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The book explores Candida and candidiasis, and Aspergillus and aspergillosis, two significant fungal infectious diseases.In the first section, various aspects of Candida infection are covered. The book delves into the epidemiology of Candida infections, highlighting their prevalence and distribution. It thoroughly discusses diagnostics and pathogenesis of candidiasis, providing valuable insights into the identification, and understanding of the disease. Additionally, the book addresses the growing concern of drug resistance and provides an overview of current therapeutics for candidiasis.Chapters in the second section examine the epidemiology of Aspergillus infections, providing a comprehensive understanding of their occurrence and impact. It discusses the diagnostics and pathogenesis of aspergillosis, shedding light on the methods for accurate diagnosis and the mechanisms by which the infection develops. It explores the host-pathogen interaction and the role of biofilms in these infections. Furthermore, the book addresses the pressing issue of drug resistance in aspergillosis and presents an overview of therapeutic approaches available for managing the disease.This book serves as a valuable resource for researchers, clinicians, and healthcare professionals seeking in-depth knowledge of these fungal infectious diseases.

This open access book provides an overview of the progress in landslide research and technology and is part of a book series of the International Consortium on Landslides (ICL). The book provides a common platform for the publication of recent progress in landslide research and technology for practical applications and the benefit for the society contributing to the Kyoto Landslide Commitment 2020, which is expected to continue up to 2030 and even beyond to globally promote the understanding and reduction of landslide disaster risk, as well as to address the 2030 Agenda Sustainable Development Goals.

This book is unique in describing the practical considerations of endoscopic cardiac surgery. It covers this topic from basic concepts such as patient selection to imaging and outlines the different approaches to particular endoscopic cardiac surgical procedures. As there is an increasing acceptance that cardiac surgery needs to be provided to older and sicker patients and more asymptomatic patients, the option of a sternotomy is becoming less appealing. The endoscope has changed the patient pathway in many surgical specialities, but until recently cardiac surgery has been slow to adopt this approach. With improvements in imaging and better imaging technology, there is a steady increase in accepted procedures and trained surgeons offering this approach. Endoscopic Cardiac Surgery: Tips, Tricks and Traps captures the experience of endoscopic cardiac surgeons from around the world and is a concise yet thorough reference book for those starting a program in this discipline. With over 3 hours of associated video material, it will be an essential primer for the discipline, therefore making it a valuable reference for trainees in cardiac surgery and experienced surgeons wishing to add this approach to their armamentarium. Via app: download the SN More Media app for free, scan a link with play button and access MP4 directly on your smartphone or tablet.

This volume of the Encyclopedia of Complexity and Systems Science, Second Edition is an authoritative single source for understanding and applying the basic tenets of complexity and systems theory, as well as the tools and measures for analyzing complex systems, to the prediction, monitoring, and evaluation of earthquakes, tsunamis, and volcanoes. Early warning, damage, and the immediate response of human populations to these extreme environmental events are also covered from the point of view of complexity and nonlinear systems. In authoritative, state-of-the art articles, world experts in each field apply such complexity tools and concepts as fractals, cellular automata, solitons game theory, network theory, and statistical physics to an understanding of these complex geophysical phenomena.

State of the Art Surgical Coronary Revascularization is the most authoritative textbook ever dedicated to the art and science of surgical coronary revascularization, with 71 chapters, organized in 9 sections, and written by over 100 recognized world experts. It covers every aspect of the surgical management of coronary artery pathology and ischaemic heart disease. It provides extensive sections detailing pathophysiology, evaluation and medical and percutaneous management of ischaemic heart disease as well general outcomes and quality assessment for coronary artery bypass grafting (CABG). Pre-, intra- and postoperative management of CABG patients is emphasized in detail as are the core surgical principles in the conduct of CABG, with special focus on the selection of conduits and how to optimize the performance of both on- and off-pump surgery to reduce morbidity and mortality. There are detailed sections on how to improve outcomes with both arterial and venous bypass grafts. This comprehensive textbook also covers in detail less invasive approaches for CABG, CABG in special clinical situations and when CABG is combined with concomitant surgical procedures. In addition to underpinning all chapters with a strong and updated evidence basis, crucial practical surgical techniques are emphasised throughout, making this textbook the indispensable companion of all adult cardiac surgeons and allied health professionals interested in surgical coronary revascularization.

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

This book is a part of ICL new book series “ICL Contribution to Landslide Disaster Risk Reduction” founded in 2019. Peer-reviewed papers submitted to the Fifth World Landslide Forum were published in six volumes of this book series. This book contains the followings:•Five keynote lectures•Recent development in physical modeling of landslides•Recent development in numerical modeling of landslides•Recent development in soil and rock testing techniques, application and analysis methods•Recent advancements in the methods of slope stability and deformation analyses•Recent development in disaster risk assessmentProf. Binod Tiwari is a Vice President of the International Consortium on Landslides (ICL). He is the Associate Vice President for research and sponsored project and Professor of civil and environmental engineering at the California State University, Fullerton, California, USA.Prof. Kyoji Sassa is the Founding President andthe Secretary-General of the International Consortium on Landslides (ICL). He has been the Editor-in-Chief of International Journal Landslides since its foundation in 2004.Prof. Peter Bobrowsky is the President of the International Consortium on Landslides. He is a Senior Scientist of Geological Survey of Canada, Ottawa, Canada.Prof. Kaoru Takara is the Executive Director of the International Consortium on Landslides. He is a Professor and Dean of Graduate School of Advanced Integrated Studies (GSAIS) in Human Survivability (Shishu-Kan), Kyoto University.

This book covers the restoration and reconstruction process and activities undertaken in Japan in the first five years since the 2011 Earthquake and Tsunami – a period widely considered to be the most intensive reconstruction phase within the 10-year restoration plan drawn up by the Japanese Government. The respective chapters explore technical, scientific, social and non-scientific (policy-related) aspects, including: reconstruction and restoration policies, infrastructure and designs for tsunami coastal defence, resilient urban areas and affected communities, housing and relocation schemes, disaster mitigation and evacuation measures, reactivation of the economy, revitalization of fisheries and coastal agriculture, and industry and tourism. The book also illustrates some of the achievements and failures in a broad range of projects and initiatives intended to address the above-mentioned issues, making it particularly relevant for experts, decision makers, students and other interested scholars.

The most comprehensive and current full-color cardiac surgery resource – updated by leading surgeons A Doody's Core Title for 2019! In Cardiac Surgery in the Adult, Fifth Edition, the world's foremost cardiovascular surgeons deliver thorough, up-to-date coverage of operative strategy, decision making, technique, and pre- and post-operative management for treating the adult cardiac patient. Unmatched in both scope and clinical rigor, this classic text contains 63 chapters that highlight every important topic in cardiovascular surgery. Presented in full color, Cardiac Surgery in the Adult takes readers through the optimal treatment of congenital, acquired, infectious, and traumatic diseases of the heart and great vessels. The book opens with a history of cardiac surgery and basic cardiac science, then moves into all types of cardiac surgery, providing both practicing surgeons and residents with insight into the very latest surgical protocols. Cardiac Surgery in the Adult is logically divided into ten sections: • Basics (includes history, anatomy, physiology, pharmacology, computed tomography, risk assessment, simulation, and the fully integrated cardiovascular center) • Perioperative/Intraoperative Care • Ischemic Heart Disease • Aortic Valve Disease • Mitral Valve Disease • Surgery of the Great Vessels • Rhythm Surgery • Other Cardiac Operations (including congenital heart disease, pericardial disease, and cardiac neoplasms) • Transplant and Mechanical Circulatory Support The Fifth Edition has been updated throughout, and includes the latest advances in minimally invasive surgery and simulation.

This text describes and illustrates with some 700 detailed anatomic and surgical drawings the whole spectrum of surgical procedures employed to treat acquired and congenital diseases of the heart and great vessels in adults and children.A rather traditional chapter on history of cardiac surgery precedes chapters dedicated to quality improvement, followed by ICU management in adult and pediatric cardiac surgery, and techniques of extracorporeal circulation in both age groups.Further special topics are cardiovascular tissue engineering, minimally invasive cardiac surgery, endovascular treatment of aortic diseases, and cardiac assist devices, including total artificial heart.Written by 71 internationally recognized experts from 40 cardiac units in Central Europe and North America, this book will be invaluable not only for both novice and experienced surgeons, but also for all physicians, nurses, and technicians caring for patients with heart disease of any type,at any age.

This book covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections. The latest available data for both diagnostic and treatment of infections associated to fungi growing in biofilms is also presented. The activity of antifungal and disinfectant agents against fungal biofilms is discussed in specific chapters and future treatments on natural sources are suggested. This book bridges the gap between basic and applied research. It is the result of many years of research work done by laboratories worldwide, all known for their expertise on fungal biofilms.

Take your surgical skills to the next level with Cardiac Surgery, a volume in the Master Techniques in Surgery series! This outstanding resource distills vast stores of knowledge from the field's most renowned surgeons into one definitive atlas. Richly illustrated, step-by-step guidance covers a full range of adult cardiac surgical techniques, and clearly demonstrates how to avoid and manage complications and achieve optimal outcomes.

This book is a comprehensive collection of state-of-the-art studies of seafloor slope instability and their societal implications. The volume captures the most recent and exciting scientific progress made in this research field.As the world's climate and energy needs change, the conditions under which slope instability occurs and needs to be considered, are also changing. The science and engineering of submarine – or more widely subaqueous – mass movements is greatly benefiting from advances in seafloor and sub-seafloor surveying technologies. Ultra-high-resolution seafloor mapping and 3D seismic reflection cubes are becoming commonly available datasets that are dramatically increasing our knowledge of the mechanisms and controls of subaqueous slope failure. Monitoring of slope deformation, repeat surveying and deep drilling, on the other hand, are emerging as important new techniques for understanding the temporal scales of slope instability. In essence, rapid advances in technology are being readily incorporated into scientific research and as a result, our understanding of submarine mass movements is increasing at a very fast rate. The volume also marks the beginning of the third IGCP project for the submarine mass movement research community, IGCP-640 S4SLIDE (Significance of Modern and Ancient Submarine Slope LandSLIDEs). The Submarine Mass Movements and Their Consequences symposium is the biannual meeting under the IGCP umbrella.

For complete, authoritative coverage of every aspect of thoracic and cardiac surgery, turn to the unparalleled guidance found in Sabiston and Spencer Surgery of the Chest, 9th Edition. Now in full-color for the first time, Drs. Frank W. Sellke, Pedro J. del Nido, and Scott J. Swanson's standard-setting set is meticulously organized so that you can quickly find expert information on open and endoscopic surgical techniques performed in the operating room. With its comprehensive coverage of thoracic as well as adult and pediatric cardiac surgery, this 9th Edition is an essential resource not only for all thoracic surgeons, but also for physicians, residents, and students concerned with diseases of the chest. - Find what you need quickly with short, focused chapters divided into three major sections: Adult Cardiac Surgery, Pediatric Cardiac Surgery, and Thoracic Surgery. - Benefit from the knowledge and expertise of global experts who provide a comprehensive view of the entire specialty. - Master all of the most important current knowledge and techniques in cardiac and thoracic surgery—whether for specialty board review or day-to-day surgical practice. - Visualize challenging surgical techniques and procedures and navigate the text more efficiently thanks to an all-new, full-color design. - Stay up to date with revised or all-new chapters including Critical Care for War-related Thoracic Surgery; Neuromonitoring and Neurodevelopment Outcomes in Congenital Heart Surgery; and Quality Improvement: Surgical Performance. - Keep abreast of cutting-edge topics such as endovascular stenting and cell-based therapies, as well as the latest innovations in imaging and diagnosis, minimally invasive cardiothoracic surgery, and percutaneous devices. - Sharpen your surgical skills with access to 21 procedural videos online, including 3 new videos covering Surgical Technique-VATS Sympathetic Block; Open pneumothorax; and Extent II repair of thoracoabdominal aortic aneurysm.

Cardiovascular Medicine: Coronary Artery Disease will offer today's most up-to-date, user-friendly guidance on the evaluation, diagnosis, and medical and surgical treatment of this most important aspect of cardiovascular disease and will be on the wish list for every trainee and practicising cardiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients. The book is dedicated to providing comprehensive coverage of every aspect of coronary arterial medicine from cardiac signs and symptoms through imaging and the genetic basis for coronary disease to surgery, interventions, treatment and also to preventive cardiology. The Editor – and a group of contributing world authorities – offer their decades of scientific and clinical experience. A major selling point is the consistent chapter organization, clear design, and engaging text that includes user-friendly features such as tables, lists and treatment boxes. The readerwill have all the guidance to diagnose and manage a full range of conditions in a series of textbook resources, while also having access to additional video material from the integral website.

The textbook is designed to provide an interdisciplinary and integrated perspective of modern vascular cure. Written by experts the text proceeds from fundamental principles quickly to advanced concepts thus allowing an easy access to the junior practitioner as well as to the seasoned expert in the field.

A comprehensive review by renowned authorities of the many exciting developments occurring across the rapidly emerging field of'minimally invasive'or'minimal access'cardiac surgery. The book's distinguished panel of contributors presents the interventional cardiologists perspective, spells out the key factors for success in beating-heart coronary bypass grafting through limited incisions, and surveys the various methods of harvesting the internal thoracic artery. Other topics treated include immobilization of the surgical field, minimal access valve and congenital surgery, alternative methods of anastomosis, and port-access coronary bypass grafting. Minimally Invasive Cardiac Surgery summarizes all the latest findings on the powerful new techniques, as well as the results, of minimally invasive coronary surgery, including valvular heart disease, congenital heart disease, and coronary revascularization.

Scientists concerned with the processes occurring in the stratosphere are becoming more and more aware of the role that the stratosphere may play in the global climate and in global change in general. This book focuses on the basic processes taking place in the stratosphere and on the stratospheric changes which may occur from either natural or anthropogenic forcing. Of major concern here is the consequence of the increasing Antarctic Ozone Hole and the possibility of similar processes occurring at northern latitudes. One of the expected consequences of the change in the stratospheric composition, mainly ozone depletion, is the change in the penetration of UV-B in the troposphere, at the surface, and in the top layers of the ocean. Monitoring and modeling of those changes are still in infancy, even though the implications may be of utmost importance for the entire biosphere. Several aspects of these consequences with regard to aquatic ecosystems, terrestrial vegetation and human health are presented by experts in these fields.

This book presents and discusses current research in the study of cardiovascular disorders. Topics discussed include cardiac rehabilitation in women; effects of exercise on the prevention and rehabilitation of diastolic heart failure; cardiac rehabilitation in children with congenital heart disease; prenatal diagnosis of congenital fetal heart disease; single ventricle anatomy, physiology, repair and outcome; cardiac tumors; pulmonary hypertension in the down syndrome population; oxidative stress and heart failure; right ventricular failure in cardiac surgery and coronary artery bypass grafting for chronic and acute heart failure.

Highly Commended, BMA Medical Book Awards 2014The development of new techniques as well as the refinement of established procedures has led to great progress in cardiac surgery. Providing an ideal synopsis of the growth in this area, Cardiac Surgery: Recent Advances and Techniques systematically reviews all the new developments in cardiac surgery,

Continuous update in critical care medicine is a real challenge due to the growing dimensions of its contents; these elements are the result of new research acquisitions, and of those clinical situations where the physician is able to intervene at a given moment, with the use of effective prevention techniques. They are also the result of new technologies able to define complex sub-clinical diagnostic aspects; lastly, they are the result of effective therapeutic techniques available, and of treatment strategies able to influence radically and positively the patient's clinical course. Critical care medicine is playing a key role in the most advanced environments, as it represents a cross-sectional field of action, involving several specialties, such as anesthesiology, general medicine, surgery, pediatrics.

In the early days of cardiac surgery, but also in the following four decades, median sternotomy and cardiopulmonary bypass were nearly always included in cardiac surgical procedures. Less invasive surgical techniques were developed with the aim of reducing perioperative trauma without compromising the surgical result, and things became more complex for cardiac surgeons. They now often had to consider the surgical access of choice and whether cardiopulmonary bypass should be used or not. Since the mid 1990s, not only have several novel minimally invasive surgical techniques been presented, but also further refinements have been recommended from time to time. This work comes to fill a gap in the field of coronary artery bypass grafting and conduit harvesting in cardiac surgery, by gathering the mature version of such new, less invasive techniques combining safety, effectiveness, simplicity, sometimes even reducing procedural costs and that always for the patient's and for the surgeon's sake.

The most authoritative, comprehensive, and current cardiac surgery resource – completely updated and in full color DVD with surgical video clips In Cardiac Surgery in the Adult, 4e the world's foremost cardiovascular surgeons and physicians deliver thorough, up-to-date coverage of operative strategy, decision-making, technique, and pre and postoperative management for treating the adult cardiac patient. Editor Lawrence H. Cohn takes you through the optimal treatment of congenital, acquired, infectious, and traumatic diseases of the heart and great vessels. The book begins with a history of cardiac surgery and basic cardiac science, then moves into all types of cardiac surgery, providing both practicing surgeons and residents insight into the very latest surgical protocols. Presented in full color for the first time, the fourth edition of Cardiac Surgery in the Adult is aligned with up-to-the-minute developments in the field including recent surgical trends in minimally invasive cardiac surgery. Unparalleled in both scope and clinical rigor, the fourth edition contains 70 chapters that highlight every important topic in cardiovascular surgery. FEATURES An update of the most recent surgical perspectives and techniques in ischemic and valvular heart disease, diseases of the great vessels, cardiac arrhythmias, and more New and refreshed content on pivotal trends and topics, including the use of robotic surgery, minimally invasive valve and coronary artery bypass surgery, stem-cell induced regenerative medicine, tissue engineering, and percutaneous valve procedures and much more New full-color design—with many illustrations enhanced expressly for this edition—facilitates the comprehension of surgical procedures throughout Important opening section on the fundamentals of cardiac surgery, from its origins to the surgical anatomy of the heart, cardiac surgical physiology, risk stratification, and the statistical treatment of surgical outcome data Key chapters on the perioperative and postoperative management of cardiac patients from internationally recognized experts in the field Coverage of trends that highlight patient demographics, with a focus cross-training surgeons in endovascular skills through coverage of such topics as percutaneous intervention and endovascular graft technology Companion DVD with procedure-simplifying video clips

Die moderne Herzchirurgie umfasst ein breites Spektrum von Eingriffen bei angeborenen und erworbenen Erkrankungen des Herzens und der herznahen Gefäße. Alle relevanten Eingriffe sind in diesem Band detailliert beschrieben und durch instruktive Zeichnungen illustriert, für jede Erkrankung werden die Operationsindikationen sorgfältig herausgearbeitet. Neben der herzchirurgischen Intensivtherapie sind auch aktuelle Entwicklungen wie Zelltherapie und Kunstherzimplantation berücksichtigt. Alle Kapitel wurden von ausgewiesenen Experten komplett neu verfasst - über 30 Autoren aus 20 herzchirurgischen Zentren vorwiegend im deutschsprachigen Raum haben zu dem Buch beigetragen. Nur ein Teil der Zeichnungen und der Titel wurden noch aus der 2.Auflage der „Herzchirurgie'übernommen, die 1991 in der Kirschnerschen Operationslehre erschienen war.

Through seven successful editions, Sabiston & Spencer Surgery of the Chest has set the standard in cardiothoracic surgery references. Now, the new 8th Edition, edited by Frank W. Sellke, MD, Pedro J. del Nido, MD, and Scott J. Swanson, MD, carries on this tradition with updated coverage of today's essential clinical knowledge from leaders worldwide. Guidance divided into three major sections-Adult Cardiac Surgery, Congenital Heart Surgery, and Thoracic Surgery-lets you quickly find what you need, while new and revised chapters reflect all of the important changes within this rapidly evolving specialty. Expert Consult functionality-new to this edition-enables you to access the complete contents of the 2-volume set from anyplace with an Internet connection for convenient consultation where and when you need it. This is an ideal source for mastering all of the most important current knowledge and techniques in cardiac and thoracic surgery-whether for specialty board review or day-to-day practice.Features short, focused chapters that help you find exactly what you need.Presents the work of international contributors who offer a global view of the entire specialty.Covers thoracic surgery as well as adult and pediatric cardiac surgery for a practical and powerful single source. Includes nearly 1,100 illustrations that help to clarify key concepts. Features online access to the complete contents of the 2-volume text at expertconsult.com for convenient anytime, anywhere reference.Covers the hottest topics shaping today's practice, including the latest theory and surgical techniques for mitral valve disease, advances in the treatment of congenital heart disease, minimally invasive surgical approaches to the treatment of adult and congenital cardiac disease and thoracic disease, stent grafting for aortic disease, and cell-based therapies. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. Each year, heart disease kills more people than cancer. Patients are treated by a variety of specialists and primary care practitioners, depending on the organ system involved. This volume enables practitioners to assess the adverse effects of the complete range of drugs used in cardiovascular medicine, including antihypertensive drugs, and drugs used in the treatment of heart failure, angina, angina pectoris, and cardiac arrhythmia and enable practitioners to prescribe preventative treatments with medications such as blood pressure reducers, aspirin, and cholesterol-lowering drugs, as well as drugs used for more aggressive therapy.The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler's Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.This volume is critical for any health professional involved in the administration of cardiovascular mediations. - Surpasses the Physician's Desk Reference © by including clinical case studies and independent expert analysis - Complete index of drug names - Most complete cross referencing of drug-drug interactions available - Extensive references to primary and secondary literature - Also includes information on adverse effects in pregnancy The book is divided into six sections: - Drugs used to treat hypertension, heart failure and angina pectoris - Diuretics – a general introduction to their adverse effects, followed by monographs on individual drugs - Antidysrhythmic drugs - a general introduction to their adverse effects, followed by monographs on individual drugs - Drugs that act on the cerebral and peripheral circulations - Anticoagulants, thrombolytic agents, and anti-platelet drugs - Cardiovascular adverse effects of non-cardiovascular drugs

Coronary bypass surgery is a procedure to allow blood to flow to the heart muscle despite blocked arteries. Coronary bypass surgery uses a healthy blood vessel taken from your leg, arm, chest or abdomen and connects it to the other arteries in the heart so that blood is bypassed around the diseased or blocked area. After a coronary bypass surgery, normal blood flow is restored. Coronary bypass surgery is just one option to treat heart disease. This new book presents the latest research in this growing field.

'Cardiovascular Medicine, 3rd edition'offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease and will be relevant to the practice of every cardiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients. Drs Willerson, Cohn, Wellens and Holmes – and over 150 world authorities – offer their decades of scientific and clinical experience. The book and DVD are designed to provide comprehensive coverage of every aspect of cardiovascular medicine from cardiac signs and symptoms and the full range of cardiac imaging techniques through management of peripheral vascular disease and the genetic basis for cardiovascular disease to preventive cardiology. DVD content: Video imagery for selected chapters; Full text of the book; Interactive narrated heart sounds database containing correlative videos and images

Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary or pharmaceutical company. Now available online for all academic, corporate or government institution as well as individuals viaScience Direct! The online version provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking and fully downloadable and printable full-text, HTML or PDF articles. - Enhanced encyclopedic format with drug monographs now organised alphabetically - Completely expanded coverage of each drug - thalidomide warranted three sentences in Meyler's 14th edition, but is now a 13 page extensive monograph - Clearer, systematic organization of information for easier reading including case histories to provide perspective on each listing - Extensive bibliography with over 40,000 references - Meyler's 15th edition incorporates all relevant citations from Meyler's 14th, but also includes relevant citations from previous editions of Meyler's and Side Effects of Drugs Annuals to give a historical perspective on the use and safety of drugs

This book discusses the principles, applications, benefits, and pitfalls of off-pump coronary artery bypass (OPCAB) surgery, and provides information on the surgical strategies adopted and the anesthetic management considerations for patient undergoing OPCAB surgery.

Questa settima edizione delle Malattie del cuore di Braunwald, punto di riferimento della moderna cardiologia, si presenta in unaveste contenutistica e grafica completamente rinnovata e ampliata.Ai 51 capitoli già esistenti, che sono stati radicalmente rivisti e aggiornati, ne sono stati aggiunti 35, scritti da 57 nuovi autori, conargomenti che spaziano dal processo decisionale in cardiologia alle manifestazioni vascolari dei disturbi autonomici,

In 1962, Thomas Kuhne coined the term “paradigm shift” while arguing that human knowledge advances by quantum leaps with interspersed smaller steps. Preparation for the major advance is generally not a concerted effort by thought leaders. Rather, a few (or one) visionaries gain insights into a process and are able to definitely demonstrate the accuracy of their worldview. Often, the epiphany does not occur during the intellectual lifetime of the discoverers. Medicine has had numerous such “paradigm shifts” including the compelling reworking of Galen's concepts of the body. Of note, the scientific world of the time explained the new views by arguing that the human body must have changed between the time of ancient Greece and modern Europe. The inauguration of cardiac surgery itself required profound shifts in medicine's view of physiology. Yet, over the ensuing 40 years, the field was fine tuned so we could provide greater than 95% success rates in elective surgery with low cost and short h- pital stays. In some parts of the world, the procedures were viewed as commodities and prices dropped as providers were unable to differentiate the quality of their work. As patients and their physicians became more demanding, the desire to make the procedures “minimally invasive” grew. In effect, what we were really searching for was a life saving procedure that also preserved quality of life. In short, “minimally invasive” has really been a code phrase for procedures that disrupt our quality of life the least.

The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting critically from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction.Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest.The Essay in Annual 26 is entitled'How safe is cannabis?'(by Professor L.L. Iversen) and there is a Historical Essay entitled'From thalidomide to pharmacovigilance: a personal account'(by Professor D.J. Finney).The special reviews in this volume include, among others: - The cognitive effects of Ecstasy - Antipsychotic drugs and weight gain - Vigabatrin-related visual abnormalities - Managing the adverse effects of morphine - The cardiotoxic effects of antihistamines - Inhaled corticosteroids and growth inhibition in children - Bioterrorism and its prevention through immunization

Cardiac surgery is performed on hundreds of thousands of patients a year, and can have an important beneficial impact on the outcomes of patients with coronary and valvular heart diseases. Despite the favorable recovery of most patients, some will have their post-operative period interrupted by the development of atrial fibrillation, with a host of potential complications including stroke. High risk subgroups may develop atrial fibrillation in more than half of cases, and often despite aggressive prophylactic measures. Treatment of atrial fibrillation and its aftermath can also add days to the hospital stay of the cardiac surgical patient. In an era of aggressive cost cutting and optimization of utilization of health care resources, the financial impact of this arrhythmic complication may be enormous. Experimental studies have led to a greater understanding of the mechanism of atrial fibrillation and potential precipitating factors in the cardiac surgical patient. Prophylactic efforts with beta-blockers, antiarrhythmic drugs and atrial pacing are being used, or are being investigated in clinical trials. New methods of achieving prompt cardioversion with minimal disruption of patient care, and prevention of the thromboembolic complications of atrial fibrillation, are also important therapeutic initiatives. This text is designed to aid health care professionals in the treatment of their patients in the recovery period after cardiac surgery, and to instigate additional research efforts to limit the occurrence of, and the complications following, this tenacious postoperative arrhythmia.