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p53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the prevalence of p53 mutations in cancers and important mechanisms underlying the impact of p53 mutations such as loss of function, dominant negative effect and gain of function. Recent findings related to the p53-mediated neuroprotective effects of natural compounds at the cellular, molecular, and behavioral level in various in vitro and in vivo models of neurodegenerative diseases are described, with a focus on Alzheimer's disease.

Phonology and Phonetics have had a tumultuous, if not always unequivocal, relationship in the past. This relationship between natural partners is now being invigorated from both sides and novel research techniques and methodologies are fostering new interdisciplinary questions. Consequently, a major issue today is whether it is necessary to draw a line between phonology and phonetics at all. This series aims to stabilize and strengthen the rapport and, by facing the big challenges, to ensure that phonetically grounded phonology and phonologically informed phonetics will have a sound future. The series is intended as a forum for the interaction of phonology and phonetics within linguistics. It welcomes joint phonological-phonetic ventures as well as initiatives from either discipline, as long as they are made with a view of the other. To discuss your book idea or submit a proposal, please contact Natalie Fecher.

Keine ausführliche Beschreibung für'JAHRESBER. DEUT. GESCHICHTE NF. 36, JG. 1984 JBDGNF E-BOOK'verfügbar.

Die im Jahre 1905 von Gustav Gröber ins Leben gerufene Reihe der Beihefte zur Zeitschrift für romanische Philologie zählt zu den renommiertesten Fachpublikationen der Romanistik. Die Beihefte pflegen ein gesamtromanisches Profil, das neben den Nationalsprachen auch die weniger im Fokus stehenden romanischen Sprachen mit einschließt. Zur Begutachtung können eingereicht werden: Monographien und Sammelbände zur Sprachwissenschaft in ihrer ganzen Breite, zur mediävistischen Literaturwissenschaft und zur Editionsphilologie. Mögliche Publikationssprachen sind Französisch, Spanisch, Portugiesisch, Italienisch und Rumänisch sowie Deutsch und Englisch. Sammelbände sollten thematisch und sprachlich in sich möglichst einheitlich gehalten sein.