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This book examines how discarded marble heaps can be repurposed, in situ, to breathe new life into the landscape, offering solutions that are as innovative as they are practical and sustainable. The author showcases the power of creativity and sustainability to revitalize communities and landscapes with new architectural buildings and public spaces. The volume combines theory with practice, including an extensive bibliography about landscape mutation, rehabilitation of quarries and waste reuse, and, at the same time, a detailed case study on the Estremoz Anticline, in Portugal, one of the world's main sites of marble extraction. Of all the material extracted from the several quarries of the Estremoz Anticline, only about 9% is marketed because of assessed of quality standards. Distinct from other research volumes in this domain, “Sustainable Buildings from Marble Waste Heaps” focuses on the regeneration of industrial landscapes through the on-site reuse of waste heaps, without removing the material from the context it belongs to or changing its morphology, preserving the identity of the place and promoting circular economy.

This volume constitutes the refereed proceedings of the 5th International Workshop, HELMeTO 2023, held in Foggia, Italy, during September 13–15, 2023. The 52 full papers were carefully reviewed and selected from 107 submission. They are categorized in the following sections: Online pedagogy and learning methodologies and Learning technologies data analytics and educational big data mining and their applications, Smart Systems for Context-aware Education, Emotions and Art in Higher Distance Education and Performing art based methodology to improve online learning experiences, E learning for providing augmented mathematics education at University level, SuperCyberKids the importance of promoting Cybersecurity Education among teacher education students, Effects of High performance Artificial Intelligence systems and Immersive Technologies in Education, The Future of Learning Exploring the Intersection of Posthumanism E Health Technologies and Artificial Intelligence in Education Innovations, Technology based learning interventions in higher education for combating inequalities and increasing the psychological well being of youngsters, Innovative Inclusive University, Beyond borders: exploring immersive environments and new didactic approaches in higher education, Learning Technologies and Faculty Development in the digital framework.

This volume constitutes selected papers presented during the Second International Conference on New Media Pedagogy: Research Trends, Methodological Challenges, and Successful Implementations, NMP 2023, held in Cracow, Poland, in November 2023. The 29 papers presented were reviewed and selected from 90 submissions. They focus on recent research and emerging concerns in the field of media pedagogy, such as determinants of teachers'functioning in computerised schools, digitally assisted didactics, ICT-based solutions for teaching support, e-learning during crisis, digital inclusion and exclusion, Artificial intelligence in education and more.

In today's fast-paced and modern world, our lifestyles have undergone a dramatic shift. The conveniences and comforts that accompany our technological advancements have come at a cost – an increased prevalence of lifestyle diseases. Lack of physical activity, stress, sedentary habits, and poor dietary choices have become leading causes of a spurt in varied health complications such as obesity, diabetes, and cardiovascular diseases. Various health awareness programmes organized by central/state governments, private organizations, and NGOs from time to time have generated interest among common people in exploring organic foods that are free from chemicals and full of nutraceuticals. There has been a growing interest in exploring the potential of nutraceuticals to address lifestyle diseases.Recognizing the urgent need to address this global health crisis, this book delves into a realm of science that offers immense potential for improving our health and well-being. Nutraceuticals, which combine'nutrition'with'pharmaceuticals,'offer a promising strategy for treating certain conditions caused by a particular way of life. They include a variety of bioactive substances obtained from plants, including fruits, vegetables, herbs, and marine organisms. Certain substances have therapeutic qualities and have shown significant promise in treating and even preventing certain disorders.Features: The chapters in this book have been meticulously curated to provide readers with a diverse range of perspectives. Provides a comprehensive exploration of nutraceuticals and their potential benefits. Examines the impact of specific nutraceuticals on various lifestyle diseases to discuss their synergistic effects and potential adverse reactions. Each chapter offers valuable insights and practical guidance for healthcare professionals, researchers, and individuals seeking to enhance their overall well-being. A systematic overview of the state-of-the-art in nutraceuticals with recent research results. This book will certainly be a valuable resource for researchers engaged in studies on nutraceuticals to develop a depth of understanding of the latest trends and tools in this field. Additionally, it can serve as a comprehensive textbook for graduate-level courses in food and nutrition, biomedical, and health sciences.

This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also features an update on the clinical management of these diseases, including new diagnostic and therapeutic tools. Written by a combination of recognized and emerging experts in the field, this book is intended as a major reference work, not only for endocrinologists and nephrologists, but also for pediatricians, neonatologists, cardiologists, and emergency medicine and intensive care specialists, who can be faced with the management of endocrine diseases responsible of salt and water imbalance. The book is part of the SpringerReference program, which provides access to ‘living editions'that are constantly updated using a dynamic, peer-review publishing process.

Balancing basic science with information on everyday clinical practice, Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 7th Edition, provides you with expert guidance and advances in the field so you can offer patients the most optimal diagnostic and surgical care. In two convenient volumes, Dr. William Jarnagin and his team of internationally recognized surgeons cover exactly what you need to know, including advances in diagnostic and surgical techniques, minimally invasive surgeries, new interventional diagnostic techniques, and all relevant diseases. This comprehensive, practical reference is designed to help you choose and perform the most appropriate procedures that will minimize inpatient hospital time, curtail costs, and reduce overall recovery time for your patients. - Presents cutting-edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in one highly regarded, authoritative reference. - Covers all surgical approaches, both open and minimally invasive. - Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform clinical decision-making. - Contains 161 chapters with updated references and additional figures—more than 1,500 illustrations in all. The imaging section has been reorganized to reflect a disease-based approach. - Includes new and expanded sections on advances in molecular characterization of benign and malignant HPB diseases, perioperative management, interventional techniques, minimally invasive surgery and robotics, and therapeutic advances for malignant disease. - Features a section dedicated entirely to operative technique, plus a new historical chapter authored by Professor Jacques Belghitti:'Hepatobiliary and Pancreatic Surgery: Historical Perspective.

Cancer Genes is a comprehensive list of the most critical genes known to contribute to cancer imitation and progression. The book delves into their location on each chromosome, providing valuable insights into the mechanisms of cancer gene dysregulation and genetic mutations which provide cancer cells with an advantage during each stage of tumorigenesis. The reference will familiarize readers with the location of cancer genes and equip them with the necessary information to identify relevant gene expression targets for research aimed at preventing the disease. The book is divided into two volumes focusing on cancer-causing genes found in chromosome pairs 1-12 (volume 1), and chromosomes 13-23 (volume 2). A key features of the book is a detailed reference list for advanced readers. The compilation is therefore a quick and handy reference on cancer causing genes for researchers, medical professionals, and anyone interested in understanding the genetic basis of cancer.

This volume constitutes selected papers presented during the First International Conference on New Media Pedagogy: Research Trends, Methodological Challenges and Successful Implementations, NMP 2022, held in Kraków, Poland, in October 2022. The 20 papers presented were thoroughly reviewed and selected from the 55 qualified submissions. They present recent research in the areas of teacher education in the information society, digitally-enhanced didactics, pedagogical innovations using ICT, e-learning, blended learning, crisis e-learning, digital inclusion and exclusion, identity of media pedagogy, and more.

Encyclopedia of Meat Sciences, Third Edition, Three Volume Set is the most up-to-date reference work on topics central to agricultural and food science researchers at all levels. With over 250 outstanding articles written by world leading experts, the book offers unparalleled coverage of the science and technology of producing and harvesting animals for meat, along with tactics for preservation and processing. Clearly divided into 12 distinct sections, topics covered include all aspects of the production of animals, poultry, fish and other species commonly'farmed'and/or'harvested', as well as the science of meat preservation and processing and consumer issues. New to this third edition are chapters covering the core scientific advancements of recent years, including gene editing of animals, sustainability and zoonotic diseases. In addition, the book introduces a templatized chapter approach, thus providing consistency to the entire work and maximizing the clarity and accessibility of its content for the reader. Chapters, once again, include a variety of images, charts, graphs, and/or diagrams to enhance the text. - Provides a'one-stop'resource that bridges the gap in knowledge since the last edition - Presents a comprehensive reference book on meat science - Intuitively organized into 12 sections over 3 volumes, providing an excellent overview of the field - Contains approximately 250 chapters written by a global team of experts in meat sciences, thus maximizing its appeal to a large audience

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. - Addresses the normal production of steroids and concentrations found in biological fluids and tissues - Presents the changes in steroid concentrations at life events as reference points for clinical investigations - Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. - Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction - Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists - Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding - - Includes chapter contributions from leading global experts

This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.

The formation of placenta can be viewed as a controlled process of inflammation or cancer development in which cell proliferation, invasion, and immune surveillance or evasion are promoted in a time- and space-specific manner. This suggests that the functions of prostasin are mainly active in pathophysiological conditions, more so than those in basic or normal physiological conditions. The uniqueness of the prostasin serine protease is its membrane anchorage via a glycosylphosphatidylinositol moiety. This anchorage exposes the entire prostasin molecule to the outside while still being immobilized on the cell membrane and gives prostasin a better chance to be used as a biomarker or drug target. As presented in placenta development, the equilibrium between growth and differentiation dictates healthy and disease states.This book provides readers with an integrated knowledge on serine protease prostasin, starting with its discovery, protein isolation, cDNA, and gene cloning, to its functions in physiology and pathophysiology, and to its application in the development of therapeutics. This is the first-of-its-kind book that covers the history, present state of knowledge, and future perspectives of the prototypic glycosylphosphatidylinositol-anchored epithelial extracellular serine protease prostasin, which is a key player in the regulation and maintenance of the extracellular fluid homeostasis. The chapters encapsulate all that has been learned about prostasin in the technical sophistication, but more importantly, also highlight a critical analysis on the problems with the current state of research and outline the challenges for the future.

Lifestyle change is universally recommended for patients with type 2 diabetes and cardiometabolic disease, yet, the majority of clinical practice, educational programs, and clinical trials within these chronic disease spaces focus on medication use and procedures, with insufficient emphasis on lifestyle medicine. The concept of lifestyle medicine can serve as a countermeasure, acting through aspects of personal choice, natural and built environments, cultural traditions, and socioeconomic influences that affect the metabolic health of an individual. Integrating Lifestyle Medicine for Prediabetes, Type 2 Diabetes, and Cardiometabolic Disease provides clinical evidence for and a mechanistic understanding of the six pillars of lifestyle medicine. It guides the reader to identify opportunities for early intervention rather than focus on the diagnosis and treatment of the established disease. Interventions at earlier points have the potential to mitigate progression, prevent complications, reduce costs, and improve a patient's overall health at all points in their lifetime. Key Features Provides mechanistic, epidemiological, and clinical understanding of all pillars of lifestyle medicine Presents information on mechanisms for lifestyle medicine in cardiometabolic disease Features a unique model that includes recognition of predisease and even pre-predisease with rationale for intervention Promotes evidence-based recommendations for all stages of cardiometabolic disease This volume in the Lifestyle Medicine series is an essential resource for clinicians and students, providing them with information to help them to prevent complications, reduce costs, and improve a patient's overall health at all points in their lifetime.

This new volume discusses the valuable contribution of immune-boosting properties of nutraceuticals and functional foods toward human health, exploring dietary antioxidants, vitamins and minerals, edible microalgae, herbs, phytonutrients, omega 3-fatty acids, and probiotics. The volume addresses the immune-boosting properties of herbs and vegetables and the pharmacological and therapeutic importance of commonly used medicinal herbs and carotenoids-containing vegetables and their immunological and biological actions for treating disease and maintaining health. Several chapters focus on marine-derived sources used to boost immunity, such as microalgae-derived compounds and compounds from coral reefs, which can promote better health and alleviate the risk of development of degenerative diseases.

Este libro tiene como objetivo visibilizar y presentar nuevas prácticas educativas que tengan como sustento la igualdad y el respeto a las diferencias entre las personas. Todo ello, sería imposible si no se contase con el apoyo inestimable de las TIC en los espacios educativos como forma de implementar nuevos modelos didácticos y pedagógicos capaces de reducir las desigualdades y cumplir con los principios de la inclusión educativa. No se trata únicamente de integrar las TIC en las aulas, sino de planificar, diseñar, implementar y evaluar propuestas socioeducativas mediadas por estos recursos. Estas transformaciones metodológicas permiten que el conocimiento llegue a todo el alumnado sin establecer distinciones y cumpliendo con el Objetivo del Desarrollo Sostenible N.º 4 que, apuesta por una educación inclusiva, equitativa y de calidad hacia un enfoque más sostenible.

NUTRITIONAL SCIENCE AND TECHNOLOGY Food science is a rapidly changing and complicated subject. This new series addresses the current state-of-the-art concepts and technologies associated with the industry and will cover new ideas and emerging novel technologies and processes. The book Nutritional Science and Technology: Concept to Application in the series, “Bioprocessing in Food Science,” is an excellent resource for any scientist, engineer, student, or other industry professional interested in this topic. It covers a wide range of topics, including human nutrition, technological processes, the health benefits of fermented foods, and food safety concerns. The content contributors and editors are experts in the field, and their primary goal is to provide extensive knowledge about recent technologies in nutritional science and technology to students, researchers, and industry professionals. Manufacturers are looking for new possibilities to occupy a growing share of the rapidly changing food market, and this book will enable them to make informed decisions about adopting appropriate processing technology, implementation, economics, and constraints of different technologies. The book also provides insights on advances in nutritional science and technology for healthy and safe nutrition, with maximum illustrations of how to ensure public health safety and adequate nutrition. Overall, this book is a comprehensive overview of this study area and a valuable resource for anyone interested in this field.

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years.Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

Autonomous weapons systems, often referred to as'killer robots', have been a hallmark of popular imagination for decades. However, with the inexorable advance of artificial intelligence systems (AI) and robotics, killer robots are quickly becoming a reality. These lethal technologies can learn, adapt, and potentially make life and death decisions on the battlefield with little-to-no human involvement. This naturally leads to not only legal but ethical concerns as to whether we can meaningful control such machines, and if so, then how. Such concerns are made even more poignant by the ever-present fear that something may go wrong, and the machine may carry out some action(s) violating the ethics or laws of war. Researchers, policymakers, and designers are caught in the quagmire of how to approach these highly controversial systems and to figure out what exactly it means to have meaningful human control over them, if at all. In Designed for Death, Dr Steven Umbrello aims to not only produce a realistic but also an optimistic guide for how, with human values in mind, we can begin to design killer robots. Drawing on the value sensitive design (VSD) approach to technology innovation, Umbrello argues that context is king and that a middle path for designing killer robots is possible if we consider both ethics and design as fundamentally linked. Umbrello moves beyond the binary debates of whether or not to prohibit killer robots and instead offers a more nuanced perspective of which types of killer robots may be both legally and ethically acceptable, when they would be acceptable, and how to design for them.

This need-based unique book deals exclusively with water buffalo (Bubalus bubalis) meat to provide much needed information to thousands of buffalo meat processors across the world. The information provided in this first-of-its-kind book on buffalo meat quality, nutritional characteristics, safety, and processing can be utilized by buffalo meat producers and meat processors for the advancement of the buffalo meat sector. It also provides valuable information to faculty members, students, researchers, and all other readers interested in this new source of meat. Owing to the limited research and scientific literature available on buffalo meat, the authors'own research findings and our experiences were included wherever required to give crisp, practical, and complete information. The information proposed in this book should be beneficial to the entire buffalo industry, from the farming and processing of buffaloes to the marketing of products. This serve as a handy guide to meat scientists, faculty members, and students willing to learn more about buffalo meat processing. Up-to-date relevant references were also included for the benefit of researchers and students to enable them to easily access further information. Above all, it provides valuable information to consumers who are interested to know this new and potential source of meat.

The Healthiest Diet for You: Scientific Aspects is unique in a sense because it focuses on the most recent advances in Nutrition, Metabolism, and Genetics that are the basic components of Personalized Nutrition. The book also emphasizes the importance of evolutionary aspects of diet and exercise and the need to select foods that are consistent with the evolutionary aspects of diet because these are the foods that contain the nutrients that our genes are programmed to respond. This book is the antidote to ultra-processed foods and imitation foods that are proinflammatory and contribute to increases in chronic diseases, especially cardiovascular disease. It is a book for Health! The aim of the book is to provide readers with the basic factual information necessary to comprehend the enormity and potential effects of nutrients and foods on overall health and well-being. This book should be of interest to the educated public, teachers, health professionals, physicians, medical students, nutritionists, dietitians, historians and policy makers. You can find an interview with the author Dr. Artemis P. Simopoulos here ••The cover of the book Healthiest Diet for you: Scientific Aspects was replaced with a new version on 21 October 2022.••

Epigenetics refers to the study of changes in organisms that are caused by modifications of gene expression instead of alteration of the genetic code itself. This volume includes 30 chapters that explore epigenetics from a variety of perspectives, including the role of epigenetics in aging, cancers, fetal brain development, epilepsy, and more.

Coronavirus disease 2019 (COVID-19) has affected millions of people across the world. Clinicians and scientists across the globe need all the information of this pandemic on one platform. Today, it is also necessary to find out the association of COVID-19 with various medical comorbidities, and its effect on vulnerable populations that require special medical attention. This information will be helpful for the management of COVID-19.COVID-19: Effects in Comorbidities and Special Populations is a concise and visual reference for information about this viral disease and its relationship with different medical conditions. The book provides comprehensive knowledge covering COVID-19 comorbidities (for example, CVD, Diabetes, lung diseases, etc.), and the incidence in specific groups (for example, children and the elderly). Chapters outline the features and the management of the disease in specific conditions. Key Features:✓ 12 chapters covering several aspects of COVID-19 management, making this a perfect text book for virologist and medical students✓ Focused and structured description of different effects of COVID-19 in specific patient groups✓ Multiple tables and figures which summarizes and highlight important points✓ Multiple choice questions for learners✓ Detailed list of references, abbreviations and symbolsThis book is an essential reference for practicing and training virologists, pulmonologists, medical students and scientists working in research labs, pharmaceutical and biotechnology industries in connection with the control of COVID-19 infection.

This book aims to provide readers with up-to-date information on clinical research, diagnostic methods and treatment choice of Kawasaki disease. First chapters describe clinical symptoms, diagnosis, treatment, and complications of Kawasaki disease. Hot topics of precision medicine, big data analysis, genetics study, psychologic problems and allergic diseases after Kawasaki diseases are also discussed in details. Written by experts with wealthy experience in the field, this book will be an invaluable reference for pediatricians and clinicians working in the field of Kawasaki disease.

Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases presents strategies for the prevention of non-communicable diseases and undernutrition through the use of functional foods and nutraceuticals. Research has shown that the use of certain functional foods and nutraceuticals, including spices, herbs, and millets, animal foods and plant foods can play a role in the treatment and prevention of various diseases and in health promotion. Finally, the book explores epigenetic modulation as a new method for the development of functional foods and functional farming. Intended for nutritionists, food scientists and those working in related health science professions, this book contributes to the discussions focused on nutritional transition, globalization, how to administer foods in the treatment of metabolic syndrome, hypertension, diabetes, heart attacks, neuropsychiatric disorders, bone and joint diseases, and carcinogenesis. - Places emphasis on food diversity to provide perfect combinations of nutritional ingredients - Presents the utility and necessity of functional food production for health promotion - Offers suggestions to increase functional food production while simultaneously decreasing production costs

This book provides a concise, yet comprehensive overview of pediatric nephrolithiasis. The text covers the epidemiology and pathophysiology of pediatric stone disease, describes the appropriate workup for children with nephrolothiasis, and reviews strategies for managing the disease and preventing stone recurrence. Examples of complex cases of pediatric stone disease are also presented in the book.Written by experts in the field, Diagnosis and Management of Pediatric Nephrolithiasis is an essential guide for medical providers who care for pediatric patients with nephrolithiasis.

••Selected for Doody's Core Titles® 2024 in Clinical Genetics•• Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. - Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice - Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine - Organized from system disorders to multi-system disorders that involve epigenetic aberrations - Examines the role of epigenetics in precision medicine

This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. - Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging - Features sections on the genetic components that influence aging and diseases of aging - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables

New two-dimensional materials based on clays and clay minerals are attracting attention for their outstanding properties that make them useful as hosts or supporting matrixes in applications such as pharmaceuticals, tissue engineering, environmental remediation, biosensors, filtration, wound dressings, drug delivery, and more. This book is a comprehensive overview of clay science and technology, focusing on synthesis, characterization, simulation, and applications. Chapters cover such topics as polymer–clay nanocomposites, the structure and properties of different clays, the use of clays for environmental remediation, and much more.

••Selected for Doody's Core Titles® 2024 with'Essential Purchase'designation in Complementary & Integrative Health••

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

This book stems from the seminal work of Robert Venturi and aims at re-projecting it in the current cultural debate by extending it to the scale of landscape and placing it in connection with representative issues. It brings out the transdisciplinary synthesis of a necessarily interdisciplinary approach to the theme, aimed at creating new models which are able to represent the complexity of a contradictory reality and to redefine the centrality of human dimension. As such, the volume gathers multiple experiences developed in different geographical areas, which come into connection with the role of representation. Composed of 43 chapters written by 81 authors from around the world, with an introduction by Jim Venturi and Cezar Nicolescu, the volume is divided into two parts, the first one more theoretical and the other one which showcases real-world applications, although there is never a total split between criticism and operational experimentation of research.

Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book's second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. - Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies - Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease - Features chapter contributions from international leaders in the field

Aging can be perceived differently during different times in one's life. Aging as a process not only influences medical and economic dimensions at an individual level but also at societal and national levels. Aging is a natural process; however, its standard definition in a healthcare context is yet unclear. To delay the aging process and to maintain quality of life until the end of life are two goals of prime importance. Various healthcare approaches are being developed and experimented on to best manage aging as if it is a disease. Nutraceuticals are value-added dietary supplement products and have an immense potential in altering key structures and functions of aging. Nutraceuticals can be a keystone in altering sub-normal performing physiological and metabolic systems due to aging. Nutraceuticals for Aging and Anti-Aging: Basic Understanding and Clinical Evidence addresses aging and anti-aging nutraceuticals based on 10 major challenges, such as cognitive health, malnutrition, substance abuse, bladder control, and oral health, among others. It examines how these challenges can be complemented with nutraceuticals and connects the applications with the traditional wisdom of the aging process. Key Features Examines the aging process, then recommends nutraceuticals for aging and anti-aging processes Describes the aging process from the western perspective, and Ayurvedic medicine (Indian traditional system) and traditional Chinese medicine perspectives Provides, whenever possible, the clinical evidence of the applications of nutraceuticals for aging and anti-aging This book is a valuable resource for physicians, clinical experts, pharmaceutical companies and their experts, nutrition specialists, entrepreneurs, chemists, pharmacists, food chemists-technologists, as well as researchers and post-graduate students involved in these specialties.Also available in the Nutraceuticals: Basic Research/Clinical Applications Series:Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues, edited by John O. Onuh, M. Selvamuthukumaran, and Yashwant V. Pathak (ISBN: 978-0-3675-1177-7)Nutraceuticals for Prenatal, Maternal and Offspring's Nutritional Health, edited by Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, and Yashwant V. Pathak (ISBN 978-1-1383-4582-9)Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications, edited by Sheeba Varghese Gupta, and Yashwant V. Pathak (ISBN 978-1-1385-9391-6)

This textbook is a practical guide to the application of the philosophy and principles of Integrative and Functional Medical Nutrition Therapy (IFMNT) in the practice of medicine, and the key role nutrition plays in restoring and maintaining wellness. The textbook provides an overview of recent reviews and studies of physiological and biochemical contributions to IFMNT and address nutritional influences in human heath overall, including poor nutrition, genomics, environmental toxicant exposures, fractured human interactions, limited physical movement, stress, sleep deprivation, and other lifestyle factors. Ultimately, this textbook serves to help practitioners, healthcare systems, and policy makers better understand this different and novel approach to complex chronic disorders. It provides the reader with real world examples of applications of the underlying principles and practices of integrative/functional nutrition therapies and presents the most up-to-date intervention strategies and clinical tools to help the reader keep abreast of developments in this emerging specialty field. Many chapters include comprehensive coverage of the topic and clinical applications with supplementary learning features such as case studies, take-home messages, patient and practitioner handouts, algorithms, and suggested readings.Integrative and Functional Medical Nutrition Therapy: Principles and Practices will serve as an invaluable guide for healthcare professionals in their clinical application of nutrition, lifestyle assessment, and intervention for each unique, individual patient.

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

This book features a selection of the best papers presented at two SIEV seminars held in Venice, Italy, in September 2017 and 2018, in the context of the Urbanpromo Green events. Bringing together experts from a diverse range of fields – economics, appraisal, architecture, energy, urban planning, sociology, and the decision sciences – and government representatives, the seminars encouraged reflections on the role of future cites in terms of sustainable development, with a particular focus on improving collective and individual well-being. The book provides a multidisciplinary approach to contemporary green urban agendas and urban sustainability, and addresses the demand for policies and strategies to strengthen resilience through concrete measures to reduce energy consumption, mitigate pollution, promote social inclusion and create urban identity.

This is an important reassessment of British and Italian grand strategies during the First World War. Stefano Marcuzzi sheds new light on a hitherto overlooked but central aspect of Britain and Italy's war experiences: the uneasy and only partial overlap between Britain's strategy for imperial defence and Italy's ambition for imperial expansion. Taking Anglo-Italian bilateral relations as a special lens through which to understand the workings of the Entente in World War I, he reveals how the ups-and-downs of that relationship influenced and shaped Allied grand strategy. Marcuzzi considers three main issues – war aims, war strategy and peace-making – and examines how, under the pressure of divergent interests and wartime events, the Anglo-Italian'traditional friendship'turned increasingly into competition by the end of the war, casting a shadow on Anglo-Italian relations both at the Peace Conference and in the interwar period.

Reproductive Technologies in Animals provides the most updated and comprehensive knowledge on the various aspects and applications of reproductive technologies in production animals as well as companion, wild, exotic, and laboratory animals and birds. The text synthesizes historical information and recent discoveries, while dealing with economical and geographical issues related to the implementation of the same technologies. It also presents the effects of reproductive technology implementation on animal welfare and the possible threat of pathogen transmission.Reproductive Technologies in Animals is an important resource for academics, researchers, professionals in public and private animal business, and students at the undergraduate and graduate levels, as it gives a full and detailed first-hand analysis of all species subjected to the use of reproductive technologies. - Provides research from a team of scientists and researchers whose expertise spans all aspects of animal reproductive technologies - Addresses the use of reproductive technologies in a wide range of animal species - Offers a complete description and historical background for each species described - Discusses successes and failure as well as future challenges in reproductive technologies

Understanding Obesity informs readers about contributing factors to obesity: from social and behavioral determinants throughout the life course, influences from before we are born to what we eat (nutrients and food contaminants which impact body weight), gut bacteria, and the way accumulated energy from nutrition is spent. Chapters will also inform readers about adipose tissue (the dynamic role of the adipose tissue during obesity development, the pressure put on to its remodeling and differences in obesity phenotypes regarding association with pathological outcomes as well as the latest advances in finding biological markers of adipose tissue dysfunction) and the latest treatment options for obesity. Special topics, such as the bidirectional relationship of stress with obesity and the influence of aging on the onset of metabolic disorders that lead to obesity are also discussed. Understanding Obesity is a valuable reference for health researchers, practitioners (endocrinologists, family physicians, nurses), as well as decision-makers in healthcare and other professional settings who are seeking a holistic understanding about the causes of obesity and ways to address it. Key Features: - 17 chapters cover obesity from a diverse range of perspectives - medical information is presented (adipose physiology and different disease conditions relevant to obesity) - educational, social and psychological issues as central when caring for obesity patients are emphasized - the latest information on obesity treatment options (including medical, pharmaceutical and surgical options) is included - bibliographic references have been provided for further reading

Master's Thesis from the year 2020 in the subject Health - Public Health, grade: 5.0, University of Port Harcourt (University), course: Master's Thesis, language: English, abstract: Socio-economic state (SES), Quality of life (QoL), as well as Lifestyle factors (LFs) are very important determining factors of wellness. They play significant role in human wellness and life successes of people. This assay has determined the SES, QoL and LFs among patients of stroke and osteoarthritis in Port Harcourt. It adopted a comparative cross-sectional assay design, drawing a sample of 264 (stroke=78, osteoarthritis=186) respondents from the chosen communities in Port Harcourt. It made used of a multistage sampling pattern for both stroke and osteoarthritis patients using a Semi-Structured Questionnaire (SSQ) containing Kuppuswamy's and WHOQOL-BREF scales for SES and QoL determination as the assay instrument. Data were worked upon using the IBM SPSS version 25. Descriptive statistics was implored to express classified variables in dimensions and continuous in mean and standard deviation while Chi-Square test statistic was implored to compare the SES, QoL and LF of stroke patients with OA patients, and also establish association between LFs and QoL of stroke and OA patients at 95% confidence intervals, and p≤ 0.05 was considered statistically significant. The results thus made it known that most of the respondents were males 161(61.0%) aged 51-60 years. Also, most of both stroke and OA patients are of middle socio-economic level 39 (56.5%) and 93 (49.7%), and also have poor QoL 53 (67.9%) and 155 (82.9%) with average scores of 2.37 ± 0.81 and 2.86 ± 0.80 for both stroke and OA respectively. The results further have shown a strong association between LFs and QoL of stroke and OA patients. The assay concluded that SES, QoL and LF are indices of public wellness importance having great association with debilitating chronic states such as stroke and OA.

This book explores how Shakespeare uses images of dreams and sleep to define his dramatic worlds. Surveying Shakespeare's comedies, tragedies, histories, and late plays, it argues that Shakespeare systematically exploits early modern physiological, religious, and political understandings of dreams and sleep in order to reshape conventions of dramatic genre, and to experiment with dream-inspired plots.The book discusses the significance of dreams and sleep in early modern culture, and explores the dramatic opportunities that this offered to Shakespeare and his contemporaries. It also offers new insights into how Shakespeare adapted earlier literary models of dreams and sleep – including those found in classical drama, in medieval dream visions, and in native English dramatic traditions. The book appeals to academics, students, teachers, and practitioners in the fields of literature, drama, and cultural history, as well as to general readers interested in Shakespeare's works and their cultural context.

Molecular Nutrition: Vitamins presents the nutritional and molecular aspects of vitamins with a specific focus on vitamins A, B1 (thiamine), B2 (riboflavin), B# (niacin), B5 (pantothenic acid), B6, (pyridoxine), B7 (biotin), B9 (folate), B12 (colbamin), C, D, E, and K. As part of the Molecular Nutrition series, this book discusses introductory aspects and general coverage of vitamins and nutrition, the molecular biology of the cell, including signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis. Final sections cover genetic machinery and its function, transcriptional processes, homeostasis genes, cancer, gene expression, mutations, and more. Emerging fields of molecular biology and important discoveries related to diet and nutritional health are also covered, rounding out the book. - Summarizes molecular nutrition in health as related to vitamins - Includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis - Presents transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms - Addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health - Covers Vitamins A, B, C, D, E, and K - Discusses their impact on health relating to cancer, diabetes, arthritis, and aging - Includes key facts, a mini dictionary of terms, and summary points

As a leading reference on pediatric cardiology and congenital heart disease, Anderson's Pediatric Cardiology provides exhaustive coverage of potential pediatric cardiovascular anomalies, potential sequelae related to these anomalies, comorbidities and neurodevelopmental problems, and current methods for management and treatment. The fully revised 4th Edition addresses significant and ongoing changes in practice, including recent developments in fetal, neonatal, and adult congenital heart conditions as well as expanded content on intensive care, nursing issues, and societal implications. The outstanding illustration program provides superb visual guidance, and is now supplemented with a remarkable collection of more than 200 professionally curated, author-narrated videos. - Offers authoritative, long-term coverage of a broad spectrum of cardiology conditions, including congenital heart disease, adult congenital heart disease (ACHD), acquired heart disease, cardiomyopathies, and rhythm disturbances. - Features exquisite specimen images by Dr. Robert Anderson and Diane Spicer dissected in easily recognizable analogous imaging planes. These are included in the over 850 anatomic, photographic, imaging, and algorithmic figures, and incorporate new images using virtual dissections of 3D datasets obtained in living patients. - An extensive new section describing the non-cardiac consequences of congenital cardiac disease and other related issues Outside the Heart, including new chapters on quality improvement in congenital cardiac disease, models of care delivery, neurocognitive assessment and outcomes, psychosocial issues for patients and families, ethics, nursing implications, acute and chronic renal complications, and telemedicine. - Three entirely new, expanded sections on the Functionally Univentricular Heart, Fetal Congenital Cardiac Disease, and Heart Failure and Transplantation. - Provides a new focus on patient and family-centered care with expert advice on how to communicate difficult diagnoses to patients and families. - Features new integration of nursing content into all disease-specific chapters, as well as updated content on genetics, congenital heart disease and follow-up, and new imaging modalities. - Contains chapters on new and emerging topics such as MRI and Quantifying the Fetal Circulation in Congenital Cardiac Disease; Congenital Anomalies of the Coronary Arteries; and The Global Burden of Pediatric Heart Disease and Pediatric Cardiac Care in Low- and Middle-Income Countries - Shares the experience and knowledge of an international team of multidisciplinary experts in medicine and advanced practice nursing. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, tables and figures from the book on a variety of devices.

Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on retinoid signaling pathways

Discover the latest information for correctly diagnosing FMS at your practiceThe National Fibromyalgia Association estimates that about 10 million Americans and approximately 3% of the population worldwide suffer with fibromyalgia syndrome, yet the criteria used by doctors to diagnose fibromyalgia is 14 years out of date. The Fibromyalgia Syndrome examines the expert consensus developed by the Health Canada Fibromyalgia Syndrome Committee with the goal of helping practitioners distinguish FMS from other syndromes/illnesses that exhibit chronic body pain. The text encompasses a very broad scope of FMS, including its clinical manifestations, diagnosis, and treatment. This resource provides you with: a new approach to case definition proposed research to validate the new case definition a practical approach to assessment of severity empathetic management what is known about pathogenesis This book meets the growing need for up-to-date information about objective abnormalities in people with FMS and for an integrated approach to its diagnosis and management by primary care physicians. The Fibromyalgia Syndrome will also encourage the scientific and academic communities to actively research the clinical care of people with FMS, ensuring that more effective therapies and medications will be available in the future. These guidelines present a flexible framework that includes the 1990 American College of Rheumatology (ACR) criteria and encompasses more of the potential symptomatic expression of patients. The Fibromyalgia Syndrome provides several appendices to help you find crucial information at a moment's notice, including: a glossary of acronyms a list of both commonly and rarely seen signs and symptoms of FMS a fibromyalgia syndrome clinical worksheet differential diagnoses of the symptoms of FMS a Symptom Severity and Hierarchy Profile (SSHP) worksheet the Pain Visual Analog Scale (PAIN VAS) and Body Pain Diagram and more The Fibromyalgia Syndrome offers proposed methods and studies to develop and validate the clinical case definition to ascertain its applicability to the clinical practice setting. With better education and increased awareness of FMS, physicians can make a diagnosis earlier in the patient's course and initiate valuable outpatient care, lessening expensive hospitalization and associated costs.

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. - Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies - Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine - Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book