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Schlösser, Wein und Savoir-vivre: Das Loiretal im Herzen Frankreichs ist berühmt für seine königlichen Prachtbauten, die Besucher mit ihrer wechselvollen Geschichte faszinieren. Einige thronen majestätisch am Flussufer, andere sind von eleganten Gärten oder weitläufigen Parks umgeben. Die Loire, der letzte ungezähmte Strom Frankreichs, und ihre Nebenflüsse bieten Naturfreunden mit reizvollen Rad- und Wanderwegen viel Raum für Entdeckungen. Die großen Städte Orléans, Tours und Angers versprechen kulinarische Genüsse, Kultur und urbanes Leben. Sehenswert sind aber auch die kleineren Orte wie Blois, Amboise oder Saumur: Hier kann man durch schmucke Altstadtgassen bummeln und sich den lokalen Wein munden lassen. Dieser aktuelle Reiseführer Loiretal ist der ideale Begleiter, um alle Facetten des Loire-Tals selbstständig zu entdecken: - Die interessantesten Orte, Sehenswürdigkeiten und Attraktionen ausführlich vorgestellt und bewertet - Die schönsten Naturerlebnisse und Ausflugsziele - Die prächtigsten Parks und Gärten - Die besten Hotspots zum Wandern, Radfahren und für Touren auf dem Fluss - Unterwegs mit Auto, Bus und Bahn oder Fahrrad - Die ganze Bandbreite der französischen Küche - Shoppingtipps für lokale Produkte von Orangenlikör bis zu Pralinen - Tipps zur Wahl der Unterkunft sowie außergewöhnliche Unterkunftskonzepte: Übernachten im Schloss, gemütliche Chambres d'hôtes und Glamping - Die lohnendsten Festivals und Feiern - Besonderheiten der Flora und Fauna - Weinbau und Champignonzucht: spannende Tipps, Exkurse und Hintergrundinfos - Alle praktischen Infos zu Anreise, Preisen, Touren, Events, Hilfe im Notfall, Verkehrsmitteln, Wetter... - Kleine Sprachhilfe Französisch mit den wichtigsten Vokabeln für den Reisealltag

A comprehensive guide for integrating pathology into a clinical setting. Pathological Basis of Oral and Maxillofacial Diseases presents the basic principles involved in disease mechanisms in an easy-to-understand way. By integrating recent advances in molecular, immunologic, and genetic understanding of oral disease, the book helps readers enhance their knowledge and its application in a clinical setting. This book is divided into nine sections, covering key topics such as inflammation, genetic diseases, and neoplasia, with contributions from over 50 international authors. Diagrams, clinical, radiographic, and histopathology images and tables supplement the text, and the editors have ensured a consistent approach throughout. Topics covered in Pathological Basis of Oral and Maxillofacial Diseases include: The influences of nutrition and the environmentCellular structure and function, causes and mechanisms of cellular pathology.Immunity and host defence mechanisms, immune dysfunctions affecting the oro-facial complex.Inflammation and inflammatory diseases of the oro-facial complex Human microbiome, with reference to dysbiosis in dental caries and periodontal diseasesOral manifestations of systemic diseases and the oral-systemic link and its impact on general and oral health Oral potentially malignant and malignant disorders that are a major threat to global public health. Bridging the gap in dental training programs from basic medical science in the initial years to clinical practice, Pathological Basis of Oral and Maxillofacial Diseases is an essential reference for dental students, trainees and practitioners seeking to grasp the pathological basis of disease and apply that knowledge to the oral and maxillofacial regions.

Is it ever possible to separate humanitarian action from politics? Drawing on the experience of both practitioners and researchers, this book is an essential guide to the thorny interplay between what are too often considered as separate worlds.The humanitarian sector aims to separate its work from politics, arguing that independence and neutrality are essential in order to gain entry into disaster and conflict settings. Yet, humanitarian claims of non-involvement in politics have also been dismissed as misleading, naive, or counter-productive. In practice, humanitarians find themselves working within political settings on a daily basis. This book investigates the theory behind depoliticisation, the political background and context behind humanitarian action, and the daily dilemmas faced by practitioners walking that fine line between principles and pragmatism. Finally, this book considers the importance of decolonising mainstream understandings of humanitarianism and politics, and of placing understandings from the Global South at the heart of the discussion.Balancing theoretical insights with empirical grounding, field examples, and recommendations for policy and practice, this book is perfect for researchers and students in humanitarian studies, political science, international relations, human rights, development studies, disaster studies, and peace and conflict studies, as well as humanitarian practitioners and policy makers.

Glorious cycling routes by the river. World-class wine tasting among the vines. Days of exploring historic châteaux. Loire Valley offers enough bucket-list experiences to fill a lifetime. Whatever your dream trip involves, this DK Eyewitness travel guide is the perfect companion.Our updated guide brings Loire Valley to life, transporting you there like no other travel guide. You'll find trusted travel advice, expert-led insights, detailed breakdowns of all the must-see sights, photographs on practically every page, and our hand-drawn illustrations, which take you inside the region's buildings and neighborhoods.You'll discover:-Our pick of Loire Valley must-sees and top experiences-The best spots to eat, drink, shop and stay-Detailed maps and walks which make navigating the region easy-Easy-to-follow itineraries-Expert advice: get ready, get around and stay safe-Color-coded chapters to each part of Loire Valley-A lightweight format, so you can take it with you wherever you goTraveling around France? Try DK Eyewitness France.

Essays illuminating a wide range of topics from Cistercian preachers and the'geography'of purgatory to royal and ecclesiastical justice and power.This volume continues the Society's commitment to historical and interdisciplinary research from the early and central Middle Ages and demonstrates its belief that the close interrogation of primary documents yields new insights into or important recalibrations of our understanding of the past. It begins by surveying the works of the Greek Fathers rendered into Latin in late antiquity, exploring their reception and deployment in England before the conquest. The twelfth century occupies a central place in this volume. Four papers offer close readings or re-readings of key authors or sources: one reconstructs William of Malmesbury's journeys in the mid-1130s; another offers a new reading of two of Aelred of Rievaulx's royal biographies; a third considers the influence of Henry of Marcy on Herbert of Clairvaux's Liber visionum et miraculorum Clarevallensium; and a fourth examines the Historia Gaufredi Ducis and its outsized impact on the history of the ritual of dubbing. Two papers address royal and ecclesiastical justice in mid-thirteenth-century France through meticulous work with archival sources: they respectively consider the case of Geoffroy de Milly and limits of sovereign authority and enquêtes as a technique of power. Further topics include the emerging'geography'of purgatory in the imagination of the twelfth and thirteenth centuries; the different dimensions of medieval institutional culture as seen in the intersection of earthly and angelic power in Angevin England (placed in dialogue with American medieval historiography); and the evolving historiographical treatment of men of the Church employed as trusted administrators by Italian communes. The volume concludes with two essays on significant moments in the history of American medieval studies: examinations of the publication history of Evelyn Faye Wilson's Stella Maris of John of Garland and of the life, scholarship and legacy of Bennett David Hill round out the volume.

This book demonstrates the extremely fascinating and interdisciplinary microbial domain. It helps in discovering the latest advances in microbiology and learns how they can help shape a more sustainable future for our planet. This comprehensive guide covers the latest breakthroughs in microbiology research and their practical applications in fields such as ecology, agriculture, biotechnology, and environmental science. Furthermore, the readers explore the cutting-edge technologies and methodologies that are driving the next generation of microbiology research. With expert insights from the leading microbiologists, this book is an essential resource for anyone interested in understanding the role of microbes in our world and harnessing their power for a better tomorrow.

Microbial Technology for Agro-Ecosystems: Crop Productivity, Sustainability, and Biofortification describes the application of competent microbes in plant growth promotion, nutrient management and recycling from molecular perspectives. Understanding of molecular mechanism of Microbial diversity in association with plant roots is very imperative for plant health and ecosystem equilibrium. - Covers fundamental mechanisms, molecular approaches and function aspects of microbial technology - Describes innovative approaches to the management, development and advancement of agro-ecosystem green technologies - Highlights improving soil biological health, microbial biomass, soil fertility and plant productivity

Die'Personalismus'genannte Bewegung hatte ihre Hochzeit in den 1930er- bis 1950er-Jahren vor allem in französischsprachigen Ländern. Ursprünglich in einem christlichen Kontext entwickelt, wurde der Personalismus auch unter Muslimen rezipiert. Exemplarisch wird daher anhand der Entwürfe führender Vertreter eines Personalismus aus christlicher bzw. aus muslimischer Inspiration dargelegt, wie beide ihre jeweiligen religiösen Ressourcen zur Artikulation des Person-Seins einbringen. Für den französischen Philosophen Emmanuel Mounier (1905–1950) wie für den Begründer der modernen marokkanischen Universitätsphilosophie, Mohamed Aziz Lahbabi (1923– 1993), stellt sich im Kontext der Moderne auch die Frage nach dem institutionellen Rahmen des Person-Seins, die sich in den letzten Jahren vor allem in der Debatte über die Staatsbürgerschaft konkretisiert hat.

This volume brings together leading international experts to offer a unique and timely perspective on geomicrobiology through their latest research and findings. Chapters address interactions of marine and freshwater microorganisms contributing to geochemical cycles, including biochemical mechanisms for mineralization and transformation of solid minerals and dissolved metals. In addition, the resilience and physiological elasticity of specific bacteria in extreme environments is discussed, such as mechanisms of metal homeostasis and electrochemistry involving extracellular electron flow. Further coverage includes resource recovery (metals, minerals) using microbial-driven processes and technologies, with the aim to contribute to a better understanding of microbial potential within the framework of circular economy. This book is designed for professionals and students, including environmental engineers, microbiologists, and individuals studying the interaction of bacteria with metals and minerals in the environment. It is also a resource for students in academic programs or short courses focused on bacterial diversity in the environment, systems of bacterial energetics, resource recovery, and bacterial activities in extreme or nutrient-stressed environments..

'Between France and England'characterises the role played by most rulers of the duchy of Brittany during the late Middle Ages, before it was finally united with Valois France. These essays (including three appearing for the first time in English) explore political and institutional aspects of the changing relationship between France and Brittany, within the context of Anglo-French relations, as well as social consequences of the development of a largely autonomous state within the larger French kingdom during a period dominated by war and economic crisis. The transformation of medieval France into an early modern state changed the traditional relationship between the king and his great feudal princes. But some princes reacted by imitating the crown, creating their own more advanced administrations and an ideological base for claims to exercise'regal rights'within their lordships, often expressed in striking visual and symbolic form. These trends are evident in the late medieval duchy of Brittany where the Montfort dynasty all but succeeded in nullifying royal control.

This edited book brings together a diverse group of researchers to address the challenges posed by global mass poisoning caused by lead contamination of soil and plants. Lead is among the elements that have been most extensively used by man over time. This has led to extensive pollution of surface soils on the local scale, mainly associated with mining and smelting of the metal and addition of organic lead compounds to petrol. Release of lead to the atmosphere from various high-temperature processes has led to surface contamination on the regional and even global scale. Lead is particularly strongly bound to humic matter in organic-rich soil and to iron oxides in mineral soil and is rather immobile in the soil unless present at very high concentrations. In addition, plants grown on lead-rich soils incorporate lead and thus the concentration of lead in crop plants may be increased. Lead enters in the food chain through consumption of plant material. A high concentration of lead has been found to be harmful to vegetation. As the lead concentration increases, it adversely affects several biological parameters and eventually renders the soil barren. The book sheds light on this global environmental issue and proposes solutions to contamination through multi-disciplinary approaches. This book contains three sections. First section describes the different sources and distribution of lead in soil and plant ecosystems. Second section explains the health risks linked to lead toxicity. Third section addresses sustainable lead toxicity mitigation strategies using the potential applications of recent biological technology. This book is a valuable resource to students, academics, researchers, and environmental professionals doing field work on contamination throughout the world.

Phylogenomics: Foundations, Methods, and Pathogen Analysis offers a deep overview of phylogenomics as a field, compelling recent developments, and detailed methods and approaches for conducting new research. Early chapters introduce phylogenomic taxonomies of organisms and pathogens, phylogenomic networks, phylogenomics of virus virulence, and ancient DNA analysis, with a second section offering methods, detailed descriptions and step-by-step instruction in genome assembly and annotation, horizontal gene transfer studies, Bayesian evaluation, phylogenetic tree building, microbial evolution modeling, and molecular epidemiology. The book's final section offers various examples of phylogenomic analysis across medically significant bacteria and viruses, including Yersinia pestis, Salmonella, Shigella, Vibrio cholera, and Mycobacterium tuberculosis, amongst others. - Offers a full overview of phylogenetics and phylogenomics, from its foundations to methods and specialized case studies - Presents methodologies and algorithms for phylogenomic research studies and analyzes medically significant microorganisms - Considers examples of phylogenomic analysis across a range of medically significant pathogens - Includes chapter contributions from leading international experts

This book follows a middle-class knightly family from France to England in 1066 and its journey over the next six centuries. It focuses on the development in the status and roles of the knight, the roles of women, and the changes in religion from Catholic to Church of England to Puritan.

This edited book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by heavy metals contamination of soil and plants. In recent years, contamination of the environment by heavy metals has become a major concern. Their multiple industrial, domestic, agricultural, medical, and technological applications have led to their wide distribution in the environment, raising concerns over their potential effects on human health and the environment. Owing to their toxic, non-degradable, and bio-accumulative nature, the health burden on the population has increased significantly. Heavy metals such as arsenic, lead, mercury, cadmium, and uranium do not play a significant role in metabolism in the human body and are thus toxic. Their exposure in high concentration can cause acute toxicity resulting in acute health conditions, which is easy to observe and regulate, while similar is not visible for immediate action when their exposure is in trace amounts over the years. Heavy metals enter in the food chain through consumption of plant material. A high concentration of heavy metals has been found to be harmful to vegetation. As the heavy metals concentration in plants increases, it adversely affects several biological parameters and eventually renders the soil barren.The book sheds light on this global environmental issue and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. This book is a valuable resource to students, academicians, researchers, and environmental professionals who are doing field work on heavy metals contamination throughout the world.

Genomics, Populations, and Society, a new volume in the Genomic and Precision Medicine in Clinical Practice series, considers the vast and thorny web of ELSI topics in genomics, from bioethics to healthcare applications, healthcare economics, genomic data management, and population dynamics. Emphasis is placed on the impact of rapid genomic advances on ethical, sociocultural and lifestyle dimensions. Healthcare and health economics topics include genomics and digital health, genome editing, and genomics and infectious disease management. Legal issues related to data ownership, equity, access, probity, consent, and confidentiality are also discussed in-depth, along with sociocultural topics such as community engagement, consanguinity, and more.Here, a range of readers from researchers to clinicians, policy administrators, lawyers, economists and social scientists will discover carefully crafted, synthesized discussions on ELSI topics in genomics to power new scientific advances and genomic medicine implementation. - Includes more than twenty-four chapters across five integrated sections on scientific dilemmas in genomics, genomic healthcare applications, sociocultural aspects of genomics, ethical aspects and global health genomics - Presents fundamental issues tied to biosociety, healthcare, law, and the bioeconomy as genomic medicine moves from research lab to the clinic - Features chapter contributions from international experts

This book covers cadmium contamination of soil and plants, its sources, acute and long-term impacts on the environment and human health, and overall challenges posed by the global poisoning issue. Cadmium is among the elements that have been most broadly used by man over time, which has led to extensive pollution of surface soils, mainly associated with the mining and smelting of the metal and the addition of organic cadmium compounds to petrol. The release of cadmium into the atmosphere from various high-temperature processes has also led to surface contamination on a regional and even global scale. Cadmium is particularly firmly bound to humic matter in organic-rich soil and to iron oxides in mineral soil and is rather immobile in the soil unless present at very high concentrations. Plants grown on cadmium-rich soils incorporate cadmium, thus increasing the concentration of cadmium in crop plants. Cadmium thus enters the food chain through the consumption of plant material, whichposes important health risks to humans and animals. In this book, readers will find out about the latest mitigation strategies, including a multi-disciplinary approach to address cadmium contamination. Recent methods in cadmium detoxification, speciation, and molecular mechanisms are included, and the book offers the knowledge required for efficient risk assessment, prevention, and countermeasure. Divided into 3 parts, this book brings together expert contributions on cadmium toxicity. In the first part, readers will find out about the different sources and distribution of cadmium in soil and plant ecosystems. The second part of the book outlines the health risks linked to cadmium toxicity, and in the final part, readers will discover sustainable cadmium toxicity mitigation strategies and potential applications of recent biological technology in providing solutions. This book is a valuable resource for students, academics, researchers, and environmental professionalsdoing fieldwork on cadmium contamination throughout the world.

Here is an informative volume on the importance of nutraceuticals and herbal remedies for bone health. It explains the probable mechanisms of nutraceuticals for the prevention, treatment, and management of bone-related diseases as well as their curable effects on bone injuries. The volume covers the progression and development of bones, which is a multifaceted process that requires an endless and ample supply of nutrients, such as calcium, phosphorus, potassium, protein, vitamin D, magnesium, and fluoride. The book delves into the beneficial effects of nutraceuticals on overall bone health and for the treatment of bone disorders such as osteoporosis, bone fractures, scoliosis and related complications, rheumatoid arthritis, Paget's disease, bursitis, gout, and carpal tunnel syndrome. It also addresses the use of nutraceuticals for inflammatory deformities and rickets.

Based on decades of research, this book explores global social change processes through the concepts of social change organisations (SCOs) and social change makers (SCMs) – the individuals working within and alongside SCOs. The book delves into a vast array of compelling social justice issues, from tackling inequality to championing human rights, bridging the realms of social movement and third sector research. Inspiring and empowering, this is essential reading for scholars, students, NGOs and activists alike.

Neurogenetics is a growing field, providing a clear link between clinical characteristics of phenotypes and exact molecular tests to reach a specific diagnosis. Neurogenetics for the Practitioner provides clinicians with a navigation tool to help diagnose and treat patients with neurological disorders using neurogenetics. The first section introduces the reader to an overview of genetic principles, including practical applications in relation to diagnosis and current limitations. Additional chapters highlight how to workup patients presenting with certain features including cerebral palsy/intellectual disability, congenital muscular dystrophy, cognitive decline/dementia, peripheral neuropathy, and paroxysmal disorder. The final section explores therapeutic strategies based on genetic interventions and genetic counselling options. Internationally contributed, this book will become the essential reference guide for neurologist. - Reviews genetic testing for diagnostic confirmation, including carrier testing and prenatal diagnosis - Explores various therapeutic strategies based on genetic interventions - Discusses when a neurologic problem may have an underlying genetic cause

This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.

Beneficial Microbes for Sustainable Agriculture under Abiotic Stress: Funtional Traits and Regulation highlights the potential for microbe-mediated stress phytolerance to be improved by presenting multiple scenarios of application and results. In most research and studies, abiotic stress is applied singularly to specific plants inoculated with a bioinoculum or a bacterial consortium to isolate specific plant-microbe responses. However, in reality, plants are continually exposed to a multitude of different stresses simultaneously occurring. This book presents bacteria functional traits and bacteria-mediated plant responses under both specific or combined stress conditions. Collectively, it provides insights into bacterial functional traits and bacteria-mediated plant responses in a wide range of conditions, providing foundational understanding of their potential benefits, and inspiring further research. The book centers on specific bacterial strains and groups which have been shown to effectively promote stress tolerance, and which could be utilized to boost agricultural production under stress conditions. Their potential utilization in stress affected lands not just improves crop production but could also be in line with sustainable agriculture. With the advancement of tools such as Omics related technologies, emerging information on bacterial functional traits and regulations on bacteria mediated phytotolerance will also allow us to develop relevant biotechnologies harnessing potentials of plant-bacteria interactions under stress conditions. The information in this volume will be of interest to those working toward these next steps. - Includes microbial functional traits and responses common to all stresses, unique to specific stress and shared by multiple stresses - Focuses on microbial strains and groups proven to be most effective in promoting stress tolerance - Explores opportunities toward improvement of sustainable agriculture and resulting food security

This book discusses the regulation of gene transcription by neuronal activity that is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back, 2nd edition illustrates how signals are transmitted to the nucleus in response to neuronal activity, which genes are regulated and how this is achieved, and how these changes in gene expression alter neuronal function. The aim of this second edition is to highlight key advances in the field since the first edition. The book is divided into four sections. The first highlights how signals get to the nucleus from the membrane in response to synaptic or neuronal activity. Included are chapters on the pathways that transmit signals from synapses to nuclei. The second section focuses on epigenetic regulatory processes of activity-induced gene transcription, an area that has exploded in the past few years. The third section navigates the role of activity-induced genes in physiological processes such as learning and memory, and human developmental disorders such as those associated with the autism spectrum. The fourth section highlights groundbreaking technological advances in the field, which have allowed activity-regulated transcription to be used as a tool to study learning and memory.

This prescient Handbook examines inequalities in humanitarianism at multiple levels, highlighting the long-lasting impact of colonialism on contemporary power relations.Silke Roth, Bandana Purkayastha and Tobias Denskus bring together esteemed experts from the global north and south who introduce crucial research ethics frameworks and methodologies in order to study humanitarianism and inequality. Adopting an intersectional approach, this Handbook demonstrates the ways in which race, gender, class and other sources of inequality intersect in relation to a range of contemporary issues including the role of the media and technology, the COVID-19 pandemic, linguistic inequality, trafficking, and refugee protection and assistance. Looking ahead, the contributors stress the need for academics and practitioners to reflect on the inequalities that both underpin and are perpetuated by humanitarian contexts.Providing a detailed overview of the ways in which inequality has affected the development and transformation of humanitarianism, this Handbook will be essential reading for academics, students and researchers of humanitarian and development studies, international relations, and sociology and social policy. It will also be of interest to public policymakers focussing on humanitarianism and striving for global equality.

O Jiu-Jitsu Brasileiro é um esporte de luta que cresce rapidamente e conta com um amplo espectro de praticantes. Esse esporte intercala exercícios anaeróbicos muito intensos com períodos mais ou menos longos de atividades de menor intensidade. Observamos que os atletas com maiores níveis de carga e tempo de prática dessa arte marcial apresentavam alterações fenotípicas dos dedos das mãos semelhantes aos pacientes idosos com osteoartrite (OA). Então, tentando compreender essa afecção, desenvolvemos estudos com a aplicação de diversos instrumentos que culminaram com a publicação desta obra. Assim, o objetivo geral deste livro é descrever as lesões dos dedos típicas do estresse crônico proveniente da prática do BJJ, tanto clínica como radiograficamente, cunhando o termo Osteoartrite Prematura das Mãos (OAPM) em atletas de Jiu-Jitsu Brasileiro, as chamadas'mãos do Jiu-Jitsu'. O leitor encontrará aqui uma extensa e profunda revisão sobre o que se sabe atualmente nas áreas de anatomia, histologia, bioquímica e genética a respeito da cartilagem articular e sobre a osteoartrite (OA), doença complexa, heterogênea e cada vez mais prevalente no planeta.

Heavy metals, in general trace elements, are one of the major environmental problems. Nowadays, increasing environmental and global public health concerns related with environmental contamination by heavy metals are well known. Moreover, human exposure has risen dramatically because of an exponential increase of their use in several activities such as agricultural, industrial, technological and urban applications. They are presented in soils, water and atmosphere and they are a serious risk for the food chain.Approximately 10 million contaminated sites have been reported globally, occupying approximately 49.42 million acres of land, of which >50% is contaminated with toxic heavy metals. This situation warrants immediate attention to limit the introduction of heavy metals into soil systems and to remove the prevailing heavy metals from polluted soils. However, the majorities of existing heavy-metal-removal technologies are expensive, inefficient, or generate secondary pollutants. Therefore, it is of great importance to develop cheaper, environmentally friendly and sustainable approaches (including the development of new immobilizing agents) to manage and rehabilitate heavy-metal-contaminated soils. In the light of the aforementioned facts, this book sheds light on this global environmental issue, and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. It addresses sustainable heavy metal contamination remediation strategies using the potential applications of recent biological technology such as biotechnology, bioremediation, phytoremediation, biochar, absorbent, genetic engineering, and nanotechnology approaches. This book is of interest to researchers, teachers, environmental scientists, environmental engineers, environmentalists, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of environmental microbiology, biotechnology, eco-toxicology, environmental remediation, waste management, and environmental sciences as well as the general audience.

This book explores how defects in extracellular matrix (ECM) proteins, their post-translational modifications, and intracellular trafficking impact cartilage and bone integrity. It underscores the ECM's role in providing structural support, establishing morphogenetic gradients, and interacting with cell surface receptors in musculoskeletal tissues. The book delves into the structure and biology of the ECM in the skeleton, discussing skeletal disorders caused by mutations in genes associated with ECM proteins, synthesis, turnover, and signal transduction. Authored by experts who have made significant discoveries in the molecular mechanisms of skeletal disorders and are developing therapeutic strategies, this book is an invaluable research for both scientists and clinicians seeking a comprehensive understanding of this growing and exciting field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Comprehensive Materials Processing, Second Edition, 13-vol set, consolidates and enhances the most up-to-date literature of the materials processing and manufacturing universe. It provides authoritative analysis of all processes, technologies, and techniques for converting industrial materials from a raw state into finished parts or products. Coverage encompasses solidification, powder, deposition, and deformation processing. Additional discussion includes plant and tool design, analysis and characterization of processing techniques, high-temperatures studies, and the influence of process scale on component characteristics and behavior. Building and expanding on the previous edition, it includes recent developments and advances in the field, such as updated processing technologies, costs and characterizations. This new edition will also explore sustainability and environmental impact of materials processing in greater detail. Comprehensive Materials Processing, Second Edition will serve as a valuable, one-stop resource to students, academics, and researchers in the fields of engineering and materials science, as well as those in adjacent fields. Industry professionals will also benefit from this comprehensive resource. - Updated to include recent developments in the field, such as updated processing technologies and costs - Explores sustainability and the environmental impact of materials - Includes practical tools such as integrated case studies, user-defined process schemata, and multimedia modeling and functionality - Maximizes research efficiency by collating the most important and established information into one concise resource with consistently formatted chapters

Bio-organic Amendments for Heavy Metal Remediation: Water, soil and plant focuses on these core continuum media to explore remediation options using microbial, organic and combined approached. A volume in the Plant Biology, Sustainability and Climate Change series, this book offers a comprehensive view of techniques and approaches for addressing contamination by heavy metals.As anthropogenic activities increasingly negatively impact natural resources, there has been significant disturbance of water, soil, and plant continuum due to the accumulation of heavy metals. The bioaccumulation of heavy metals in the food chain could pose life-threatening effects on plants as well as humans, and there is need to find effective and sustainable remediation options. The application of bio-organic amendments could serve as a sustainable solution to this problem.Employing microbial, organic and combined approaches to reduce the accumulation of heavy metals in the food chain ultimately would lead to the production of safe food for humans.This book provides a comprehensive view of the challenge with a focus on the bioremediation of heavy metals contamination using ecotechnological approaches to protecting the soil, water and plant continuum. - Highlights remediation techniques/approaches for heavy metals under water, soil and plant continuums - Presents case-studies for real-world insights as well as current practices - Includes regulatory aspects for ensuring safe implementation

Global Progress on Molten Salt Reactors: A Companion to Dolan's Molten Salt Reactors and Thorium Energy, Second Edition presents global perspectives on the latest research and technological advances. Each case study utilizes a comprehensive template that guides the reader through country specific research. Useful data which can be applied to work and research is included, along with a list of references for further research. Researchers, professional engineers and policymakers will gain a broad picture of worldwide MSR activity and a deep understanding of how theory and practical guidance is applied in a variety of settings, including budgets, approaches and constraints. - Provides a collection of case studies from 23 countries, presenting their latest research and activities on Molten Salt Reactors - Based on chapter 26 of the first edition of Dolan's Molten Salt Reactors and Thorium Energy, this companion title presents expanded and more complete coverage of global activities and research - Includes advanced technologies, reactor designs and safety and management strategies

This book contains a set of papers which explore the links among climate change, health, and hazards and demonstrate how they interact. It emphasizes the urgency of immediate and more ambitious action to address climate risks. According to the Intergovernmental Panel on Climate Change (IPCC), human-induced climate change is known to be causing dangerous and widespread disruptions in nature and is affecting the lives of billions of people around the world, despite efforts to reduce the risks. Climate change is also negatively influencing health and is mounting threat to our wellbeing and a healthy planet. The world is also facing significant climate hazards over the next two decades, with global warming expected to soon reach 1.5°C. Even temporarily exceeding this warming level will result in additional severe impacts, some of which may be irreversible. There is therefore a perceived need for publications which may foster a greater understanding of how climate changeconnects to human health and the role played by hazards in this context. It is against this background that this book is being prepared.

The extensively revised third edition of this text offers an in-depth practical guide to clinical conditions encountered in pediatric nephrology. Extensively updated disease-specific chapters offer detailed coverage of relevant basic science, diagnostic work-up, laboratory evaluation methods, appropriate management options and potential complications. Topics covered include disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, chronic kidney disease, dialysis, kidney transplantation and hypertension. Information is also provided on important related issues, including the genetic origins of diseases, the role of complement in the pathogenesis of kidney disease, and pharmacological aspects related to the kidney. Pediatric Kidney Disease comprehensively reviews a range of clinical conditions encountered in pediatric nephrology, assisting the reader to develop their skills and improve their clinical decision-making. It is a vital resource for trainees and practicing clinicians alike and a useful reference for those preparing for pediatric nephrology board examinations.

Si l'on excepte Auray (1364) et Najerá (1367), les défaites françaises face aux Anglais, après Crécy et Poitiers, cessèrent avec le sacre de Charles V, roi du miracle, qui annula les conséquences du traité de Brétigny par la « recouvrance » des provinces perdues. Mais la brièveté de son passage sur le trône, l'évitement des chocs frontaux avec l'ennemi en bataille rangée, stratégie prudente, et des décisions malheureuses – confiscation avortée du duché de Bretagne, affaire du schisme dans l'Église, suppression des impôts par foyer et maintien des Anglais en zones portuaires, portes d'accès – empêchèrent de terminer le travail, achevé sous Charles VII. Les personnes sur lesquelles Charles V s'appuya, Bureau de La Rivière et Jean de La Grange, ne furent pas toujours de bon conseil. Pour ces raisons, il était temps de rouvrir le dossier biographique de ce roi, dont la réputation de sagesse a longtemps dissimulé que les choses furent loin d'être parfaites.

Nano-enabled Sustainable and Precision Agriculture is the first single-volume resource to cover this important field using a whole systems approach that considers both opportunities and challenges. The book provides a comprehensive understanding of the role of nanotechnology in agriculture from broad aspects, but also includes a comprehensive view of the interaction of nanomaterials with soil-plant systems. It highlights aspects not described in previous books, including the application of nanoinformatics and artificial intelligence in nano-enabled sustainable agriculture, the application of nanotechnology in alternative forms of agriculture such as hydroponics, and regulatory frameworks for this research field.The book addresses all these aspects by including sections on enhanced sustainability, reduced pollution and enhanced ecosystems'health, and the role of nanoinformatics and machine learning. - Provides foundational insights and resources for each area, including soil science, water chemistry, nanoscience, plant science, microbiology and nanoinformatics - Focuses on mechanisms of action, transformations and the underpinning chemistry and biochemistry - Includes linkages and cross-referencing between chapters to ensure a cohesive and comprehensive resource

Le tour de l'Hexagone à la rencontre de notre mémoire Au cœur de nos régions et de nos villes, nous côtoyons les traces de la riche et rebondissante histoire de notre pays. Chacune de nos cités a vu se dérouler des événements qui ont fait la France : Auxerre, haut lieu de la renaissance carolingienne, Rochefort et l'arsenal du Roi-Soleil, Nice, fière héritière des ducs de Savoie, Ajaccio, berceau de Napoléon Ier, Le Havre, symbole de la reconstruction… Les plumes éclairées du magazine Historia racontent 50 villes, 50 histoires singulières qui ont contribué à tisser notre histoire commune. Abondamment illustré, ce beau livre s'appuie sur une iconographie variée (gravures, peintures, cartes et photographies) pour nous proposer la visite captivante des lieux dont nous sommes les héritiers. Suivez le guide! Remontez le temps, au fil des rues, places, quartiers et monuments de ces cités qui racontent notre histoire! Aix-en-Provence • Ajaccio • Amiens • Angers • Annecy • Arles • Auxerre • Avignon • Bayonne • Besançon • Biarritz • Blois • Bordeaux • Bourges • Brest • Caen • Carcassonne • Chambéry • Chartres • Clermond-Ferrand • Colmar • Dijon • Dunkerque • Grenoble • La Rochelle • Le Havre • Le Mans • Lille • Lorient • Lyon • Marseille • Metz • Montpellier • Nancy • Narbonne • Nice • Nîmes • Orléans • Paris • Poitiers • Reims • Rennes • Rochefort • Rouen • Saint-Malo • Strasbourg • Toulon • Toulouse • Tours • Versailles

This book comprehensively discusses the applications of molecular genetics, functional and structural genomics, and proteomics vis-a-vis bioinformatics, artificial intelligence, and robotics in livestock healthfulness and productivity. It reviews the biotechnological approaches in veterinary sciences for increasing productivity and resistance to disease. The book emphasizes the approaches based on artificial intelligence to analyze the data collected on animals, pathogens, and their environment. It underscores artificial intelligence applications in disease diagnosis, epidemiological studies, and detecting biological phenomena, including heat-detection, pregnancy, docility, and infections. Further, the book examines the genomics and proteomics approaches for understanding the gut microbiota and the role of pathogen-host interactions in animal health and disease. Lastly, it explores both pathogenic and non-pathogenic microbial transfer between humans, animals, and the environment across one health spectrum. ​

'Mémoires d'outre-tombe'est un livre écrit par François-René de Chateaubriand, publié à titre posthume en 1849. C'est une autobiographie qui relate la vie de Chateaubriand, de sa jeunesse jusqu'à sa mort. L'auteur y évoque de nombreux épisodes marquants de son existence, comme son voyage en Amérique du Nord, son amitié avec Napoléon Bonaparte, sa carrière diplomatique, sa vie amoureuse.'Mémoires d'outre-tombe'est bien plus qu'une simple autobiographie : c'est un témoignage sur une époque, sur la France de la fin du XVIIIe et du début du XIXe siècle. Chateaubriand y décrit avec précision la société de son temps, les bouleversements politiques et sociaux qui ont secoué la France et l'Europe, ainsi que les changements de mentalité et de sensibilité qui ont marqué la période romantique.À PROPOS DE L'AUTEURFrançois-René de Chateaubriand (1768-1848) est un écrivain et homme politique français célèbre pour ses œuvres littéraires telles que'Les Mémoires d'Outre-Tombe'et'Atala'. Il est considéré comme l'un des précurseurs du romantisme en France et est connu pour sa prose poétique et son lyrisme.

This book is a unique resource for professionals seeking a comprehensive understanding of microbiologically influenced corrosion in concrete sewers (MICC), which play a critical role in modern urban infrastructure. Corrosion can lead to structural collapse and significant financial losses due to the costly rehabilitation and replacement of damaged sewer systems. In the United States alone, sewer asset losses attributed to corrosion are estimated to reach $14 billion annually.The book provides a cross-disciplinary approach to understanding the physical, chemical, and biological processes that contribute to microbiologically influenced concrete corrosion. Readers will learn about corrosion rate measurement and characterization methods, controlling environmental factors, corrosion prediction models, and mitigation and control strategies. The book also covers the development of corrosion-resistant concrete. Written for civil engineers, environmental engineers, concrete technologists, and sewer operators and managers, this book is both informative and practical. It not only provides fundamental knowledge of the development of corrosion but also offers practical solutions that are economically and environmentally sustainable. By collating a range of corrosion analytics and control measures, this book is an essential reference for anyone seeking to prevent and manage concrete corrosion in sewer systems.

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and'WELLNESS'molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograftrejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.

This book explores, in a comprehensive and systematic manner, Surgical Research methodologies to the design and development of investigational studies in the field of implant-based oral rehabilitation. Such studies are linked in a chain binding in vitro, in vivo, ex vivo, and digital evaluations. An ambitious objective consists in exposing how investigators can generate and deliver knowledge by capturing synergy coming from preclinical and clinical trials. Accordingly, throughout the book, translational aspects are closely scrutinized. The opening chapters consider materials, methods and procedures for preclinical and clinical studies in which approaches and models are extensively described. The focus then moves to the process by which application of histology, biomechanics, biomarkers, cellular/molecular biology, and imaging technologies lead to new results and consequently novel treatment concepts in implant dentistry, implant borne prosthetic rehabilitations and the replacement or regeneration of tissues. Finally, the exciting opportunities afforded by the digital world are addressed. This book shall be a valuable resource and time-saving tool for a wide audience of researchers, students, practitioners, and academics.

Dames de France – 50 reines, favorites et femmes célèbres offre aux lecteurs une immersion dans l'Histoire à travers cinquante portraits de femmes qui ont laissé leur empreinte en France grâce à leurs contributions. Parmi elles se trouvent des reines, des courtisanes, des aventurières, des artistes et des écrivaines. De Clotilde, épouse de Clovis, à Eugénie de Montijo, épouse de Napoléon III, ces femmes, certaines célèbres et d'autres moins connues, méritent d'être honorées pour leur destin exceptionnel. Elles ont influencé, suppléé, entrepris et se sont engagées en faveur de la reconnaissance du rôle des femmes dans la société.À PROPOS DE L'AUTEURMaurice Masdoumier est arrivé à l'écriture par la poésie, art que lui a fait découvrir son professeur de français alors qu'il était en classe de première. Malgré son parcours dans le secteur industriel et ses nombreux voyages, il a toujours su trouver du temps pour le plaisir et la détente qu'offre l'écriture. De plus, Maurice a une profonde fascination pour l'histoire. Ainsi, après avoir publié deux recueils de poésie et un livre de fables, il s'est lancé dans une étude centrée sur le rôle des femmes dans l'histoire de France.

Geoffroy of Villehardouin, Marshal of Champagne by Theodore Evergates traces the remarkable life of Geoffroy of Villehardouin (c. 1148–c. 1217) from his earliest years in Champagne through his last years in Greece after the crusade. The fourth son of a knight, Geoffroy became marshal of Champagne, principal negotiator in organizing the Fourth Crusade, chief of staff of the expedition to and conquest of Constantinople, garrison commander of Constantinople and, in his late fifties, field commander defending the Latin settlement in the Byzantine empire against invading Bulgarian armies and revolting Greek cities. Known for his diplomatic skills and rectitude, he served as the chief military advisor to Count Thibaut III of Champagne and later to Emperor Henry of Constantinople.Geoffroy is remarkable as well for dictating the earliest war memoir in medieval Europe, which is also the earliest prose narrative in Old French. Addressed to a home audience in Champagne, he described what he did, what he saw, and what he heard during his eight years on crusade and especially during the fraught period after the conquest of Constantinople. His memoir, The Book of the Conquest of Constantinople, furnishes a commander's retrospective account of the main events and inner workings of the crusade—the innumerable meetings and speeches, the conduct (not always commendable) of the barons, and the persistent discontent within the army—as well as a celebration of his own deeds as a diplomat and a military commander.

Rhizosphere: Ecology, Management and Application highlights the use of the rhizosphere microbiome to improve plant and soil health, including strengthening stress resistance and remediating negatively impacted soils. The book focuses on current developments and applications of related low input management strategies in high-value crops as well as non-food plants. Further sections provide insights into the ecology and functions of these interactions, including evidence that plant microbiota is vital for plant growth and stress resilience and health. It highlights fundamental microbiome research to help readers better understand the dynamics within microbial communities and their interactions with various plant hosts and the environment. Microbial-root associations are essential to assist plants under abiotic and biotic stresses and are necessary and beneficial to enhancing agricultural crop production. Numerous studies have enhanced our vision of the complex interactions between the plant, the associated microbial communities, and the environment. Further, microbe – microbe interactions allow the simulation microbial community interactions naturally, and is one of the many modern methods for the development of novel and effective metabolites. - Includes insights on the sustainable use of valuable soil rhizobiome - Explores the latest biotechnological developments in the harnessing of rhizosphere potential - Proposes potential applications and microbial communities in modern agricultural systems, soil bioremediation and environmental restoration - Assesses the role of the rhizosphere microbial communities in increasing the growth of crop plants

This ambitious study of all proper names in the Chanson de Roland is based for the first time on a systematic survey of the whole geographical and historical literature from antiquity to after 1100 for the Geographica, and on working through (almost) the entire documentary tradition of France and its neighbouring regions from 778 to the early 12th century for the personal names. The overall result is clear: the surviving song is more tightly and profoundly structured, even in smaller scenes, than generally assumed, it is also richer in depicting reality, and it has a very long prehistory, which can be traced in outline, albeit with decreasing certainty, (almost) back to the Frankish defeat of 778. Here are some individual results: for the first time, a detailed (and ultimately simple!) explanation not only of the ‘pagan'catalogue of peoples, but also of the overarching structure of Baligant's empire, the organisation of North Africa, the corpus of the Twelve Anti-Pairs as well as the ‘pagan'gods are given, and individual names such as Bramimunde and Jurfaret, toponyms such as Marbrise and Marbrose are explained. From Roland's Spanish conquests (v. 196–200), the course of the elapsed set anz toz pleins is reconstructed. Even the names of the weapons prove to be a small structured group, in that they are very discreetly adapted to their respective ‘pagan'or Christian owner. On the Christian side, the small list of relics in Roland's sword is also carefully devised, not least in what is left out: a relic of the Lord; this is reserved for Charlemagne's Joiuse. The author explains for example, why from the archangel triad only Michael and Gabriel descend to the dying Roland, whereas ‘the'angel Cherubin descends in Rafael's place. Munjoie requires extensive discussion, because here a (hitherto insufficiently recorded) toponym has been secondarily charged by the poet with traditional theological associations. The term Ter(e) major is attested for the first time in reality, namely in the late 11th century in Norman usage. For the core of France, the fourth cornerstone – along with Besançon, Wissant and Mont-Saint-Michel – is Xanten, and its centre is Aachen. The poet's artful equilibration of Charles's ten eschieles and their leaders is traced. The'Capetian barrier'emerges as a basic fact of epic geography. Approximatively, the last quarter of the study is devoted to the prehistory of the song, going backwards in time: still quite clearly visible is an Angevin Song of Roland from around 1050, in which Marsilĭe, Olivier, Roland, Ganelon, Turpin and Naimes already have roles similar to those in the preserved Song. Behind it, between about 970 and shortly after 1000, is the Girart de Vienne from the Middle Rhône, already recognised by Aebischer, with the newly invented Olivier contra Roland. Finally, in faint outlines, an oldest attainable, also Middle Rhône adaptation of the Roland material from shortly after 870 emerges. For the Chanson de Roland, Gaston Paris and Joseph Bédier were thus each right on the main point that was close to their hearts: the surviving song has both the thoroughly sophisticated structure of great art that Bédier recognised in it, and the imposingly long prehistory that Paris conjectured.

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.

EU Procedural Law provides a rigorously structured analysis of the system of judicial protection in the European Union and the procedure before the Union Courts (the Court of Justice and the General Court). It examines the various types of proceedings which may be brought before the Union Courts, such as the actions for infringement, annulment, failure to act, and damages, along with special forms of procedure involving, for example, interim relief, appeals, staff cases, and intellectual property rights. It also addresses the relationship between the Court of Justice and the national courts through the preliminary ruling procedure and the interplay between European Union law and the national procedural and remedial frameworks more generally. Throughout, this book takes account of important jurisprudential and institutional developments, including the restructuring of the EU judicial system and reforms in the procedure of the Union Courts. In its second edition, this thoroughly updated work will continue to be the first port of call for practitioners, civil servants, and academics seeking guidance on the various components of EU procedural law.

This edited book covers various bioinoculants for sustainable crop production under the changing global climate. The book envisages a compilation of articles relevant to the current status of production and use of novel microbial inoculants for different crops and highlights their role in mitigating global climate challenges. These include nutrient deficiencies, salinity, drought, and emerging pathogens. In addition, success stories and commercialization aspects are also discussed. Growing environmental concerns related to climate change can potentially decrease the global yield capacity of agricultural systems. Agricultural productivity is severely affected by major biotic and abiotic factors. The phytomicrobiome plays a critical role in the survival of the holobiont, particularly for plants growing in extreme environments. The use of microbial-based agricultural inputs has a long history, beginning with a broad-scale rhizobial inoculation of legumes in the early twentieth century. Microbial inoculants are considered one of the best and most effective strategies for sustainable agriculture under climate change, and a viable solution to meet the twin challenges of global food security and environmental sustainability. It is therefore imperative to understand the current status and development in the area of bioinoculants from a global perspective. The chapter's focus would be on major agro-ecologies, covering all major crops across the globe, along with the commercialization status of different bioinoculants in different countries The book caters to the needs of the students, faculty, policymakers, and researchers working in the area of microbiology, biotechnology, environmental sciences, and botany.

Charles le Téméraire, chronique historique, paraît pour la première fois à Bruxelles en 1857. Se focalisant sur le destin de l'État bourguignon, elle débute avec la bataille de Poitiers du 19 septembre 1356. Alexandre Dumas retrace la constitution de ce vaste ensemble territorial par Philippe II le Hardi et ses successeurs : Jean Ier sans Peur, Philippe III le Bon et Charles le Téméraire. Peu de souverains ont été aussi honnis ou admirés des siècles après leur mort que Charles le Téméraire. Alexandre Dumas fait du prince de Bourgogne le héros d'une tragédie politique. Il évoque le destin d'un homme d'État flamboyant prisonnier de ses valeurs médiévales, qui avait voulu devenir un nouvel Alexandre et dont les rêves de grandeur vont se heurter à la diplomatie cynique de Louis XI et aux attaques des Suisses. L'écrivain raconte avec le souffle narratif que les lecteurs lui connaissent les batailles de Grandson et de Morat. Sous sa plume, le duc de Valois devient un héros caractéristique de l'époque romantique.

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With sequencing costs continuously dropping and our ability to generate large datasets rising, data analysis becomes more important than ever. Next-Generation Sequencing Data Analysis walks readers through next-generation sequencing (NGS) data analysis step by step for a wide range of NGS applications. For each NGS application, this book covers topics from experimental design, sample processing, sequencing strategy formulation, to sequencing read quality control, data preprocessing, read mapping or assembly, and more advanced stages that are specific to each application. Major applications include: RNA-seq: Both bulk and single cell (separate chapters) Genotyping and variant discovery through whole genome/exome sequencing Clinical sequencing and detection of actionable variants De novo genome assembly ChIP-seq to map protein-DNA interactions Epigenomics through DNA methylation sequencing Metagenome sequencing for microbiome analysis Before detailing the analytic steps for each of these applications, the book presents introductory cellular and molecular biology as a refresher mostly for data scientists, the ins and outs of widely used NGS platforms, and an overview of computing needs for NGS data management and analysis. The book concludes with a chapter on the changing landscape of NGS technologies and data analytics. The second edition of this book builds on the well-received first edition by providing updates to each chapter. Two brand new chapters have been added to meet rising data analysis demands on single-cell RNA-seq and clinical sequencing. The increasing use of long-read sequencing has also been reflected in all NGS applications. This book discusses concepts and principles that underlie each analytic step, along with software tools for implementation. It highlights key features of the tools while omitting tedious details to provide an easy-to-follow guide for practitioners in life sciences, bioinformatics, biostatistics, and data science. Tools introduced in this book are open source and freely available.