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Ce volume consacré aux neuropathies périphériques aborde l'organisation et les fonctions du système nerveux périphérique, sa physiopathologie et la classification de ses atteintes. Une équipe de 28 auteurs francophones, reconnus aux niveaux national et international, apportent par leur expérience les données nécessaires à la révision et à la compréhension de l'anatomie, de l'histologie et de la physiologie. Richement illustrés de schémas et figures, d'un résumé didactique, les différents chapitres décrivent :• les apports attendus des explorations fonctionnelles, de l'imagerie, des biopsies de nerf et peau, des analyses génétiques ;• les clés utiles pour une orientation étiologique et à une prise en charge dans les centres de référence ;• l'ensemble des neuropathies focales et générales, en fonction de leurs différentes expressions cliniques et électrophysiologiques, de leurs causes et de leurs prises en charge ;• les échelles et scores de fonction qui permettent la quantification et le suivi clinique. Cet ouvrage destiné aux neurologues et internistes désireux de consulter une référence unique par son abord didactique, scientifique et clinique des maladies du système nerveux périphérique, est complété d'un volume consacré à l'étiologie des neuropathies périphériques spécifiques de causes définies.

The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice. In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency. - Includes clinical applications of genomic and molecular new knowledge, along with advances in the practice of cardiovascular medicine and surgery - Provides wide coverage of all major clinical and preventive aspects of clinical cardiology, including multi-disciplinary team care - Focuses on targeted gene and molecular therapy in clinical cardiovascular medicine and surgery

Pulmonary Assessment and Management of Patients with Pediatric Neuromuscular Disease covers the broad medical problems and specific pulmonary conditions in patients with pediatric neuromuscular disease, ranging from the different types of neuromuscular disease, their pathophysiology, and assessment and management, including both novel disease modifying pharmacotherapies and state-of-the-art clinical management. This book provides evidence-based guidance for pediatric patients with neuromuscular disease, and is a valuable resource to pediatric pulmonologists, critical care physicians, and respiratory therapists who want an update and understanding on the cutting-edge therapies and standards of care for managing this population. - Provides a single comprehensive source of information to properly guide pulmonary assessments of pediatric neuromuscular disease - Discusses recent advancements in both medications and clinical respiratory management for pediatric patients - Covers different types of neuromuscular disease, including spinal muscular atrophy, Duchenne muscular dystrophy, congenital muscular dystrophy, and more

The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications. - Provides comprehensive coverage of evaluation and diagnosis, treatments, and outcomes, including the latest management tools and targeted therapeutic strategies. - Includes the latest updates in the field: genetic causes of hereditary disease, new autoimmune diseases, promising new therapies such as antisense oligonucleotides and gene therapies, and more. - Features numerous drug tables, treatment algorithms, and clinical images throughout to aid in diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Elektromyographie und Elektroneurographie sind die unverzichtbare Erweiterung der klinisch- neurologischen Diagnostik im täglichen Einsatz in neurologischen Kliniken und Praxen. Der'EMG-Atlas'von Stöhr begleitet dabei seit rund 40 Jahren zuverlässig das Erlernen und Anwenden dieser wertvollen Diagnostikverfahren. Die 7. Auflage ist komplett überarbeitet und neu gegliedert: Im ersten Teil sind die Untersuchungstechniken sowie deren Befundung und Aussagekraft detailliert dargestellt. Der zweite Teil beschreibt ihre diagnostische Anwendung bei Erkrankungen peripherer Nerven, neuromuskulären Erkrankungen und ZNS-Funktionsstörungen. Dabei werden neben häufigen auch seltenere Anwendungen aufgezeigt. Neben über 300 Abbildungen bietet die Neuauflage neue, präzisierte Normwerttabellen sowie über 60 Videobeispiele zum Download. Das Werk lässt sich somit als fundiertes Lehrbuch, Nachschlagewerk und anschaulicher Atlas in der Aus- und Weiterbildung sowie im klinischen Alltag ideal einsetzen.

With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology,immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk–benefit ratios when managing patients with rheumatic irAE.Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.