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Natural and Synthetic Hydrogels: Rational Design, Synthesis and Biomedical Applications provides a comprehensive text on hydrogels and their biomedical uses, covering both fundamental and applied aspects of hydrogels. Hydrogels are three-dimensional network of cross-linked polymers or particles that contain a large amount of water. They have received tremendous attention for applications in biomedicines, which has led to significant progress in the design and engineering of the hydrogels to meet the needs for such applications. The book covers the recent developments that have been made in this field, including new applications of hydrogels, providing a new and fresh overview of hydrogels and their applications. Natural and Synthetic Hydrogels: Rational Design, Synthesis and Biomedical Applications is valuable to upper level undergraduate and graduate students, researchers, and progressors teaching fundamental and applied aspects of hydrogels. • Provides a complete description for design approaches, synthetic strategies, and their characterizations• Covers responsive hydrogels from the synthesis and application point-of-view• Evaluates modern techniques to prepare hydrogels and their characterizations

Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information. - Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts - Ideal for new researchers and clinicians who will have a single resource that includes general topics to get them started - Includes access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care

There have been several advancements made in high-throughput protein technologies creating immense possibilities for studying proteomics on a large scale. Researchers are exploring various proteomic techniques to unravel the mystery of plant stress tolerance mechanisms. Plant Proteomics: Implications in Growth, Quality Improvement, and Stress Resilience introduces readers to techniques and methodologies of proteomics and explains different physiological phenomena in plants and their responses to various environmental cues and defense mechanisms against pathogens. The main emphasis is on research involving applications of proteomics to understand different aspects of the life cycle of plant species including dormancy, flowering, photosynthetic efficiency, nitrogen assimilation, accumulation of nutritional parameters, secondary metabolite production, reproduction and grain yield as well as signalling responses during abiotic and biotic stresses. The book takes a unique approach, encompassing high throughput and sophisticated proteomic techniques while integrating proteomics with other “omics.”Features: Integrates the branch of proteomics with other “omics” approaches including genomics and metabolomics, giving a holistic view of the overall “omics” approaches Covers various proteomics approaches for the identification of biological processes, future perspectives, and upcoming applications to identify diverse genes in plants Presents readers with various proteomics tools for the improvement of plant growth, quality, and resilience against climate change, and pathogen infection Enables researchers in identifying novel proteins that could be used as target to generate plants with improved traits

Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more. - Includes contributions from a world-renowned editorial board and expert contributors with wide-ranging backgrounds in toxicology - Thoroughly updated with the latest advances in the science - Contains concise and accessible content, providing an authoritative reference resource for non-specialists and readers from undergraduate level upwards, as well as advanced healthcare providers - Covers new topics such as computational toxicology, alternatives to animal testing, pharmaceutical ingredients, artificial intelligence models of toxicological exposure and effects, wildfires and effects of their smoke, vaping, high throughput transcriptomics, and the effect of environmental chemicals on the microbiome

A reference text with the latest information and research for educators, students, and researchers!World hunger and malnutrition remain an alarming concern that spurs researchers to develop quality technology. The Handbook of Seed Science and Technology is an extensive reference text for educators, students, practitioners, and researchers that focuses on the underlying mechanisms of seed biology and the impact of powerful biotechnological approaches on world hunger, malnutrition, and consumer preferences. This comprehensive guide provides the latest available research from noted experts pointing out the likely directions of future developments as it presents a wealth of seed biology and technological information.Seed science is the all-important foundation of plant science study. The Handbook of Seed Science and Technology provides an integrative perspective that takes you through the fundamentals to the latest applications of seed science and technology. This resource provides a complete overview, divided into four sections: Seed Developmental Biology and Biotechnology; Seed Dormancy and Germination; Seed Ecology; and Seed Technology. The Handbook of Seed Science and Technology examines: the molecular control of ovule development female gametophyte development cytokinins and seed development grain number determination in major grain crops metabolic engineering of carbohydrate supply in plant reproductive development enhancing the nutritive value of seeds by genetic engineering the process of accumulation of seed proteins and using biotechnology to improve crops synthetic seeds dormancy and germination hormonal interactions during dormancy release and germination photoregulation of seed germination seed size seed predation natural defense mechanisms in seeds seed protease inhibitors soil seed banks the ecophysiological basis of weed seed longevity in the soil seed quality testing seed vigor and its assessment diagnosis of seed-borne pathogens seed quality in vegetable crops vegetable hybrid seed production practical hydration of seeds of tropical crops seed technology in plant germplasm The Handbook of Seed Science and Technology is extensively referenced and packed with tables and diagrams, and makes an essential source for students, educators, researchers, and practitioners in seed science and technology.

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment. The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice. - Provides up-to-date information on current cancer proteomics research developed globally - Presents basic research aspects to clinical implications of proteomics on cancer diagnosis and potential treatments - Discusses challenges and future developments of the field to leverage further research and applicability in clinical setting

New Frontiers in Astrobiology presents a simple and concise overview of the emerging field of astrobiology. Astrobiology studies the evolution, origin, and future of life on Earth and beyond. This book provides a brief overview of the current research and future status of this fascinating field. The book covers a wide range of topics from the history of astrobiology, the big bang, prebiotic chemistry, theories of the origin of life, extreme environments on Earth, and the quest for intelligent life in space. Currently, there is a critical gap in knowledge related to the future scope of astrobiology and its applications in science and society. The hallmark of the book is that it takes critical perspectives to analyze the new frontiers in astrobiology post Mars 2020/ExoMars missions that encompass the latestdevelopments in the detection of biosignatures and habitability beyond our Solar System (exomoons, exoplanets). The book will be a valuable resource for students, researchers, and scientists who seek greater insights into understanding the current status and future of astrobiology. - Explores the background and historical developments in astrobiology - Provides concise cutting-edge reviews on fundamental questions on origin and distribution of life on Earth, habitability beyond Earth, and future of life on Earth - Integrates contemporary and critical views in new frontiers in astrobiology

This contributed volume discusses the most important physiological aspects of phosphate metabolism, and how its pathological dysregulation can induce organ damage, which includes but is not limited to blood vessels, kidney, bone and tumor. The editor has selected a varied group of world renowned experts to provide a basic understanding of normal phosphate regulation, to then move on to explain the complex molecular mechanisms of abnormal phosphate regulation, also shedding some light on the downstream clinical consequences owing to phosphate toxicity. Each chapter clearly presents the biochemically important problems related to phosphate dysregulation with the necessary illustrations. Readers will be able to use the proposed book as a quick reference for updated information on phosphate metabolism, ranging from cellular system to physiology, from pathology to toxicity, also including the associated clinical consequences, without much prior acquaintance with the field.

Dairy foods account for a large portion of the Western diet, but due to the potential diversity of their sources, this food group often poses a challenge for food scientists and their research efforts. Bringing together the foremost minds in dairy research, Handbook of Dairy Foods Analysis, Second Edition, compiles the top dairy analysis techniques and methodologies from around the world into one well-organized volume. Exceptionally comprehensive in both its detailing of methods and the range of dairy products covered, this handbook includes tools for analyzing chemical and biochemical compounds and also bioactive peptides, prebiotics, and probiotics. It describes noninvasive chemical and physical sensors and starter cultures used in quality control. This second edition includes four brand-new chapters covering the analytical techniques and methodologies for determining bioactive peptides, preservatives, activity of endogenous enzymes, and sensory perception of dairy foods, and all other chapters have been adapted to recent research. All other chapters have been thoroughly updated.Key Features: Explains analytical tools available for the analysis of the chemistry and biochemistry of dairy foods Covers a variety of dairy foods including milk, cheese, butter, yogurt, and ice cream Analysis of nutritional quality includes prebiotics, probiotics, essential amino acids, bioactive peptides, and healthy vegetable-origin compounds Includes a series of chapters on analyzing sensory qualities, including color, texture, and flavor. Covering the gamut of dairy analysis techniques, the book discusses current methods for the analysis of chemical and nutritional compounds, and the detection of microorganisms, allergens, contaminants, and/or other adulterations, including those of environmental origin or introduced during processing. Other methodologies used to evaluate color, texture, and flavor are also discussed. Written by an international panel of distinguished contributors under the editorial guidance of renowned authorities, Fidel Toldrá and Leo M.L. Nollet, this handbook is one of the few references that is completely devoted to dairy food analysis – an extremely valuable reference for those in the dairy research, processing, and manufacturing industries.

With more consumers moving away from traditional cereal-based foods due to concerns about health impacts, including wheat intolerance, the sector must develop next generation nutritionally-enhanced cereal products to maximise market potential. Improving the nutritional and nutraceutical properties of wheat and other cereals provides a comprehensive coverage of the research into nutritional components of cereals, their interactions with the gut and the way processing can inhibit or optimise benefits. Despite the collection's strong focus on wheat and its nutritional properties, other cereal products, including oats, rye, spelt, sorghum and millet are discussed in terms of their own nutritional value. Edited by Professor Trust Beta, University of Manitoba, Canada, Improving the nutritional and nutraceutical properties of wheat and other cereals will be an excellent reference framework for academic researchers in cereal science, arable farmers, manufacturers/suppliers of cereal nutrition products, as well as government and private sector agencies supporting cereal production.

Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology: An Interdisciplinary Approach to the Life Sciences presents cutting-edge research associated with the beneficial implications of biotechnology on human welfare.The volume mainly focuses on the highly demanding thrust areas of biotechnology that are microbiology, molecular biology, and nanotechnology. The book provides a detailed overview of the beneficial roles of microbes and nanotechnology-based engineered particles in biological developments. Also, it highlights the role of epigenetic machinery and redox modulators during the development of diseases. In addition, it provides research on nanotechnology-based applications in tissue engineering, stem cell, and regenerative medicines.Overall, the book provides an extended platform for acquiring the methodological knowledge needed for today's biotechnological applications, such as DNA methylation, redox homeostasis, CRISPR, nano-based drug delivery systems, proteomics, genomics, metagenomics, bioluminescence, bioreactors, bioremediation, biosensors, etc.Divided into three sections, the book first highlights some recent trends in applied microbiology used in different areas, such as crop improvement, wastewater treatment, drug delivery, healthcare management, and more. The volume goes on to cover some advances in cellular and molecular mechanisms, such as CRISPR technology in biological systems, induced stem cells in disease prevention, integrated omics technology, and others. The volume also explores the indispensable role of nanotechnology in the precisely modulating intricate functioning of an organism in diagnostic and therapy along its application in tissue engineering and regenerative medicine and in food science as well as its role in ecological sustainability.This multidisciplinary volume will be highly valuable for the researchers, scientists, biologists, and faculty and students striving to expand their horizon of knowledge in their respective fields.

Distributed systems intertwine with our everyday lives. The benefits and current shortcomings of the underpinning technologies are experienced by a wide range of people and their smart devices. With the rise of large-scale IoT and similar distributed systems, cloud bursting technologies, and partial outsourcing solutions, private entities are encouraged to increase their efficiency and offer unparalleled availability and reliability to their users. The Research Anthology on Architectures, Frameworks, and Integration Strategies for Distributed and Cloud Computing is a vital reference source that provides valuable insight into current and emergent research occurring within the field of distributed computing. It also presents architectures and service frameworks to achieve highly integrated distributed systems and solutions to integration and efficient management challenges faced by current and future distributed systems. Highlighting a range of topics such as data sharing, wireless sensor networks, and scalability, this multi-volume book is ideally designed for system administrators, integrators, designers, developers, researchers, academicians, and students.

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

The book “A closer look at proteolysis” is conceived as a review of modern knowledge from various fields related to proteolytic processes. Due to the simple approach to explaining various aspects of the topics related to proteolysis, it will be of interest to a wide audience, as well for the scientific community. The first chapter provides an overview of basic concepts related to proteolysis, and the classification of proteases with an emphasis on proteases that have been identified as key in various pathophysiological conditions. After that, in the second chapter, the reader is introduced to proteases that participate in the development of malignancy. The proteases that are perceived as potential candidates for the development of anticancer treatments are highlighted. The third chapter provides an insight into the basics of intracellular proteolysis, with an emphasis on proteolysis of the intrinsically disordered proteins and the consequences that proteolysis of these proteins has in plant cells particularly. In the fourth chapter, the authors provide the latest knowledge on the possibility of using a standard protease for mass spectrometry to determine post-translational modifications of proteins, which is the most recent challenge in proteomics-based research. Although often used as therapeutics, peptides and proteins are susceptible to proteolysis under physiological conditions, so the design of drugs that mimic the action of proteins and peptides is a big challenge for medicinal chemists. In the fifth chapter, the authors elaborate on the ways to overcome proteolysis in potential therapeutic agents, using the rational design of modern peptidomimetics. The authors of the sixth chapter look at the correlation between the stability to proteolytic digestion and the allergenicity of food proteins. Chapters seven and eight are devoted to microbial proteases. The author of the seventh chapter gives an overview of the yeast proteases characterized so far, while the authors of the eighth chapter consider the possibilities for the production of purification of Bacillus proteases and their application in various biotechnological processes. In the last, ninth chapter, the technological significance of proteolytic processes in the food industry is emphasized. The authors presented methodologies that can be used to determine different bioactive peptides produced during cheese ripening.

This book gives a comprehensive overview on the various aspects of Trichoderma, a filamentous fungus ubiquitously present in soil. Topics addressed are the biology, diversity, taxonomy, ecology, biotechnology and cultivation of Trichoderma, to just name a few. Basic as well as applied aspects are covered and a special focus is given on use of Trichoderma in agriculture and beyond. Trichoderma species are widely distributed throughout the world in soil, rotting plant material, and wood. Although they are often considered as a contaminants, Trichoderma species are also known for their ability to act as biocontrol agents against various plant pathogens and plant diseases, and also as biostimulants promoting plant growth. The contents of this book will be of particular interest to, agricultural scientists, biotechnologists, plant pathologists, mycologists, and microbiologists, students, extension workers, policy makers and other stakeholders.

The book entitled “Applied Computational Biology and Statistics in Biotechnology and Bioinformatics” is aimed to cater to the growing demand of academia, researchers and commercial ventures. Altogether there are forty four s divided into the following broad sections like 1. Bioinformatics, Genomics and Proteomics, 2. Phylogeny 3. Drug Design and Epigenomics 4. Advanced Computational Tools and Techniques 5. Statistical methods for computational biology, data mining and visualization 6. Socio Economics and Ethics. This book presents the foundations of key problems in computational molecular biology and bioinformatics. It contains basic molecular biology concepts, tools, techniques and ways to measure sequence similarity, presents simple applications of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of gene expression and motif finding. Interestingly, it is attempted to introduce computational biology without formulas that presents the biological and computational ideas in a relatively simple manner. It focuses on computational and statistical principles applied to genomes, and introduces the computational statistics that are crucial for understanding and visualization of problems. This makes the material accessible to Statistician and computer scientists without biological training, as well as to biologists with limited background in Statistics and computer science. Furthermore one has been exclusively devoted to computational biology and computational statistics as applied in biotechnology illustrated with methodology, application and interpretation of results. More than four hundred figures, illustrations and diagrams reinforce concepts and present key results from the primary literature that will be very much useful to grasp on the subject, visualize the output and make right interpretation of the result. The book will be useful for all those working in Biotechnology sector in general and particularly researchers working in the laboratories of ICAR, CSIR, SAU's and many more institutions engaged R&D activities.

The book entitledis aimed to cater to the growing demand of academia, researchers and commercial ventures. Altogether there are forty four s divided into the following broad sections like 1. Bioinformatics, Genomics and Proteomics, 2. Phylogeny 3. Drug Design and Epigenomics 4. Advanced Computational Tools and Techniques 5. Statistical methods for computational biology, data mining and visualization 6. Socio Economics and Ethics. This book presents the foundations of key problems in computational molecular biology and bioinformatics. It contains basic molecular biology concepts, tools, techniques and ways to measure sequence similarity, presents simple applications of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of gene expression and motif finding. Interestingly, it is attempted to introduce computational biology without formulas that presents the biological and computational ideas in a relatively simple manner. It focuses on computational and statistical principles applied to genomes, and introduces the computational statistics that are crucial for understanding and visualization of problems. This makes the material accessible to Statistician and computer scientists without biological training, as well as to biologists with limited background in Statistics and computer science. Furthermore one has been exclusively devoted to computational biology and computational statistics as applied in biotechnology illustrated with methodology, application and interpretation of results. More than four hundred figures, illustrations and diagrams reinforce concepts and present key results from the primary literature that will be very much useful to grasp on the subject, visualize the output and make right interpretation of the result. The book will be useful for all those working in Biotechnology sector in general and particularly researchers working in the laboratories of ICAR, CSIR, SAU's and many more institutions engaged R&D activities.

Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. - Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology - Offers a wide range of perspectives for basic and translational research - Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications

This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned'Advanced Biotechnology'book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.

This book explores the potential beneficial health effects of donkey milk, and provides valid scientific evidence for a better appraisal of this product. Milk is the most complete natural food available and is a basic ingredient of the human diet for both children and adults. Milk produced by all mammals contains basically the same nutrients, but considering the differences in nutritional requirements, milk's chemical composition differs in each mammalian species.The use of donkey milk in human nutrition has been known from the Roman age. Recent clinical trials have tested it as a possible replacement for dairy cows milk in infants affected by cow milk protein allergy. The results have clearly demonstrated that donkey milk's chemical and nutritional properties are very similar to those determined in human milk.This book will appeal to pediatricians, allergists, and nutritionists, as well as farmers and veterinarians.

Proteogenomics examines various aspects of technologies thathave been adopted in the field of Proteogenomics. It includes the meaning of Proteogenomics and various tools required tohave an in-depth understanding of these kinds of studies. Providethe reader with the insights into the development of biologicalresearch which would help in utilizing the combination ofproteomics, genomics, and transcriptomics to aid in the discoveryand identification of peptides.

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Paracrine and autocrine regulation of cardiac function by'endothelial'mediators is becoming important both physiologically and pathophysiologically. This volume brings the researcher completely up to date with all aspects of endothelial regulation and cardiac function. Acknowledged experts in each field have contributed, making this work indispensable for researchers and of great interest to the clinical cardiologist. The Endothelial Cell Research Series publishes significant reviews by experts in the field. The individual volumes provide invaluable guides to researchers studying endothelial cells and are effective reference texts for anyone working in the general areas of vascular biology and neurotransmission. Endothelium was originally considered to be an inert lining for the blood vessels, but during the last fifteen years, this view has had to be completely revised. It is now accepted that the endothelium plays an important role in many diverse functions. This volume concentrates on the effect of the endothelium on cardiac function. It has been widely demonstrated that the endothelium exerts a paracrine influence on contraction of adjacent cardiac muscle through the release of several mediators, such as endothelin and nitric oxide. Recent studies also show that the effects of such mediators upon the heart are not limited to contraction alone.

Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research. - Includes at each section resource pages containing a list of available curated raw and processed data that can be used by researchers in the field - Provides demonstrative and relevant examples that serve as a general tutorial - Presents a list of algorithm names and computational tools available for basic and clinical researchers

This book provides the most recent knowledge on almost all key aspects of the health impact of tobacco smoking. Its 21 chapters focus on both preclinical and clinical studies. The contents are broad, covering the epidemiology of tobacco smoking; genetic epidemiology; identification of susceptibility genomic regions, genes, and pathways as determined by both human and animal studies; evolutionary relations among the different nAChR subunit genes that are so important to the nicotine response; smoking-related diseases; E-cigarettes; and smoking cessation. Furthermore, each chapter includes a detailed and comprehensive list of key references. For both clinical and basic researchers, this book is a valuable resource on nicotine dependence and other addictions.

Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 2 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care. - Covers various aspects of biotechnology and bio-engineering using omics technologies - Focuses on the latest developments in the field, including biofuel technologies - Provides key insights into omics approaches in personalized and precision medicine - Provides a complete picture on how one can utilize omics data in molecular biology, biotechnology and human health care

Cancer is a leading cause of death that affects numerous people at every age and their relatives. In recent years, there has been a tremendous advancement in imaging and biotechnology technologies and techniques for aiding in the detection, diagnosis, and treatment of cancer. Emerging Developments and Practices in Oncology provides research on recent advances in oncology aiming to improve early detection and personalized treatment of cancer. While highlighting applied methods of therapy, such as body radiotherapy, chemoradiotherapy, and immunotherapy, readers learn about the transforming approach to oncology in modern medicine and new technologies used to diagnose and treat cancer. This book is an important resource for medical trainees, graduate students, active practitioners, researchers, and clinical scientists seeking current research on oncology trends and applications.

This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book's final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.

Proteomics in Food Science: From Farm to Fork is a solid reference providing concepts and practical applications of proteomics for those in various disciplines of food science. The book covers a range of methods for elucidating the identity or composition of specific proteins in foods or cells related to food science, from spoilage organisms, to edible components. A variety of analytical platforms are described, ranging from the usage of simple electrophoresis, to more sophisticated mass spectrometry and bio-informatic platforms. The book is designed for food scientists, technologists, food industry workers, microbiologists, and public health workers, and can also be a valuable reference book for students. - Includes a variety of analytical platforms, ranging from simple electrophoresis to more sophisticated mass spectrometry and bio-informatic platforms - Presents analytical techniques for each food domain, including beverages, meats, dairy and eggs, fruit, fish/seafood, cereals, nuts, and grains that range from sample collection, proportion, and storage analysis - Provides applications of proteomics in hot topics area of food safety, including food spoilage, pathogenic organisms, and allergens - Covers major pathogens of concern e.g., Salmonella and applications to animal husbandry

Nutrients in Dairy and Their Implications for Health and Disease addresses various dairy products and their impact on health. This comprehensive book is divided into three sections and presents a balanced overview of the health benefits of milk and milk products. Summaries capture the most salient points of each chapter, and the importance of milk and its products as functional foods is addressed throughout. - Presents various dairy products and their impact on health - Provides information on dairy milk as an important source of micro-and macronutrients that impact body functions - Addresses dietary supplements and their incorporation into dairy products

This book explores the recent advances and integrations in molecular technology in food research platforms, which have revolutionized the way we discover and trace potential allergens in our food and drugs and how we utilize that for diagnosis and management. These different technologies for global allergenomic profiling in different kinds of food are discussed, including mass spectrometry, chromatography, and nuclear magnetic resonance. The book also addresses multiomics research with bioinformatics strategies in food allergy in terms of allergen characterization and quantitation, and covers applications in food allergy research from discovery to routine analysis.

This book provides comprehensive coverage on current trends in marine omics of various relevant topics such as genomics, lipidomics, proteomics, foodomics, transcriptomics, metabolomics, nutrigenomics, pharmacogenomics and toxicogenomics as related to and applied to marine biotechnology, molecular biology, marine biology, marine microbiology, environmental biotechnology, environmental science, aquaculture, pharmaceutical science and bioprocess engineering.

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. - Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems - Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system - Features additional coverage throughout and a new volume on toxicology of the hematopoietic system - Presents in-depth, comprehensive coverage from an international author base of domain experts

This book introduces readers to food safety assessment research on Genetically Modified Organisms (GMOs). As is broadly known, the main concerns about GM foods'adverse effects on health are the nutrients, toxicity, allergenicity and unexpected effects. Before GMOs can be made commercially available, a comprehensive food safety assessment – taking these concerns into account – must first be performed. Exploring these aspects, the book is divided into two parts: the first part focuses on the safety assessment guidelines of the CAC, while the second highlights new methods used for the evaluation of GMOs'safety. Offering an essential, practical guide, it will be of interest to researchers and graduate students in the fields of food science and public health.

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer's disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson's disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging.Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer's Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

The authors of this book address all individuals approaching the study of nanomedicine for the first time ever, as well as those already profitably working in the field either as scientists, doctors, lawyers, or entrepreneurs. Teeming with accurate, up-to-date, and enjoyable content, the book describes some enlightening facts and figures pertaining

This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients.The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer.New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Advances in Potato Chemistry and Technology, Second Edition, presents the latest knowledge on potato chemistry, including the identification, analysis, and uses of chemical components in potatoes. Beginning with a brief description of potato components, the book then delves into their role during processing, then presenting information on strategies for quality optimization that provides students, researchers, and technologists working in the area of food science with recent information and updates on state-of-the-art technologies. The updated edition includes the latest information related to the identification, analysis, and use of chemical components of potatoes, carbohydrate and non-carbohydrate composition, cell wall chemistry, an analysis of glycoalkaloids, phenolics and anthocyanins, thermal processing, and quality optimization. In addition, new and sophisticated methods of quality determination of potatoes and their products, innovative and healthy potato-based foods, the future of genetically modified potatoes, and the non-food use of potatoes and their products is discussed. - Includes both the emerging non-food uses of potato and potato-by-products as well as the expanding knowledge on the food-focused use of potatoes - Presents case studies on the problems, factors, proposed solutions, and pros and cons of each, allowing readers facing similar concerns and issues to effectively and efficiently identify an appropriate solution - Written by a global collection of experts in both food and non-food potato science

Nesta coleção a intenção foi reunir, em uma obra didática, sucinta e objetiva, os fatos mais recentes na literatura com os conhecimentos clássicos dos temas disponíveis em obras separadas. Para se ter todo o escopo de Biotecnologia Aplicada à Saúde e Biotecnologia Aplicada à Agro&Indústria, dividimos o primeiro tema em três volumes e o segundo em um, totalizando 4 volumes, sendo que todos os tópicos são abordados nos cursos de pós-graduação em Biociências e Biotecnologia, dentre outros. Seguindo essa direção e no sentido de produção de um livro que seja para o uso tanto de alunos de graduação como de pós-graduação e para aqueles profissionais que queiram se introduzir na área de biotecnologia utilizando técnicas modernas e o uso com qualquer tipo de modelo celular, disponibilizamos, em um tópico de cada capítulo, as metodologias e procedimentos para a realização de experimentos. Um guia prático e simples para a bancada de experimentos complexos. Neste terceiro volume, você aprenderá que sequências de RNA, DNA, peptídeos e fagos funcionam como ligantes, e como selecioná-las contra alvos específicos. Você encontrará os RNAs não codificantes e descobrirá como as diferenças entre humanos e macacos podem estar neles. Para todo genoma também temos os metabolomas, proteomas, transcriptomas, técnicas inovadoras, sequenciamento de nova geração e análises de todo genoma por bioinformática. Aprenderá também a aplicar tudo isso na clínica, da farmacogenômica às doenças inflamatórias; da surdez às análises de DNA forenses e toxicologia. E conhecerá a visão das técnicas desenvolvidas pelas mais conceituadas empresas de biotecnologia do mundo.

Since the time of domestication more than 10,000 years ago, cattle have played an increasingly crucial role in the development of human civilizations. Progress has been quite remarkable since the turn of the century; the sequencing of the bovine genome in 2009 launched new avenues for furthering our understanding of theoretical and practical aspects of cattle genetics. Covering a vast array of questions, this book reviews major topics from molecular and developmental genetics, disease resistance and immunogenetics to genetic improvement of dairy and beef breeds, addressing all current problems in the field. This second edition includes a new team of authors and completely new chapters on the genetics of fat production, nutrition, feed intake and efficiency, growth and body composition. Fully updated throughout, it provides a valuable resource on cattle genetics for researchers, breeders, veterinarians and postgraduate students.

Plant genomics and biotechnology have recently made enormous strides, and hold the potential to benefit agriculture, the environment and various other dimensions of the human endeavor. It is no exaggeration to claim that the twenty-first century belongs to biotechnology. Knowledge generation in this field is growing at a frenetic pace, and keeping abreast of the latest advances and calls on us to double our efforts. Volume II of this two-part series addresses cutting-edge aspects of plant genomics and biotechnology. It includes 37 chapters contributed by over 70 researchers, each of which is an expert in his/her own field of research.Biotechnology has helped to solve many conundrums of plant life that had long remained a mystery to mankind. This volume opens with an exhaustive chapter on the role played by thale cress, Arabidopsis thaliana, which is believed to be the Drosophila of the plant kingdom and an invaluable model plant for understanding basic conceptsin plant biology. This is followed by chapters on bioremediation, biofuels and biofertilizers through microalgal manipulation, making it a commercializable prospect; discerning finer details of biotic stress with plant-fungal interactions; and the dynamics of abiotic and biotic stresses, which also figure elsewhere in the book.Breeding crop plants for desirable traits has long been an endeavor of biotechnologists. The significance of molecular markers, marker assisted selection and techniques are covered in a dedicated chapter, as are comprehensive reviews on plant molecular biology, DNA fingerprinting techniques, genomic structure and functional genomics. A chapter dedicated to organellar genomes provides extensive information on this important aspect. Elsewhere in the book, the newly emerging area of epigenetics is presented as seen through the lens of biotechnology, showcasing the pivotal role of DNA methylation in effecting permanent and transient changes to the genome.Exclusive chapters deal with bioinformatics and systems biology. Handy tools for practical applications such as somatic embryogenesis and micropropagation are included to provide frontline information to entrepreneurs, as is a chapter on somaclonal variation.Overcoming barriers to sexual incompatibility has also long been a focus of biotechnology, and is addressed in chapters on wide hybridization and hybrid embryo rescue. Another area of accomplishing triploids through endosperm culture is included as a non-conventional breeding strategy. Secondary metabolite production through tissue cultures, which is of importance to industrial scientists, is also covered.Worldwide exchange of plant genetic material is currently an essential topic, as is conserving natural resources in situ. Chapters on in vitro conservation of extant, threatened and other valuable germplasms, gene banking and related issues are included, along with an extensive account of the biotechnology of spices – the low-volume, high-value crops. Metabolic engineering is another emerging field that provides commercial opportunities. As is well known, there is widespread concern over genetically modified crops among the public. GM crops are covered, as are genetic engineering strategies for combating biotic and abiotic stresses where no other solutions are in sight. RNAi- and micro RNA- based strategies for crop improvement have proved to offer novel alternatives to the existing non-conventional techniques, and detailed information on these aspects is also included. The book's last five chapters are devoted to presenting the various aspects of environmental, marine, desert and rural biotechnology. The state-of-the-art coverage on a wide range of plant genomics and biotechnology topics will be of great interest to post-graduate students and researchers, including the employees of seed and biotechnology companies, and to instructors in the fields of plant genetics, bree

Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Determining the biological bases for behavior, and the extent to which we can observe and explain their neural underpinnings, requires a bold, broadly defined research methodology. The interdisciplinary entries in this handbook are organized around the principle of'molecular psychology,'which unites cutting-edge research from such wide-ranging disciplines as clinical neuroscience and genetics, psychology, behavioral neuroscience, and neuroethology. For the first time in a single volume, leaders in diverse research areas use molecular approaches to investigate social behavior, psychopathology, emotion, cognition and stress in healthy volunteers, patient populations, and an array of non-human species including rodents, insects, fish, and non-human primates. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.