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Autrice bestseller della Campus Series Fenomeno di TikTok Casey Tresscott non si sente più padrona della sua vita da tanto tempo. Dopo l'incidente d'auto che le è quasi costato tutto, si è abituata tanto all'apprensione della sua famiglia quanto ai pettegolezzi implacabili a scuola, sebbene la feriscano profondamente. Del resto, Casey ha trovato un porto sicuro nel legame con Fenn Bishop, il ragazzo d'oro del Sandover... o almeno così crede. Fenn, infatti, nasconde una verità pericolosa sulla notte in cui Casey è quasi morta. Lui ha pensato che mentirle fosse la scelta giusta, ma se il suo segreto venisse scoperto, potrebbe perderla per sempre. Perché Casey è stanca di essere presa di mira. Tanto che un giorno, finalmente, decide di riprendere il controllo. Affronta le bulle che la perseguitano, si unisce ai più ribelli del Sandover e ignora il rigido coprifuoco imposto dal padre preside, senza curarsi delle conseguenze. Fenn, disperato, si allea con il fratellastro RJ e gli altri delinquenti del Sandover per indagare sull'incidente di Casey, nella speranza di riavere indietro la ragazza di cui si è innamorato. Ma se, nonostante tutto, quella ragazza non esistesse più? Benvenuti al Sandover, dove i segreti si annidano nelle tenebre e nessuno è al sicuro… Una storia d'amore sexy e oscura, firmata Elle Kennedy, una delle autrici più amate dal Booktok. «Elle Kennedy è la dea dei romance. I suoi libri sono unici: divertenti, sexy e appassionanti.» Penelope Ward Elle KennedyÈ cresciuta a Toronto. I suoi libri sono ai primi posti delle classifiche USA. La Newton Compton ha pubblicato la Campus Series (Il contratto. The Deal, Lo sbaglio. The Mistake, Il tradimento. The Score, L'imprevisto. The Goal, L'eredità. The Legacy), la Briar U Series (Resta con me per sempre. The Chase, Il mio rischio sei tu. The Risk, Sei l'amore che cercavo. The Play, Ti ho trovato quasi per caso. The Dare), la Avalon Bay Series (Il complesso della brava ragazza. Good Girl Complex, Una ragazza (quasi) cattiva. Bad Girl Reputation, Cattiva ragazza per un'estate. The Summer Girl), la Prep Series (Il segreto tra noi due. Misfit e La verità tra di noi. Rogue), la Campus Diaries Series (Effetto amore. The Graham Effect e Nessuna regola in amore. The Dixon Rule) e Ti ho incontrato a mezzanotte.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Genomics, Populations, and Society, a new volume in the Genomic and Precision Medicine in Clinical Practice series, considers the vast and thorny web of ELSI topics in genomics, from bioethics to healthcare applications, healthcare economics, genomic data management, and population dynamics. Emphasis is placed on the impact of rapid genomic advances on ethical, sociocultural and lifestyle dimensions. Healthcare and health economics topics include genomics and digital health, genome editing, and genomics and infectious disease management. Legal issues related to data ownership, equity, access, probity, consent, and confidentiality are also discussed in-depth, along with sociocultural topics such as community engagement, consanguinity, and more.Here, a range of readers from researchers to clinicians, policy administrators, lawyers, economists and social scientists will discover carefully crafted, synthesized discussions on ELSI topics in genomics to power new scientific advances and genomic medicine implementation. - Includes more than twenty-four chapters across five integrated sections on scientific dilemmas in genomics, genomic healthcare applications, sociocultural aspects of genomics, ethical aspects and global health genomics - Presents fundamental issues tied to biosociety, healthcare, law, and the bioeconomy as genomic medicine moves from research lab to the clinic - Features chapter contributions from international experts

Lana Parker ha festeggiato più fidanzamenti che compleanni. Tutto è cominciato al liceo, dopo una catastrofica rottura con il suo primo amore, Seth Carson. Da quel momento la vita è stata un susseguirsi di relazioni sfortunate, una più disastrosa dell'altra. Non c'è da stupirsi che talvolta il lavoro la stressi… Eh, già, perché Lana ha conquistato il cuore di migliaia di lettrici con una rubrica sull'amore, pubblicata da uno dei web magazine più seguiti a Los Angeles. Cene a lume di candela e appuntamenti romantici sono il suo pane quotidiano. Possibile che sia l'unica a non meritare un lieto fine, come quelli che racconta nei suoi articoli? Dopo l'ennesima delusione, ha deciso di prendersi una pausa per ritrovare sé stessa. Ma non ha fatto i conti con Seth, che riappare all'improvviso come collega-rivale, disposto a tutto pur di mettersi in mostra con il capo. A sfidarsi saranno i loro punti di vista – opposti – sull'amore. Fuoco e fiamme sono assicurati, ma chi la spunterà? In palio c'è il lavoro dei sogni, ma con un ex di troppo «Seth e Lana hanno una chimica esplosiva. È uno spasso leggere i loro infuocati battibecchi.» Kirkus Reviews «Un romanzo unico e ironico. Una storia di seconde occasioni, con personaggi intelligenti e irresistibili.» Booklist Falon BallardÈ nata a Los Angeles. Dopo essersi laureata in Scrittura creativa, ha fatto l'insegnante per otto anni, per poi dedicarsi all'organizzazione di eventi. Ama la Marvel, la Disney e i reality.

Hepatology: An Evidence-Based Clinical Compendium provides current and comprehensive insights into the field of hepatology, covering various aspects such as diagnosis, management, control, techniques, procedures, and technology. By offering the latest information, the book ensures that readers stay up-to-date with the rapidly evolving landscape of hepatology. The comprehensive scope covers a wide range of topics related to liver diseases, including epidemiology, pathogenesis, and pathophysiology. It features contributions from esteemed experts worldwide and is enhanced with high-quality diagrams. The book serves as a valuable resource for scientists and researchers, offering a solid foundation for their investigations and clinical inquiries.Moreover, the book goes beyond the discussion of epidemiology, pathogenesis, and pathophysiology, and presents updated treatment and management guidelines for liver diseases, making it a go-to reference for Clinicians treating liver diseases. - Presents current and comprehensive insights into the diagnosis, management, control, techniques, procedures, and technology in hepatology - Facilitates evidence-based decision-making for better patient care, enabling practitioners to effectively incorporate research findings into their treatment approaches - Guides the selection of optimal treatment and management options, equipping readers with valuable resources to overcome challenges encountered in clinical practice - Enhances knowledge and skills for clinical practice, offering valuable support to healthcare professionals seeking to improve their expertise

This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book: Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. - Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics - Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine - Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout - Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction - Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

LLEGA ADELAIDE ADAMSUna miss Marple de Arkansas, irónica, artrítica y deslenguada. «Yo, Adelaide Adams, soltera, estaba tejiendo en el vestíbulo del Richelieu la mañana que todo comenzó. Aunque en aquel momento no era consciente de que estuviera empezando nada. No me considero una mujer timorata y sé que ocasionalmente algunos miembros poco serios de las jóvenes generaciones me han tildado de vieja arpía. No obstante, de haber sospechado el desenfrenado derramamiento de sangre en el que pronto nos veríamos inmersos habría salido de allí pitando sin mirar atrás a pesar de mi rodilla artrítica y mi exceso de peso. Sin embargo, aquella luminosa mañana del mes de abril no habría sido fácil encontrar un rincón de apariencia más apacible que el vestíbulo de nuestro pequeño hotel residencial. Porque lo único que tiene de grandilocuente el Richelieu es su nombre». Maestra indiscutible del Had-I-but-known, la narración de Blackmon asombra por su inquietante trama y por la sagacidad e ironía de su atípica detective. «Una detective atípica, que no dejará indiferente a nadie».The Atlantic Monthly

This book is the first comprehensive compilation of current knowledge on mulberry (Morus L.) covering botany, cytogenetics, biodiversity, genetics and breeding, tissue culture and genetic transformation, biotic and abiotic stresses, molecular mapping, QTL identification, whole genome sequencing and elucidation on functional genomics. As mulberry is one of the most economically important trees in Asian countries, it has attracted the attention of both academicians as well as industrialists. Being highly heterozygous due to long juvenile life coupled cross pollination among species, the genetics of this important crop species is yet to be unravelled. Nonetheless, the recent success of sequencing the genomes of haploid and diploid domesticated species has ushered in an era of intense molecular and genetic research to understand this crop well for its better utilization for mankind.In this book, efforts have been made to bring together key information on origin and distribution, taxonomy, morphological features, economic importance, abiotic stress responses, disease and pest resilience, current breeding strategies and their constraints, progress and prospects of gene mapping, elucidation of genes controlling metabolic and physiological pathways, and their utilization in crop improvement which are elaborated in about 250 pages over 13 chapters authored by globally leading experts on the species presented.This book is useful to the sericulture community in the world in general and students, teachers, and scientists in the academia for forage and fruit production, genetics, breeding, pathology, entomology, physiology, molecular genetics, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to seed and biofuel industries.

Pensavamo che connettere il mondo avrebbe portato a una pace duratura. La pace, invece, ci sta allontanando. Nei tre decenni seguiti alla fine della Guerra fredda i leader mondiali hanno lavorato per far nascere un mondo connesso: hanno integrato l'economia, i trasporti e le comunicazioni a livello planetario, abbattendo le frontiere nella speranza di rendere impossibile la guerra. Così facendo, hanno inconsapevolmente creato un formidabile arsenale di armi per nuovi tipi di tensioni e ostilità. È preoccupante osservare oggi un aumento dei conflitti a tutti i livelli, dai singoli individui sui social media fino alla guerra vera e propria in Europa orientale. Nell'ultimo decennio abbiamo assistito a un nuovo antagonismo tra Stati Uniti, Russia e Cina; all'incapacità di cooperare su questioni globali come il cambiamento climatico e la risposta alle pandemie; e a un crollo della distinzione tra guerra e pace, dal momento che il teatro del conflitto si è allargato fino a includere le sanzioni, la guerra informatica e le pressioni dei grandi flussi migratori. Mark Leonard, autorità di spicco nel campo delle relazioni internazionali, illustra i modi in cui la globalizzazione ha infranto la sua promessa fondamentale di rendere il nostro mondo più sicuro e più prospero, cercando di capire come strappare un futuro di maggiore speranza per quest'epoca di non-pace.

Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors'environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics. - Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease - Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner - Features chapter contributions from international leaders in the field

The Six Bricks® initiative is a teaching and learning method that encourages focused engagement in the classroom by all learners, from the foundation phase to adulthood. By using six simple, colourful DUPLO® bricks, an element of play is introduced into a situation that inevitably leads to all individuals focusing and interacting. This is one of the major contributions to all teaching and learning disciplines and promotes the audience to learn with enjoyment, enthusiasm and concentration. Along with this, communication is promoted, sparking unimaginable creativity and creation. This book provides the reader with an alternative focus to the original educational application of the Six Bricks® activities. This Six Bricks® initiative focuses on the therapeutic application and processes in communities, schools and within individuals themselves. As each author has had an intimate connection with Six Bricks® initiative, they are all more than qualified to provide their autoethnographic reflections on this initiative, which holds so much promise and excitement for learning and teaching. Therefore, each author's contributions were original and personalised, providing a new field in the avenues of research in the South African context, as South Africa does not have – as yet – much research on this topic. The methodology used in this qualitative research study was primarily from each author's perspective; thus, their self-reflection and anecdotal personal experiences form the core of these chapters. Therefore, this autoethnographic is a self-reflective form of writing which involves self-observation and reflective investigation in the context of ethnographic fieldwork and writing.

Estos diálogos nos hablan del comienzo de una nueva era en los museos, porque estamos ante el comienzo de una nueva era en el mundo. Pero aquí, como en cualquier rincón del planeta, los cambios no surgieron de la nada. Fueron germinando a lo largo de décadas, a medida que olas de transformaciones sociales planteaban nuevas exigencias a las instituciones culturales y se postulaban ideas progresistas sobre qué es un museo. El nuevo siglo ha marcado una fase de pluralismo para las instituciones de arte. Ya no están obligadas a copiar viejos modelos ni a importar ideas foráneas. Se ha abierto un campo fértil de posibilidades para los museos, sobre todo para aquellos que funcionan por fuera de los que se consideraban centros del arte occidental.

Fenomeno di TikTok RJ Shaw non è certo un ragazzo modello, ma da quando ha conosciuto i suoi nuovi compagni di classe ha riconsiderato parecchie cose della vita e di sé stesso. Studia alla Sandover Prep, un prestigioso college popolato da rampolli dell'alta società di cui – suo malgrado – è diventato parte. Già, perché sua madre ha avuto la splendida idea di sposarsi in tutta fretta con un uomo ricchissimo, stravolgendo da un giorno all'altro la loro vita. Non è facile frequentare le lezioni in compagnia di ragazzi che si comportano da perfetti delinquenti. Ma a tormentarlo è soprattutto Sloane Tresscott: dal primo momento in cui l'ha vista, RJ non ha desiderato altro che baciarla. Il problema è che lei è la figlia del preside, e ha messo bene in chiaro che tra loro non potrà mai funzionare. Soprattutto perché l'anno prima ha frequentato uno dei ragazzi più popolari della Sandover, uno che non esiterebbe a rendere la vita impossibile a qualunque rivale. RJ non ha mai sopportato le regole. E la sua ossessione per Sloane potrebbe spingerlo a infrangere tutte quelle della nuova scuola in un colpo solo... Dall'autrice del bestseller Il contratto Oltre un miliardo di visualizzazioni sui social Tradotta in tutto il mondo «L'attrazione tra RJ e Sloane è semplicemente da brividi, pura perfezione. Un libro che si divora pagina dopo pagina.» «Adoro i romanzi che hanno personaggi secondari ben sviluppati e protagonisti di cui è impossibile non innamorarsi.» «La regina delle storie sexy.» Elle KennedyÈ cresciuta a Toronto. I suoi libri sono ai primi posti delle classifiche usa. La Newton Compton ha pubblicato la Campus Series (Il contratto, Lo sbaglio, Il tradimento, L'imprevisto, L'eredità), i primi quattro romanzi della Briar U Series (Resta con me per sempre, Il mio rischio sei tu, Sei l'amore che cercavo, Ti ho trovato quasi per caso), Ti ho incontrato a mezzanotte, Il segreto tra noi due. Misfit e i primi titoli della Avalon Bay Series: Il complesso della brava ragazza. Good Girl Complex e Una ragazza (quasi) cattiva. Bad Girl Reputation.

The ultimate guide to dissemination and implementation research for public health, medicine, and the social sciences In the past twenty years, dissemination and implementation (D&I) research has sought to narrow the gap between the discovery of new knowledge and its application in public health, mental health, and health care settings. The challenges of moving research to practice and policy are universal, and future progress calls for collaborative partnerships and cross-country research. The fundamental tenet of D&I research-taking what we know about improving health and putting it into practice-must be the highest priority. Dissemination and Implementation Research in Health is the definitive roadmap to effecting change in health and science from today's leading D&I researchers. With insights from around the globe, these scholars collectively address key issues in the field including how to evaluate evidence based on effective interventions, how to design an appropriate study, and how to track a set of essential outcomes. Their work has been updated in this third edition with a strong focus on health equity and new chapters on de-implementation, scale-up and sustainment, and training and capacity building. This new edition also focuses on barriers to uptake of evidence-based interventions in the communities where people live their lives and from the social service agencies, hospitals, and clinics where they receive care. Now in its third edition, Dissemination and Implementation Research in Health remains the quintessential guide to making research more consequential for researchers and practitioners in health and the social sciences.

Treatment of pediatric obesity, to date, has largely focused on lifestyle therapy. While lifestyle therapy is essential for obesity management, it is often insufficient, particularly for youth who have severe forms of the disease. Underlying the limitations of lifestyle therapy is the recognition that obesity is a biological disorder of the energy regulatory system and accordingly, to effectively manage obesity, the underpinning pathophysiology needs to be addressed. This pathophysiology can be targeted with more advanced therapies including anti-obesity medications and metabolic and bariatric surgery, two treatment strategies supported by the American Academy of Pediatrics. Written by leading experts in the field, A Practical Guide to Managing Pediatric Obesity is comprised of thirteen chapters, each including suggested protocols and case examples. The first chapter details the complex pathophysiology of obesity and sets the stage for why advanced therapies are critical for effective obesity management. Chapter two provides guidance on best practices for communicating with patients and families about obesity. The next three chapters provide direction on how to do a comprehensive patient assessment, and employ dietary and physical activity interventions. The heart of this guidebook is the chapter on pharmacological treatments, which details the mechanisms of action, research results, and recommendations for anti-obesity medication selection and monitoring outlined in a step-by-step fashion. Pre- and post-operative care for the pediatric bariatric surgery patient is detailed in the next chapter. Assessment and management of behavioral and psychological complications, type 2 diabetes, non-alcoholic fatty liver disease, polycystic ovary syndrome, hypertension, and dyslipidemia are covered in the subsequent five chapters. Syndromic and monogenic obesity are discussed in the final chapter.

Quando Dennis Brinkley, un appassionato collezionista di vecchie macchine da guerra e strumenti di tortura, rimane schiacciato sotto uno dei suoi dispositivi, tutto il villaggio di Forbes Abbot è sconvolto da questa raccapricciante fine. La sua morte viene inizialmente considerata un incidente, ma la sua migliore amica Benny è convinta del contrario, e non è la sola. I suoi sospetti vengono confermati dalla sensitiva locale Ava Garrett, e infatti assicura che durante la sua prossima seduta spiritica chiederà a Dennis di identificare il suo assassino. L'inafferrabile colpevole, però, la mette a tacere prima che l'incontro abbia luogo, lasciando l'ispettore capo Barnaby e il sergente Troy con due orribili omicidi tra le mani. I sospettati non mancano anche perché Dennis Brinkley ha un passato piuttosto ambiguo, tra soci d'affari disonesti, amici non così stretti e relazioni pericolose.

This book analyzes behavioral distortions in public schools and delineates outcome-based performance measurement systems that can prevent and mitigate them. An instrumental view of dynamic performance management (DPM) is used to support the endeavor by identifying how performance drivers affect end results of outcome and output, how end results affect strategic resources, and how strategic resources and benchmarks define the dynamics of performance drivers. This approach is also used to promote a shift from an output-oriented to an outcome-oriented view in performance management, with the aim of achieving sustainable results in the long term. The book also includes a comprehensive literature review at the end of each chapter, intended to strengthen readers'knowledge and encourage further research. Given its scope, the book will appeal to graduate students in public management, researchers in performance management, system dynamics, and education, and decision-makers in public schools.

Nel placido villaggio di Fawcett Green, in un'insospettabile giornata di giugno, molte cose iniziano a non quadrare. Simone, bella e annoiata moglie dell'uomo d'affari Alan Hollingsworth, non si presenta alle prove per uno spettacolo con le campane. Stufa della routine e delle violenze del marito, è forse scappata? Oppure è andata semplicemente a visitare la madre malata? Se la vecchia Mrs. Molfrey, sua vicina di casa, non avesse segnalato la sua scomparsa all'ispettore capo Barnaby, nessuno a Fawcett Green se ne sarebbe accorto o sorpreso. Anche Barnaby non è inizialmente preoccupato, finché non viene trovato il corpo di Alan... E, come se non bastasse, poco dopo sparisce anche la figlia trentenne dei vicini, in circostanze davvero insolite. Man mano che il mistero si infittisce, emergono i numerosi segreti del villaggio e dei suoi abitanti, mentre Barnaby e Troy non posso far altro che scavare nel passato turbolento degli Hollingsworth.

Poor diet and substandard nutrition are underlying causes of many diseases including cardiovascular disease, diabetes, and cancer. Collectively, these ailments are the leading causes of premature death, most of which are preventable. Cooking for Health and Disease Prevention: From the Kitchen to the Clinic helps demonstrate cooking as a fundamental bridge between ideal nutrition and long-term health. Clinicians, patients, and the public often lack adequate knowledge to help select and prepare foods for optimal disease management. This book provides information to clinicians and their patients about foods and cooking principles to help prevent common health conditions.Features: Focuses on disease endpoints, reviewing the disease biology and epidemiology and presenting dietary interventions for disease prevention. Provides recommendations for translating dietary and culinary principles of health prevention into clinical practice and includes a recipe appendix with practical examples. Features information on healthy cooking techniques as well as food selection, storage, and preparation to help maximize nutritional value. Introduces the reader to fundamental concepts in nutrition and culinary principles explaining the relationship between food processing and food preparation and nutritional quality of foods. This book is accessible to patients and offers evidence-based practical interventions for healthcare professionals. It is authored by Nicole Farmer, physician scientist at the NIH Clinical Center, and nutrition researcher Andres Ardisson Korat, awarded a doctorate degree in nutrition and epidemiology from the Harvard T.H. Chan School of Public Health.

Modern medicine is undergoing a paradigm shift from a'one-size-fits-all'strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response.Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.

Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans.We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine. - Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care - Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability - Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human's physiology

Chantaje emocional Carole Mortimer No estaba dispuesta a sucumbir a un chantaje emocional. Georgie seguía enamorada de su exmarido, Jed, pero se había resignado a seguir viviendo sin él porque estaba segura de que jamás podría darle lo que ella quería: amor; y ella nunca podría darle lo que él deseaba: un hijo. Pero Jed Lord siempre conseguía lo que quería. Y, en ese momento, lo único que le preocupaba era recuperar a su esposa... e iba a lograrlo aunque para ello tuviera que chantajearla. Esperanza de un futuro Penny Jordan El país del príncipe Luc D'Urbino estaba inmerso en el caos y solo una boda real podía resolver sus problemas. Años atrás, Carrie Broadbent había compartido una noche de pasión con Luc, pero después él la había rechazado. Por eso se quedó tan sorprendida cuando regresó para pedirle que se casara con él... naturalmente su orgullo le dijo que debía negarse. Pero entonces él amenazó con sacar a la luz un secreto familiar que podía arruinar su reputación. Carrie tenía que aceptar aquella proposición... y quedarse a su lado para siempre. Sería su reina y su amante.

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer's and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States'Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century inits third edition serves as a comprehensive resource to students and researchers alike.

3 grandi thriller N°1 in Inghilterra 3 romanzi in 1 Nei libri di Laura Elliot la tensione psicologica aumenta a ogni pagina, fino al sorprendente, agghiacciante finale. La figlia appena nata di Carla Kelly, top model di successo, è stata rapita. Dalle autorità e dalla stampa nazionale, però, Carla ottiene solo biasimo per come si è comportata nei mesi precedenti, quando, per guadagnare visibilità, è apparsa su tutti i media con il pancione. Dovrà iniziare la sua indagine personale, scavando a ritroso nei segreti del passato. In una calda mattina d'estate, la tredicenne Constance Lawson scompare nel nulla dopo un acceso litigio con i genitori. Quando il suo corpo senza vita viene ritrovato, i sospetti ricadono sullo zio Karl, che si proclama innocente. Ma la giornalista Amanda Bowe cavalca lo scoop dipingendolo come un mostro, fino a rendergli la vita impossibile… L'auto di Amelia Madison finisce in mare, davanti a Mason's Pier. Il suo corpo non verrà mai ritrovato. Due anni dopo, il vedovo Nicholas Madison trova conforto nell'amore di Elena Langdon. Lei non sa molto sul passato di Nicholas, ma un'inquietante lettera, ritrovata per caso, la spinge a farsi delle domande. Troppe domande… Un'autrice ai primi posti delle classifiche in Inghilterra Tre grandi thriller da leggere con il fiato sospeso «Intrigante dall'inizio alla fine: protagonisti credibili, suspense che non lascia scampo.» Booklist «Ci sono così tanti colpi di scena che è impossibile non venire risucchiati tra le pagine.» «Adoro la scrittura di Laura Elliot: ti porta su un ottovolante di emozioni.» «Magistrale, commovente, toccante, incalzante. Ti tiene sempre incollato.» «Laura Elliot dà vita a personaggi ricchi e poliedrici, personaggi con luci e ombre, vittime che diventano carnefici, colpevoli che vedranno sgretolarsi ogni sicurezza conquistata.» Laura ElliotÈ lo pseudonimo con cui June Considine, giornalista e scrittrice di libri per bambini, firma i suoi libri per adulti. È nata a Dublino, e vive a Malahide, una città costiera sul lato nord dell'Irlanda. Ha all'attivo romanzi di grande successo. La Newton Compton ha pubblicato Non parlare con gli sconosciuti, Colpevole e Due anni dopo.

Un thriller épico, ameno y apasionante que ha vendido 5 millones de ejemplares en un año en Reino Unido. La serie protagonizada por Cormoran Strike, convertida en una gran producción de la HBO. El detective privado Cormoran Strike, que se halla en Cornwall visitando a su familia, es abordado en plena calle por una mujer que le pide ayuda para encontrar a su madre, Margot Bamborough, desaparecida en 1974 en extrañas circunstancias. A pesar de que nunca se ha enfrentado a un caso ocurrido tantos años atrás y de ser consciente de las escasas posibilidades de éxito, Cormoran Strike y su compañera en la agencia, Robin Ellacott, que sigue atrapada entre un divorcio tormentoso y sus sentimientos hacia Cormoran, acaban aceptando el caso. A medida que se van sumergiendo en la investigación, los dos detectives se topan con una historia terriblemente compleja poblada de cartas de tarot, un asesino en serie psicópata y testigos que son poco de fiar. Porque incluso un hecho ocurrido hace décadas puede ser mortal. La crítica ha dicho... «Una muestra trepidante del género negro.» Sunday Times «Una narración magistral.» The Daily Telegraph «Un alarde creativo de primer orden.» The Guardian «Una serie policíaca genial. [...] Espléndida.» Sunday Mirror «Comienzas a leer atrapado por los giros inesperados de la trama y acabas fascinado por la relación principal perfectamente trazada.» The Independent «Increíblemente entretenida.» Financial Times

This book summarizes the advanced computational methods for mapping high-density linkages and quantitative trait loci in the rice genome. It also discusses the tools for analyzing metabolomics, identifying complex polyploidy genomes, and decoding the extrachromosomal genome in rice.Further, the book highlights the application of CRISPR-Cas technology and methods for understanding the evolutionary development and the de novo evolution of genes in rice.Lastly, it discusses the role of artificial intelligence and machine learning in rice research and computational tools to analyze plant-pathogen co-evolution in rice crops.

Pack 232 Convénceme Molly Jennings tenía un secreto: era escritora de novelas eróticas con un gran éxito de ventas. Sin embargo, su inspiración se acabó un día por culpa de un exnovio repulsivo y manipulador. Así pues, decidió dejar la ciudad en la que vivía y volver a su pueblo natal, Tumble Creek, en Colorado. Provócame Lori Love siempre había deseado salir de Tumble Creek, pero diez años atrás había heredado el taller de su padre y se había quedado en el pequeño pueblo. Ahora, según su amiga Molly, lo que necesitaba era algo excitante, preferentemente en forma de ardiente aventura, sin ataduras y con sexo a raudales. Sígueme El hombre equivocado podía ser el hombre perfecto para ella. La pura atracción animal… era algo que desdeñaba la directiva Jane Morgan, siempre tan correcta y recatada. Así pues, ¿por qué se sentía tan atraída por William Chase, que tenía los bíceps llenos de tatuajes y llevaba botas con refuerzo de acero en la puntera? ¡Aquel hombre se ganaba la vida haciendo saltar cosas por los aires! Una novela con una temática real e interesante, divertida, con muy buenas escenas hot pero sin llevar el protagonismo y con buenos personajes. Lectura Adictiva

Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Over the course of the last decade, political and mental entities at large have embraced global mental health: the idea that psychiatric health is vital to improved quality of life. Physicians globally have implemented guidelines recommended by the National Institute of Mental Health (NIMH) in 2007, thereby breaking down barriers to care and improving quality of life in areas where these practices have been implemented. Programs for training and education have expanded as a result. Clinicians benefit more from both local resources in some regions as well as in international collaboration and technological advancements. Even amidst all of these positive outcomes, clinicians still face some stumbling blocks. With worldwide statistics estimating that 450 million people struggle with mental, neuropsychiatric, and neurological disorders—25 percent of the world's non-communicable disease burden—rising to these challenges prove to be no small feat, even in wealthy Western nations. Various articles and books have been published on global mental health, but few of them thoroughly cover the clinical, research, innovative, and social implications as they pertain to psychiatry; often, only one of these aspects is covered. A comprehensive text that can keep pace with the rapidly evolving literature grows more and more valuable each day as clinicians struggle to piece together the changes around the world that leave open the possibility for improved outcomes in care. This book seeks to boldly rectify this situation by identifying innovative models of service delivery, training, education, research funding, and payment systems that have proven to be exemplary in implementation and scalability or have potential for scalability. Chapters describe specific barriers and challenges, illuminating effective strategies for improved outcomes. This text is the first peer-reviewed resource to gather prestigious physicians in global mental health from around the world and disseminate their expertise in the medical community at large in a format that is updateable, making it a truly cutting-edge resource in a world constantly changed by medical, scientific, and technological advances. Innovations in Global Mental Health is the ultimate resource for psychiatrists, psychologists, primary care physicians, hospitalists, policy makers, and all medical professionals at the forefront of global mental health and its implications for the future.

Sin culpa Virgil Skinner cumplió una condena de catorce años por un asesinato que no había cometido. Finalmente, fue absuelto. Sin embargo, no podía escapar de la banda mafiosa a la que se había unido en la cárcel para poder sobrevivir. Ellos estaban dispuestos a hacer lo que fuera con tal de impedir que contara todo lo que sabía. La subdirectora Peyton Adams se oponía a tener a Virgil en su cárcel. ¿Cómo podría protegerlo si las cosas salían mal? Además, se sentía demasiado atraída por él. Tanto, que deseaba desesperadamente mantenerlo a salvo… Perseguida Han vuelto… Laurel Hodges había cambiado dos veces de identidad. Llevaba cuatro años huyendo. Por fin había encontrado la paz y la estabilidad en el pequeño pueblo, en Montana. Sin embargo, justo cuando creía que sus hijos y ella estaban seguros… la pesadilla comenzó de nuevo. El sheriff Myles King se había convertido en el ángel de la guardia de Laurel. Él sabía que la atracción que sentía por ella era cada vez más intensa, hasta el punto de que estaba empezando a pensar en el matrimonio y la familia. Sin salida La verdad podía matar… La madre de Claire O'Toole, Alana, había desaparecido hacía quince años, y aquel suceso había provocado una conmoción en Pineview, Montana, la clase de pueblo donde nunca ocurría nada. Un año antes, el marido de Claire, David, había muerto a causa de un extraño accidente justo después de empezar a investigar la desaparición de Alana. ¿Había muerto Alana o simplemente había abandonado a su marido y a sus hijas? Claire estaba empeñada en averiguarlo, y su antiguo novio, Isaac Morgan, quería ayudarla. Y, sin embargo, solo volvió a formar parte de su vida cuando empezó a sospechar que la muerte de David no había sido un accidente.

Events Management 4e helps organisers embrace the multidimensional nature of events management and cultivate organisers'leadership skills and attitudes. The fourth edition consists of: real life event scenarios illustrations, combination of theoretical principles and practice, case studies demonstrate real-life issues and provide a framework for discussion, resource lists providing further reading at the end of each chapter, end-of-chapter discussion questions draw out various issues.

Comprehensive, authoritative, and up to date, Pizzo and Poplack's Pediatric Oncology, 8th Edition, remains your most trusted source of information on the care and research of children with cancer. This award-winning text is the single most comprehensive reference on the biology and genetics of childhood cancer, its diagnosis and multimodal treatment, and long-term management. In the tradition of excellence established by Drs. Philip A. Pizzo and David G. Poplack, this 8th Edition keeps you fully informed while helping you collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families.

È Halloween, e a Braxton si sta scatenando la voglia di intagliare le zucche di Jack-O'Lantern, andare in giro per i fienili infestati e correre attraverso lo spettrale labirinto di mais del Festival d'Autunno. Nonostante gli avvertimenti dell'ex occupante, Kellan ristruttura e si trasferisce in una misteriosa vecchia casa. Quando un fantasma spietato promette vendetta, il nostro impavido professore si rivolge all'eccentrico storico della città e a un inquietante sensitiva per mettersi in contatto con lo spirito. Nel frattempo, i lavori di ristrutturazione della Biblioteca Memoriale, riportano alla luce i resti di un cadavere scomparso cinquant'anni prima. Mentre Kellan e April cedono alla chimica nata tra loro, si verifica un incidente sospetto al Festival d'Autunno. Kellan si vede quindi costretto a indagare nella vera storia e negli orribili segreti della famiglia Grey. Riuscirà a catturare lo sfuggente assassino e placare il fantasma in cerca di vendetta?

Questo breve libro è il testo di una conferenza che ha cambiato la vita di migliaia di persone. Il suo autore, il grande filantropo Russell Herman Conwell, non solo difende la ricchezza materiale, presentandola come una condizione essenziale per fare del bene al prossimo e alla società, ma ci indica anche come conseguirla. Prendendo le mosse dalla storia del contadino persiano che desiderava possedere una miniera di diamanti senza accorgersi che questi si nascondevano già nel suo terreno, e analizzando altri racconti di successi e insuccessi, Conwell ci dimostra come le migliori opportunità siano spesso sotto i nostri occhi e stia a noi vederle e coglierle. È quello che hanno saputo fare uomini e donne d'affari di successo, che grazie al loro genio sono riusciti ad accumulare ingenti patrimoni. Oggi le occasioni per fare fortuna non sono cambiate dai tempi di Conwell, e questo classico della letteratura inspirational ci invita a guardare dentro di noi e attorno a noi – la nostra vita, le nostre conoscenze, le nostre relazioni e amicizie –, per scoprire il nostro potenziale «campo di diamanti» e farlo fruttare.

Nel lontano 1962 Rachel Carson denunciava per la prima volta i pericoli dell'eccessivo e sregolato sfruttamento dell'ambiente nel suo lungimirante Primavera silenziosa. Oggi più che mai l'urgenza di una consapevolezza ecologica informa la ricerca umanistica e scientifica a livello globale. Partita dagli studi letterari, l'ecocritica è stata recentemente declinata in un numero sempre maggiore di settori del sapere. In questo volume gli autori propongono originali riflessioni sul rapporto tra cultura, storia e ambiente in un'ottica multidisciplinare. Per indagare cosa ci possa dire di nuovo l'ecocritica sul mondo in cui viviamo, sulle sue rappresentazioni e sul rapporto che con esso intessiamo, il libro rilegge in chiave ambientalista figure come lo scrittore britannico W. Somerset Maugham, lo scienziato ottocentesco Quirico Filopanti, ammirato da Garibaldi, il disaster movie americano, la chanson engagée in Francia, la didattica in Italia e in Europa, nonché l'attuale e la possibile futura giurisprudenza in materia.

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. - Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease - Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research - Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare - Features chapter contributions from a wide range of international researchers in the field

The problems related to the process of industrialisation such as biodiversity depletion, climate change and a worsening of health and living conditions, especially but not only in developing countries, intensify. Therefore, there is an increasing need to search for integrated solutions to make development more sustainable. The United Nations has acknowledged the problem and approved the “2030 Agenda for Sustainable Development”. On 1st January 2016, the 17 Sustainable Development Goals (SDGs) of the Agenda officially came into force. These goals cover the three dimensions of sustainable development: economic growth, social inclusion and environmental protection. The Encyclopedia of the UN Sustainable Development Goals comprehensively addresses the SDGs in an integrated way. It encompasses 17 volumes, each devoted to one of the 17 SDGs. This volume addresses SDG 4, namely'Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all'and contains the description of a range of terms, to allow a better understanding and foster knowledge.Concretely, the defined targets are:Ensure that all girls and boys complete free, equitable and quality primary and secondary education leading to relevant and effective learning outcomesEnsure that all girls and boys have access to quality early childhood development, care and pre-primary education so that they are ready for primary educationEnsure equal access for all women and men to affordable and quality technical, vocational and tertiary education, including universitySubstantially increase the number of youth and adults who have relevant skills, including technical and vocational skills, for employment, decent jobs and entrepreneurshipEliminate gender disparities in education and ensure equal access to all levels of education and vocational training for the vulnerable,including persons with disabilities, indigenous peoples and children in vulnerable situationsEnsure that all youth and a substantial proportion of adults, both men and women, achieve literacy and numeracyEnsure that all learners acquire the knowledge and skills needed to promote sustainable development, including, among others, through education for sustainable development and sustainable lifestyles, human rights, gender equality, promotion of a culture of peace and non-violence, global citizenship and appreciation of cultural diversity and of culture's contribution to sustainable developmentBuild and upgrade education facilities that are child, disability and gender sensitive and provide safe, non-violent, inclusive and effective learning environments for allSubstantially expand globally the number of scholarships available to developing countries, in particular least developed countries, small island developing states and African countries, for enrollment in higher education, including vocational training and information and communications technology, technical, engineering and scientific programmes, in developed countries and other developing countriesSubstantially increase the supply of qualified teachers, including through international cooperation for teacher training in developing countries, especially least developed countries and small island developing statesEditorial BoardOlivia A.M. Freeman, Johannes M. Luetz, Petra Molthan-Hill, Theam Foo Ng, Umesh Chandra Pandey, Rudi Pretorius, Valeria Ruiz Vargas, Pinar Gökçin Özuyar

Climate resilience, or the capacity of socio-ecological systems to adapt and upkeep their functions when facing physical-chemical stress, is a key feature of ecosystems and communities. As the risks and impacts of climate change become more intense and more visible, there is a need to foster a broader understanding of both the impacts of these disruptions to food, water, and energy supplies and to increase resilience at the national and local level. The Handbook of Climate Change Resilience comprises a diverse body of knowledge, united in the objective of building climate resilience in both the industralised and the developing world. This unique publication will assist scientists, decision-makers and community members to take action to make countries, regions and cities more resilient.

Now in its fully revised and expanded third edition, this comprehensive text represents a compilation of the critical endocrinology topics in the areas of sports medicine, kinesiology and exercise science, written by leading experts in the field. As in previous editions, the focus here is on the critical issues involved in understanding human endocrinology and hormonal workings with regards to physical activity, exercise and sport and how such workings impact the full range of medical conditions, overall health and physiological adaptation. Chapters included discuss the effect of exercise on the HPA axis, the GH-IGF-1 axis, thyroid function, diabetes, and the male and female reproductive systems, among other topics. Additional chapters present the current evidence on circadian endocrine physiology, exercise in older adults, exercise and hormone regulation in weight control, and the effects of overtraining in sports. Chapters brand new to this edition present the role of hormones in muscle hypertrophy, the effect of exercise on hormones in metabolic syndrome patients, how exercise impacts appetite-regulating hormones in clinical populations, and the relative energy deficiency in sport (RED-S) condition.

This book informs and enlighten health professionals on how the recognition of fearing women can change their episode of care during childbearing. It gives practical advice on the way women present to services and the challenges that this invokes. This work is the first of its kind aimed at clinicians to deconstruct ideology around childbearing myths and its challenges. The authors review the evidence that exists and how modern maternity systems are responding to fear and shaping healthcare. Whilst some worry and anxiety is expected and indeed considered normal during childbearing, it has been suggested that this has now proliferated to a degree of abnormal for many women. Why is that and how is this panic spread? Media portrayal of birth is suggested as unrealistic material and to show only that which is dramatic and horrific. This has been considered as one factor influencing modern women. Medicalisation, technology and demandupon services is another consequence of providing almost all maternity care in hospitals. Given that the majority of childbearing women are fit and healthy is this another causative factor? By removing women from their homes and families at such a vulnerable time has a serious consequence for how she will experience her greatest leap of faith into motherhood. All of these issues are explored and examined in the book with ideas and practical suggestions of what may be done to change this increasingly common problem. This book is intended at midwives and clinicians working in maternity settings.

Esta es la tercera edición de Física nuclear y de partículas, un libro de texto que aborda con rigor y claridad temas importantes puestos al día, tales como los conocimientos sobre núcleos, la variedad de desintegraciones y reacciones nucleares y sus aplicaciones, así como el estudio de los constituyentes más elementales de la materia: quarks y leptones. Su contenido se dirige a los estudiantes de físicas, de ingenierías y otras titulaciones afines. No obstante, científicos y tecnólogos encontrarán asimismo capítulos de interés relativos a la radiación nuclear, una descripción de los aceleradores y detectores de partículas, los métodos de análisis de datos y los fundamentos y aplicaciones de las reacciones de fisión y fusión nuclear.

Ethical Debates in Orangutan Conservation explores how conservationists decide whether, and how, to undertake rehabilitation and reintroduction (R&R) when rescuing orphaned orangutans. The author demonstrates that exploring ethical dilemmas is crucial for understanding ongoing disagreements about how to help endangered wildlife in an era of anthropogenic extinction. Although R&R might appear an uncontroversial activity, there is considerable debate about how, and why, it ought to be practised. Drawing on in-depth qualitative research with orangutan conservation practitioners, this book examines how ethical trade-offs shape debates about R&R. For example, what if the orphan fails to learn how to be an orangutan again, after years in the company of humans? What if she is sent into the forest only to slowly starve? Would she have been better off in a cage? Could the huge cost of sending a rescued ape back to the wild be better spent on stopping deforestation in the first place? Or do we have a moral obligation to rescue the orphan regardless of cost? This book demonstrates that deconstructing ethical positions is crucial for understanding ongoing disagreements about how to help our endangered great ape kin and other wildlife. Ethical Debates in Orangutan Conservation is essential reading for those interested in conservation and animal welfare, animal studies, primatology, geography, environmental philosophy, and anthropology.

Lawson Scott è stato prigioniero per tre anni. È stato sottoposto a tortura, degradazione e a numerosi test da parte di umani che volevano il sangue dei mutaforma. È convinto che passerà il resto della sua vita incatenato a un muro fino a quando la scienziata sexy, Liv Kimbro, non sarà assegnata al suo caso. Lei è la prima umana a mostrare un'oncia di compassione e la loro attrazione è forte nonostante il suo disprezzo per la sua specie. Sviluppa un piano di fuga e Lawson vede fino a che punto Liv si spingerà per liberarlo. La passione esplode e si scatena un bisogno primordiale e crudo quando soccombono al loro desiderio l'uno per l'altra. Lawson raggiungerà il suo rifugio sicuro e troverà una compagna di vita quando Liv catturerà il suo cuore o le loro differenze distruggeranno loro e tutti quelli che ama?

Miközben Gwendolyn Kidd Cosmopolitan koktélt iszik, találkozik álmai férfijával. És a találkozásból furcsa kapcsolat lesz a titokzatos férfival, aki éjszakáról éjszakára megjelenik a szobájában, mindig többet akarva.

May Delancy necesitaba a alguien que fingiera ser su novio, y su vecino, un soltero muy atractivo, era la solución perfecta. A May no se le pasaba por la cabeza enamorarse de él, ya que el arrebatador Rick Lawson era un hombre que estaba casado con su trabajo, y parecía empeñado en no renunciar a su soltería. Sin embargo, Rick interpretó el papel de atento enamorado de un modo tan convincente que ella no pudo evitar pensar en el matrimonio...

Iba a usar todos sus encantos para seducirla… Los clientes de Hoot's Roots siempre habían tenido suficiente con las hamburguesas, por eso cuando Stephanie Lawson decidió, con la aprobación de la clientela femenina, convertir la cafetería familiar en un restaurante de lujo, estaba claro que se desencadenaría una guerra de sexos. Pero los hombres tenían un arma secreta: el cowboy Quint Ryder, cuya misión consistía en utilizar sus encantos para seducir a Stephanie y hacer que olvidara su afición por la alta gastronomía. Sin embargo, Stephanie parecía ser la única fémina inmune a su atractivo. ¿Conseguiría Quint conquistar su corazón, o acabaría rindiéndose como habían hecho otros?

Ha commesso un terribile sbaglio. Ora tutta la sua famiglia è in pericolo. In una calda mattina d'estate, la tredicenne Constance Lawson scompare nel nulla dopo un acceso litigio con i suoi genitori. Qualche giorno dopo, viene ritrovato il suo corpo senza vita e i sospetti ricadono sullo zio Karl, l'unico adulto con il quale la ragazza avesse un rapporto di complicità. I media, infatti, scalpitano per individuare un colpevole e Karl fa proprio al caso loro: la giornalista Amanda Bowe non ha nessuna intenzione di lasciarsi sfuggire l'occasione di uno scoop epocale, raccontando per prima la storia dell'uomo che potrebbe avere ucciso la nipote. Sono passati sei anni e la vita di Karl è un disastro. Il suo matrimonio è naufragato, la sua famiglia è distrutta. La donna che l'ha rovinato, invece, ha tutto quello che si possa desiderare: una carriera brillante, un marito che la ama e un bellissimo bambino. Il mondo di Amanda è perfetto. Fino al giorno in cui riceve una telefonata e, in un lampo, si ritrova intrappolata senza scampo nel suo peggior incubo. Un solo errore potrebbe distruggere la tua famiglia «Intrigante dall'inizio alla fine: protagonisti credibili, suspense che non lascia scampo.» Booklist «Ci sono così tanti colpi di scena che è impossibile non venire risucchiati tra le pagine.» «L'ho divorato in pochissimo tempo, avevo bisogno di sapere!» «Una trama costruita egregiamente e personaggi realistici.» Laura Elliotè lo pseudonimo con cui June Considine, giornalista e scrittrice di libri per bambini, firma i suoi libri per adulti. È nata a Dublino, e vive a Malahide, una città costiera sul lato nord dell'Irlanda. Ha all'attivo romanzi di grande successo. Prima di Colpevole, la Newton Compton ha già pubblicato Non parlare con gli sconosciuti.

The Second Handbook of English Language Teaching provides a comprehensive examination of policy, practice, research and theory related to English language teaching in international contexts. Over 70 chapters focus on the research foundation for best practices, frameworks for policy decisions, and areas of consensus and controversy in second-language acquisition and pedagogy. In countries around the globe, English has become the second language taught most frequently and intensively. In many countries, particularly in Asia, government policies have made English a part of the curriculum from primary school on. Demand for English teaching by parents and adult learners is fueled by the desire to increase economic competitiveness, globalization of the workforce, immigration, and a move toward lifelong learning. Immigration has led to an increased demand for English-language teaching even in countries where English is the dominant language.

El libro en que se basa la nueva película de Martin Scorsese, protagonizada por Leonardo DiCaprio y Robert De Niro, entre otros. El autor de Z, la ciudad perdida, David Grann, regresa con un emocionante True Crime que desvela una de las conspiraciones más monstruosas de la historia de Estados Unidos. Best Seller de The New York Times, mejor libro del 2017 según Amazon y Ganador del Edgar Allan Poe Award al Best Fact Crime. En los años veinte, la comunidad india de los Osage en Oklahoma era la población de mayor renta per cápita del mundo. El petróleo que yacía bajo sus propiedades les convirtió en millonarios: construyeron mansiones, tenían chóferes privados y mandaban a sus hijos a estudiar a Europa. Pero un espiral de violencia asoló esta comunidad indígena cuando sus miembros empezaron a morir y a desaparecer en extrañas circunstancias. La familia de una mujer Osage, Mollie Burkhart, se convirtió en un objetivo principal. Sus tres hermanas fueron asesinadas. Una fue envenenada, otra murió a tiros y la tercera falleció en una explosión. Otros miembros de la los Osage morían en circunstancias misteriosas, y muchos de los que se atrevieron a investigar los crímenes fueron también asesinados. Cuando el número de muertos alcanzó los veinticuatro, el recién inaugurado FBI decidió intervenir y fue uno de sus primeros grandes casos de homicidio. Después de que la investigación resultara un desastre, el joven director J. Edgar Hoover acudió al antiguo comandante de Texas, Tom White, para que desvelase el misterio. White estableció un equipo infiltrado, incluyendo a un agente nativo en el grupo. En este apasionante true crime,que Martin Scorsese y Leonardo DiCaprio llevarán a la gran pantalla, se revelan nuevos secretos de una de las conspiraciones más siniestras contra la comunidad indígena de Estados Unidos. Como ya hizo en Z, la ciudad perdida, Grann se sumerge en una profunda y exhaustiva investigación para desvelar uno de los episodios más oscuros y despiadados de la Historia norteamericana. La crítica ha dicho: «Los asesinos de la luna es un relato perturbador, agonizante y sin parangón, capaz de estrujarte el estómago en un puño y no soltarlo hasta leer la deliberación final, que invito a que conozcas de la mano de Grann» Alba R.Prieto, Negra y mortal «Una historia increíble y monstruosamente disparatada, pero desgraciadamente cierta, estupendamente bien contada en un espléndido ejercicio de nuevo periodismo. Una vez más, la realidad supera a la ficción.» Antonio F. Rodríguez, La Antigua Biblos «Los asesinos de la luna es un libro magnífico, una cautivadora historia real de avaricia, asesinatos en serie e injusticia racial [...]. David Grann es un periodista extraordinario, y esta obra es quizá lo mejor que ha escrito.» Jon Krakauer «Perturbador y fascinante [...] abrasará tu alma.» Dave Eggers, The New York Times Book Review «La historia criminal que cuenta es atroz y repleta de héroes y villanos reales. Hará que te estremezcas ante la inhumanidad del hombre hacia sus congéneres.» Dwight Garner, The New York Times «Como un maestro de la historia detectivesca, Grann sabe guardarse lo mejor para el final. Es ahí donde su investigación meticulosa, paciente y detallada finalmente penetra la neblina de mentiras y pruebas comprometedoras para llegar al sólido territorio de la verdad.» The Wall Street Journal