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Die 3. Auflage des Handbuchs bietet Klinikern, Laboratoriumsmedizinern, experimentell Forschenden sowie allen, die sich für den Liquor cerebrospinalis interessieren, in der täglichen Praxis eine schnelle und fundierte Orientierung über den aktuellen Wissensstand der Liquordiagnostik. Methoden und Indikationsstellungen zur Gewinnung des Liquor cerebrospinalis sowie die Analyseverfahren, Messparameter und Befundkonstellationen werden im Licht der neuesten Erkenntnisse ausführlich dargestellt. Das Buch ermöglicht eine umfassende Einsicht in methodische und interpretatorische Aspekte aller klinisch bedeutsamen Liquorparameter sowie in den Stellenwert der Liquordiagnostik heute. Neben den aktuellen Entwicklungen in Immunologie, Molekularbiologie und Proteinanalytik sowie der Standardisierung und Qualitätssicherung ist in der Neuauflage erstmals ein 50-seitiger Zytologieatlas mit exemplarischen Fallbeschreibungen Teil dieses Lehrbuches, welcher sich konzeptionell am stufenweisen Erfassen eines zytologischen Präparats orientiert und daher auch besonders für Einsteiger in die Liquorzytologie geeignet ist. Mit Unterstützung der Deutschen Gesellschaft für Liquordiagnostik und Klinische Neurochemie e.V. (DGLN).

This book offers an insightful exploration into the relationship between diet and Multiple Sclerosis (MS), aiming to address a crucial question: Can dietary interventions serve as effective preventative and therapeutic measures for patients with MS? Delving into this question, the book examines various nutritional components and regimens, shedding light on their potential impacts on the progression, relapse rate, and development of MS. It offers readers valuable insights into how dietary choices can influence the management of this condition. Backed up by evidence gathered from review and clinical trial papers, the book discusses the role of vitamins such as A, B, and D, as well as dietary supplements like caffeine, carnitine, and lipoic acid in benefiting patients with MS. Particular attention is given to the significance of vitamin D in lowering the risk of developing MS and its immunomodulatory effects on the inflammatory processes associated with the disease. In parallel, the book also addresses the detrimental effects of diets such as the Western or high salt diet (HSD) on MS prognosis, emphasizing how these dietary regimens can harm the gut microbiome and exacerbate inflammatory responses, ultimately promoting demyelination of the central nervous system (CNS). The book then explores alternative dietary approaches that confer a protective effect on the gut microbiome and the CNS, including whole grain, fasting, Mediterranean, and ketogenic diets. This comprehensive resource is an essential reading for patients with MS seeking to understand the potential impacts of diet on their overall health, as well as healthcare professionals and researchers interested in exploring dietary interventions for MS management.

This book aims to provide a comprehensive and systematic understanding of research on extracellular vesicles (EVs). Extracellular vesicles, including exosomes and microvesicles, are nano-sized lipid bilayer encapsulated membranes carrying proteins, lipids, nucleic acids. They are shed by the majority of the cells into the extracellular milieu and present in many biological fluids (blood, urine, saliva, breast milk, cerebrospinal fluid, follicular fluid, semen, lung lavage, and tears). With numerous research publications in recent years, the study of EVs is the emerging field across plenty of disciplines. Many researches and efforts have shown their biogenesis, multiple roles in physiological and pathophysiological processes, and their potential roles as therapeutic agents. The book is organized by outstanding scientists in EV field from the Chinese Society for Extracellular Vesicle (CSEV). It covers the biological basic research of EVs, especially on technologies and methods, as well as the clinical application of EVs as biomarkers for disease diagnosis and therapy.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Emergence of lifestyle diseases, e.g., type II diabetes, cancers, obesity, cardiovascular disorders, liver cirrhosis, etc., are exponentially increasing day by day. Modern drifts toward the utilization of herbal medicines in different healthcare aspects necessitate (demand) the replacement of synthetic molecules with phytoconstituents because of their biocompatibility, biodegradability, economic extraction process, and ready availability from the natural source. This book provides a thorough insight into the comprehensive and up-to-date trends of phytomedicines in the management of lifestyle diseases and its mechanisms, modern methods of extraction and purification of phytoconstituents, and chemical characterization as well as standardization of phytoconstituents using modern equipments.

Multiple Sclerosis (MS) is an inflammatory autoimmune disease affecting the brain and spinal cord. Despite significant advances in treatment modalities the prognosis of this patient population is still poor. New Updates on Clinical Aspects of Multiple Sclerosis reviews the clinical guidelines for diagnosis and treatment management for both pediatric and adult patients with Multiple sclerosis (MS). Multiple chapters present the various subtypes of MS in a case-based format, providing readers with the presentation of differential diagnosis. This book will also review the advancements in methods of assessing demyelinating plaques including, 7T MRI, DTI, PET, and MR spectroscopy. Multi-contributed, this book will become the essential guide for anyone in the field of MS - Explores the practical applications of optical coherence tomography (OCT) and OCT angiography (OCTA) in assessing MS. - Delves into utilizing advanced imaging modalities and corresponding radiological findings for the diagnosis and monitoring. - Includes cutting-edge technologies: 7 Tesla (7T) magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance spectroscopy (MR spectroscopy).

According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents. - Epidemiology of neurological disorders and pathogenesis. - Explores neuroinflammation, ligand-receptors binding, and neurodegeneration. - Discusses aging and associated disorders in the onset of neurological disorders. - Neuropharmacology and the protective role of bioactive compounds in neuroprotection.

The second volume of the book Emerging Human Viral Diseases discusses pathogenesis, diagnostics, and therapeutic strategies against viral encephalitis, gastroenteritis, and human immunodeficiency viral infections. The chapters discuss symptoms, diagnostics, and preventive strategies against viral infections. The book also reviews the epidemiology and evolution of viruses causing these infections. It also examines symptoms and strategies for developing novel diagnostics and the vaccine against these viruses. Toward the end, it discusses various biosafety principles for handling emerging viruses and reviews various bioinformatics tools and databases in virology research. This timely book offers valuable resource for the scientists working in the field of emerging viral infections and those involved in preventing, controlling, and managing viral diseases. Inclusively this book will be valuable guide covering most recent scientific progress in emerging human viral diseases and management and will serve as the best resource for undergraduates, graduates, medical professionals, researchers, public health physicians, and national and international health authorities.

It is almost 120 years since Alzheimer's disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer's Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer's disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.

Modern Inference Based on Health Related Markers: Biomarkers and Statistical Decision Making provides a compendium of biomarkers based methodologies for respective health related fields and health related marker-specific biostatistical techniques. These methodologies may be applied to various problems encountered in medical and epidemiological studies. This book introduces correct and efficient testing mechanisms including procedures based on bootstrap and permutation methods with the aim of making these techniques assessable to practical researchers. In the biostatistical aspect, it describes how to correctly state testing problems, but it also includes novel results, which have appeared in current statistical publications. The book discusses also modern applied statistical developments that consider data-driven techniques, including empirical likelihood methods and other simple and efficient methods to derive statistical tools for use in health related studies. The title is a valuable source for biostaticians, practitioners, theoretical and applied investigators, and several members of the biomedical field who are interested in learning more about efficient evidence-based inference incorporating several forms of markers measurements. - Combines modern epidemiological and public health discoveries with cutting-edge biostatistical tools, including relevant software codes, offering one full package to meet the demand of practical investigators - Includes the emerging topics from real health fields in order to display recent advances and trends in Biomarkers and associated Decision Making areas - Written by researchers who are leaders of Epidemiological and Biostatistical fields, presenting up-to-date investigations related to the measuring health issues, emerging fields of biomarkers, designing health studies and their implementations, clinical trials and their practices and applications, different aspects of genetic markers

Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches. Despite the limited number of nanocarriers approved for human use, they have demonstrated significant potential in preclinical and, in some instances, clinical trials. In alignment with this objective, the chapters of the book are structured to offer a comprehensive overview of recent advancements in medication and dosage form development, specifically emphasizing the nanoparticulate system for targeting the brain. This book aims to furnish readers with a thorough understanding of the clinical application of nanocarrier systems for treating neurodegenerative disorders, encompassing the latest developments, challenges, safety concerns, toxicity issues, regulatory considerations, prospects, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain will find valuable insights in this resource.Key Features Provides a comparative perspective of various nanocarrier systems, therefore facilitating the researcher's selection of appropriate nanoparticulate carriers Highlights the related restrictions of brain delivery and current available medicines Includes information on the advantages and disadvantages of various biomaterials utilized in the development of nanocarriers for brain targeting Emphasizes distinct facets of surface functionalization according to the brain area of interest Presents the current advances, preclinical and clinical development, and the future potential of multiple brain-targeting technologies

For the first time, Drs. Usrey and Sherman, along with a who's who of luminaries in neuroscience research, seek to codify the roles that the cortex and thalamus and their interdependence on each other play for sensation, action, and cognition. The thalamus, in addition, has often been treated as a minor, rather insignificant player in cortical functioning. In the not too distant past, the thalamus was considered a rather boring, machine-like relay of subcortical information to the cortex. Over the past decade, there has been a groundswell of new and renewed interest in the thalamus and thalamocortical interactions, leading to discoveries demonstrating the thalamus's ongoing and essential role in cortical functioning and, likewise, the significance of the cortex for thalamic functioning. The Cerebral Cortex and Thalamus is a groundbreaking volume bringing together a cohesive account of cortical and thalamic mechanisms for control of behavior with an emphasis on the importance of interactions between the two structures. The book elucidates the research that makes it increasingly clear that the cortex and thalamus are necessary partners for sensory, motor, and cognitive functions. Interactions between thalamus and cortex are not only essential for proper brain function, they are also sensitive to a range of diseases that can have devastating consequences on individuals and society. An essential text for graduate students, early career investigators, and investigators looking to shift their research focus, The Cerebral Cortex and Thalamus is organized into topical sections covering circuit properties of thalamus and cortex, thalamocortical and corticothalamic motifs, sensory systems, motor systems, interareal cortical communication, cognitive properties, development and plasticity, evolution, computation, and disease.

Virus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves into the molecular and cellular aspects of viral infections, providing a wealth of knowledge about various viruses and their effects on cellular mechanisms. The first part of the book covers general/technical aspects, introducing the reader to the field of virology and providing an overview of the techniques used to study virus-infected cells. It covers topics such as the visualisation of virus-infected cells by cryo-electron tomography and the assessment of necroptosis, a type of programmed cell death, in virus-infected cells. In addition, the book explores the role of apoptosis and phagocytosis as antiviral mechanisms, as well as the intricate process of viral membrane fusion and penetration. It also discusses the tracking of viral entry into living cells and the use of correlative cryo-imaging to study the biology of virusesin cells and tissues. Finally, the book examines the cytopathic effect induced by viruses, shedding light on the damage caused to infected cells. The second section of the book explores specific viruses and their interactions with host cells. Each chapter focuses on a specific virus and provides an in-depth look at its behaviour within infected cells. The book covers a wide range of viruses, including human papillomavirus, respiratory syncytial virus, Japanese encephalitis virus, African swine fever virus, coronavirus, influenza A virus and human endogenous retroviruses. Each chapter examines unique aspects of virus-host interactions, such as viral assembly, impact on the cytoskeleton, critical host-virus interactions mediated by viral RNA, mechanisms of cell entry, and the involvement of cholesterol in virus budding and scission. This volume in the Subcellular Biochemistry series is a valuable resource for researchers, virologists and students interested in understanding the complex dynamics between viruses and the cells they infect. With its detailed exploration of general and specific aspects of virus-host interactions, this book provides a comprehensive understanding of the molecular and cellular mechanisms involved in viral infections.

Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more. - Explains how inflammation in the central nervous system impacts tissue microstructure - Presents imaging methods that are useful for assessing neuroinflammation - Describes preclinical models of neuroinflammation - Reviews the role of neuroinflammation in human injury and disease states

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the'How'in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision'medicine'–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more

Vivez de manière autonome - même avec la sclérose en plaques! Le diagnostic peut être effrayant - mais faire l'autruche? Définitivement pas! Parce qu'il existe de nombreuses possibilités et façons de mener une vie heureuse et autonome, même avec la sclérose en plaques. La seule question est : par où commencer? Quelle est la bonne voie pour moi? Ce livre montre clairement quelles sont les options qui s'offrent à vous en plus de la médecine conventionnelle pour influencer positivement l'évolution de la maladie dans la sclérose en plaques et prendre votre propre santé en main. Toutes les mesures proposées sont scientifiquement prouvées. Ils ont aussi le pouvoir d'enrichir sa vie au-delà de la maladie. Parce que la SEP n'est pas la fin, c'est le début d'un nouveau chapitre! Ce qui vous attend : • 9 actions réalisables -'Une vie saine pour une vie saine!'Le livre présente 9 mesures auto-implémentables qui peuvent influencer positivement l'évolution de la SEP. Il résume l'essentiel de plusieurs centaines d'études scientifiques. Toutes les recommandations sont faciles à comprendre et à mettre en œuvre! • Une histoire personnelle -'Du diagnostic à aujourd'hui'Accompagnez l'auteur à travers vos propres antécédents médicaux. Vous trouverez des aperçus très personnels du diagnostic aux expériences de fatigue et de rechutes, spécialement marqués encore et encore tout au long du livre. • Connaissances de base -'La médecine conventionnelle et le mode de vie se complètent!'Par conséquent, toutes les personnes concernées doivent connaître la maladie et avoir accès aux informations sur les options de traitement. Vous y trouverez des chapitres qui expliquent la SEP, mais montrent également diverses thérapies de base et leur efficacité. Utilisez ces chapitres pour approfondir votre compréhension de la SEP et comme référence et base de discussion avec votre médecin.

Filling a major gap in neuropsychological references and training materials, this is the first guide to conducting effective clinical interviews as a core component of neuropsychological practice. Prominent experts provide state-of-the-art information about clinical interviewing in the context of 16 different adult populations and settings. Chapters outline critical areas of inquiry and key considerations for differential diagnosis, as well as what initial and follow-up questions to ask, rapport-building strategies, and common interviewing pitfalls. Tips for record reviews and behavioral observations are also offered. Chapters follow a consistent format and include extensive tables for easy reference.

This book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases. The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, the potential of oxysterols as biomarkers for some of these diseases is also highlighted. The book concludes with an outlook on the pharmacological and nutritional effects of oxysterols and phytosterols and their potential use by the food, and pharmaceutical industries. Aiming to provide an in-depth overview of the biological and the chemical properties of oxysterols and phytosterols and their implications for human health, this book will be of interest to basic and clinical scientists, as well as to anyone working in the food or pharmaceutical industry who is exploring the potential of oxysterols and phytosterols.

The unique contribution of The Decisions to Open a Relationship: To Three or Not to Three is how James K. Beggan considers the social and psychological processes involved in how someone makes the decision to transition from a monogamous to a consensually nonmonogamous relationship. Informed by extensive research drawn from sociology, psychology, and the decision-making literature, Beggan provides a comprehensive analysis of processes associated with expressing the desire to open a previously closed romantic relationship, with special emphasis on the unique dynamics of the triad. His analysis provides valuable insights into managing jealousy, maintaining trust, and establishing healthy boundaries. He examines moral issues associated with breaking the promise of a monogamous relationship to satisfy goals related to personal growth. The book addresses issues related to intersectionality that involve sexual orientation, gender identity, and race.

Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease. - Covers both neuroprotective and neurotoxic outcomes resulted from the exposure of brain cells to natural molecules - Analyzes numerous natural compounds, including animal, vegetal, fungal, bacterial, and marine-derived molecules - Discusses the effects of the metabolism of microbiota on the biotransformation of natural molecules and the consequences of these processes on brain cells - Contains a section focused on the nanotechnology-related strategies utilized to enhance the bioavailability of natural molecules to brain cells

Nutrition for Health, Fitness and Sport uses a question-answer approach, which is convenient when you may have occasional short periods to study, such as riding a bus or during a lunch break. In addition, the questions are arranged in a logical sequence, the answer to one question often leading into the question that follows. Where appropriate, cross-referencing within the text is used to expand the discussion. No deep scientific background is needed for the chemical aspects of nutrition and energy expenditure, as these have been simplified. Instructors who use this book as a course text may add details of biochemistry as they feel necessary.

In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus. - Fully revised and updated by a global group of experts, dedicated to and in honor of Noel Rose - Includes 52 completely updated chapters with the latest developments in the field - Is the only book directed specifically at the interactions between infectious agents and autoimmunity - Describes the prevalence and incidence of global issues and current therapeutic approaches - Addresses in full, details of the mechanisms behind the emergence of autoimmune diseases secondary to infections - Brings the reader up-to-date and allows easy access to individual topics in one place

As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be theturning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

Fatigue is a major symptom in patients with multiple sclerosis (pwMS) and is mainly responsible for unemployment, early retirement but also social withdrawal. This book combines reporting of actually existing scientific knowledge with guidance for clinical practice. As such the book helps health care professionals in all countries to better understand fatigue symptoms but also to help patients to better cope with them.

This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in phytonutrient isolation, characterization and therapeutic applications, giving particular emphasis to mechanisms and safety profiles. The book takes toxicological considerations into account, including adverse drug reactions, toxicokinetics and toxicodynamics. Sections cover bioactive compound classes and biosynthesis pathways, general considerations, including quality control, standardization, and technology, and toxicology. This title is a comprehensive work on the latest research in phytonutrients and neurological disorders that will be useful to researchers and medical practitioners. - Presents a comprehensive resource on phytonutrients and their relationship to neurological disorders - Analyzes the isolation, characterization and mechanisms of phytonutrients in neurology - Focuses on various signaling pathways followed by phytonutrients in neuroprotection - Gives the latest thinking on quality control parameters and specifications for phytonutrient study - Considers the toxicology of phytonutrients, including adverse drug reactions, toxicokinetics and toxicodynamics

Eine Dysbiose des intestinalen Mikrobioms wird mit vielen lokalen und systemischen Erkrankungen in Verbindung gebracht. Durch die Entdeckung der „Darm-Hirn-Achse“ kam die Frage auf, welche Rolle das Mikrobiom bei Erkrankungen des ZNS wie z.B. Multiple Sklerose spielt und welche Möglichkeiten die Darmflora zur Prävention oder Therapie dieser Krankheiten bietet. Ziel dieses Buches ist es, die bisherige Studienlage zum Zusammenhang zwischen Mikrobiom und Multipler Sklerose anhand von drei Fragestellungen darzulegen. Es soll geklärt werden, ob bzw. welche Unterschiede in der Zusammensetzung der intestinalen Mikrobiota zwischen MS-Patienten und gesunden Personen vorliegen, welche (patho-)physiologischen Mechanismen den Zusammenhang zwischen Darmmikrobiom und MS erklären könnten und welche Mikrobiom-assoziierten Interventionen zur Prävention und Therapie der Erkrankung denkbar wären.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Diet, Inflammation, and Health introduces concepts of inflammation, the role of acute inflammatory responses in good health, and the association of chronic systemic inflammation with mental distress, cognitive decline, and chronic diseases, ranging from diabetes to cardiovascular diseases, stroke, and cancer. The book also describes the pathophysiology of inflammation and its effects on insulin insensitivity and blunted immune response to carcinogenesis. Researchers and allied health care professionals working in dietetics and medicine, as well as students studying related fields will benefit from this reference and its recommendations on areas where future research is needed. - Addresses the role of acute inflammatory responses in achieving and maintaining good health - Covers the association of chronic system inflammation with various conditions and diseases - Describes the effect of inflammation on mechanisms ranging from insulin insensitivity and immune response to carcinogenesis

Lebe selbstbestimmt - auch mit Multipler Sklerose! Die Diagnose kann erschreckend sein - doch den Kopf in den Sand stecken? Ganz sicher nicht! Denn es gibt viele Möglichkeiten und Wege, wie man auch mit Multipler Sklerose ein erfreuliches und selbstbestimmtes Leben führen kann. Die Frage ist bloß: Wo setze ich an? Welcher ist der richtige Weg für mich? Dieses Buch zeigt übersichtlich, welche Möglichkeiten es zusätzlich zur herkömmlichen Schulmedizin gibt, um den Krankheitsverlauf bei Multipler Sklerose positiv zu beeinflussen und die eigene Gesundheit selbst in die Hand zu nehmen. Alle vorgeschlagenen Maßnahmen sind wissenschaftlich belegt. Außerdem haben sie die Kraft, das eigene Leben über die Krankheit hinaus zu bereichern. Denn MS ist nicht das Ende, es ist der Anfang eines neuen Kapitels! Das erwartet Sie: • 9 umsetzbare Maßnahmen -'Gesund Leben für ein Gesundes Leben!'Das Buch zeigt 9 selbst umsetzbare Maßnahmen, die den Verlauf der MS positiv beeinflussen können. Es fasst hierbei die Essenz aus mehreren hundert wissenschaftlichen Studien zusammen. Alle Empfehlungen sind einfach verständlich und umsetzbar! • Eine persönliche Geschichte -'Von der Diagnose bis heute'Begleiten Sie die Autorin durch Ihre eigene Krankheitsgeschichte. Sehr persönliche Einblicke von der Diagnose bis hin zu Erfahrungen mit Fatigue und Schüben finden Sie speziell markiert immer wieder im ganzen Buch. • Hintergrundwissen -'Schulmedizin und Lebensstil ergänzen sich!'Daher sollte auch jede/r Betroffene über die Erkrankung Bescheid wissen und Zugang zu Informationen über Behandlungsmöglichkeiten haben. Sie finden Kapitel, die die MS erklären, aber auch verschiedene Basistherapien und deren Wirksamkeit aufzeigen. Nutzen Sie diese Kapitel um Ihr Verständnis von MS zu vertiefen und als Referenz und Grundlage für das Gespräch mit dem/ der behandelnden Arzt/ Ärztin.

'If you or someone that you love is impacted by MS this book is a must read.'- Dr Aaron Boster, The Boster Center for Multiple Sclerosis, Columbus, Ohio'This highly recommended book highlights the importance of a holistic approach to MS management.'- Professor Richard Nicholas, Imperial College London A long, healthy, happy life is possible after a diagnosis of multiple sclerosis. Around the world, thousands of people are living active and fulfilling lives on the Overcoming Multiple Sclerosis Program. The Overcoming Multiple Sclerosis Handbook explains what MS is, and outlines the scientifically credible and evidence-based 7 step self-management program originally devised by Professor George Jelinek. It covers all aspects of living on the program, from first diagnosis to later life, with chapters from medical specialists and other experts on choosing your healthcare team, improving resilience, work, pregnancy and progressive MS. The book taps into the wealth of knowledge and experience in the community of people following the Overcoming Multiple Sclerosis Program, with personal stories from across the world. If you have recently been diagnosed with MS, if you have been living with MS for years, or if you have a family member with MS, the Overcoming Multiple Sclerosis Handbook is your best companion. It is also an invaluable resource for doctors treating people with MS.

Free radicals are continuously produced in cells as a part of normal cellular function. However, excess generation of free radicals plays a critical role in the pathophysiology of many disease conditions, especially cancer, atherosclerosis, Alzheimer's disease, etc. Oxidation is a major chemical process that produces free radicals and initiates chain reactions that cause cellular damage. Compounds that inhibit oxidation are called antioxidants; phenols are known to possess excellent antioxidant properties. Phenolic compounds are abundant in plants in a wide variety of chemical structures. Natural phenolic compounds include phenolic acids and ester derivatives, flavonoids and benzopyran derivatives, quinones, tannins, lignins, lignans, stilbenes, essential oils, chalcones, etc. Nutraceuticals, in the name of dietary supplements and functional foods, are being consumed as prophylactics for the prevention of many diseases throughout the world. Most of these products are polyphenols; hence, this book provides an insight on therapeutic potentials of natural and synthetic polyphenols, emphasizing their pharmacology.

This book in the two volume set provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting into autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases.Contributions in the book focuses on the role of microbiota/probiotics and their distinct mechanisms exerted in management of autoimmune liver, skin, thyroid, rheumatic and myopathic diseases. This could help in better understanding to design therapeutic strategies that can be deployed to prevent these autoimmune diseases.The book has an interdisciplinary appeal and scholars with an interest immunology, medical microbiology and nutritional sciences will value its contribution. Overall, the book gives a new dimensions and insight in the aspects of microbial role in autoimmune disease pathogenesis and therapeutic aspects.

Dit boek geeft artsen (in opleiding), praktijkondersteuners en verpleegkundigen, apothekers, paramedici, ggz-medewerkers en andere professionals in en om de zorg een heel praktisch en actueel overzicht van de leefstijlgeneeskunde. Wat is het? Wat werkt en wat niet? En hoe kan ik het inzetten in mijn klinische praktijk, met en bij mijn patiënten?Het boek is recent geactualiseerd ten opzichte van de eerste druk; het hoofdstuk over diabetes is herzien en een hoofdstuk over immunologie is, gezien de recente ontwikkelingen, toegevoegd. Tot voor kort werd leefstijl vooral gezien als een middel ter preventie van aandoeningen. In toenemende mate worden voeding, beweging, ontspanning, slaap, sociale contacten en zingeving ook succesvol ingezet bij de behandeling van chronische aandoeningen. In dit boek presenteren vooraanstaande hoogleraren de evidence en goede praktijkvoorbeelden op hun vakgebied. Dit boek behandelt preventie en behandeling van veel voorkomende aandoeningen vanuit het perspectief van de leefstijlgeneeskunde. Het geeft context en praktische handvatten over hoe mensen te motiveren en te bewegen tot een andere leefstijl. Een aanrader voor iedereen die werkt in de zorg en die zich wel eens afvraagt of het ook anders kan; meer gezondheid en kwaliteit van leven, minder medicijnen en bijwerkingen, meer eigen regie van patiënten en meer werkplezier.

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a “Who's Who” in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients'ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever.

Der Arzneimittel-Kompass 2022, der sowohl als Open-Access-Publikation als auch als gedrucktes Buch erscheint, widmet sich dem Schwerpunktthema „Qualität der Arzneimittelversorgung“. Dabei stehen die Qualitätssicherung und das Qualitätsmanagement in der zweiten Ausgabe des Arzneimittel-Kompass im Fokus. Namhafte Autorinnen und Autoren analysieren Stärken und Schwächen in der Arzneimittelversorgung und beschreiben die Umsetzungsherausforderungen, die der komplexe Prozess einer optimalen Versorgung der Bevölkerung mit Arzneimitteln mit sich bringt. Der Arzneimittel-Kompass 2022 geht unter anderem den folgenden Fragen nach:Was wird unter Qualität in der Arzneimittelversorgung verstanden?Wie ist die Qualität in der Arzneimittelversorgung spezifischer Gruppen von Patientinnen und Patienten wie beispielsweise von Kindern, älteren Menschen oder MS-Erkrankten zu bewerten?Sind Defizite bei der Verordnung von Kontrazeptiva, bei der Hormonersatztherapie, an der Schnittstelle von ambulanter und stationärer Versorgung oder von Patientinnen und Patienten mit Covid-19 erkennbar?Welche Hürden und Hindernisse gilt es zu bewältigen, um diese Defizite auszugleichen?Wie kann das Wissen über eine qualitativ hochwertige Arzneimittelversorgung auch in der Praxis umgesetzt werden?Zentrale Entwicklungen im Arzneimittelmarkt werden analysiert und beschriebenDie Ausgaben für Arzneimittel und Impfstoffe, die im Jahr 2021 mit 52,0 Mrd. € einen neuen Höchststand erreicht haben, werden differenziert in den Blick genommen. Die Auswertungen basieren auf 810 Millionen Verordnungen von mehr als 210.000 Ärztinnen und Ärzten für 73,3 Mio. GKV-Versicherte. Besondere Beachtung gilt den Trends in den Marktsegmenten Generika, Biosimilars, Patentarzneimittel und Orphan Drugs. Die Wirksamkeit der gesetzlichen Regulierungsinstrumente wird gleichfalls betrachtet. Ein Blick aufdie Arzneimittelversorgung in Deutschland im Vergleich zu anderen europäischen Ländern rundet diesen Teil ab.Die Herausgeberinnen und HerausgeberDer Arzneimittel-Kompass 2022 wird von Helmut Schröder, Dr. Carsten Telschow und Dr. Melanie Schröder vom Wissenschaftlichen Institut der AOK (WIdO), Prof. Dr. med. Petra Thürmann von der Universität Witten-Herdecke und Prof. Dr. med. Reinhard Busse von der Technischen Universität Berlin herausgegeben.

Wie sieht eine zeitgemäße und rationale Therapie der Multiplen Sklerose aus? Angesichts der dynamischen Therapieentwicklung und der Verfügbarkeit unterschiedlicher Medikamente zur Immuntherapie der MS fällt es zunehmend schwerer, den Überblick zu behalten und Patienten auf ihrem Weg durch die Erkrankung adäquat zu beraten. Dieser Band unterstützt Kliniker beim Management von MS-Patienten. Anhand von Fallbeispielen werden typische klinische Fragestellungen skizziert, Strategien erläutert und entsprechende Hintergrundinformationen gegeben, die eine gemeinsame therapeutische Entscheidungsfindung bahnen können. Neben modernen Immuntherapien werden auch symptomatische, nichtmedikamentöse und komplementäre Therapiekonzepte vorgestellt.

This comprehensive book is divided into 6 parts that cover all topics related to cerebrospinal fluid (CSF) rhinorrea. It provides in-depth theoretical and practical knowledge, and includes teaching material as well as evidence-based scientific content.The introductory part presents the skull base anatomy, CSF physiology, pathophysiology of skull base defects as well as the role of imaging in this condition. The second and third parts provide details of different diagnostic features and conservative management. The fourth and central part thoroughly illustrates surgical approaches for this clinical condition and follows a similar structure, describing each surgical procedure step-by-step. The fifth part sheds light on the postoperative management and the long-term follow up, while the last part addresses miscellaneous topics, such as quality of life, outcome measures, and medico-legal issues. The book is enriched by a wealth of high-quality figures and online videos that illustrate real-world clinical cases, and each chapter features a summary box, key points and a conclusion. The contributors are leading experts in the field and include authorities and inventors of skull base surgical approaches and reconstruction techniques. The multidisciplinary panel of authors – from 6 continents – consists of neurosurgeons, radiologists and anesthesiologists. The book is intended for medical, surgical and paramedic professionals, and is a valuable resource for all levels – from medical students to consultants.

Addresses the psychology and treatment of diseases that affect the memory of an aging population The aging population is growing, with a significant portion of the population over the age of 65. Epidemiological research suggests that rates of age-related conditions like Alzheimer's disease will increase. Older individuals and their families face a host of problems related to the diagnosis, treatment, and psychological management of these conditions. There is a growing demand for healthcare personnel and professionals in the human and social services who have the knowledge and skills to meet the needs of this special population. Dementia and Memory: Introduction for Professionals in Health and Human Services aims to provide an introduction to dementia and memory disorders for professionals in public health, nursing, social work, gerontology, psychology, and beyond. This book offers a scientifically rigorous approach with an approachable writing style, making it an ideal resource for all helping professions. All chapters take a multi-disciplinary approach to instruction, and all diseases are presented with applicable historical background. For each condition covered, from Alzheimer's and Parkinson's to depression and frailty, you'll find a description of the condition, epidemiological data, pathophysiology, diagnostic criteria, clinical presentation, treatment strategies, and a case vignette. You'll also learn about older adults'daily needs, behavioral interventions, caregiver stress, and more. Gain background knowledge of age-related conditions including Alzheimer's, Parkinson's, Lewy Body dementia, multiple sclerosis, and more Learn about the neuroanatomy of the aging brain and how its manifestations lead to unique caregiving issues and challenges Discover pharmacological, management, and intervention techniques that will help you better care for aging adults Combat caregiver stress and compassion fatigue when dealing with difficult memory disorders and dementiaAnyone who works with older adults in community, clinical, or research settings will benefit from this in-depth information on conditions of aging and dementia.

Pathy's PRINCIPLES AND PRACTICE OF GERIATRIC MEDICINE The latest edition of the gold standard in geriatric medicine references Pathy's Principles and Practice of Geriatric Medicine, Sixth Edition delivers a comprehensive overview of the subject, offering up-to-date, evidence-based, information about the many, and varied, problems suffered by ageing patients. In this latest edition, the authors take a refreshed approach to the material by rigorously applying the latest scientific research to clinical practice and increasing the use of visual examples, algorithms, and clinical practice points. Thoroughly updated throughout, the chapters give readers a truly global perspective on geriatric medicine that reflect the most recent changes in treatment options and medical conditions. In addition to new chapters on a range of recent and emerging topics, clinical practice points, and visual evidence—including MRI scans—the book also offers a: Thorough introduction to relevant biological, social, and community perspectives on caring for mature and ageing patients, as well as medicine prescribing for older patients Comprehensive exploration of eating disorders that commonly occur in the aged and how to maximize the nutritional health of ageing patients Practical discussions of haematological and cardiovascular disorders and diseases in ageing patients In-depth examination of special issues in elder care, including elder abuse, alcoholism and substance abuse, transportation issues, and end-of-life care Perfect for all clinicians working with mature patients, Pathy's Principles and Practice of Geriatric Medicine will also continue to earn a place in the libraries of allied healthcare workers with ageing patients and clients.

A complete guide to a healthy and active life with MS on the Overcoming Multiple Sclerosis Program, with chapters from a team of international experts and personal stories from around the world.A long, healthy, happy life is possible after a diagnosis of multiple sclerosis. Around the world, thousands of people are living active and fulfilling lives on the Overcoming Multiple Sclerosis Program.The Overcoming Multiple Sclerosis Handbook explains what MS is, and outlines the scientifically credible and evidence-based 7 step self-management program originally devised by Professor George Jelinek. It covers all aspects of living on the program, from first diagnosis to later life, with chapters from medical specialists and other experts on choosing your healthcare team, improving resilience, work, pregnancy and progressive MS. The book taps into the wealth of knowledge and experience in the community of people following the Overcoming Multiple Sclerosis Program, with personal stories from across the world.If you have recently been diagnosed with MS, if you have been living with MS for years, or if you have a family member with MS, the Overcoming Multiple Sclerosis Handbook is your best companion. It is also an invaluable resource for doctors treating people with MS.'If you or someone that you love is impacted by MS this book is a must-read.'- Dr Aaron Boster, The Boster Center for Multiple Sclerosis, Columbus, Ohio'This highly recommended book highlights the importance of a holistic approach to MS management.'- Professor Richard Nicholas, Imperial College London'Overcoming MS is now the essential mainstay of MS management, before or alongside drug therapy, offering the best chance of a full and healthy life for people with MS.'- Dr Peter Silbert, Clinical Professor of Neurology, University of Western Australia Medical School

Live self-determined - even with multiple sclerosis! The diagnosis can be frightening - but stick your head in the sand? Definitely not! Because there are many possibilities and ways how you can lead a happy and self-determined life even with multiple sclerosis. The only question is: where do I start? Which is the right path for me? This book clearly shows what options there are in addition to conventional medicine to positively influence the course of the disease in multiple sclerosis and to take your own health into your own hands. All proposed measures are scientifically proven. They also have the power to enrich one's life beyond the illness. Because MS is not the end, it is the beginning of a new chapter! What awaits you: • 9 Actionable Measure -'Healthy Living for a Healthy Living!'The book shows 9 self-implementable measures that can positively influence the course of MS. It summarizes the essence of several hundred scientific studies. All recommendations are easy to understand and implement! • A Personal Story -'From Diagnosis to Today'Accompany the author through her own medical history. You will find very personal insights from the diagnosis to experiences with fatigue and relapses, specially marked again and again throughout the book. • Background knowledge -'Conventional medicine and lifestyle complement each other!'Therefore, everyone affected should know about the disease and have access to information about treatment options. You will find chapters that explain MS, but also show various basic therapies and their effectiveness. Use these chapters to deepen your understanding of MS and as a reference and basis for discussion with your doctor.

Disruption often drives innovation, and 2020 was certainly an extraordinary year for all health professionals. Not only did it stretch individual providers and healthcare systems to their limits, it highlighted the urgent and rapid need to mobilize digital health technology, as well as pressure-testing digital health in ways and under timeframes not previously imagined. Many saw the rapid deployment and uptake of telehealth services, partly out of necessity to maintain continuity of care, but also to ensure that those who needed healthcare were still able to access it no matter what their situation or location. This book presents 17 selected papers from the Australian Health Informatics Conference (HIC 2020) – Healthier Lives, Digitally Enabled, held online from 5 – 25 November 2020. This annual conference usually marks the coming together of the nation's digital health community to discuss, share and showcase current and future initiatives that support the progression of digital health, but in 2020, it took the form of satellite events, culminating with an online Digital Health Institute Summit. The papers presented here reflect highly topical themes across various areas and disciplines, including: digital health in the care of the elderly, mental health, COVID-19, public health, and workforce. Familiar topics, such as wearables, mobile health and remote monitoring, interoperability, and data privacy are also covered, as well as telehealth, automation, bots, and other AI applications. The book will be of interest to all health professionals, especially those working in the fields of digital health informatics and telemedicine.

The perfect balance of theory and practice! Here's the practical introduction you need to understand the essential theoretical principles of clinical immunology and the serological and molecular techniques commonly used in the laboratory. You'll begin with an introduction to the immune system; then explore basic immunologic procedures; examine immune disorders; and study the serological and molecular diagnosis of infectious disease. An easy-to-read, student-friendly approach emphasizes the direct application of theory to clinical laboratory practice. Each chapter is a complete learning module with learning outcomes, chapter outlines, theoretical principles, illustrations, and definitions of relevant terminology. Review questions and case studies help you assess your mastery of the material. A glossary at the end of the book puts must-know information at your fingertips. An access code inside new printed texts unlocks Lab Exercises and Branching Case Studies online at FADavis.com that offer more opportunities to apply theory to clinical laboratory practice.

This book features case studies of ten individuals with acquired neurological disorders. These disorders have implications for speech, language, and communication, but to date they have not been the focus of research in speech-language pathology.Chapters present a brief medical overview of each condition, followed by detailed linguistic analysis. A carefully assembled narrative captures the impact of each neurological disorder on an individual's daily life and social activities. This structured approach, supported by further reading and exercises, gives readers a nuanced understanding of each disorder's clinical presentation and language and communication features, and the complex interrelationship between language, communication, and cognitive and motor symptoms.The book will be of interest to students of all levels, researchers, and clinicians in speech-language pathology and related disciplines, including neurology, psychiatry, and psychology.

This book presents the timeline of immunodiagnostics evolution, including advancements in immunological/nucleic acid probes, assay design, labelling techniques, and devices for signal transduction and acquisition. In the past few years, enzyme and nanocatalyst-based immune assays have undergone numerous modifications to enhance their sensitivity and potential for automation. Further, to reduce production costs and the use of laboratory animals, engineering small antibodies and nucleic acid probes (aptamers) has become increasingly popular in the development of novel and powerful bioassays. In light of the notable advancements in immunodiagnostics, this book highlights the combined efforts of clinicians, biotechnologists, material scientists, nanotechnologists and basic scientists in a coherent and highly structured way. The book takes readers on the journey of immunodiagnostic technologies, from their introduction to the present.

Endoscopic orbital procedures are at the forefront of today's multidisciplinary patient care and team approach to problem-solving. Endoscopic Surgery of the Orbit offers state-of-the-art, expert guidance on minimally invasive orbit techniques that promise a more streamlined approach to comprehensive patient care, improved patient satisfaction, and superior outcomes. This unique resource reflects the contemporary, unparalleled partnership between otolaryngology, neurosurgery, and ophthalmology that often also includes a cohesive team of clinicians from many other specialties. - Provides expert perspectives from thought leaders in various specialties, including otolaryngologists, ophthalmologists, neurosurgeons, endocrinologists, medical and radiation oncologists, radiologists, and pathologists. - Details the two-surgeon, multi-handed surgical techniques that have revolutionized the management of complex pathologies involving the orbit and skull base. - Covers the full breadth of endoscopic orbital procedures—from advanced intraconal tumor removal and intracranial techniques involving the optic nerve and optic chiasm to more routine endoscopic procedures such as orbital decompressions, E-DCR, fracture repair, and subperiosteal abscess drainage. - Reviews key topics such as neuromonitoring in orbital and skull base surgery, endoscopic surgery of the intraconal space for tumor resection, Transorbital NeuroEnodscopic Surgery (TONES), and reconstruction of the orbit. - Includes tips and pearls on safe and effective procedures as well as novel approaches and innovations in the equipment used to perform these popular procedures. - Provides superb visual reinforcement with more than 400 high-definition images of anatomy, imaging, and surgical techniques, as well as procedural videos.

'Venomous'Bites from'Non-Venomous'Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called'rear-fanged snakes'). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided'one-stop shopping'by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of'venom'and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term'venomous.'- Fills a gap in toxicological, medical, and herpetological literature by providing a comprehensive review of this entire assemblage of non–front-fanged snakes, with particular attention given to their capacity to cause harm to humans - Offers a patient-centered, evidence-based approach which is applied to analyzing documented case reports of bites inflicted by a broad representation of species - Provides expanded and updated detailed information on the clinical management of medically significant bites from non–front-fanged snakes, which is also methodically reviewed, and specific recommendations are provided - Includes updates of the fluid taxonomy of advanced snakes and also of terminology with particular regard to the definition of'venom'and the nonmedical criteria used to define the biological basis of the'venomous condition'in snakes and lizards

This book constitutes revised selected papers from the 16th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2019, which was held in Bergamo, Italy, during September 4-6, 2019. The 28 full papers presented in this volume were carefully reviewed and selected from 55 submissions. The papers are grouped in topical sections as follows: Computational Intelligence Methods for Bioinformatics and Biostatistics; Algebraic and Computational Methods for the Study of RNA Behaviour; Intelligence methods for molecular characterization medicine; Machine Learning in Healthcare Informatics and Medical Biology; Modeling and Simulation Methods for Computational Biology and Systems Medicine.

The book is a practical guide for neurosurgeons and radiation oncologists willing to better understand the contemporary multimodal management of neurosurgical diseases including, but not limited to, stereotactic radiosurgery (SRS). Since its invention 1950s, SRS has dramatically impacted the treatment and prognosis of several neurosurgical diseases such as brain and spine metastases, intracranial and spinal arteriovenous malformations, benign head and spine tumors, functional neurological diseases, etc. The book is formed by 35 chapters encompassing all aspects of SRS, from basic principles to the traditional and novel clinical applications. Each chapter points out the current evidence-based indications, contraindications, and adverse effects of SRS and other techniques that should be considered as an alternative or as a complement to SRS.