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多様性を持つデジタル時代のコレクションの概念を再考する デジタルコンテンツの収集、保存、活用を巡る諸問題に対処するには、異なる分野のステークホルダー間の協力が不可欠である。 既に多くの分野で進められている取り組みを踏まえ、コンテンツの収集、保存、活用に関連する概念や理論を総合的に検討。また、ネットワークを通じたコレクションの構築、マイクロコンテンツの活用など、現代における具体的な事例を提示し、さらにこれまでの理論と実践を基に、デジタルコンテンツの収集、保存、活用に関するさらなる議論を展開する。

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

Das Standardwerk für alle in der Geburtshilfe und Perinatalmedizin tätigen Ärztinnen und Ärzte und Interessierte liegt nun unter neuer Herausgeberschaft vor. In der 6. Auflage komplett aktualisiert und dem aktuellen evidenzbasierten Wissen und Methoden angepasst. Mehr als die Hälfte der Kapitel mit neuer Autorenschaft und erweitert um neue Themen, u.a. Adipositas und Schwangerschaft, Geburtsmodus bei fetalen Fehlbildungen, Management von Placenta increta, Patient Blood Management. Plus: Von der Evidenz zur Handlungsempfehlung, praktisches geburtshilfliches multiprofessionelles Traning. „Die Geburtshilfe“ beantwortet die zahlreichen Fragen, die sich Ärztinnen und Ärzte und Hebammen rund um die Themen Schwangerschaft, Geburt und Perinatalmedizin stellen. Verständlich, klar strukturiert und an der Praxis orientiert mit eindeutigen Angaben zur Dosierung von Medikamenten, Algorithmen und Hinweisen auf Komplikationen. Als ebook und Live-Reference ermöglicht es den direkten Zugriff zu jeder Zeit sowie auf Links zu wichtigen Websites. Für eine kompetente und einfühlsame Betreuung und Begleitung der werdenden Mutter von der Schwangerschaft bis nach der Entbindung.

Nanotherapeutics for Inflammatory Arthritis: Design, Diagnosis, and Treatment highlights nanobiotechnology and its therapeutic applications in the field of inflammatory arthritis, the interaction of nanomaterials in the biological systems, and clinical development of nanomedicines. It also covers the discovery of personalized therapeutics, diagnostics, and nanoparticular delivery systems, the role of bioinformatics nanobiotechnology in personalized oncology. The use of nanosensors for the detection and current challenges in the development of personalized medicine is explained including recent nanotechnology-based strategies.Features: Covers all the fundamental information about nanotechnology and inflammatory arthritis. Highlights the interaction of nanomaterials in the biological systems, and the clinical development of nanomedicines for inflammatory arthritis. Explores the discovery of personalized therapeutics, diagnostics, and nanoparticle delivery systems. Reviews the current challenges in the development of personalized medicine as well as translation of nanomedicine with combination therapy. Discusses the toxicology of using nanomedicines and the risks associated with the use of these nanomedicines. This book is aimed at researchers and professionals in nanotechnology, biomaterial, drug delivery, and inflammatory arthritis.

Nel Medioevo si credeva davvero che la Terra fosse piatta? Violaine Giacomotto-Charra e Sylvie Nony tracciano la storia di questo luogo comune e cercano di comprenderne la genesi. A partire dalle fonti antiche, questo libro rigoroso e vivace esplora la storia della scienza e del sapere durante il Medioevo e il Rinascimento e si concentra sulla genealogia del mito della Terra piatta per capire perché persista nonostante le evidenze scientifiche contrarie. Una riflessione, non priva di umorismo, su come le idee errate possono resistere nel tempo e sul modo in cui le credenze si diffondono nella società.

O Jiu-Jitsu Brasileiro é um esporte de luta que cresce rapidamente e conta com um amplo espectro de praticantes. Esse esporte intercala exercícios anaeróbicos muito intensos com períodos mais ou menos longos de atividades de menor intensidade. Observamos que os atletas com maiores níveis de carga e tempo de prática dessa arte marcial apresentavam alterações fenotípicas dos dedos das mãos semelhantes aos pacientes idosos com osteoartrite (OA). Então, tentando compreender essa afecção, desenvolvemos estudos com a aplicação de diversos instrumentos que culminaram com a publicação desta obra. Assim, o objetivo geral deste livro é descrever as lesões dos dedos típicas do estresse crônico proveniente da prática do BJJ, tanto clínica como radiograficamente, cunhando o termo Osteoartrite Prematura das Mãos (OAPM) em atletas de Jiu-Jitsu Brasileiro, as chamadas'mãos do Jiu-Jitsu'. O leitor encontrará aqui uma extensa e profunda revisão sobre o que se sabe atualmente nas áreas de anatomia, histologia, bioquímica e genética a respeito da cartilagem articular e sobre a osteoartrite (OA), doença complexa, heterogênea e cada vez mais prevalente no planeta.

Holistically addresses women's health, encompassing the needs of transgender and nonbinary individuals and considering ethnicity, social class, and disability/ableness Delivering incisive and comprehensive information on the healthcare needs of women, transgender, and nonbinary persons, the third edition of this distinguished text incorporates a strong focus on the provision of high value, equitable, and unbiased care. It expands research and clinical frameworks for understanding women's health to encompass transgender and nonbinary persons and places women's health within a holistic perspective considering ethnicity, social class, and disability/ableness. All chapters are significantly updated with new evidence-based research, clinical updates and guidelines, drug information, Covid-related information, racism, and health disparities. This text also covers current and pertinent health topics such as substance use and abuse, mental health, early pregnancy decision-making, and LGBTQ+ care, as well as abundant integrated information on care of transgender and nonbinary individuals, and enhanced information on pregnancy and primary care issues that disproportionately affect females. The book is organized for ease of use and is comprised of three distinct but interrelated sections on theoretical frameworks to guide approach and care, health promotion and prevention, and managing health conditions. Rich instructor resources include mapping content to AACN Essentials, case studies, a test bank, and PowerPoint slides. New to the Third Edition: Focuses on providing equitable, unbiased care for all women including transgender and nonbinary individuals Updated with new evidence-based research, clinical updates and guidelines, drug information, Covid-related information, and racism and health disparities information Expanded information on care of transgender individuals Enhanced content on pregnancy and related issues Four-color presentation to enhance readability Incorporates content in WHNP and CNM national certification examination blueprints Key Features: Distills cutting-edge information on women's health issues through a sociocultural framework Edited by renowned scholar/educators for AP nursing students Organized to provide easy retrieval of clinical information Addresses genetics, LGBTQ+ health, endocrine-related problems, health considerations for women caregivers, dementia care, and more Includes relevant web resources and apps in each chapter Provides extensive instructor toolkit to foster critical thinking

This book presents one of the most extensive MRI image collections of wrist pathology, including common, less frequent, unusual and combined pathology to enhance the common knowledge of radiologists and wrist surgeons to an expert level. Additionally, the comprehensive overview allows the reader to compare MRI exams in the clinic to the provided extensive database and helps with diagnostic and clinical solutions. The currently available basic theoretical information can already be found in many other publications, and will be limited to the essentials that are needed to explain and/or understand the MR images. This book goes beyond the basic information and aims to provide a unique guide for a wide range of wrist pathologies. In addition, rather difficult test images are added at the end in order to encourage the reader to closely observe and analyse key details in the images.

Critical Care Obstetrics Improve medical outcomes for both mothers and children with this essential guide For the first time in decades, maternal mortality rates are climbing in the United States. Factors including lack of access to prenatal care, un- or underinsured populations, rising rates of cardiovascular disease, and more combine to make pregnancy and childbirth more dangerous prospects. In this environment, the study of critical care obstetrics has never been more essential. Critical Care Obstetrics, Seventh Edition a fully updated guide to the medical management of serious conditions in pregnancy and childbirth. Beginning with basic principles, it surveys the potential serious complications occurring in pregnancy and delivery and the techniques and procedures for maximizing patient outcomes for both pregnant people and fetuses. This clear, accessible text promises to continue the essential work of earlier editions. Readers of the seventh edition of Critical Care Obstetrics will also find: Detailed protocols for implementing life-saving treatments in emergencies New chapters on topics including ECMO, antibiotics, and pneumonia Authorship by internationally renowned experts in emergency obstetrics Critical Care Obstetrics is ideal for working clinical obstetricians and for trainees in obstetrics and gynecology.

Queenan's Management of High-Risk Pregnancy The new edition of the long-standing classic text, covering all areas of perinatal medicine Continuing to set the standard for maternal-fetal practice, the seventh edition of Queenan's Management of High-Risk Pregnancy provides practical, clinically useful information on the full spectrum of perinatal care. Focused on clinical decision-making, this invaluable reference contains authoritative, evidence-based information on the factors of high-risk pregnancy, biochemical and biophysical monitoring, maternal disease, obstetric complications, patient safety in labor and delivery, and more. With more than 50 concise chapters, this text has been written by leading experts, and contains evidence-based protocols, algorithms, case studies, potential outcome measures, medications, and illustrative case reports to ensure the best possible outcomes for fetal and maternal patients. This text offers clear guidance on the common problems encountered in the day-to-day management of high-risk pregnancies. The seventh edition of Queenan's Management of High-Risk Pregnancy includes new and updated chapters with the most current evidence-based information and protocols available on topics such as infectious diseases in pregnancy, vaping, operative vaginal delivery, postpartum hemorrhage, pregnancies in women with disabilities, maternal anemia, malaria, and HIV infection. Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Seventh Edition, remains an indispensable reference and guide for obstetricians, gynecologists, OB/GYN trainees, midwives, and primary and general practitioners.

Biosensors in Precision Medicine: From Fundamentals to Future Trends covers important topics regarding biomarkers, including biomarker discovery, validation, application in precision medicine, the principles of biosensors, their use in precision medicine, important analytical parameters, recent advances in bioreceptors and transduction, and more. Finally, the hottest trends of biosensors in precision medicine, including lab-on-a-chip and wearable devices, advances towards telemedicine, machine learning, artificial intelligence and the commerciality of these devices are discussed. - Provides a timely review of the state-of-the-art developments in biosensors and their applications in precision medicine - Presents an evaluation of case studies, along with real-life examples - Addresses recent trends on biosensors for precision medicine

This book provides a comprehensive compilation of standard rheumatology ultrasound scans. It systematically incorporates normal and pathological sonography findings of various structures and rheumatic disorders. The format of this book presents standard scans that cover a whole range of anatomic sites: shoulder, elbow, wrist, fingers, hip, knee, ankle, forefoot and toes. Each scan is accompanied by a picture showing the position of the probe, an anatomic drawing, an ultrasound image and an explanation of the ultrasound scan. At the end of each section on an anatomical site, the relevant ultrasound-guided injection procedure is explained. Musculoskeletal Ultrasound for the Rheumatologist: An Introductory Guide, 3rd Edition has been fully updated while maintaining the highly readable, well-organized structure found in the previous editions. The book provides a clear introduction to the rapidly growing field of sonography in rheumatology and is a conciseand efficient tool for self-teaching. Clinicians seeking to refine their basic and advanced skills in rheumatological sonography will find this book to be an essential resource for their everyday practice.

Management of Infertility: A Practical Approach offers an accurate and complete reference for the management of infertility and a robust step-by-step guide for assisted reproduction technologies (ARTs), including how to plan, design and organize a clinical setting and laboratory. The book also provides an evidence-based, complete and practical description of the available methods for diagnosis and management of male and female infertility. This will be an ideal resource for researchers, students and clinicians who want to gain complete knowledge about both basic and advanced information surrounding the diagnosis and management of infertility and related disorders. - Provides a step-by-step guide on how to design, plan and organize an Assisted Reproductive Technology (ART) unit and laboratory - Deeply discusses both male and female factor infertility, providing a complete guide for the diagnosis and treatment of the different causes of infertility - Addresses all the techniques of assisted reproduction and in vitro fertilization, discussing their use in different clinical settings

This book comprehensively reviews the phytochemistry, functional properties, and health-promoting effects of bioactive compounds found in oil processing by-products, and it also explores the food and non-food applications of these by-products. Several oilseeds, vegetables, and fruits are cultivated for their oils and fats, wherein the oil extraction industry generates a huge amount of waste (meal or cake). The valorisation of this waste would be very beneficial not only from the economic and environmental perspectives, but also for the potential applications in food, cosmetics and pharmaceutical industries, in which phytochemicals derived from vegetable oil and oilseed processing by-products play an important role in, for instance, extending the shelf life of several products and providing added-value properties with their antioxidant and antimicrobial properties. In this work, expert contributors discuss about the added-value of biowaste from common and non-traditional vegetable oils and oilseeds processing, as well as fruit oils processing, and offer an extensive overview of the different bioactive compounds found in extracts from oil processing by-products and their chemical composition. The book also collects several examples in which oil processing by-products are integrated into industrial activities such as food production, livestock production and in pharmaceutical and cosmetics industries. Professionals and scholars alike interested in the recycling of agro-industrial wastes derived from vegetable oil and oilseed processing by-products will find this book a handy reference tool.

This book is a comprehensive work that spans the gap between basic knowledge and clinical significance of the placenta. Starting from normal development, it deals with the histopathology of the placenta, leads the reader on to functional disorders and insufficiencies and explains their effects on mother and child. Based on this, the authors convey in a practical and user-friendly manner everything worth knowing about diagnostics and therapy and provide valuable information for the optimal care of the pregnant patient.

Handbook of Current and Novel Protocols for the Treatment of Infertility is a valuable resource of well-organized, comprehensive scientific data with practical guides and step-by-step protocols for infertility management. Written by contributors located worldwide, this book discusses different practice patterns and approaches used internationally, along with innovative topics including preimplantation genetic testing, time lapse imaging and the role of artificial intelligence in ART. This book provides up-to-date, evidence-based guidance on daily practice and is a valuable resource for infertility providers, including trainees in the field of reproductive endocrinology and infertility, embryologists, specialists in reproductive medicine and gynecologists.The field of Assisted Reproductive Technology (ART) is rapidly evolving and stimulation protocols, fertility strategies and aspects of infertility treatments are constantly being updated as advances and new discoveries are made. - Presents protocols for infertility management and new developments in practical techniques and understanding, including discussions on in vitro maturation, in vitro fertilization and ovarian stimulation - Discusses innovative topics such as the role of artificial intelligence in infertility management, protocols using progesterone to prevent ovulation, dual-stim protocols, random start protocols, complications in IVF, and management of these complications - Chapter written by well-known experts on infertility management from different parts of the world, thus providing a worldwide perspective

Das Buch beschreibt die immunologischen Regulationsmechanismen, angefangen von der Implantation bis hin zur Schwangerschaft in Theorie und Praxis und gibt einen Ausblick zur Immunonkologie. Bisher hat sich die Reproduktionsmedizin stark auf die Herbeiführung der extrakorporalen Fertilisation fokussiert, doch werden Einnistungsprobleme immer evidenter.Expertinnen und Experten auf diesem Gebiet der Reproduktionsmedizin beantworten umfassend Fragen zu Implantationsproblemen, rezidivierenden Aborten, Schwangerschaftskomplikationen und Autoimmunerkrankungen auf der Basis von immunologischen Fehlregulationen.Kennen Sie die wichtigsten Grundlagen zu immunologischen Regulationsmechanismen bei Implantation und Schwangerschaft und deren Auswirkungen auf das immunologische Milieu, dann behandeln Sie Ihre Patientinnen optimal. Das Buch richtet sich an Reproduktionsmediziner, Pränatalmediziner, Geburtshelfer sowie interessierte Onkologen.

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via textbookscom.support@elsevier.com.

This book proposes new technologies and discusses future solutions for ICT design infrastructures, as reflected in high-quality papers presented at the 8th International Conference on ICT for Sustainable Development (ICT4SD 2023), held in Goa, India, on August 3–4, 2023. The book covers the topics such as big data and data mining, data fusion, IoT programming toolkits and frameworks, green communication systems and network, use of ICT in smart cities, sensor networks and embedded system, network and information security, wireless and optical networks, security, trust, and privacy, routing and control protocols, cognitive radio and networks, and natural language processing. Bringing together experts from different countries, the book explores a range of central issues from an international perspective.

PROLOG: Obstetrics is the premier learning tool for staying up to date in the specialty area. Consisting of an assessment and critique book, PROLOG is an effective, self-directed study resource and reference for both obstetricians - gynecologists and those in training. The content is peer-reviewed, current, and clinically relevant. Put your knowledge to the test and earn up to 25 CME credits with this volume.Upon successful completion, users of this unit will be able to:Demonstrate an understanding of maternal and fetal physiology and pathophysiology and the effects on normal and complicated pregnanciesIdentify components of antepartum care that optimize maternal and perinatal outcomes in uncomplicated pregnancies, including education regarding normal pregnancyDiagnose and plan efficacious and cost-effective management of medical and obstetric conditions encountered during the antepartum periodIdentify the risks and prognosis of selected complications of pregnancy and in the neonateDescribe antenatal genetic screening and diagnostic tests and identify the indications, risks, and predictive value for eachDiagnose problems and manage obstetric emergenciesSelect appropriate management strategies for intrapartum care and deliveryConsider medical-legal principles, risk management, and office management guidelines in obstetric practiceOrder PROLOG: Obstetrics, Ninth Edition, today!A complimentary, online study tool— PROLOG Games— is included with purchase of this print copy.

Featuring a wide array of perspectives, Transforming the Authority of the Archive details new roles for archives in undergraduate pedagogy and new roles for undergraduates in archives. While there has long been a place for archival exploration in undergraduate education (especially primary source analysis of items curated by archivists and educators), the models offered here engage students not only in analyzing collections, but also in the manifold challenges of building, stewarding, and communicating about collections. In transforming what archives are to undergraduate education, the projects detailed in this book transform the authority of the archive, as students and community partners claim powers to curate and create history. Contributions to this volume represent a range of institutions including small liberal arts colleges, HBCUs, Ivy Leagues, large research institutions, and community-based collections. The assignments, projects, and initiatives described across this volume are fundamentally concerned with the challenge to model digital archival collections so as to center individual and community voices that are historically under-engaged in the archives. To address this challenge, contributors describe various approaches to substantively, often radically, redistribute archival resources and authority. The chapters within Transforming the Authority of the Archive offer thoughtful and creative pedagogical approaches to counter the presumed neutrality of the archive and advocate a shared understanding of the contingency of archival collections. This book is a must-read for liberal arts faculty, graduate students, archivists (both community- and institutionally-affiliated), information-studies professionals, librarians, and other professionals working and teaching in archives, museums, libraries, and other cultural heritage institutions.

The second edition comprehensively reviews the wide field of rare pulmonary diseases. Issues such as less common diseases affecting the airways, systematic disorders with lung involvement, interstitial lung diseases, and many other orphan conditions of the lungs are explored in this book. The progress and advances made in the field and the limited number of patients presenting each condition makes it very difficult for clinicians to be up-to-date in this field. Readers will discover how to diagnose and manage these rare orphan diseases. Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease is a practical, informative book written by a team of international authors with much experience in rare pulmonary diseases Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease, second edition provides synthesized and easily accessible information about the main orphan lung diseases, to aid clinicians in charge of patients with rare disease,or who consider the diagnosis of a rare disease in their patient. It is a practical, informative guide written by a team of international experienced authors in rare pulmonary diseases.

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.

In achieving civic engagement and social justice in smart cities, literacy programs are offered in the society by three essential information service providers: libraries, archives, and museums. Although the library and museum services are documented in literature, there is little evidence of community-led library or museum services that make a full circle in understanding community-library, community-archive, and community-museum relationships. The Handbook of Research on the Role of Libraries, Archives, and Museums in Achieving Civic Engagement and Social Justice in Smart Cities examines the application of tools and techniques in library and museum literacy in achieving civic engagement and social justice. It also introduces a new outlook in the services of libraries and museums. Covering topics such as countering fake news, human rights literacies, and outreach activities, this book is essential for community-based organizations, librarians, museum administrations, education leaders, information professionals, smart city design planners, digital tool developers, policymakers engaged in diversity, researchers, and academicians.

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Nutritional Management of Renal Disease, Fourth Edition, offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease and serves as an in-depth reference source concerning nutrition and kidney disease. This classic translational reference provides correct diagnosis - and therefore correct treatment - of renal, metabolic, and nutritional disorders. Nephrologists, diebetologists, endocrinologists, dieticians, and nutritionists depend on a strong understanding of the molecular basis for the disease. This fourth edition includes thorough new case reports, offering expert advice on how to use the latest research and clinical findings in counseling patients about dietary and lifestyle options. Readers gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient. - Includes the latest comprehensive KDOQI clinical practice guidelines for the nutritional management of kidney disease from the National Kidney Foundation and the Academy of Nutrition and Dietetics, covering recommendations for each essential nutrient, as well as for some nonessential nutrients - Presents a comprehensive, translational look at all aspects of metabolic and nutritional disorders in one reference - Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to assimilate information and discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease - Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics

This book had its beginning in 1967 when Shirley G. Driscoll and Kurt Benirschke wrote in English the volume on placental pathology for the Henke-Lubarsch, the noted German Handbook of Pathology. There seemed to be a need for wider distribution of the text and it was reprinted by Springer Verlag, New York, essentially the only book available devoted just to the human placenta. Dr. Benirschke authored 5 subsequent editions in collaboration with Peter Kaufmann, Rebecca Baergen and Graham Burton in 1990 (2nd edition), 1995 (3rd edition), 2000 (4th edition), 2006 (5th edition) and 2012 (6th edition). In the early editions, the most important material was in a larger font than the extensive review of exceptions and the discussion in the literature. Since 1967, many other shorter placenta books have been published in English, French and German. None of these have included the breadth of discussion or the voluminous references which includes details of many historicarticles, not readily available. Interest in the placenta has wildly expanded over the intervening 50+ years with the vast majority of Pathologists, Obstetricians and Pediatricians recognizing its value. In addition, there are now quite a few new journals, societies and meetings devoted to the placenta in both clinical and research areas. The interest extends into areas of study well beyond the realm of anatomic pathology.The 7th edition will, of necessity, differ from the prior editions which Dr. Benirschke wrote largely himself at first, and later with the help of the above noted co-authors. It will now be an international multi-authored book with nearly 40 contributors revising one or more chapters. The explosion of new information as necessitating some reordering of chapters and adding completely new chapters including Chapters 31 and 32, “Innovations in Placental Pathology” and “Imaging in Placental Pathology”. Dr. Burton's section has been extensively edited, as well. The editors gave the new authors considerable latitude in how to write the new and/or edited chapters. Many of the revised chapters retain much of Dr. Benirschke's anecdotal information as well as the voluminous references. Others are more modern in their approach. All contain substantial new references and current information. It is our hope that Benirschke's Pathology of the Human Placenta will remain as a mainstay reference in placental pathology.It aims to help readers gain a broad understanding of how placental architecture is shaped during normal development, with a view to appreciating how this may be perturbed in complications of pregnancy.

Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. - Provides detailed immunological background for understanding the etiology and management of reproduction failure - Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure - Gives insights into various immunological and therapeutic approaches for reproduction failure

A comprehensive review of the most subspecialties in Gynecology. The content has been expanded with the recent advances extensively. Transformative technologies have been discussed for the clinical diagnosis and management. Strong emphasis on evidence-based medicine is given. Hundreds of clinical problems and topics have been covered. Profusely illustrated, numerous boxes, tables, imaging studies graphs and few rare photographs have been incorporated. Clinically oriented Questions and Answers, SBAs and EMQs are presented for practice. Model answers are framed in a concise and structured format. Focused on practical aspects of clinical diagnosis and management. Uniformity and consistency of standard for each chapter is an added beauty.

Now in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included here are updated chapters on major reproductive endocrinology and infertility issues, such as polycystic ovary syndrome (PCOS), pubertal disorders, amenorrhea, menopause, management of endometriosis and fibroids (including interventional radiology), laboratory and clinical aspects of assisted reproductive technologies (ART), imaging modalities such as ultrasonography and sonohysterography, hysteroscopic and laparoscopic techniques, an expansion of female infertility and fertility, preimplantation diagnosis and screening, osteoporosis, and contraception and sterilization. Chapters new to this edition discuss third-party reproduction and uterine transplantation. In addition, chapters opens with a list of bulleted key points and end with multiple choice review questions, and most include vibrant clinical case material to illustrate important concepts. Residents, fellows, and new clinicians in obstetrics and gynecology interested in reproductive endocrinology and infertility will find this fourth edition of Clinical Reproductive Medicine and Surgery: A Practical Guide a valuable and focused reference.

機能性表示食品やトクホ(特定保健用食品)の開発担当者，これから臨床試験を計画されている方の必携図書。 機能性表示食品として実際に届出された臨床試験において，消費者庁の検証事業の結果，実施における問題点や，報告・記入の不備が多いことが明らかになっている。それらの結果も反映させながら，臨床試験を計画・実施・報告するための重要ポイントを解説。また，2021年 6 月 30 日に施行された「人を対象とする生命科学・医学系研究に関する倫理指針（新倫理指針）」下で行われる臨床試験についてもわかりやすく解説している。

Pathy's PRINCIPLES AND PRACTICE OF GERIATRIC MEDICINE The latest edition of the gold standard in geriatric medicine references Pathy's Principles and Practice of Geriatric Medicine, Sixth Edition delivers a comprehensive overview of the subject, offering up-to-date, evidence-based, information about the many, and varied, problems suffered by ageing patients. In this latest edition, the authors take a refreshed approach to the material by rigorously applying the latest scientific research to clinical practice and increasing the use of visual examples, algorithms, and clinical practice points. Thoroughly updated throughout, the chapters give readers a truly global perspective on geriatric medicine that reflect the most recent changes in treatment options and medical conditions. In addition to new chapters on a range of recent and emerging topics, clinical practice points, and visual evidence—including MRI scans—the book also offers a: Thorough introduction to relevant biological, social, and community perspectives on caring for mature and ageing patients, as well as medicine prescribing for older patients Comprehensive exploration of eating disorders that commonly occur in the aged and how to maximize the nutritional health of ageing patients Practical discussions of haematological and cardiovascular disorders and diseases in ageing patients In-depth examination of special issues in elder care, including elder abuse, alcoholism and substance abuse, transportation issues, and end-of-life care Perfect for all clinicians working with mature patients, Pathy's Principles and Practice of Geriatric Medicine will also continue to earn a place in the libraries of allied healthcare workers with ageing patients and clients.

Les bifurcations sont fréquentes chez des géographes physiciens qui, à un moment de leurs itinéraires scientifiques, délaissent la géographie physique « pure et dure » pour travailler sur des problématiques sociales. Quel est leur intérêt? Qu'ont apporté ces expériences à la production et à la validation des connaissances géographiques, à la construction de son objet d'étude? Il est mis en évidence l'émergence d'une géographie socio-environnementale qui fait suite ou se substitue, au moins partiellement, à la géographie physique, ne serait-ce que dans l'espace francophone et plus spécifiquement celui de l'Afrique subsaharienne.

Growing numbers of women who experience pregnancy loss of all kinds - from early spontaneous miscarriage to stillbirth - seek help from practitioners of complementary and alternative medicine (CAM) in their recovery and preparation for future pregnancy. However, CAM is largely unregulated, and can be an unfamiliar and confusing area for mainstream health professionals. Many of these also have questions about the efficacy and safety of complementary or alternative treatments, and what they may be able to offer. Meanwhile, CAM practitioners may be unaware of the medical investigations and treatments available for conditions such as miscarriage, ectopics, gestational trophoblastic disease, preterm labour, foetal reduction, intrauterine death and stillbirth, and other less common complications. This book, written by an experienced CAM practitioner, aims primarily to provide medical professionals with the knowledge and confidence to advise women seeking complementary or alternative treatments. The author draws on her experience as a CAM practitioner to illustrate key areas where integrating sound and professional CAM into standard practice can offer women benefits, including improved psychological recovery from pregnancy loss. It also gives CAM practitioners greater insight into conventional medicine, and aids them to better understand, respect and care for women experiencing pregnancy loss. This book will be essential reading for all those who work with women who have experienced pregnancy loss, including health visitors, midwives, GPs, practice nurses, counsellors, psychotherapists, and CAM practitioners of all kinds.

Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This new edition of an acclaimed text reviews the evidence for best practice in Maternal-Fetal Medicine, to present the reader with the right information, with appropriate use of proven interventions and avoidance of ineffectual or harmful ones. The information is presented in the right format by summarizing evidence succinctly and clearly in tables and algorithms. The aim is to inform the clinician, to reduce errors and'to make it easy to do it right.'The volume can be purchased separately or together with the companion volume on Obstetric Evidence Based Guidelines (set ISBN 9780367567033).The Series in Maternal-Fetal Medicine is published in conjunction with the Journal of Maternal-Fetal and Neonatal Medicine.From reviews of previous editions:'An excellent resource with quick and easy protocols… this book has a permanent spot on my shelf.'— Doody's Review Service

While French laïcité is often considered something fixed, its daily deployment is rather messy. What might we learn if we study the governance of religion from a dynamic bottom-up perspective? Using an ethnographic approach, this book examines everyday secularism in the making. How do city actors understand, frame and govern religious diversity? Which local factors play a role in those processes? In Urban Secularism: Negotiating Religious Diversity in Europe, Julia Martínez-Ariño brings the reader closer to the entrails of laïcité. She provides detailed accounts of the ways religious groups, city officials, municipal employees, secularist actors and other civil-society organisations negotiate concrete public expressions of religion.Drawing on rich empirical material, the book demonstrates that urban actors draw and (re-)produce dichotomies of inclusion and exclusion, and challenge static conceptions of laïcité and the nation. Illustrating how urban, national and international contexts interact with one another, the book provides researchers with a deeper understanding of the multilevel governance of religious diversity.

The collection of essays reviews, explores, and reports state-of-the-art autoimmune diseases and their diagnostics. It provides a comprehensive presentation of autoimmune diseases, diagnostic approaches with current trends, and possible developments in health sciences. As such, it is a unique resource for medical educators, medical practitioners, and academics.

Colonial Geopolitics and Local Cultures in the Hellenistic and Roman East (3rd century BC – 3rd century AD) presents contributions taken in the main from a panel held during the Celtic Conference in Classics 2014 (Edinburgh, Scotland, June 25-28th 2014), but also incorporates a number of papers given previously at another panel which convened at Mamaia (Romania, September 23-27th, 2012). What changes in the material culture can we observe, when a state is overwhelming a local population with soldiers, katoikoi, and civil officials or merchants? One of the main concerns of local geopolitics was the central question of how agricultural land was distributed to the Greek or Roman colonists after it had been seized from the native population? In what way did the state watch over and administer the colonised territories? What were the exact social, legal, cultural and political relationships between the natives and the newcomers? Did the language of the colonists dominate the local vernacular language or not, and in what way? Did onomastics change or not in particular regions over centuries? What were the mutual influences between native and colonial cultures? This collection addresses these questions, focusing on the Hellenistic and Roman East.

••Selected for Doody's Core Titles® 2024 in Clinical Genetics•• Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Perinatal and Reproductive Genetics, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies in this growing field. The book is ideal for medical students, residents, physicians and researchers involved in the care of patients with genetic conditions. This comprehensive, yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. Chapters from leading international researchers and clinicians focus on topics ranging from single gene testing to whole genome sequencing, whole exome sequencing, gene therapy, genome editing approaches, FDA regulations on genomic testing and therapeutics, and ethical aspects of employing genomic technologies. - Fully revised and up-to-date, this new edition introduces genetic researchers, students and healthcare professionals to genomic technologies, testing and therapeutic applications - Examines key topics and developing methods within genomic testing and therapeutics, including single gene testing, whole genome and whole exome sequencing, gene therapy and genome editing, variant Interpretation and classification, and ethical aspects of applying genomic technologies - Includes color images that support the identification, concept illustration, and method of processing - Features contributions by leading international researchers and practitioners of medical genetics - Provides a robust companion website that offers further teaching tools and links to outside resources and articles to stay up-to-date on the latest developments in the field

Nanotechnology is an interdisciplinary research field that integrates chemistry, engineering, biology, and medicine. Nanomaterials offer tremendous opportunity as well as challenges for researchers. Of course, cancer is one of the world's most common health problems, responsible for many deaths. Exploring efficient anticancer drugs could revolutionize treatment options and help manage cancer mortality. Nanomedicine plays a significant role in developing alternative and more effective treatment strategies for cancer theranostics. This book mainly focuses on the emerging trends using nanomaterials and nanocomposites as alternative anticancer material's. The book is divided into three main topic areas: how to overcome existing traditional approaches to combat cancer, applying multiple mechanisms to target the cancer cells, and how nanomaterials can be used as effective carriers. The contents highlight recent advances in interdisciplinary research on processing, morphology, structure, andproperties of nanostructured materials and their applications to combat cancer.Cancer Nanotheranostics is comprehensive in that it discusses all aspects of cancer nanotechnology. Because of the vast amount of information, it was decided to split this material into two volumes. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy, including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials and nano-antibodies. In the second volume, we discuss the nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nano-erythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, the safety of nano-biomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics.

This new volume in the Reproductive Medicine for Clinicians series focuses on the practical clinical impact of problems linked to infertility, discussing topics such as luteal support in ART cycles, ovulation induction using pulsatile administration of GnRH, how to deal with the metabolic changes in PCOS, treatment to restore fertility in endometriosis and how to improve implantation, which are common aspects of daily clinical practice.It also addresses significant novel areas like the biological clock in human reproduction, reproduction at advanced parental age and medical and social egg freezing, offering valuable insights for patients and their doctors. Further, the book covers various areas of growing importance, such as how to access the uterine cavity; the future of imaging in reproduction; non-invasive prenatal testing; ART and male infertility; as well as breast cancer and fertility preservation.Last but not least, it examines the medical, ethical and legal aspects of a number of challenges for current and future reproductive medicine, including uterine transplantation and human genetic modification.Bringing together updates on some of the most important problems in reproductive medicine and also covering ethical and legal bases, this book offers an overview of potential treatments for infertility. As such, it is a valuable resource for gynecologists, obstetricians, endocrinologists and all specialists dealing with reproductive health.

This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.

Meta-analysis is the application of statistics to combine results from multiple studies and draw appropriate inferences. Its use and importance have exploded over the last 25 years as the need for a robust evidence base has become clear in many scientific areas, including medicine and health, social sciences, education, psychology, ecology, and economics.Recent years have seen an explosion of methods for handling complexities in meta-analysis, including explained and unexplained heterogeneity between studies, publication bias, and sparse data. At the same time, meta-analysis has been extended beyond simple two-group comparisons of continuous and binary outcomes to comparing and ranking the outcomes from multiple groups, to complex observational studies, to assessing heterogeneity of effects, and to survival and multivariate outcomes. Many of these methods are statistically complex and are tailored to specific types of data.Key features Rigorous coverage of the full range of current statistical methodology used in meta-analysis Comprehensive, coherent, and unified overview of the statistical foundations behind meta-analysis Detailed description of the primary methods for both univariate and multivariate data Computer code to reproduce examples in chapters Thorough review of the literature with thousands of references Applications to specific types of biomedical and social science data Supplementary website with code, data, sample chapters, and errata This book is for a broad audience of graduate students, researchers, and practitioners interested in the theory and application of statistical methods for meta-analysis. It is written at the level of graduate courses in statistics, but will be of interest to and readable for quantitative scientists from a range of disciplines. The book can be used as a graduate level textbook, as a general reference for methods, or as an introduction to specialized topics using state-of-the art methods.

The Mediterranean Diet: An Evidence-Based Approach, Second Edition provides authoritative material on the many facets surrounding the complex interrelationships between diet, nutrition, health and well-being. The book discusses historical, cultural and scientific foundations, with chapters delving into nutritional adequacy, agricultural practices, food culture, mortality, quality of life, children and adolescents, behavior, cardiovascular diseases, diet quality, nutritional knowledge, nuts, minerals, olive oil, hydroxytyrosol, water, antioxidant nutritional status, ketogenics, adiposity, metabolic syndrome, type 2 diabetes, cardiovascular risk, nutrigenetics, epigenetics, the link between epigenetics and pregnancy, gene polymorphisms bone health, insulin signaling inflammatory gene expression, and more. - Provides supportive evidence to embrace a holistic approach in understanding the Mediterranean diet, from the cell to the well-being of geographical populations - Addresses concepts, overviews, components of the diet, and medical, health and nutritional aspects - Contains coverage of emerging fields of diet science and important discoveries relating to diet and nutrition

The Oxford Textbook of Obstetrics and Gynaecology is an objective and readable text that covers the full speciality of obstetrics and gynaecology. This comprehensive and rigorously referenced textbook will be a vital resource in print and online for all practising clinicians. Edited by a team of four leading figures in the field, whose clinical and scientific backgrounds collectively cover the whole spectrum of obstetrics and gynaecology with particular expertise in fetomaternal medicine and obstetrics, gynaecological oncology, urogynaecology, and reproductive medicine, the textbook helps inform and promote evidence-based practice and improve clinical outcomes worldwide across all facets of the discipline. The editors are supported by contributors who are internationally renowned specialists and ensure high quality and global perspective to the work. Larger sections on the Basics in Obstetrics and Gynaecology, Fetomaternal Medicine, Management of Labour, Gynaecological problems, and Gynaecological Oncology are complimented by specialist sections on areas such as Neonatal Care and Neonatal Problems, Reproductive Medicine, and Urogynaecology and Pelvic Floor Disorders to name a few. The evidence-based presentation of diagnostic and therapeutic methods is complemented in the text by numerous treatment algorithms, giving the reader the knowledge and tools needed for effective clinical practice. The Oxford Textbook of Obstetrics and Gynaecology is essential reading for obstetricians and gynaecologists, subspecialists, and trainees across the world.

This practical and comprehensive book provides succinct and up-to-date information on the value of the various diagnostic radiological measurements made using all the imaging modalities currently employed in the management of a wide spectrum of musculoskeletal disorders, including developmental, paediatric, traumatic, degenerative, metabolic, tumoural and rheumatological conditions. The book has a unique design, with three distinct but dove-tailed sections. In the first section, the physico-chemical principles of the various imaging modalities used in measurements are explained, and the strengths and weaknesses of each modality are considered. The second section examines the application of the imaging modalities to obtain accurate measurements across all musculoskeletal anatomical sites. The final section focusses on the role of measurements in specific disease states, namely arthritis, metabolic bone disease, bone marrow disease and tumours of bone and soft tissue. All chapters arewritten by experts in the field, drawn from across Europe, and the book is lavishly illustrated throughout. It will provide an invaluable and easy-to-use reference on the performance and significance of imaging-based measurements at different anatomical sites and in different disease states.

Cardiac disease is one of the leading causes of maternal morbidity and mortality. Catastrophic outcomes typically encountered are due to gaps in knowledge and communication between health care providers. There is a great need for a standardized approach for care of this very high-risk group of pregnant women. The book encompasses detailed obstetrics and cardiology perspectives that are crucial in the management of the commonly encountered cardiac conditions in pregnancy. This text aims to provide guidance to the whole team caring for a pregnant cardiac patient consisting of obstetricians, maternal-fetal medicine, hospitalists, cardiologists, obstetric anaesthesiologists, emergency physicians, primary care providers and nurses. Features: Cardio-Obstetric team organization Preconception counselling and family planning considerations Cardiovascular disease screening and risk stratification of a pregnant cardiac patient Management of a wide spectrum of cardiovascular diagnoses through use of checklists and algorithms in a simple format Essential key points for each cardiac diagnosis

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. - Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents - Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis - Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders