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The Vocal Athlete, Third Edition is written and designed to bridge the gap between the art of contemporary commercial music (CCM) singing and the science behind voice production in this ever-growing popular vocal style. Revised and expanded, this edition is a “must have” for vocal pedagogy courses and speech-language pathologists, singing voice specialists, and voice teachers. Heavily referenced, this text is ripe with current research on singing science as it relates to the CCM voice. Anyone who trains singers will gain insight into the current research and trends regarding commercial music artists.

Mangelnde Gesundheit kostet die deutsche Wirtschaft jährlich große Summen. Umso wichtiger ist es, ein funktionierendes und durchdachtes Betriebliches Gesundheitsmanagement (BGM) am Arbeitsplatz aufzubauen. Der Autor beschreibt, wie unterschiedliche Datenquellen (Gefährdungsbeurteilung, Gesundheitsbefragung, Altersstrukturanalyse und Gesundheitsreports der Krankenkassen) analysiert werden, um die fürs eigene Unternehmen wichtigsten Wirkhebel zu finden. Er zeigt konkret, wie man im BGM, gerade über digitale BGM-Formate und die Nutzung von verschiedenen Medien, Gesundheitskompetenzentwicklung bei Mitarbeiter:innen organisieren und umsetzen kann. Dabei werden kurze Erklärtexte mit Schemata und Grafiken ergänzt und konkrete Prozessbeschreibungen durch Fall- und Praxisbeispiele veranschaulicht. Inhalte: - Das Prinzip der datengestützten, punktgenauen Interventions- und Maßnahmenplanung - Mit Stressmedizin und Somatopsychologie den psychischen Erkrankungen und Atemwegsinfektionen effektiv begegnen - Interne Themenkampagnen und Gesundheitsmarketing mit analogen Marketingmethoden und digitalen BGM-Lösungen realisieren - Gesundheitsorientiertes Führen haltungs- und verhaltensverändernd gestaltenNeu in der 2. Auflage: - Entwicklung von Gesundheitskampagnen - Digitales und hybrides BGM in der Praxis - Körperliche Ursachen von psychischen Erkrankungen: ein neuer Ansatz zur Reduktion von Fehltagen wegen psychischer Erkrankungen - Vorschlag zur Einführung einer innerbetrieblichen Beratungsstelle für die individuelle Unterstützung von Mitarbeitenden und zur Entlastung von Führungskräften - Strukturierung von Rückkehr-, Fürsorge- und Fehlzeitengesprächen Die digitale und kostenfreie Ergänzung zu Ihrem Buch auf myBook+: - Zugriff auf ergänzende Materialien und Inhalte - E-Book direkt online lesen im Browser - Persönliche Fachbibliothek mit Ihren BüchernJetzt nutzen auf mybookplus.de.

Mangelnde Gesundheit kostet die deutsche Wirtschaft jährlich große Summen. Umso wichtiger ist es, ein funktionierendes und durchdachtes Betriebliches Gesundheitsmanagement (BGM) am Arbeitsplatz aufzubauen. Der Autor beschreibt, wie unterschiedliche Datenquellen (Gefährdungsbeurteilung, Gesundheitsbefragung, Altersstrukturanalyse und Gesundheitsreports der Krankenkassen) analysiert werden, um die fürs eigene Unternehmen wichtigsten Wirkhebel zu finden. Er zeigt konkret, wie man im BGM, gerade über digitale BGM-Formate und die Nutzung von verschiedenen Medien, Gesundheitskompetenzentwicklung bei Mitarbeiter:innen organisieren und umsetzen kann. Dabei werden kurze Erklärtexte mit Schemata und Grafiken ergänzt und konkrete Prozessbeschreibungen durch Fall- und Praxisbeispiele veranschaulicht. Inhalte: - Das Prinzip der datengestützten, punktgenauen Interventions- und Maßnahmenplanung - Mit Stressmedizin und Somatopsychologie den psychischen Erkrankungen und Atemwegsinfektionen effektiv begegnen - Interne Themenkampagnen und Gesundheitsmarketing mit analogen Marketingmethoden und digitalen BGM-Lösungen realisieren - Gesundheitsorientiertes Führen haltungs- und verhaltensverändernd gestaltenNeu in der 2. Auflage: - Entwicklung von Gesundheitskampagnen - Digitales und hybrides BGM in der Praxis - Körperliche Ursachen von psychischen Erkrankungen: ein neuer Ansatz zur Reduktion von Fehltagen wegen psychischer Erkrankungen - Vorschlag zur Einführung einer innerbetrieblichen Beratungsstelle für die individuelle Unterstützung von Mitarbeitenden und zur Entlastung von Führungskräften - Strukturierung von Rückkehr-, Fürsorge- und Fehlzeitengesprächen Die digitale und kostenfreie Ergänzung zu Ihrem Buch auf myBook+: - Zugriff auf ergänzende Materialien und Inhalte - E-Book direkt online lesen im Browser - Persönliche Fachbibliothek mit Ihren BüchernJetzt nutzen auf mybookplus.de.

This is a comprehensive textbook that covers the basic principles and concepts of chemistry. It serves as a foundation for students who are just starting their journey in the field of chemistry. The book covers topics such as atoms, molecules, chemical reactions, stoichiometry, thermodynamics, and chemical bonding. It also includes practical applications of chemistry, such as environmental issues, energy production, and pharmaceuticals. This book is an essential resource for anyone seeking a thorough understanding of chemistry.

Encyclopedia of the Human Brain, Second Edition, Seven Volume Set builds on the success of the first edition, providing neuroscience researchers with the ideal'one-stop'resource on all topics related to human brain understanding. Given the length of time since the first edition published, EHB2 is thoroughly revised, with substantial updates on many new and exciting topics, including areas such as human neuroimaging, non-invasive brain stimulation, molecular biology (including genetics and epigenetics), and the clinical diagnoses of brain disorders, along with chapters exploring the introduction of new theoretical and methodological ideas in areas ranging from cognitive neuroscience to evolution of the human brain. In total, there are 440 articles – a vast increase from 224 previously - thus reflecting the huge explosion in neuroscience research during the last 20 years. EHB2 provides a brand new generation of neuroscientists with the perfect tool with which to learn and master the fundamentals of how and why the human brain operates as it does. - Provides a comprehensive and up-to-date resource for exploring the human brain - Includes timely, key topics, providing an excellent overview of the field in a thematically structured one-stop shop location - Moves from an alphabetical structure to a systems/topic approach that is more fruitful for specialized readers and allows easier serendipity to less expert readers

Praise for previous editions:'The evidence-based protocols are designed as a primary reference and are useful, substantive, and timely....The broader contributions of useful format and succinct review of the evidence make it likely that this text will continue to be the leading resource in nursing education and practice.'--The Gerontologist'As a gerontological clinical educator/research nurse, I will often use this as a reference. The format and the content are good, and the explanations of how to best use the evidence simplify the process of sifting through mountains of information to figure the best practice.'Score: 97 --Doodys The result of a collaboration between expert practitioners and educators in geriatric nursing, the seventh edition of this acclaimed reference has been updated and revised with new information on chronic conditions and emerging models of care presented in 10 completely new chapters. It provides the most current, evidence-based protocols for improving both quality of care and patient outcomes when caring for older adults in multiple disciplines and settings. As in past editions, the seventh edition is distinguished by its use of a rigorous systematic method (AGREE: Appraisal of Guidelines for Research and Evaluation) to improve the validity of the book's evidence-based content. Chapters provide assessment and management principles, clinical interventions, and information on specialty practice and models of care. Included in most chapters are protocols developed for each clinical condition by experts in that specific area. Evidence is current and derived from all settings of care, including community, primary, acute, and long-term care. Protocols include an overview and evidence-based assessment and intervention strategies. Illustrative case studies with discussion are presented in most chapters, along with chapter objectives and references with evidence ratings. Instructor's resources include an AACN Mapping Grid, Course Cartridge, Transition Guide, PowerPoints, and Test Bank. New to the Seventh Edition: Updated to encompass the latest trends in older adult care, chronic conditions, and emerging models of care New chapters on care and management of diabetes and respiratory care New chapters on issues surrounding nutrition and dementia, and mental illness New chapter on care and comfort at the end of life New chapters on adopting principles of diversity, equity, and inclusion and an age-friendly health system into practice New chapters on models of care in long-term, community-based, and primary care Key Features: Delivers easy-to-follow geriatric protocols for best practices Updates evidence regularly to reflect current practice standards Encompasses a broad scope of content including detailed information rarely covered in professional literature Offers case studies and discussions to illustrate application of protocol to practice Written by renowned leaders in geriatric nursing education and practice Use of AGREE (Appraisal of Guidelines for Research and Evaluation) to improve the validity of evidence throughout the text

As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research. This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. Combining both conventional and innovative approaches to the topic, the book offers a valuable guide for readers working in medicinal chemistry, the life sciences and allied fields. It summarizes the available data on the fundamentals of neurotransmitters, treatment of and advanced care for neurodegenerative diseases; and outlines current and future research directions in this field.

Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field's definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween's is a convenient, one-stop resource for use in the reporting room as well as in personal study. - Shares the knowledge and experience of a'who's who'list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher. - Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion. - Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine. - Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. - Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. - Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout. - Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

The rapidly increased understanding of the molecular background of complex diseases facilitated the development of highly advanced therapeutic concepts. Such concepts aiming to consider individual signatures of genomic and proteomic biomarkers including pharmacogenomics as well as advanced diagnostic tools have been successfully implemented in clinical practice in various fields leading to significant improvement of treatment successes. This volume gives an up-to-date overview on applications of precision medicine in various clinical entities, on advanced techniques as well as on economic considerations.

This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues.Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented.Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Long-Covid und Post-Vac betreffen immer mehr Menschen - während die Schulmedizin häufig keine Antworten und Lösungen findet. Betroffene fühlen sich allein gelassen und verlieren die Hoffnung. Dieses Buch erklärt worum es bei beiden Syndromen geht - wie sie funktionieren, wie man sie erkennt und was therapeutisch getan werden kann. Ausführlich und verständlich werden die unterschiedlichen Aspekte erläutert, denn nur wer versteht kann zielgerichtet handeln. Welche Untersuchungen werden benötigt? Was bedeuten die Ergebnisse? Welche Therapie macht wann bei wem Sinn? Was kann in Eigenregie angegangen werden, wann wird welche medizinische Hilfe benötigt?

Manual for Long-Covid and Post-Vac: How do they work, which are the problems? How can they be detected and diagnosed? Which investigations and lab markers are crucial? What can we learn from them? Which tools do we have, to get back our health - may they be drugs, supplements, micronutrients, nutrition or instrument-based? The book provides comprehensive but comprehensible explanations, protocols and procedures.

This book presents an overview of the science of superconducting materials. It covers the fundamentals and theories of superconductivity. Subjects of special interest involving mechanisms of high temperature superconductors, tunneling, transport properties, magnetic properties, critical states, vortex dynamics, etc. are present in the book. It assists as a fundamental resource on the developed methodologies and techniques involved in the synthesis, processing, and characterization of superconducting materials. The book covers numerous classes of superconducting materials including fullerenes, borides, pnictides or iron-based chalcogen superconductors ides, alloys and cuprate oxides. Their crystal structures and properties are described. Thereafter, the book focuses on the progress of the applications of superconducting materials into superconducting magnets, fusion reactors, and accelerators and other superconducting magnets. The applications also cover recent progress in superconducting wires, power generators, powerful energy storage devices, sensitive magnetometers, RF and microwave filters, fast fault current limiters, fast digital circuits, transport vehicles, and medical applications.

Leichte Impfreaktionen sind normal. Doch manche sind nach COVID-Impfungen auch von starken und nicht selten anhaltenden Impfreaktionen betroffen. Impfreaktionen beruhen ebenso wie schwere COVID-Verläufe oft auf einem Mastzellaktivierungssyndrom. Dabei gibt es gute Möglichkeiten sich zu schützen und das Risiko für Impfreaktionen erheblich zu senken sowie vorhandene Impfnebenwirkungen deutlich zu reduzieren. Der neue Ratgeber von Dr. med. L.M. Jacob gibt Hintergrundinformationen zu Impfreaktionen, beschreibt Ursachen und Symptome und geht dem Zusammenhang von Impfreaktionen und Mastzellen tiefer auf den Grund. Mit ausführlichen Informationen zu Prävention und Behandlung von Impfreaktionen bietet der Ratgeber zudem praktische Hilfe für Impfzögerer und Betroffene. Das Buch beinhaltet ein ausführliches Literaturverzeichnis mit allen wissenschaftlichen Quellen zum Nachlesen und Vertiefen.

Der Arzneimittel-Kompass 2022, der sowohl als Open-Access-Publikation als auch als gedrucktes Buch erscheint, widmet sich dem Schwerpunktthema „Qualität der Arzneimittelversorgung“. Dabei stehen die Qualitätssicherung und das Qualitätsmanagement in der zweiten Ausgabe des Arzneimittel-Kompass im Fokus. Namhafte Autorinnen und Autoren analysieren Stärken und Schwächen in der Arzneimittelversorgung und beschreiben die Umsetzungsherausforderungen, die der komplexe Prozess einer optimalen Versorgung der Bevölkerung mit Arzneimitteln mit sich bringt. Der Arzneimittel-Kompass 2022 geht unter anderem den folgenden Fragen nach:Was wird unter Qualität in der Arzneimittelversorgung verstanden?Wie ist die Qualität in der Arzneimittelversorgung spezifischer Gruppen von Patientinnen und Patienten wie beispielsweise von Kindern, älteren Menschen oder MS-Erkrankten zu bewerten?Sind Defizite bei der Verordnung von Kontrazeptiva, bei der Hormonersatztherapie, an der Schnittstelle von ambulanter und stationärer Versorgung oder von Patientinnen und Patienten mit Covid-19 erkennbar?Welche Hürden und Hindernisse gilt es zu bewältigen, um diese Defizite auszugleichen?Wie kann das Wissen über eine qualitativ hochwertige Arzneimittelversorgung auch in der Praxis umgesetzt werden?Zentrale Entwicklungen im Arzneimittelmarkt werden analysiert und beschriebenDie Ausgaben für Arzneimittel und Impfstoffe, die im Jahr 2021 mit 52,0 Mrd. € einen neuen Höchststand erreicht haben, werden differenziert in den Blick genommen. Die Auswertungen basieren auf 810 Millionen Verordnungen von mehr als 210.000 Ärztinnen und Ärzten für 73,3 Mio. GKV-Versicherte. Besondere Beachtung gilt den Trends in den Marktsegmenten Generika, Biosimilars, Patentarzneimittel und Orphan Drugs. Die Wirksamkeit der gesetzlichen Regulierungsinstrumente wird gleichfalls betrachtet. Ein Blick aufdie Arzneimittelversorgung in Deutschland im Vergleich zu anderen europäischen Ländern rundet diesen Teil ab.Die Herausgeberinnen und HerausgeberDer Arzneimittel-Kompass 2022 wird von Helmut Schröder, Dr. Carsten Telschow und Dr. Melanie Schröder vom Wissenschaftlichen Institut der AOK (WIdO), Prof. Dr. med. Petra Thürmann von der Universität Witten-Herdecke und Prof. Dr. med. Reinhard Busse von der Technischen Universität Berlin herausgegeben.

Der neue Ratgeber von Dr. med. L.M. Jacob gibt Hintergrundinformationen zu Long Covid, beschreibt Ursachen und Symptome und geht dem Zusammenhang von Long Covid und Mastzellen auf den Grund. Mit ausführlichen Informationen zu Prävention und Behandlung von Long Covid bietet der Ratgeber zudem praktische Hilfe für Betroffene. 44 Seiten, inkl. Literaturverzeichnis

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

In the US medical environment where medical mistakes, over-diagnosis, and over-treatment have become the third leading cause of death, leadership consultant and long-time charity CEO Edward Morgan argues that protecting yourself with medical wisdom can add 10-15 years to your life.We're a nation on meds, where 60% of adults are now diagnosed with some chronic condition. We're listening to unwise advice and becoming permanent patients.Longevity is declining in America, even though medical costs in the US are twice that of other developed nations. Don't get caught in medical misadventures that escalate into permanent conditions, screenings that cascade into fear-driven decisions, prescriptions that simply suppress symptoms, or worst of all, end up dying in an ICU in the vain hope for a few more days.Smart is not the same as wise. Medical wisdom and discernment will extend your life. Taking today's aggressive, profit-driven advice will quite possibly shorten it. Living to see your grandchildren grow up is your responsibility, not your doctor's. This is a must read for anyone already feeling like a patient for life. With courage and wisdom you can become a well person again and live out your full lifespan.

Keep current with the latest clinical practice guidelines and policies from the American Academy of Pediatrics (AAP), covering more than 40 conditions plus every AAP policy statement, clinical report, and technical report though December 2021. KEY FEATURESNew clinical practice guideline: Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days OldNew and revised AAP policy statements, clinical reports, and technical reportsPrinted text and eBook access, including full text of all AAP clinical practice guidelines and full text of 2021 AAP policy statements, clinical reports, and technical reportsMore than 600 policy statements, clinical reports, and technical reportsQuick Reference Tools, including coding tips, patient education handouts, and moreFive-section organization for ease of use

Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

“Ehlers-Dan… Was?” Das hören Betroffene der seltenen Ehlers-Danlos-Syndrome (EDS) fast täglich. Die meisten Menschen in ihrem Umfeld haben nie von der Gruppe von angeborenen Bindegewebserkrankungen gehört oder verbinden damit nur dehnbare Haut und flexible Gelenke. Doch die EDS sind viel mehr als das! Zusätzlich zu den Symptomen der EDS, die den ganzen Körper betreffen können, treten diverse andere Erkrankungen zusammen mit den Ehlers-Danlos-Syndromen auf, wie z. B. Dysautonomie, Mastzellaktivierungssyndrom und viele mehr.Die EDS stellen sowohl Betroffene als auch deren Ärzt•innen vor große Herausforderungen. Oft sind die Betroffenen daher auf sich alleine gestellt. Sie müssen selbst Expert•innen für ihre Erkrankung werden, wenn sie eine optimale Versorgung erwarten.Durch eine Mischung aus fachlichen Informationen, Expert•innenmeinungen und Tipps zum praktischen Umgang mit der Gruppe von komplexen Bindegewebserkrankungen bietet dieses Buch vor allem Neueinsteiger•innen - Betroffenen, Angehörigen, Interessierten sowie Hausärzt•innen und anderem medizinischen Personal - einen kompakten Überblick über alle Facetten der Ehlers-Danlos-Syndrome. 18 interessante Videos mit Interviews mit deutschsprachigen und internationalen Expert•innen bereichern das Buch und machen es zu einem multimedialen Erlebnis.

Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease. Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches. - Provides detailed immunological background for understanding the etiology and management of reproduction failure - Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure - Gives insights into various immunological and therapeutic approaches for reproduction failure

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future.Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

A Handbook of Geriatric Neuropsychology: Practice Essentials (Second Edition) brings together experts in the field to integrate the knowledge and skills needed to understand and treat older adults who are experiencing problems with memory and other thinking skills. With three new sections, including coverage of other conditions beyond neuropsychological disorders, special assessment contexts, and more on interventions and ethics, as well as multiple new chapters, and significant updates from the first edition, this book provides a strong foundation for clinicians, educators, and researchers invested in the wellbeing of older adults.The impact and experience of aging, like the practice of neuropsychology, evolves over time. Similarly, through advances in science and professional techniques, neuropsychological practice has continued to evolve. Neuropsychological evaluation remains the most effective method of diagnosing age-related cognitive decline, cognitive difficulties that result from psychological factors, and other related disorders, as well as determining how the various disorders impact functioning and quality of life. This book explores these areas and offers state-of-the-art assessment techniques to assess changes in cognition and behavior and to distinguish normal changes from neuropathology.This book is a go-to resource and key reference for psychologists who serve older adults with known or suspected cognitive problems, as well as those who are invested in promoting brain wellness. It provides much of the information needed to establish and improve foundational and functional competencies in geriatric neuropsychology and establish practices that are personally and professionally rewarding, all aimed at promoting the understanding and wellbeing of older adults.

Deutschland hat in Zeiten von Corona und angesichts neuer gesetzlicher Initiativen in den vergangenen drei Jahren durch eigene neue Angebote eine deutliche Belebung der digitalen Gesundheitsanwendungen erfahren. Große Teile der Bevölkerung nehmen Angebote wie den digitalen Impfnachweis als sinnvoll wahr und signalisieren in Umfragen eine hohe Bereitschaft für digitale Begleiter. Dieses Buch gibt einen Überblick über die sich konkret realisierenden digitalen Gesundheitsangebote in der zentralen Infrastruktur für digitalen Austausch im Gesundheitswesen – die Telematikinfrastruktur (TI). Diese erlebt derzeit einen grundlegenden Wandel. Mit der „TI 2.0“ stellt die gematik künftig eine moderne Plattform für digitale Medizin zur Verfügung: zeitgemäß und nutzenorientiert, interoperabel und stabil für einen sicheren Betrieb. Dafür braucht es jetzt einen Technologiesprung und eine Neudefinition des Angebots und Auftrags der gematik. So schafft die gematik nun als Nationale Agentur für Digitale Medizin eine gemeinsame Arena für alle Akteure. Die gematik unterstützt mit Infrastruktur und Diensten, damit Teamwork und Spitzenleistungen in der Gesundheitsversorgung und dem Gesundheitsmanagement möglich werden. Es geht dabei um nichts Geringeres als um die Digitalisierung des deutschen Gesundheitswesens, eines der größten IT-Projekte Europas mit dem Ziel, die Gesundheitsversorgung aller Bundesbürgerinnen und Bundesbürger zu verbessern. Das vorliegende Buch beschreibt ganz konkret, wohin sich das digitale Gesundheitswesen in den kommenden Jahren entwickeln wird, und richtet den Blick auf den aktuellen Veränderungsprozess in einem ganz zentralen Versorgungsbereich der Gesellschaft. Expertinnen und Experten der gematik geben Einblicke in den Wandel von gematik und Telematikinfrastrukur und zeigen, wie die neuen Wege und Werte insgesamt die E-Health-Entwicklungen in Deutschland stärken. Beiträge aus Politik und Gesundheitswirtschaft beleuchten den ausgedehnten Kontext der Arbeit an einer TI 2.0 und welche gemeinsamen Wege dabei möglich und nötig sind. Trotz verbindlicher Spielregeln in der gemeinsamen Arena entsteht Spielraum für Neues und Zukunftsweisendes, von dem alle profitieren können und werden.

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson's disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book's discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. - Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms - Analyzes preclinical models of Parkinson's disease therapies based on exogenous neurotoxins and why they have failed - Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins - Proposes a more physiological model directly related to the metabolism of dopaminergic neurons - Provides the basic concepts and mechanisms of dopamine metabolism

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. - Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics - Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression — A Selection of Readings for Health Services Providers presents an edited and annotated collection of recent medical journal publications and abstracts illustrating new approaches to treatment derived from the metabolic theory of cancer. It intends to shed an early light on a relatively new approach to our understanding of the cancer cell idiosyncratic metabolic dysfunction, and on evidence-based new treatment strategies derived from that understanding. The book discusses topics such as tumor starvation by L-arginine deprivation; L-canavanine depriving tumors of L-arginine in pancreatic, multiple myeloma and breast cancer; glucose deprivation and intermittent fasting; glutamine uptake in cancer; the relation of oxygen-starved cancer cells with aspartate; and reducing tolerance of tumor cells to nutrition starvation. The content is presented in a contextualized and practical way in order to facilitate the transition from bench to bedside. This is a valuable resource for practitioners, oncologists and other members of healthcare chain who are interested in learning more about the most recent tumor cell starvation strategies and how they can improve overall treatment outcome. - Provides extensive comments on scientific publications detailing recent findings about tumor cell auxotrophy applied to tumor cell starvation strategies - Helps the reader to find relevant and practical information on cancer cell starvation, otherwise spread through niched specialized journals, in one single place - Comments on the recent findings putting them in context of clinical practice in order to provide the reader with means of translating high level research to the clinics

本書は、応用物理学会 超伝導分科会から出版されたスクールテキスト『高温超伝導体（下）―材料と応用―』の改訂版として企画されました。初版が出版された2005年頃は、高温超伝導体の発見から18年が経過し、初期の重要な研究成果を知らない若手研究者が増えてきた時期でしたが、それからさらに15年以上が経過し、超伝導技術を取り巻く状況も大きく変わりました。鉄系超伝導体など新たな超伝導物質が発見されたことに加え、応用という観点では、すでに実用化フェーズに入っている研究開発もあり、そこでは高温超伝導体だけではなく従来の金属超伝導体が使われているケースも多々あります。そのため、本書では、応用研究にフォーカスして内容を完全に刷新することとしました。 本書は、パワー応用からエレクトロニクス応用まで、超伝導技術のほぼ全域を網羅しているため、内容をより深く理解するためには、その基礎となる薄膜、線材、ジョセフソン接合等の製造方法についても、基礎知識が必要です。そこで、「第1部 製法」と「第2部 応用」の2部構成とし、超伝導に関する基礎知識のない読者でも内容が理解できるよう配慮しました。高温超伝導体の発見による超伝導フィーバーから30年が経過し、着実に応用が進む超伝導技術の最前線の臨場感が読者に伝われば、企画者の望外の喜びです。

Zum Thema COVID-19 erschienen bis September 2021 etwa 160.000 wissenschaftliche Arbeiten. Trotz dieser Wissensexplosion wird die Öffentlichkeit mit widersprüchlichen Botschaften überflutet. Dieser Ratgeber zeigt einen vernünftigen Mittelweg zwischen Verharmlosung und Panikmache auf. Statt Halbwahrheiten liefert er Fakten, die jeder kennen sollte – ganzheitlich, wissenschaftlich und praxisnah – und weist den Weg durch den Corona-Meinungsdschungel. Was macht die Delta-Variante von SARS-CoV-2 so gefährlich? Wo besteht das höchste Infektionsrisiko? Welche Rolle spielen das Immunsystem und der Allgemeinzustand? Worauf ist bei Masken besonders zu achten, damit sie wirklich schützen? Welche Impfstoffe haben das beste Nutzen-Risiko-Verhältnis und wie können Impfreaktionen reduziert werden? Welche Mikronährstoffe und Naturstoffe helfen in klinischen Studien? Warum spielen Mastzellen bei Impfreaktionen, schweren COVID-19-Krankheitsverläufen und Long Covid eine zentrale, aber kaum bekannte Rolle? Wie führt der Teufelskreis aus überschießender Entzündungsreaktion, Sauerstoffmangel, Azidose und dem „Calcium-Paradox“ zu schwersten und tödlichen COVID-19-Verläufen? Der Ratgeber beantwortet diese und mehr Fragen und beleuchtet die wirklichen Ursachen einer schweren COVID-Erkrankung und deren Therapiemöglichkeiten. Durch die richtigen Mittel und Maßnahmen können wir selbst das Infektionsrisiko reduzieren, den Krankheitsverlauf stark abmildern, Long Covid vermeiden und insgesamt gesünder leben.

Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com

In dem vorliegenden Open-Access-Buch identifizieren Studierende und Lehrende interprofessionell Entwicklungen und Problemfelder der Assistiven Technologien. Diese halten zunehmend Einzug ins Leben versorgungsbedürftiger, häufig älterer Menschen. Nach einigen Jahren der Entwicklung kann konstatiert werden, dass der Transfer von Entwicklung zur Anwendung im Alltag infolge unterschiedlicher Perspektiven und Zielsetzungen nur unzureichend stattfindet. Die Beitragsautoren bieten kreative Lösungsansätze, die zu einer nachhaltigen Umsetzung führen sollen.​​Dies ist ein Open-Access-Buch.

Learn how to reduce the impact of environmental toxins on brain development, functioning, and health. The human brain is a marvelously complex organ that has evolved great new capabilities over the past 250,000 years. During most of that period, daily life was vastly different from our lives today. Exercise was not optional - one literally had to run for one's life, livelihood, and sustenance. The Stone Age diet was not a fad, but the only food available. Periods of fasting arose from food scarcity, and hence the earliest keto-diet was commonplace. Life changed greatly with the advent of agriculture and industry. Diseases that were previously unknown or uncommon began to surface as by-products of civilization's advance.Changes in our ways of living have altered the nature of illness as well as its diagnosis and treatment. From the 1970s to the present, tens of thousands of chemicals with applications in all aspects of our lives have grown more than 40-fold. Exposure to these new substances has impacted many aspects of our health, especially the delicate parts of the brain and nervous system. In parallel with the changes in our environment, we have seen the growth of brain disorders including Alzheimer's Disease and autism in previously unimaginable ways. Here, Arnold Eiser elucidates some features of diseases affecting the nervous system that are increasing in incidence with a focus on those disorders that appear related to environmental toxins that modern life has introduced. He takes readers behind the scenes of the science itself to discover the human stories involved in the discovery and management of these illnesses. Offering insights from a variety of scientific disciplines, Eiser clearly and succinctly illustrates the impact of toxins on our brains and how we might better protect ourselves from negative outcomes. With interviews from leading authorities in the field of neuroscience, environmental toxicology, integrative medicine, neurology, immunology, geriatrics, and microbiology (re the gut microbiome), this book offers a robust understanding of the complex threats to our brains, and the healthy brain's dependence upon many other systems within our bodies. This is a voyage of discovery into the science, history, and human struggle regarding disorders challenging the brain as well as their possible prevention.

Deutschland hat in Zeiten von Corona und angesichts neuer gesetzlicher Initiativen in den vergangenen drei Jahren durch eigene neue Angebote eine deutliche Belebung der digitalen Gesundheitsanwendungen erfahren. Große Teile der Bevölkerung nehmen Angebote wie den digitalen Impfnachweis als sinnvoll wahr und signalisieren in Umfragen eine hohe Bereitschaft für digitale Begleiter. Dieses Buch gibt einen Überblick über die sich konkret realisierenden digitalen Gesundheitsangebote in der zentralen Infrastruktur für digitalen Austausch im Gesundheitswesen – die Telematikinfrastruktur (TI). Diese erlebt derzeit einen grundlegenden Wandel. Mit der „TI 2.0“ stellt die gematik künftig eine moderne Plattform für digitale Medizin zur Verfügung: zeitgemäß und nutzenorientiert, interoperabel und stabil für einen sicheren Betrieb. Dafür braucht es jetzt einen Technologiesprung und eine Neudefinition des Angebots und Auftrags der gematik. So schafft die gematik nun als Nationale Agentur für Digitale Medizin eine gemeinsame Arena für alle Akteure. Die gematik unterstützt mit Infrastruktur und Diensten, damit Teamwork und Spitzenleistungen in der Gesundheitsversorgung und dem Gesundheitsmanagement möglich werden. Es geht dabei um nichts Geringeres als um die Digitalisierung des deutschen Gesundheitswesens, eines der größten IT-Projekte Europas mit dem Ziel, die Gesundheitsversorgung aller Bundesbürgerinnen und Bundesbürger zu verbessern. Das vorliegende Buch beschreibt ganz konkret, wohin sich das digitale Gesundheitswesen in den kommenden Jahren entwickeln wird, und richtet den Blick auf den aktuellen Veränderungsprozess in einem ganz zentralen Versorgungsbereich der Gesellschaft. Expertinnen und Experten der gematik geben Einblicke in den Wandel von gematik und Telematikinfrastrukur und zeigen, wie die neuen Wege und Werte insgesamt die E-Health-Entwicklungen in Deutschland stärken. Beiträge aus Politik und Gesundheitswirtschaft beleuchten den ausgedehnten Kontext der Arbeit an einer TI 2.0 und welche gemeinsamen Wege dabei möglich und nötig sind. Trotz verbindlicher Spielregeln in der gemeinsamen Arena entsteht Spielraum für Neues und Zukunftsweisendes, von dem alle profitieren können und werden.

This eight-volume encyclopedia brings together a comprehensive collection of work highlighting established research and emerging science in all relevant disciplines in gerontology and population aging. It covers the breadth of the field, gives readers access to all major sub-fields, and illustrates their interconnectedness with other disciplines. With more than 1300 cross-disciplinary contributors—including anthropologists, biologists, economists, psychiatrists, public policy experts, sociologists, and others—the encyclopedia delves deep into key areas of gerontology and population aging such as ageism, biodemography, disablement, longevity, long-term care, and much more. Paying careful attention to empirical research and literature from around the globe, the encyclopedia is of interest to a wide audience that includes researchers, teachers and students, policy makers, (non)governmental agencies, public health practitioners, business planners, and many other individuals and organizations.

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. - Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease - Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins - Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery - Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) - Features chapter contributions from international leaders in the field

Der Arzneiverordnungs-Report ist seit 1985 eine gemeinsame Publikation von Autoren aus Pharmakologie, Klinik, Praxis, Gesundheitsökonomie und Krankenversicherung. Basis sind die Verordnungsdaten von Arzneimitteln für ambulante Patienten der gesetzlichen Krankenversicherung (GKV). Datenbasis des Jahres 2020 sind ca. 820 Mio. Verordnungen von 150.363 Vertragsärzten und 62.876 Vertragszahnärzten für 73,4 Mio. GKV-Versicherte. Die allgemeine Verordnungs- und Marktentwicklung wird in 6 Kapiteln behandelt, in denen u.a. neue Arzneimittel des Jahres 2020, die Kosten-Nutzen-Analyse von onkologischen Arzneimitteln, Marktsteuerungsmechanismen und Preise von Biologika bzw. Biosimilars sowie die Klassifizierung von Arzneistoffgruppen diskutiert werden.Die Nettokosten für Arzneimittel in der GKV sind 2020 weiter um 5% auf rund 46 Mrd. € gestiegen, vor allem durch neue, hochpreisige Patentarzneimittel. Hauptkostentreiber waren Onkologika (9,5 Mrd. €, + 12,4%)und Antidiabetika (2,8 Mrd. €, + 16,8%). Ein wesentlicher Grund für die Kostenprobleme ist der seit Jahren beobachtete Anstieg der Jahrestherapiekosten neu eingeführter Arzneimittel. Dieser Trend zu hochpreisigen Patentarzneimitteln ist durch das Arzneimittelmarktneuordnungsgesetz (AMNOG) sogar 10 Jahre nach seiner Einführung nicht genügend abgeschwächt worden, auch wenn mit der Vereinbarung von Erstattungsbeträgen 2020 insgesamt 3,7 Mrd. € an Einsparungen erzielt werden konnten.

While bookshelves groan with works on the capital ships of the German Third Reich, there is little in English devoted to their predecessors of the Second Reich, so this new book will fill a clear gap in its study of German cruisers of the period, from wooden-hulled corvettes, through the fusion of ‘overseas'and ‘home'vessels into the modern small cruisers that evolved and fought in the First World War. The book covers the full range of cruising vessels operated or ordered by the Imperial German Navy between 1871 and 1918, excluding the large cruisers, previously covered by the author's companion volume The Kaiser's Battlefleet. These include corvettes, avisos, sloops, torpedo cruisers, III- and IV-class cruisers and small cruisers, and are described and arranged in a chronological narrative. This includes both design and operational histories, the latter continuing down to the end of ships'service after the fall of Imperial Germany, and it is accompanied by an extensive selection of many rare photographs. The ships'technical details are tabulated in the second half of the book which also includes sketches of ships'internal layouts and armour and changes in appearance over time. The authors have made extensive use of archival material, particularly relating to the political and technical background to design and procurement, and present a developmental history of this ship class which is unique in the English language. It will have huge appeal to all those with an interest in the German navy and to those who have been waiting avidly for the sequel to The Kaiser's Battlefleet.

This text provides a critical look at the state of the evidence in the most compelling areas of laryngology. Rather than being a comprehensive text covering every single possible area, it focuses on published works in the 9 areas that are of the most interest to laryngologists as well as speech pathologists, general otolaryngologists, and head and neck oncologists managing laryngologic issues. The state of the literature is succinctly summarized and tabulated in each area, allowing the reader to see which areas have high-grade evidence (Levels 1 or 2) to support decision making, and which areas are in need of better quality studies. Each chapter is divided into three main sections: Diagnosis and Pathophysiology, Surgical management, and Non-surgical management. This makes it easier for the reader to browse to the area of interest in each section and to find the evidence basis for a given concept.Evidence-Based Laryngology will be an invaluable resource to otolaryngologists, residents, speech-language pathologists, and other clinicians who manage laryngological problems and would like to know the evidence basis behind different treatment options.

The latest edition of this textbook provides a comprehensive, state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The textbook begins with a section on gastroenterology and nutrition that presents the overall scope of issues encountered in children suffering from disorders of the gastrointestinal tract, pancreas, and/or presenting nutritional issues, as well as current and future prospects on the use of prebiotics, probiotics, and postbiotics. The second section is centered around hepatology, reviewing congenital and acquired disorders of the biliary tract and liver, as well as analyzing available diagnostic and therapeutic procedures and future perspectives.Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide, Second Edition is an indispensable resource for students, trainees, and clinicians, sure to distinguish itselfas the definitive reference on this topic.

This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment.Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance, eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa.Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.

Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain.This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions.Features· Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations.· Enables practitioners to shift from a “one size fits all'treatment approach toward individualized patient care.· Includes case studies to help educate the provider on how to implement treatment plans in practice.Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

This book serves as a comprehensive but concise, practical, in-depth resource for practitioners who see and treat anaphylaxis. It meets the market need for a reference that relays an advanced understanding of the condition and its management. This unique reference covers management beyond the basics, including discussions around prevention of biphasic anaphylaxis, optimal post-stabilization protocols and how to work up intraoperative anaphylaxis. Additionally, various chapters delve into the practical application of equipping one's office for the management of anaphylaxis, specifically in the setting of a reaction to a food challenge or immunotherapy injection. Anaphylaxis: A Practical Guide is an essential resource for allergists, emergency room physicians, and pediatricians, and those in training to become members of these specialties.

In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of extracellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The monograph sums up the facts that demonstrate the complexity of the human organism-inhabiting microbial consortium comprising a wide variety of biofilm-forming eukaryotic, bacterial and archean cells. The microbiota is involved in maintaining microecological, metabolic, epigenetic, neuro-endocrine and immune homeostasis that normally stabilizes the brain-gut-microbiota axis. Microbially produced neuroactive chemicals include peptides, amino acids, amines, short-chain fatty acids, purines and gaseous substances that are used as nutrients, effectors, cofactors and signals by the host organism. In the present-day world, the human organism has to deal with a large number of environmental stress factors that overpower the organism's protective system and disrupt the functioning of symbiotic microbiota predominantly located in the gastro-intestinal (GI) tract. Homeostasis disruption may impede communication between microbial cells and the human organism and cause physical or mental health problems. The operation of the brain-gut-microbiota axis can be improved by useful microorganisms (probiotics) including psychobiotics that directly impact the human brain and behavior. In the authors'opinion, the lifelong epigenetic developmental program of the organism can be ameliorated and genetic and epigenetic disruptions in the human metagenome (comprising all nuclear, mitochondrial and microbial genes) can be prevented by supplementing the diet with traditional, organic and individualized functional food items that relieve the effects of various detrimental stress factors and agents. A reasonably designed lifestyle based on gut microbiota optimization will undoubtedly help human individuals live a decent healthy life and attain active longevity. Current research on the population organization, social behavior and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology.

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects ofdiet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided.Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient.