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Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature.The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.

Whole health is physical, behavioral, spiritual, and socioeconomic well-being as defined by individuals, families, and communities. Whole health care is an interprofessional, team-based approach anchored in trusted relationships to promote well-being, prevent disease, and restore health. It aligns with a person's life mission, aspiration, and purpose. It shifts the focus from a reactive disease-oriented medical care system to one that prioritizes disease prevention, health, and well-being. It changes the health care conversation from'What's wrong with you?'to'What matters to you?'The Department of Veterans Affairs (VA), the Samueli Foundation, and the Whole Health Institute commissioned the National Academies of Sciences, Engineering, and Medicine to establish a committee to provide guidance on how to fill gaps and create processes to accelerate the transformation to whole health care for veterans, both inside and outside the VA system, and the rest of the U.S. population. The resulting report presents findings and recommendations that provide a roadmap for improving health and well-being for veterans and the nation.

The biggest barrier to effective evidence-based practice (EBP) is the failure to effectively translate available knowledge, research, and clinical expertise into action This failure is rarely due to lack of information, understanding, or experience. In fact, it usually comes down to a simple lack of tools and absence of a clear plan to integrate EBP into care. Problem solved! Evidence-Based Practice in Action, Second Edition, is a time-tested, application-oriented EBP resource of The Iowa Model Revised: Evidence-Based Practice to Promote Excellence in Health Care. This book offers a proven, detailed plan to help nurses and healthcare professionals promote and achieve EBP adoption and implementation.

High-quality primary care is the foundation of the health care system. It provides continuous, person-centered, relationship-based care that considers the needs and preferences of individuals, families, and communities. Without access to high-quality primary care, minor health problems can spiral into chronic disease, chronic disease management becomes difficult and uncoordinated, visits to emergency departments increase, preventive care lags, and health care spending soars to unsustainable levels. Unequal access to primary care remains a concern, and the COVID-19 pandemic amplified pervasive economic, mental health, and social health disparities that ubiquitous, high-quality primary care might have reduced. Primary care is the only health care component where an increased supply is associated with better population health and more equitable outcomes. For this reason, primary care is a common good, which makes the strength and quality of the country's primary care services a public concern. Implementing High-Quality Primary Care: Rebuilding the Foundation of Health Care puts forth an evidence-based plan with actionable objectives and recommendations for implementing high-quality primary care in the United States. The implementation plan of this report balances national needs for scalable solutions while allowing for adaptations to meet local needs.

After decades of misinformation about cannabis largely due to the well-funded propaganda campaign in the 1930s, public attitudes toward the drug have finally begun to evolve. In 1996, California became the first state to legalize medical marijuana and since then, 28 other states, 2 U.S. territories, and the District of Columbia have followed suit. Now countless patients are reaping the benefits of this amazing resource which has been used to effectively treat everything from chronic pain to debilitating illnesses.In The Medical Marijuana Guide: Cannabis and Your Health, Dr. Patricia Frye takes a direct, no-nonsense approach to educating readers about cannabis and its medicinal qualities. After having retired from medicine, Dr. Frye was offered an opportunity to practice cannabis treatment. Intrigued, she educated herself on this emerging alternative and is now ready to share with others what she has learned.In this book, using humorous and touching stories from the many situations she has encountered in her practice over the years, Dr. Frye provides valuable information about the undeniable medicinal qualities of cannabis. This book helps to de-stigmatize this misunderstood drug and educate readers on the history of cannabis and how it is used by the medical community today. This is an accessible, enjoyable resource that will not only entertain readers, but may change their lives for the better.

COST (European Cooperation in the field of Scientific and Technical Research) is an intergovernmental initiative in science and research intended to promote the coordination of nationally funded research in Europe. Four working groups discuss the housing of animals, their environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the activities of these working groups, this book provides the European best practices for individuals and institutions working with laboratory animals. The text also discusses the ethical evaluation of experiments and procedures involving animals.

While replacing and reducing the use of laboratory animals are integral parts of the 3Rs-replace, reduce, refine-which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestsel

While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics an

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrieno

approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg­ ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com­ mittee gratefully acknowledges the support ofVysis, Inc., in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi­ tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.

Composites are now one of the most important classes of engineered materials, as they offer several outstanding properties as compared to conventional materials. These materials have found increasingly wider applications in the general areas of chemistry, physics, nanotechnology, material science and engineering. This new book compiles and examines a variety of contributions from over forty-nine experts of interdisciplinary fields of science to broadly explore the developments in the field of composite materials.

'This title evolved from a two day British Sedimentological Research Group meeting on the 22-23 June 2000 held at the Southampton Oceanography Centre in the UK'--Acknowledgements.

'This is the third edition of a near standard survey of the intellectual life of the age of faith. Artz on the arts, as on philosophy, politics and other aspects of culture, makes lively and informative reading.'—The Washington Post