and interventional radiologists involved in assessing these intricate conditions.

This book focuses on the advantages and disadvantages of each of the commonly used quantitative proteomic methods in terms of accuracy, sensitivity, and reproducibility. It also concentrates on the effective applications of these methods that resulted in many discoveries of the role of the proteins expressed in living cells and biological fluids. T

A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.