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In the dynamic environment of healthcare, the fusion of Computational Intelligence and Healthcare Industry 4.0 has enabled remarkable advancements in disease detection and analysis. However, a critical challenge persists – the limitations of current computational intelligence approaches in dealing with small sample sizes. This setback hampers the performance of these innovative models, hindering their potential impact on medical applications. As we stand at the crossroads of technological innovation and healthcare evolution, the need for a solution becomes paramount. The Achilles'heel lies in the insufficient sample information, thwarting the effectiveness of computational intelligence in medical settings. To bridge this gap and unlock the full potential of these transformative technologies, healthcare professionals, researchers, and academics must adapt to novel approaches. The imperative is clear; we need a solution that seamlessly integrates small sample learning techniques into established computational intelligence methods. Advances in Computational Intelligence for the Healthcare Industry 4.0 is a comprehensive guide addressing the very heart of this challenge. Designed for academics, researchers, healthcare professionals, and stakeholders in Healthcare Industry 4.0, this book serves as a source of innovation. It not only illuminates the complexities of computational intelligence in healthcare but also provides a roadmap for overcoming the limitations posed by small sample sizes. From fundamental principles to innovative concepts, this book offers a holistic perspective, shaping the future of healthcare through the lens of computational intelligence and Healthcare Industry 4.0.