Search

Understand functional coatings and their role in three key industries of the future Functional coatings play a huge range of roles in industries from automotive to aerospace to electronic and beyond. They offer protection, performance enhancement, corrosion resistance, self-cleaning properties, and more. Recent developments in the field have allowed for ever more precise optimization of functional coatings, with the result that demand for these key tools is only likely to increase. Functional Coatings for Biomedical, Energy, and Environmental Applications offers a comprehensive overview of these coatings and their applications in three explosively productive industries. A team of expert contributors provides chapters analyzing the latest developments in this growing area of production, with a particular focus on the dynamic relationship between functional coatings and their many applications. The result is an interdisciplinary text which will serve as an essential resource for researchers and industry professionals worldwide. Readers will also find: Analysis of functional coatings for dental implants, pool boilers, solar cells, and many more Detailed discussion of coating properties including superhydrophobicity, self-cleaning, controlled drug release, and more Key contributions to the great environmental challenges of the twenty-first century This book is a must-own for researchers in chemistry, engineering, energy, materials science, and more, as well as for industry professionals working with coating and other aspects of research and development in biomedical, energy, or environmental industries.

Biopolymers for Biomedical Applications The twenty chapters written by experts in the field of biopolymers and biomedical engineering, provide a complete resource that systematically discusses the most widely used biopolymers and their biomedical applications, and presents all the important research and developments that have occurred in the field. In recent decades, significant progress has been made in polymer science for biomedical applications. The use of biopolymers specifically attracted the focus on the development of therapeutic polymeric systems. The exclusive features of biopolymers, such as biodegradability and biocompatibility make them highly sought after, and major research conducted with them has resulted in various therapeutic systems. However, until now only a few showed a potential to be appropriate for human use. Each chapter covers a single biopolymer, its properties, and biomedical applications. The chapters are arranged systematically, with the most common biopolymers discussed early in the book to give more insight into the field. Further, a specific chapter is dedicated to the application of biopolymers for wound healing. Later, specific chapters are dedicated to the application of bioplastics and biopolymers for the development of medical devices and biosensors, respectively. Additionally, a chapter is dedicated to the application of biopolymers in the field of dentistry, with a special focus on their risk to human health. Keeping in mind recent advanced technologies, a chapter is dedicated solely to the latest progress of biopolymers in 3D and 4D printing for biomedical applications. The final chapter comprehensively explains the future perspectives of biopolymers in the biomedical field. Audience The book is a reference source for scientists, research scholars, chemical and polymer engineers, biologists, biotechnologists, polymer technologists, industrialists, health experts, and policymakers.

Amongst thermoplastic biodegradable polymers, polylactic acid (PLA) has been widely used in many different applications but it still has limited use in various industrial sectors such as medical, packaging, textile, water, and wastewater treatment. To increase the use of these materials more information is needed on their properties, characterization, processing, safety, and sustainability. Natural Fibre-Reinforced PLA Composites: Processing, Characterization and Applications reviews the thermal, physico-chemical, fire retardant, mechanical, tribological, biodegradable and anti-microbial properties of these materials. Fabrication of PLA biocomposites using advanced fabrication techniques like additive manufacturing and electrospinning are also discussed in detail. The book will be a valuable reference for academic and industrial researchers, materials scientists and engineers working in the development of polymers, bioplastics, polymer composites and biocomposites as well as industrial manufacturers. - Covers all aspects of polylactide biocomposites, and discusses their properties and characterization - Discusses compostability, the influence of water uptake, and other aging conditions - Covers Lifecycle assessment, end of life options and recycling of bio-based products from PLA - Discusses Socioeconomic aspects, sustainability, and future-prospects

This book offers a complete coverage of microbial refinery for exopolysaccharides (EPS) production, including genetic improvements, production techniques, biotechnological applications in food, cosmetics, health and environment sector, economic perspectives, and commercialization of EPS products. It focuses on exopolysaccharides production from an organism perspective to offer a complete picture from isolation of microbes to commercialization of EPS-based products. It covers strategies for EPS production and future perspectives and the potential of microbial refinery.Features: Provides a concise introduction to the science, biology, technology, and application of exopolysaccharides (EPS) Details upstream and downstream steps in EPS production from microbial resources Acts as a complete guide from production to commercialization Explores the potential application of EPS for socioeconomical benefits Discusses the EPS applications in food, cosmetics, health, and bioremediation approach for clean and sustainable development This book is aimed at researchers and graduate students in fermentation technology, biochemical engineering, and biotechnology.

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these unique materials and their usage in a range of biomedical applications. The book is evenly divided between fundamentals, processing methods and modeling approaches, and includes detailed coverage of a variety of applications, such as drug delivery, medical devices and wound healing. Key aspects including biocompatibility, biodegradability and toxicology are also thoroughly covered, enabling the reader to be fully informed when fabricating and utilizing their selected bioresorbable polymer. This book is an interdisciplinary and important reference for researchers in the fields of materials science, biomedical engineering, pharmaceutical science and regenerative medicine, as well as R&D groups in the development of medical devices. - Introduces the reader to various processing and modeling techniques for bioresorbable polymers, including electrospinning, molecular and finite element modeling - Covers a range of key bioresorbable composites, such as PCL, PLA/PLLA and PHA/PHB/PHBV - Explores a wide selection of biomedical applications of bioresorbable polymers, from tissue engineering and stents, to biosensors and medical devices/implants

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. - Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems - Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market - Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

This book outlines the latest research on the design and fabrication of the biomaterials used in mimicked scaffolds for tissue engineering for maxillofacial and orthopedic applications. The book is written based on integration and optimized concepts of 3 main parts 1) principle of tissue engineering; 2) mimicking of structure and function of scaffolds which is similar to extracellular matrix (ECM); and 3) mimicked scaffolds for tissue engineering in maxillofacial and orthopedic surgery. The content of this book which is interdisciplinary in nature caters to medical product designers, materials scientists and engineers, biologists, and surgeons who have interest in the field of bone tissue engineering.

BIODEGRADABLE MATERIALS AND THEIR APPLICATIONS Biodegradable materials have ascended in importance in recent years and this book comprehensively discusses all facets and applications in 29 chapters making it a one-stop shop. Biodegradable materials have today become more compulsory because of increased environmental concerns and the growing demand for polymeric and plastic materials. Despite our sincere efforts to recycle used plastic materials, they ultimately tend to enter the oceans, which has led to grave pollution. It is necessary, therefore, to ensure that these wastes do not produce any hazards in the future. This has made an urgency to replace the synthetic material with green material in almost all possible areas of application. Biodegradable Materials and Their Applications covers a wide range of subjects and approaches, starting with an introduction to biodegradable material applications. Chapters focus on the development of various types of biodegradable materials with their applications in electronics, medicine, packaging, thermoelectric generations, protective equipment, films/coatings, 3D printing, disposable bioplastics, agriculture, and other commercial sectors. In biomedical applications, their use in the advancement of therapeutic devices like temporary implants, tissue engineering, and drug delivery vehicles are summarized. Audience Materials scientists, environmental and sustainability engineers, and any other researchers and graduate students associated with biodegradable materials.

Nanotechnology in Medicine and Biology brings together a multidisciplinary team of experts from the fields of materials science, nanotechnology, medicine and biomedical engineering to introduce new nanoscale biomaterials and their applications, diagnosis and treatment of disorders of the human body. The book presents the fundamentals for understanding the design, properties and selection of nanobiomaterials as well as their real-world applications in medicine. Each chapter addresses current regulations, manufacturing processes, and translation issues of nanobiomaterials for key applications. A discussion of current protocols and their benefits and disadvantages is also included. This book provides comprehensive background and knowledge in the field of nanobiomaterials that is suitable for academics, scientists and clinicians. - Provides fundamental understanding on the design, properties and selection of biomaterials for applications in medicine and biology - Reviews current regulations, protocols, manufacturing processes and translation issues of nanobiomaterials for medical applications - Discusses tissue repair, wound healing, regenerative medicine, drug delivery, imaging and medical device applications

A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.

Explore the world of biocomposites with this one-stop resource edited by four international leaders in the field Bio-based Composites: Characterization, Properties, and Applications delivers a comprehensive treatment of all known characterization methods, properties, and industry applications of bio-based composites materials. This unique, one-stop resource covers all major developments in the field from the last decade of research into this environmentally beneficial area. The internationally recognized editors have selected resources that represent advances in the mechanical, thermal, tribological, and water sorption properties of bio-based composites, and cover new areas of research in physico-chemical analysis, flame retardancy, failure mechanisms, lifecycle assessment, and modeling of bio-based composites. The low weight, low cost, excellent thermal recyclability, and biodegradability of bio-based composites make them ideal candidates to replace engineered plastic products derived from fossil fuel. This book provides its readers with the knowledge they'll require to understand a new class of materials increasingly being used in the automotive and packaging industries, aerospace, the military, and construction. It also includes: An extended discussion of the environmental impact of bio-based composites using a lice cycle methodology A review of forecasts of natural fiber reinforced polymeric composites and its degradability concerns An analysis of the physical and mechanical properties of a bio-based composite with sisal powder A comprehensive treatment of the mechanical, thermal, tribological, and dielectric properties of bio-based composites A review of processing methods for the manufacture of bio-based composites Perfect for materials scientists in private industry, government laboratories, or engaged in academic research, Bio-Based Composites will also earn a place in the libraries of industrial and manufacturing engineers who seek a better understanding of the beneficial industrial applications of biocomposites in industries ranging from automobiles to packaging.

Laser powder bed fusion of metals is a technology that makes use of a laser beam to selectively melt metal powder layer-by-layer in order to fabricate complex geometries in high performance materials. The technology is currently transforming aerospace and biomedical manufacturing and its adoption is widening into other industries as well, including automotive, energy, and traditional manufacturing. With an increase in design freedom brought to bear by additive manufacturing, new opportunities are emerging for designs not possible previously and in material systems that now provide sufficient performance to be qualified in end-use mission-critical applications. After decades of research and development, laser powder bed fusion is now enabling a new era of digitally driven manufacturing. Fundamentals of Laser Powder Bed Fusion of Metals will provide the fundamental principles in a broad range of topics relating to metal laser powder bed fusion. The target audience includes new users, focusing on graduate and undergraduate students; however, this book can also serve as a reference for experienced users as well, including senior researchers and engineers in industry. The current best practices are discussed in detail, as well as the limitations, challenges, and potential research and commercial opportunities moving forward. - Presents laser powder bed fusion fundamentals, as well as their inherent challenges - Provides an up-to-date summary of this advancing technology and its potential - Provides a comprehensive textbook for universities, as well as a reference for industry - Acts as quick-reference guide

Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials. - Provides updated and new information on ceramic and polymer biomaterials for tissue engineering - Presents readers with systematic coverage of the processing, characterization and modeling of each material - Includes content that will be relevant to a range of readers, including biomedical engineers, materials scientists, and those interested in regenerative medicine

An in-depth look at the latest breakthroughs in our understanding of the material record that deep time leaves behind.Understanding the complex interplay of physical and chemical processes leading to fossilization is crucial to elucidating the 3800 million years of life on earth. And yet, the process of fossilization also leads to the loss of pivotal biological information, placing constraints on the very same understanding of ancient life it preserves. Over the last decade, however, remarkable advances in approaches, techniques, tools, and instrumentation have helped scientists to transcend these constraints by enabling high-resolution analysis of fossil material—even down to the nanoscale. Fossilization provides a critical look at these cutting-edge innovations in the science of fossil preservation and provides a road map for future research. Drawing from the fields of paleontology, organic and inorganic chemistry, microbiology, and high-resolution imaging and analysis, and spanning the diversity of life from plants to vertebrates and invertebrates, this resource details expert findings on• fossilization of hard and soft part tissues in dinosaurs• high-resolution chemical analysis of organic and inorganic tissues• arthropods preserved in amber• experimental silicification of wood• chemical defenses and color in fossil plants • confocal Raman spectroscopy• microprobe analysis• radioisotopic studies• and much moreA true interdisciplinary undertaking, the book is authored by paleontologists, mineralogists, geochemists, organic chemists, microbiologists, and materials scientists who have worked together to investigate questions around substance fossilization and the limits of the fossil record. A special color section contains SEM, Raman, and other striking images of vertebrates, invertebrates, and plants. Fossilization is a trailblazing reference book for research scientists and specialists in related fields, as well as for advanced undergraduates and graduate students interested in fossilization, emerging research techniques, and fresh approaches in the analysis of plant and animal fossils.Contributors: H. Jonas Barthel, Aurore Canoville, Carole T. Gee, Thorsten Geisler, Jens Götze, Conrad C. Labandeira, Sashima Läbe, Moritz Liesegang, Victoria E. McCoy, Martina Menneken, Jes Rust, P. Martin Sander, Frank Tomaschek, Torsten Wappler, Kayleigh Wiersma, Tzu-Ruei Yang

Oral tissue engineering involves the study of current approaches for in vitro regeneration of soft and hard tissues located into the oral cavity. In this context, recent approaches involves the use of innovative biomaterials to replace the lost or damaged human oral tissues. Recent discoveries in materials science and nanotechnology are drastically changing the traditional approach to dentistry by the design of innovative devices able more efficiently supporting the natural regeneration process. The objective of this book is to highlight current progress in tissue engineering for various dental hard/soft tissues including enamel, dentin, pulp, alveolar bone, periodontium, gum and oral mucosa, by emphasizing the role of materials and their specific applications.

The handbook provides an understanding of consolidated processing and biorefinery systems for the production of bio-based chemicals and value-added bioproducts from renewable sources. The chapters look at a variety of bioenergy technological advances and improvements in the energy and materials sectors that aim to lower our dependence of fossil fuels and consequently reduce greenhouse gas (GHG) emissions. The volume looks at a selection of processes for the production of energy and biomaterials, including the Fischer–Tropsch process, gasification, pyrolysis, combustion, fermentation from renewable sources (such as, plants, animals and their byproducts), and others. Applications that are explored include transportation fuels, biodiesel production, wastewater treatment, edible packaging, bioplastics, physical rehabilitation, tissue engineering, biomedical applications, thermal insulation, industrial value compounds, and more. All of the topics covered in this publication address consolidated processes that play a pivotal role in the production of bioenergy and biomaterials because these processes require fewer unitary operations needed in the process, leading to a more direct method of production. This type of production system contributes to decreasing negative effects on the environment, lowering costs, saving energy and time, and improving profitability and efficiency. This volume will be valuable for the industrial sector, for researchers and scientists, as well as for faculty and advanced students.

In the last few years, an extended range of applications from medicine to material science has arisen a renewed interest in gels. These latter ones are dilute cross-linked systems, which manifests no flow when in the steady-state. This book reviews the recent advances in gel chemistry, considering their properties and applications. In particular, it treats supramolecular gels, metal-organic gels, hydrogels, dynamic covalent gels, polymer gels, and inorganic gels.

Offers a comprehensive guide to the isolation, properties and applications of chitin and chitosan Chitin and Chitosan: Properties and Applications presents a comprehensive review of the isolation, properties and applications of chitin and chitosan. These promising biomaterials have the potential to be broadly applied and there is a growing market for these biopolymers in areas such as medical and pharmaceutical, packaging, agricultural, textile, cosmetics, nanoparticles and more. The authors – noted experts in the field – explore the isolation, characterization and the physical and chemical properties of chitin and chitosan. They also examine their properties such as hydrogels, immunomodulation and biotechnology, antimicrobial activity and chemical enzymatic modifications. The book offers an analysis of the myriad medical and pharmaceutical applications as well as a review of applications in other areas. In addition, the authors discuss regulations, markets and perspectives for the use of chitin and chitosan. This important book: Offers a thorough review of the isolation, properties and applications of chitin and chitosan. Contains information on the wide-ranging applications and growing market demand for chitin and chitosan Includes a discussion of current regulations and the outlook for the future Written for Researchers in academia and industry who are working in the fields of chitin and chitosan, Chitin and Chitosan: Properties and Applications offers a review of these promising biomaterials that have great potential due to their material properties and biological functionalities.

Biopolymer-Based Formulations: Biomedical and Food Applications presents the latest advances in the synthesis and characterization of advanced biopolymeric formulations and their state-of-the-art applications across biomedicine and food science. Sections cover the fundamentals, applications, future trends, environmental, ethical and medical considerations, and biopolymeric architectures that are organized in nano, micro and macro scales. The final section of the book focuses on novel applications and recent developments. This book is an essential resource for researchers, scientists and advanced students in biopolymer science, polymer science, polymer chemistry, polymer composites, plastics engineering, biomaterials, materials science, biomedical engineering, and more. It will also be of interest to R&D professionals, scientists and engineers across the plastics, food, biomedical and pharmaceutical industries. - Provides in-depth coverage of methods for the characterization of the physical properties of biopolymeric architectures - Supports a range of novel applications, including scaffolds, implant coatings, drug delivery, and nutraceutical encapsulation systems - Includes the use of experimental data and mathematical modeling, thus enabling the reader to analyze and compare the properties of different polymeric gels

Fracture Management for the Small Animal Practitioner offers practical strategies and helpful approaches for managing fractures in dogs and cats. • Contains all the information needed to successfully manage the most common fractures in dogs and cats • Emphasizes clinically oriented tips for treating fractures from experienced surgeons • Offers an abundance of color photographs to illustrate the techniques

Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses is an essential guide to bioactive glasses, offering an overview of all aspects of the development and utilization of this cutting-edge material. The book covers vital issues, including mesoporosity, encapsulation technologies, scaffold formation and coatings for a number of applications, including drug delivery, encapsulation, scaffolds and coatings. Readers will gain a strong understanding and practical knowledge of the therapeutic aspects of bioceramics, with a focus on glasses from a clinical point-of- view. Researchers, students and scientists involved in bioceramics, bone tissue engineering, regeneration and biomedical engineering will find this to be a comprehensive resource. - Presents detailed coverage of bioactive glasses, including technologies and applications - Includes all the major development areas related to bioactive glasses, enabling readers to understand the latest research - Considers the potential future developments of bioactive glasses as a drug carrier

This book provides the latest research & developments and future trends in photoenergy and thin film materials—two important areas that have the potential to spearhead the future of the industry. Photoenergy materials are expected to be a next generation class of materials to provide secure, safe, sustainable and affordable energy. Photoenergy devices are known to convert the sunlight into electricity. These types of devices are simple in design with a major advantage as they are stand-alone systems able to provide megawatts of power. They have been applied as a power source for solar home systems, remote buildings, water pumping, megawatt scale power plants, satellites, communications, and space vehicles. With such a list of enormous applications, the demand for photoenergy devices is growing every year. On the other hand, thin films coating, which can be defined as the barriers of surface science, the fields of materials science and applied physics are progressing as a unified discipline of scientific industry. A thin film can be termed as a very fine, or thin layer of material coated on a particular surface, that can be in the range of a nanometer in thickness to several micrometers in size. Thin films are applied in numerous areas ranging from protection purposes to electronic semiconductor devices. The 16 chapters in this volume, all written by subject matter experts, demonstrate the claim that both photoenergy and thin film materials have the potential to be the future of industry.

This title gives an overview of composites and biocomposites. It discusses the history of CaPO4/ /polymer biocomposites and hybrid biomaterials, as well as analyzing the latest developments in the field. It also covers bioactivity and biodegradation of CaPO4-based biomaterials.

Biomaterials and Bionanotechnology examines the current state of the field within pharmaceutical sciences and concisely explains the history of biomaterials including key developments. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biomaterials and bionanotechnology within drug discovery and drug development. Each chapter delves into a particular aspect of this fast-moving field to cover the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable dosage form, with particular focus on biomaterials and bionanomaterials. This book provides a comprehensive examination suitable for researchers working in the pharmaceutical, cosmetics, biotechnology, food and related industries as well as advanced students in these fields. - Examines the most recent developments in biomaterials and nanomaterials for pharmaceutical sciences - Covers important topics, such as the fundamentals of polymers science, transportation and bio interaction of properties in nanomaterials across biological systems, and nanotechnology in tissue engineering as they pertain specifically to pharmaceutical sciences - Contains extensive references for further discovery on the role of biomaterials and nanomaterials in the drug discovery process

Biocompatibility and Performance of Medical Devices, Second Edition, provides an understanding of the biocompatibility and performance tests for ensuring that biomaterials and medical devices are safe and will perform as expected in the biological environment. Sections cover key concepts and challenges faced in relation to biocompatibility in medical devices, discuss the evaluation and characterization of biocompatibility in medical devices, describe preclinical performance studies for bone, dental and soft tissue implants, and provide information on the regulation of medical devices in the European Union, Japan and China. The book concludes with a review of histopathology principles for biocompatibility and performance studies. - Presents diverse insights from experts in government, industry and academia - Delivers a comprehensive overview of testing and interpreting medical device performance - Expanded to include new information, including sections on managing extractables, accelerating and simplifying medical device development through screening and alternative biocompatibility methods, and quality strategies which fasten device access to market

Electrospinning: Nanofabrication and Applications presents an overview of the electrospinning technique, nanofabrication strategies and potential applications. The book begins with an introduction to the fundamentals of electrospinning, discussing fundamental principles of the electrospinning process, controlling parameters, materials and structures. Nanofabrication strategies, including coaxial electrospinning, multi-needle electrospinning, needleless electrospinning, electro-netting, near-field electrospinning, and three-dimensional macrostructure assembling are also covered. Final sections explore the applications of electrospun nanofibers in different fields and future prospects. This is a valuable reference for engineers and materials scientist working with fibrous materials and textiles, as well as researchers in the areas of nanotechnology, electrospinning, nanofibers and textiles. - Explores controllable fabrication of electrospun nanomaterials and their multifunctional applications - Explains the electrospinning technique as used in nanofabrication and nanofibers - Outlines the applications of electrospun nanofibrous materials in tissue engineering, filtration, oil-water separation, water treatment, food technology, supercapacitors, sensors and so on

As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as biocomposites and hybrid biomaterials, self-setting formulations, as well as the workings of their dissolution mechanism. Topics discussed include the major constituents of biocomposites and hybrid biomaterials for bone grafting, preparation, properties and the available knowledge on interactions among the phases for various types of CaPO4-based biocomposites. Additionally, the major types, preparation, properties and the available knowledge on the reinforced formulations for various types of self-setting CaPO4-based compositions, followed by the detailed description of their biomedical applications and in vivo behavior are discussed. The comprehensive description of currently available dissolution mechanisms of calcium apatites in acids, followed by the successful attempt to create the general dissolution mechanism is given in the last section of this book.

Biocomposites are exciting, “new” materials which have experienced a renaissance in the 21st century in response to the societal concerns regarding global warming and environmental pollution, shifting the focus towards materials made from renewable, biodegradable and recyclable resources. As a consequence, research and development of these materials has increased in recent years, which is reflected in their applications in various industries, particularly the automotive and construction industries. These materials are estimated to experience a compound annual growth rate of 11.7% in the next five years, which is almost double that of conventional composite materials over the same time period. This book attempts to increase the knowledge base of these materials, particularly in terms of their properties, performance and applications. It contains precisely referenced chapters, complete with illustrations and tables that maximize the reader's insight into the current state-of-the-art applications on biocomposites. The chapters have been written by the leading experts of this field with various backgrounds and expertise. Apart from review articles, the book also contains chapters on recent developments in this field. A distinguishing feature of this book is the emphasis on the uses of these materials in biomedical applications. This reference book is an invaluable source of guidance for researchers, academics and entrepreneurs working in the field of biocomposites.

As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as bioceramics, deposits (coatings, films and layers) and in dentistry. Topics discussed include chemical composition and preparation, forming and shaping, sintering and firing for CaPO4-based bioceramics, chemical composition and preparation, pre- and post-deposition treatments for CaPO4-based deposits, followed by the detailed description of their major properties, biomedical applications and in vivo behavior. The detailed description of current CaPO4 applications in dentistry both for dental caries prevention and as various types of dental treatments is given in the last section of this book.

A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications on three popular types of CaPO4: nano-scaled (nano-dimensional), multiphasic (polyphasic) and amorphous CaPO4. Topics discussed include the preparation, structure, composition, properties and biomedical applications of these types of CaPO4 combined with the specific information for each type. Namely, occurrence in the calcified tissue of mammals is discussed for both nano-scaled and amorphous types of CaPO4; both known and potential formulations, as well as their stability are discussed for multiphasic CaPO4, while both the morphology and the available knowledge on amorphous-to-crystalline transformations are discussed for amorphous CaPO4.

Bioceramics are an important class of biomaterials. Due to their desirable attributes such as biocompatibility and osseointegration, as well as their similarity in structure to bone and teeth, ceramic biomaterials have been successfully used in hard tissue applications. In this book, a team of materials research scientists, engineers, and clinicians bridge the gap between materials science and clinical commercialization providing integrated coverage of bioceramics, their applications and challenges. The book is divided into three parts. The first part is a review of classes of medical-grade ceramic materials, their synthesis and processing as well as methods of property assessment. The second part contains a review of ceramic medical products and devices developed, their evolution, their clinical applications and some of the lessons learned from decades of clinical use. The third part outlines the challenges to improve performance and the directions that novel approaches and advanced technologies are taking, to meet these challenges. With a focus on the dialogue between surgeons, engineers, material scientists, and biologists, this book is a valuable resource for researchers and engineers working toward long-lasting, reliable, customized biomedical ceramic and composites devices. - Edited by a team of experts with expertise in industry and academia - Compiles the most relevant aspects on regulatory issues, standards and engineering of bioceramic medical devices as inspired by commercial and clinical needs - Introduces bioceramics, their evolution and applications in hard tissue engineering and medical devices

Biomineralization is a natural process by which living organisms form minerals in association with organic biostructures to form hybrid biological materials such as bone, enamel, dentine and nacre among others. Scientists have researched the fundamentals of these processes and the unique structures and properties of the resulting mineralized tissues. Inspired by them, new biomaterials for tissue engineering and regenerative medicine have been developed in recent years. Biomineralization and biomaterials: fundamentals and applications looks at the characteristics of these essential processes and natural materials and describes strategies and technologies to biomimetically design and produce biomaterials with improved biological performance. - Provides a thorough overview of the biomineralization process - Presents the most recent information on the natural process by which crystals in tissues form into inorganic structures such as bone, teeth, and other natural mineralized tissues - Investigates methods for improving mineralization - Explores new techniques that will help improve the biomimetic process

This book focuses on the applications of bioglasses in the biomedical field. It starts with the history and evolution of bioglasses before moving on to the structure and percolation theory, and lastly investigating their current and potential future applications in various fields including dentistry, tissue engineering, bone regeneration, ophthalmology, and drug delivery. The chapters were written by a team of international experts in the field and will be of great interest not only to material scientists, but also to medical doctors and other health sector professionals.

Reflecting the advances made in recent years, this is a comprehensive overview of calcium orthophosphates for bioceramics and biocomposites with a special focus on the detailed description of all those available, including their biological and geological occurrence, preparation, chemical composition, structure-property relationships and applications. In particular, the book discusses the suitability of these orthophosphates for biomedical applications and their use as bone grafts in surgery and medicine. The result is a useful reference for researchers with an academic, medical or commercial background.

Ceramic materials are inorganic and non-metallic porcelains, tiles, enamels, cements, glasses and refractory bricks. Today,'ceramics'has gained a wider meaning as a new generation of materials influence on our lives; electronics, computers, communications, aerospace and other industries rely on a number of their uses. In general, advanced ceramic materials include electro-ceramics, optoelectronic-ceramics, superconductive ceramics and the more recent development of piezoelectric and dielectric ceramics. They can be considered for their features including mechanical properties, decorative textures, environmental uses, energy applications, as well as their usage in bio-ceramics, composites, functionally graded materials, intelligent ceramics and so on. Advanced Ceramic Materials brings together a group of subject matter experts who describe innovative methodologies and strategies adopted in the research and development of the advanced ceramic materials. The book is written for readers from diverse backgrounds across chemistry, physics, materials science and engineering, medical science, pharmacy, environmental technology, biotechnology, and biomedical engineering. It offers a comprehensive view of cutting-edge research on ceramic materials and technologies. Divided into 3 parts concerning design, composites and functionality, the topics discussed include: Chemical strategies of epitaxial oxide ceramics nanomaterials Biphasic, triphasic and multiphasic calcium orthophosphates Microwave assisted processing of advanced ceramic composites Continuous fiber reinforced ceramic matrix composites Yytria and magnesia doped alumina ceramic Oxidation induced crack healing SWCNTs vs MWCNTs reinforcement agents Organic and inorganic wastes in clay brick production Functional tantalum oxides Application of silver tin research on hydroxyapatite

Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials presents novel approaches regarding nanostructured drug delivery systems, revealing the most investigated materials for the development of particular nanobioshuttles. This book brings the results of current research to reach those who wish to use this knowledge in an applied setting, providing one coherent text, with focused chapters and easily accessible information. At its core, it is a collection of titles, bringing together many of the novel applications these materials have in biology, also discussing the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment, there is no other comparable book series covering all the subjects approached in this set of titles. - Provides up-to-date and well-structured reference material for students, researchers, and practitioners working in the biomedical, biotechnological, and engineering fields - Presents a valuable guide to recent scientific progress, along with most known applications of nanomaterials in the biomedical area - Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine/nanobiology

Bioinspired Materials for Medical Applications examines the inspiration of natural materials and their interpretation as modern biomaterials. With a strong focus on therapeutic and diagnostic applications, the book also examines the development and manipulation of bioinspired materials in regenerative medicine. The first set of chapters is heavily focused on bioinspired solutions for the delivery of drugs and therapeutics that also offer information on the fundamentals of these materials. Chapters in part two concentrate on bioinspired materials for diagnosis applications with a wide coverage of sensor and imaging systems With a broad coverage of the applications of bioinspired biomaterials, this book is a valuable resource for biomaterials researchers, clinicians, and scientists in academia and industry, and all those who wish to broaden their knowledge in the allied field. - Explores how materials designed and produced with inspiration from nature can be used to enhance man-made biomaterials and medical devices - Brings together the two fields of biomaterials and bioinspired materials - Written by a world-class team of research scientists, engineers, and clinicians

Material-Tissue Interfacial Phenomena: Contributions from Dental and Craniofacial Reconstructions explores the material/tissue interfacial phenomena using dental and craniofacial reconstructions as a model system. As the mouth is a particularly caustic environment, the synthetic and/or bio-enabled materials used to repair damaged tissues and restore form, function, and esthetics to oral structures must resist a variety of physical, chemical, and mechanical challenges. These challenges are magnified at the interface between dissimilar structures such as the tooth/material interface. Interfacial reactions at the atomic, molecular, and nano-scales initiate the failure of materials used to repair, restore, and reconstruct dental and craniofacial tissues. Understanding the phenomena that lead to failure at the interface between dissimilar structures, such as synthetic materials and biologic tissues, is confounded by a variety of factors that are thoroughly discussed in this comprehensive book. - Provides a specific focus on the oral environment - Combines clinical views and basic science into a useful reference book - Presents comprehensive coverage of material-interfacial phenomena within the oral environment

Reflecting the progress in recent years, this book provides in-depth information on the preparation, chemistry, and engineering of bioceramic coatings for medical implants. It is authored by two renowned experts with over 30 years of experience in industry and academia, who know the potentials and pitfalls of the techniques concerned.Following an introduction to the principles of biocompatibility, they present the structures and properties of various bioceramics from alumina to zirconia. The main part of the work focuses on coating technologies, such as chemical vapor deposition, sol-gel deposition and thermal spraying. There then follows a discussion of the major interactions of bioceramics with bone or tissue cells, complemented by an overview of the in-vitro testing methods of the biomineralization properties of bioceramics. The text is rounded off by chapters on the functionalization of bioceramic coatings and a look at future trends.As a result, the authors bring together all aspects of the latest techniques for designing, depositing, testing, and implementing improved and novel bioceramic coating compositions, providing a full yet concise overview for beginners and professionals.

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a'who's who'of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications. Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including: Properties of peptide scaffolds in solution and on solid substrates Nanostructures, peptide assembly, and peptide nanostructure design Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids Functionalization of carbon nanotubes with peptides Adsorption of peptides on metal and oxide surfaces Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.

This book introduces readers to the structure and characteristics of nanomaterials and their applications in dentistry. With currently available implant materials, the clinical failure rate varies from a few percent to over 10 percent and new materials are clearly needed. Nanomaterials offer the promise of higher strength, better bonding, less toxicity, and enhanced cytocompatibility, leading to increased tissue regeneration. Mieczyslaw Jurczyk, director of the Institute of Materials Science and Engineering at the Poznan University of Technology in Poland, has drawn from work in his laboratory and elsewhere in Poland to show that nanomaterials have important biological applications including in the stomatognathic system consisting of mouth, jaws, and associated structures. The book is written from a materials science and medical point of view and has 13 chapters and about 400 pages. The book can be divided approximately into three sections: the first five chapters introduce nanobiomaterials, the next five chapters describe their dental applications, and the last chapters describe their biocompatibility. Chapter 3 is a compendium on metallic biomaterials such as stainless steel, cobalt alloys, and titanium alloys; bioactive, bioresorbable polymers; and composites and ceramic biomaterials. The'top-down'approach to producing nanomaterials such as high-energy ballmilling and severe plastic deformation, as well as Feynman's'bottom-up technique'of building atom by atom, are discussed in the next chapter. Subsequent chapters discuss each material in depth and point out how new architectures and properties emerge at the nanoscale. Chapter 8 is devoted to shape-memory materials, which now include not only NiTi but also polymers and magnetic materials. In order to improve bonding, nanomaterials can be used to synthesize implants with surface roughness similar to that of natural tissues. Chapter 9 is devoted to different surface treatments for Ti-based nanomaterials, such as anodic oxidation to improve the bioactivity of titanium and improve the corrosion resistance of porous titanium and its alloys. The use of carbon in various forms—nanoparticles, nanofibers, nanotubes, and thin films—is discussed next with emphasis on the microstructure and properties of these materials, their implant applications, and their interaction with subcutaneous tissues. Nanomaterials can be used in preventive dentistry and therefore can reduce the amount of dental treatment that is necessary to maintain a healthy mouth as argued in chapter 11. In a subsequent chapter, the author explains osseointegration (direct bone-to-metal interface) from a biological point of view and early tissue response. The mechanism of the interaction between the implanted materials with the cellular protein in the tissues is described. The last chapter discusses the application of new nanostructured materials in permanent and bioresorbable implants, nanosurface dental implants, and nanostructured dental composite restorative materials. This book not only focuses on nanomaterials but also on nanoengineering to achieve the best results in dentistry. It is recommended to anyone interested in nanomaterials and their applications in dental science. People with a background in materials, chemistry, physics, and biology will benefit from it.

The surface of materials is routinely exposed to various environmental influences. Surface modification presents a technological challenge for material scientists, physicists, and engineers, particularly when those surfaces are subjected to function within human body environment. This book provides a comprehensive coverage of the major issues and topics dealing with interaction of soft living matter with the surface of implants. Fundamental scientific concepts are embedded through experimental data and a broad range of case studies. First chapters cover the basics on biocompatibility of many different thin films of metals, alloys, ceramics, hydrogels, and polymers, following with case studies dealing with orthopedic and dental coatings. Next, a novel and low-cost coating deposition technique capable of production of several types of nanostructures is introduced through simple calculations and several illustrations. Moreover, chapter 6 and 7 present important topics on surface treatment of polymers, which is a subject that has seen many developments over the past decade. The last chapters target mainly the applications of coatings in biology such as in bio-sensing, neuroscience, and cancer detection. With several illustrations, micrographs, and case studies along with suitable references in each chapter, this book will be essential for graduate students and researchers in the multidisciplinary field of bio-coatings.

Selected, peer reviewed papers from the 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (ISCM 2012), October 21-24, 2012, Fukuoka, Japan

Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration.The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering.The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.

Membrane Modification: Technology and Applications is written for engineers, scientists, graduate students, and researchers in the field of membrane science and technology, materials science, applied physics, chemistry, and environmental science. The book presents the complete range of membrane modification techniques used to increase efficiency of

This book presents current research from across the globe in the study of the types, biological activities and health effects of bioactive compounds. Topics discussed include calcium orthophosphate bioceramics in biomedical applications; the biological and toxicological effects of naphthoquinones; probiotics, bioactive compounds and vaccines used in bovine mastitis; supercritical fluid extraction of bioactive compounds; microalgae as a promising source of bioactive compound and flavonoid compounds and their antioxidant activity.