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The complex area of ocular oncology requires adaptable approaches to treatment depending on the type and anatomical region of the tumor, tumor characteristics, the patient's age, co-morbidities, and response to first-line treatment. Through the use of practical, case-based content, Clinical Cases in Ocular Oncology helps you familiarize yourself with clinical decision making in this challenging field, providing expert guidance on diagnosis, management, and treatment planning. - Includes 66 cases covering a range of patient presentations and scenarios that mirror day-to-day practice. - Covers a variety of ophthalmic tumors, including intraocular melanoma, lymphoma of the eye, retinoblastoma, conjunctiva, choroidal melanoma, squamous cell carcinoma, lacrimal gland tumors, and tumors of the eyelid. - Presents each case in an easy-to-read, templated format covering an overview of patient history, questions to ask, assessment, differential diagnosis, multimodal testing and results, management, follow-up care, and key points. - Provides outstanding visual guidance with numerous pathology slides and clinical photos, as well as current diagnostic imaging modalities such as optical coherence tomography (OCT), ultrasound, fluorescein angiography (FA), and indocyanine green angiography (ICG). - Features diagnostic and management algorithms that assist in differential diagnosis and decision making for even the most complex cases.

This new edition elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. This new edition is updated throughout and includes several new chapters, including: palliative radiation therapy for leptomeningeal disease, preoperative treatment for brain metastases, advanced neuroimaging for brain tumors, and MR-LINAC for brain tumors. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

This book covers the clinical application of nano-bio-materials in hard tissue repair and regeneration which are materials designed to interact with biological systems to restore and regenerate damaged tissues. These materials serve as scaffolds that mimic the natural extracellular matrix (ECM), providing structural support and biochemical cues necessary for cellular activities. The physical and chemical properties of biomaterials can be tailored to specific applications, such as bone regeneration, cartilage repair, wound healing, and organ transplantation. Biomaterials influence cell behavior and tissue formation by controlling factors like mechanical strength, porosity, and surface topography. This book is suitable for students, academics, and clinical practitioners who are interested in the advancements of regenerative medicine.

The story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.

Während sich mit dem Begriff'Dogma'Vorstellungen wie Autorität, Unveränderlichkeit, Erstarrung verbinden, versteht sich Dogmatik als das theologische Fach, das die christliche Botschaft in den Denkformen der jeweiligen Zeit und Kultur formuliert. Dies muss immer wieder neu geschehen, der Auftrag zur Inkulturation ist nie abgeschlossen. Damit erweist sich Dogmatik als ein dynamischer Denkprozess, der davon lebt, dass er durch ständig neue Impulse angeregt wird und diese verarbeitet. In der Ekklesiologie, der Lehre von der Kirche, wird die Dogmatik praktisch. Hier wird thematisiert, welche Konsequenzen die biblische Botschaft bei denen hat, die ihr folgen, welche Formen und Strukturen sie angenommen hat, aber auch welche Impulse in ihr stecken, die noch nicht rezipiert wurden. Und es wird bedacht, ob derzeit bestehende Formen gegebenenfalls dazu führen, dass die Botschaft nicht fruchtbar wird. Reform erweist sich als Wesenselement von Kirche. Der Band umfasst Referate und Aufsätze, die der Verfasser in den letzten rund 30 Jahren vorgetragen und publiziert hat und die Impulse bringen zur Reform der Kirche und ihrer Verkündigung.

This book comprehensively describes bone metabolism and diverse bone metabolic disorders from an endocrine medicine perspective. Moreover, it addresses not only common bone diseases, but also more recent discoveries concerning rare skeletal disorders. Recognizing endocrinologists'growing interest in the field of bone metabolism, it provides expert guidance and represents an innovative and unique compendium. The book is intended as a major reference source for endocrinologists, basic and clinical scientists alike. It is published as part of the SpringerReference program, which offers access to “living” editions constantly updated through a dynamic peer-review publishing process

This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner's guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists.

Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students. This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers. This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample. This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field. - Provides a unique collection of genetics and epigenetics in genitourinary - Covers the subject of genetic and epigenetics in urological malignancies, infertility, and urolithiasis - Gives novel insights into genitourinary diseases even the rare ones and sheds light on genitourinary diseases from DNA methylation to CIN

Neurogenetics is a growing field, providing a clear link between clinical characteristics of phenotypes and exact molecular tests to reach a specific diagnosis. Neurogenetics for the Practitioner provides clinicians with a navigation tool to help diagnose and treat patients with neurological disorders using neurogenetics. The first section introduces the reader to an overview of genetic principles, including practical applications in relation to diagnosis and current limitations. Additional chapters highlight how to workup patients presenting with certain features including cerebral palsy/intellectual disability, congenital muscular dystrophy, cognitive decline/dementia, peripheral neuropathy, and paroxysmal disorder. The final section explores therapeutic strategies based on genetic interventions and genetic counselling options. Internationally contributed, this book will become the essential reference guide for neurologist. - Reviews genetic testing for diagnostic confirmation, including carrier testing and prenatal diagnosis - Explores various therapeutic strategies based on genetic interventions - Discusses when a neurologic problem may have an underlying genetic cause

Plastic and reconstructive surgery represents one of the broadest and most extensive medical specialties, where the pathologies studied can range from head to toe. The abundance of information generated from established or new concepts, knowledge, and techniques are difficult to assimilate and apply in daily medical practice, so the reader may get lost on the journey from time to time. This up-to-date book provides key elements of plastic and reconstructive surgery in a practical and useful approach. It enhances understanding through questions and answers, clinical cases, algorithms, and tips and tricks. The questions and answers reflect what is frequently asked in written or clinical examinations of all stripes, making this title a complement tool which allows the readers to check whether the content is being retaining. Divided in sixteen sections, this work encompasses fundamentals concepts, sutures and needles, flaps, grafts, tissue expansion, anesthesia and burns, among other various relevant topics. It also features illustrative pictures, clinical maneuvers, pathognomonic signs and trans operative and postoperative key events. Plastic and Reconstructive Surgery Fundamentals - A Case-Based and Comprehensive Review is developed for plastic and reconstructive surgery residents and graduates, general surgeons, dermatologists and medical students interested in the area. It will also serve as a support guide for the initial and subsequent certification of any council of plastic, aesthetic and reconstructive surgery.

The field of transient receptor potential (TRP) channels has gained momentum in recent years not only because of the 2021 Nobel Prize in Physiology or Medicine awarded to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch, but also because of the growing appreciation of the diverse and important physiological and pathophysiological functions of this diverse family of cation channels. In the past decade, there have been important discoveries in the TRP field: resolution of the 3-D structures of major subfamilies using single-particle cryogenic electron microscopy and X-ray crystallography, identification and development of selective agonists and antagonists for most TRP subfamily members, discovery of new human diseases associated with TRP gene mutations, as well as improved understanding of TRP channel function and regulation in various systems. These new discoveries are addressed in TRP-Mediated Signaling, a volume in the Methods in Signal Transduction book series.Key Features• Summarizes recent advances in the study of TRP channels• Written by a team of leading international researchers• Reviews physiological and pathophysiological functions of TRP channels• Identifies diseases associated with TRP gene mutations• Examines the evolution of temperature-sensing TRP channels

As scientific research continues to expand the scope of Neuropathology, the amount of information that both students and practicing pathologists must assimilate and master can be challenging, and at times even daunting. The previous editions of this book summarized the essentials of neuropathology with the goal of providing an overview of neuropathology and to provide a framework for preparing for in-service and board examinations. This third edition summarizes the essentials of neuropathology in outline form. The objectives are twofold: 1) to provide an overview of neuropathology for those initially encountering the discipline and, 2) to provide a framework for review for those preparing for in-service and board examinations in the disciplines of neurology, neurosurgery, and pathology, which require some knowledge of neuropathology. The book provides an update of the essential elements of the neuropathology curriculum for all those seeking a concise, up-to-date overview of the subject. Topics range from basic information on the spectrum of neurologic-related disease to pertinent pictorial examples of many neuropathologic conditionsThe first part presents basic information on the spectrum of neurologic-related disease (Chapters 1-11). A set of self-assessment questions, some of which include key images for review, are included at the end of each chapter. These are designed to aid with comprehension and understanding of the material. The second part (Chapters 12 and 13) present pertinent pictorial examples of a spectrum of neuropathologic conditions in a question format with answers and brief explanations provided.Concise yet comprehensive, Neuropathology Review 3rd Edition provides an easy-to-use refresher course for those working pathologists, neurologists and neurosurgeons wishing to update their skills and knowledge.

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Vitamins and Hormones series - Updated release includes the latest information on the Adrenal Gland

The Ultimate OCN Exam Prep Toolkit: Comprehensive Study Guide and Practice Question Bank is your all-in-one resource for mastering the Oncology Certified Nurse (OCN) exam. This essential toolkit provides a thorough and detailed study guide covering all exam topics, along with over 1,000 practice questions complete with detailed rationales to reinforce your understanding and test your knowledge. Key features include: Extensive Coverage of All OCN Exam Topics: Comprehensive chapters that delve into cancer biology, treatment modalities, symptom management, and more. 1,000+ Practice Questions: Test your knowledge with a vast bank of practice questions, each accompanied by detailed explanations to enhance learning. Interactive Study Planner and Progress Tracker: Customize your study schedule, set goals, and track your progress with tools designed to fit your learning style. Expert Tips and Strategies: Benefit from the wisdom and insights of OCN-certified professionals, including study strategies, exam-day tips, and personal anecdotes to keep you motivated and on track. If you're a seasoned oncology nurse or new to the field, this guide is designed to provide the knowledge, tools, and confidence you need to excel on the OCN exam and advance your career in oncology nursing.

Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer. Covers both the conceptual bases and the clinical applications Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice Covers the whole range of cancers in practical detail

This book aims to provide more nuanced diagnostic information beyond the standard ABCDEs of melanoma diagnosis to help screen atypical presentations alongside common presentations. By providing up-to-date diagnosis, staging, and therapy information with an emphasis on dermoscopy, this unique guide provides what longer, more comprenhensive texts cannot - a succinct and concise educaitonal guide for ease of use. While there are other longer references regarding melanoma, this book attempts to provide only essential information for optimal usability across disciplines. Though small in size, the book is comprehensive in its coverage, offering chapters on staging and diagnosis while going more in depth on chapters covering melanoma in childhood and during pregnancy. Images are primarily sourced from actual patients through extensive use of the dermatoscope to get the highest definition photo available. Melanoma - From Diagnosis to Therapy is a valuable resource for practicing dermatologists and residents as well as practitioners who work in general clinical settings and patients looking for a more detailed understanding of the disease.

This section presents materials in two parts: Part I, Ophthalmic Pathology, and Part II, Intraocular Tumors. The hierarchy of the chapters in Part I moves from general to specific to help clinicians derive a differential diagnosis for a specific issue. Part II is a compilation of selected clinical aspects of importance to the general ophthalmologist—this section contains extensive discussion of intraocular tumors.

Offering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date Pocket Companion makes it easy to locate essential information on the go. The condensed, at-a-glance format, organized to parallel the parent text, is ideal for quick review—anytime, anywhere. - Features cutting-edge information on important topics such as novel therapies for hepatitis C, personalized medicine, the role of microbiome and metabolome in non-communicable disease, and much more. - Includes new gross and microscopic figures for clarity of morphology and new artwork depicting the latest advances in molecular pathogenesis of cancers. - Reflects updated page references and content changes found in to Robbins and Cotran Pathologic Basis of Disease, 10th Edition. - Contains all the key data and principles needed for the USMLE Step 1, in-course exams, and rotations.

The management of cutaneous findings in genodermatoses is challenging to the practicing clinician, especially when all hues of skin and skin types are contemplated, and first-line therapies often inadequate. This carefully crafted Atlas includes all sorts of different ethnic skin types, while featuring a wealth of over 1000 commented images collected in more than a decade, including 200 rare genodermatoses, and providing the reader with key points for correct dermatological diagnosis. The contents start with disorders of keratinization and pigmentation, as well as bullous, acantholytic, dermal, hair and nail diseases. Successively, immunodeficiency syndromes and their skin related symptoms, hamartoneoplastic syndromes and defective excision repair syndromes are presented. The addition of vascular disorders, as well as syndromes with premature aging grant full topic coverage. This Atlas of Common and Rare Genodermatoses will be a valued companion to dermatologists and paediatric specialists in their daily practice.

Diferentemente dos livros-texto médicos tradicionais, as origens do agora lendário Manual de Neurocirurgia, de Mark Greenberg, criaram raízes no final da década de 1980, nas anotações que o autor fazia enquanto cuidava de seus pacientes, em suas apresentações semanais nas grand rounds e na literatura que lia. Agora em sua 10ª edição, o livro que é frequentemente chamado de a'bíblia dos neurocirurgiões'cresceu organicamente ao longo dos anos, incluindo mais tópicos de importância para aqueles que prestam assistência médica a pacientes com doenças neurológicas e refletindo os avanços na compreensão e no tratamento das condições e doenças subjacentes. Ao longo de 23 seções e 116 capítulos, o texto, generosamente ilustrado, abrange informações que vão desde a pediatria até a geriatria. O livro, abrangente e convenientemente compacto, fornece informações detalhadas de alto valor, que podem ser acessadas rapidamente para aprimorar o tratamento do paciente, eliminando, assim, a necessidade de vasculhar materiais supérfluos. É também um companheiro de estudo perfeito na preparação para provas de certificação. Principais Recursos: • Classificação atualizada e critérios de diagnóstico de tumores do sistema nervoso central e periférico, com base nas classificações mais recentes da WHO • Reformulação de várias seções, incluindo conceitos atuais de pseudotumor cerebral, classificação de convulsões e muito mais • Adição de novos capítulos, incluindo escoliose idiopática, LOVA e tuberculose do CNS • Princípios atuais de tratamentos não cirúrgico e cirúrgico, incluindo fatores de risco, indicações, diagnósticos, prognósticos, contraindicações e diagnósticos diferenciais • Cerca de 500 figuras, incluindo novos fluxogramas resumidos, ilustrações e diagra_x0002_mas simplificados para alunos iniciantes, melhoram a compreensão do conteúdo discutido no texto • Como nas edições anteriores, milhares de referências para estudos adicionais Esta obra, única, abrange uma grande variedade de tópicos neurocirúrgicos em um formato de leitura fácil, o que a torna uma referência diária indispensável para todos os residentes de neurocirurgia, bolsistas, neurocirurgiões e profissionais de saúde.

Este é o quinto Volume da Série Guia Prático de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço – Urgência e Emergência, editado pelas Disciplinas de Otorrinolaringologia e de Cirurgia de Cabeça e Pescoço da Faculdade de Medicina da Universidade de São Paulo. Foi concebido com o objetivo de fornecer aos profissionais atuantes em serviços de pronto-socorro um recurso atualizado, cientificamente embasado, de fácil leitura e de rápido acesso. De forma análoga ao suporte de vida avançado no trauma (ATLS), os capítulos são estruturados para incluir informações diretas, com pontos-chave destacados e fluxogramas que permitem consulta ágil e eficiente. Está estruturado em sete partes, que cobrem diferentes aspectos das emergências otorrinolaringológicas e cirúrgicas. Os capítulos foram distribuídos em temas voltados às urgências infecciosas, síndrome otovestibular, sangramentos, traumas, vias aéreas, investigação, tratamento e complicações, e avaliação por imagem. Assim, o conteúdo aborda desde conceitos básicos até tópicos mais específicos, que muitas vezes não estão prontamente disponíveis em outras publicações. Destina-se não apenas a especialistas em otorrinolaringologia e cirurgia de cabeça e pescoço, mas a todos os profissionais que atuam no contexto de emergências.

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

•An invaluable asset to the postgraduate students in ophthalmology. •The topics have been updated to reflect contemporary advancements in this ever-growing field of ophthalmology. •Two entirely new sections have been created, one on instrumentation and the second on question bank, which will further help the exam-going students to face the examinations with confidence. •The section on the management of ophthalmic conditions can be used as a rehearsal tool for the oral examinations.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Translational Bioinformatics is an emerging field in the direction of biomedical research. High throughput technologies can be applied to the generated biological data to develop the vaccine and personalized medicine. This volume consists of the chapters from different stalwart of the field covering the topics such as drug development, vector engineering, vaccine development and translational genomics. Chapters covered in this volume discuss the translational research related with cancer, Alzheimer disease and cardiovascular diseases. This volume includes the chapter describing the importance of computational resources and chemoinformatics for the translational health research. How Omics studies are helping to translate the laboratory data into the development of tools which are beneficial in the clinics have been described. How translational bioinformatics helpful in plant genomics to improve the crops have also been included in this volume. This volume has a chapter which describes the secrets of resistance development and further how these resistance are associated with human infectious diseases. This volume will be useful to the early career researcher in the development of research idea and develop their methodologies in the direction of bioinformatics and it will also give the insight to translate their findings. - Translational Bioinformatics - Health Informatics - Multi-omics

Pediatric Endocrinology covers all of the main aspects of translational endocrinology and clinical practice, making it an ideal resource for both paediatricians and endocrinologists. The book emphasizes the newer translational aspects of the topics covered, as well as molecular advances in diagnosis and therapy, although clinical relevance, with a particular focus on evidence-based clinical management, remains paramount. Further, transitions from childhood to adolescence and adulthood are discussed wherever appropriate. Written by a combination of respected and emerging experts in the field, this book is intended to serve as a major reference work for pediatric endocrinologists at all stages of their careers, as well as general pediatricians with an interest in endocrinology and diabetes, and endocrinologists in adult practice who may also treat children and adolescents. The book is part of the SpringerReference program, which provides access to ‘living editions'thatare constantly updated using a dynamic peer-review publishing process.

This book provides a practical overview of infantile anterior segment disorders in a clear and concise format. Genetics, new diagnostics, and surgical options for anterior segment disorders in children are highlighted with numerous high-quality illustrations as well as the pediatric spectrum of systemic diseases based on the experience of internationally active experts. Infantile Anterior Segment Disorders is an essential resource for all ophthalmologists seeking an easy-to-use resource for optimizing clinical expertise and outcomes related to these conditions.

This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.

Das Buch Umfassender Überblick zu Tumorentitäten und Behandlungskonzepten. -Klassifikation, Klinik, Diagnostik -aktuelle, evidenzgesicherte Behandlungskonzepte -Empfehlungen und gängige Therapieschemata -Onkologische Notfälle, Supportivmaßnahmen und Palliativmedizin -Medikamentenübersicht Verfasst von interdisziplinären Autorenteams. Mit evidenzbasierten Handlungsempfehlungen. Für die tägliche Arbeit in Praxis und Klinik - für konzentrierten Überblick und zum Selbststudium. Online-Version Die Online-Version des Taschenbuchs Hämatologie und Onkologie ist unter www.onkologie2024.de zugänglich.

This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

The Oxford Handbook of Pathology provides a concise, easy to navigate guide to pathology for medical trainees and all non-specialists. With a focus on common and important topics, the handbook starts with basic pathologic principles and then covers diseases by organ system. Each chapter is written by an expert in the field ensuring that the information is accurate and up-to-date. More than 120 colour images are included to aid learning and understanding of pathology. A particular emphasis is placed on tumour pathology including relevant immunohistochemical and molecular information. In this new third edition, updates include revisions to all existing chapters from more expert contributors in the field. There is a particular emphasis on advances in tumour pathology (classifications, immunohistochemistry, molecular pathology & staging). A new chapter discusses the technical aspects of histopathology including immunohistochemistry and molecular pathology techniques, while COVID-19 has been added as a new topic in infectious diseases. This handbook continues to be an indispensable resource in the field for all non-specialists including medical students, trainees, nurses, and allied health professionals.

This book focuses on the latest research on the genetic basis of the regulation of sleep and wakefulness and of sleep and circadian rhythm disorders, which has been expanding rapidly due to advances in genetics. The book reviews the latest genetic discoveries in animals and humans and explores their implications for getting a good night's sleep. Philp Gehrman, Alex Keene, Struan Grant, and a cadre of top sleep researchers and clinicians explore the genetics of sleep and sleep disorders in depth. The book should appeal to sleep medicine specialists, psychiatrists, geneticists, and neuroscientists.

This book is a comprehensive and desirable resource for the modern and busy learner. This textbook provides a robust review of pediatric otolaryngology tightly packaged into segments of high yield information. Subject matter authorities from prestigious institutions have written up-to-date and succinct material to provide bullet point concepts and practical guidelines. The reader will find both important details and consensus statements on management decisions for common and rare pediatric otolaryngology conditions. This is a textbook ready for daily use as a quick reference, or review material, for anyone managing ear, nose, and throat disorders in the youngest population.

Covering the entire spectrum of this fast-changing field, the fourth edition of Diagnostic Imaging: Pediatric Neuroradiology is an invaluable resource for general radiologists, pediatric neuroradiologists, neurologists and neurosurgeons, and trainees—anyone who requires an easily accessible, highly visual reference in this complex area of imaging. Drs. Kevin R. Moore, Luke L. Linscott, and a team of highly regarded experts provide up-to-date information on nearly 280 diagnoses in short, detailed chapters to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool for readers at all levels of experience as well as a handy reference for daily practice. - Provides a comprehensive, expert reference for quickly accessible, detailed information about neoplastic and nonneoplastic disorders affecting the brain, head, neck, and spine of children to help you make specific diagnoses and recommendations for further imaging or referral - Contains numerous new chapters and sweeping updates throughout, covering advances in vessel wall imaging that provide more specific diagnoses of focal cerebral arteriopathy in children; newly identified pediatric infectious diseases, including human parechovirus; congenital brain malformations; MOGAD and NMOSD correlating to newly developed consensus standards; an up-to-date approach to pediatric demyelinating disorders; and more - Includes current tumor criteria from the WHO Classification of Tumours: Central Nervous System Tumours (fifth edition), including advancements in molecular genomics and newly determined categories that identify tumor types/subtypes and facilitate differentiating subtypes - Features more than 5,500 images (in print and online), including radiologic images, full-color medical illustrations, clinical and gross pathology photographs, and histologic images - Clearly demonstrates procedural steps, complications, treatment alternatives, variant anatomy, and more?all fully annotated to highlight the most important diagnostic information - Offers a vivid, full-color design that makes the material easy to read, with an extensive image gallery and'thumbnail'visual differential diagnoses for each entity - Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care - Additional digital ancillary content may publish up to 6 weeks following the publication date.

Genodermatoses are often considered rare diseases seldom seen by practicing clinicians, but as a result, professionals often have little experience or confidence with their diagnosis when they are called upon for a clinical case.This text presents a comprehensive illustrated overview of almost 200 inherited diseases of the skin, hair, and nails. Examples have been expanded, with new images added to provide clear examples, alongside coherent and comprehensive explanations to enable clinicians to easily identify and source relevant information. This resource encompasses a varied range of skin diseases, providing accessible and in-depth information to help familiarise clinicians. The entry for each disease provides background, followed by common characterisations, manifestations, laboratory findings, genetics, cutaneous and extracutaneous findings, differential diagnosis, an overview of complications and recommended follow-ups.Authored by dermatologists and geneticists, this is an atlas of scientific research which updates established information with current studies and references. In its third edition, this text becomes an invaluable resource for dermatologists and pediatricians.

This book serves as a concise surgical manual that quickly references the latest information essential for determining the policies of surgical patient care and pre-and post-operative treatment. It is a necessary guide not only for surgical residents and medical students but also for practicing surgeons.Features of this book:1. Provides information on surgical care through a systematic approach to surgery-related topics.2. Reflects the latest research findings and recommendations on the rapid development and evolution of the surgical field.3. Covers a wide range of topics and areas in surgical surgery, including patient management before and after surgery, basic techniques and procedures, management of complications, fluids, and nutrition.4. Offers practical guidance that can help in real surgical situations and practice.5. Available in a pocket size that can be easily referred to at any time.6. An English edition that can be referenced by medical professionals both in the Korea and abroad.Table of contentsContributors Preface to the 5th edition of SNU Manual of Surgical Preface to the 1st edition Preface to the 2nd edition Preface to the 3rd edition Preface to the 4th edition I. Basic Considerations 01 Surgical Infections and Antibiotics 02 Fluids and Nutrition 03 Critical Care Medicine 04 Surgical Complications 05 Preoperative Evaluation and Management for Medical Disease 06 Basic Surgical Skills 07 Symptomatic Surgical Management II. Specific Considerations 01 Liver 02 Bile Duct and Pancreas 03 Gastrointestinal Tract 04 Small Intestines 05 Colon, Rectum and Anus 06 Breast 07 Endocrine 08 Vascular 49109 Kidney and Pancreas Transplantation 10 Pediatric Surgery 11 Trauma 12 Liver Transplantation Index

This book overviews ongoing and upcoming clinical applications of basic immunology. Recent advances in our knowledge of immunology coupled with new technologies have aided in the development of efficient cancer immunotherapy, as well as the control of emerging microorganisms such as SARS-CoV-2. However, knowledge of basic immunology has not been fully utilized even after the discoveries of immune checkpoint inhibition for cancer immunotherapy and the development of mRNA vaccination against SARS-CoV-2. There is still room for improving the clinical application of basic immunology. The book summarizes the achievements in clinical applications of basic immunology and highlights what can be further extended to make immunology a more practical human science. Basic immunology and its clinical applications are two wheels of the same cart in the immunology field, which aids in the development of more efficient cancer immunotherapy and rapid control of infectious diseases against microorganisms, including new viruses and classical toxoplasmosis. The exploration of ongoing and upcoming applications of basic immunology in this book makes it a useful resource for immunologists, physicians, molecular and genome biologists, bioinformaticians, and students in these fields.

The latest edition of the world's leading dermatology textbook Rook's Textbook of Dermatology, 10th Edition is the most definitive, comprehensive and illustrated reference work in dermatology worldwide. Fully updated by experts from around the world, the book highlights the latest key evidence-based developments in pathogenesis, diagnosis and treatment of skin disorders. A highly intuitive resource and invaluable clinical companion for both those training and those fully qualified in dermatology, other highlights of Rook's Textbook of Dermatology, 10th Edition include: 1. Comprehensive review of essential basic science, skin biology and pharmacology 2. More than 3000 clinical illustrations 3. Histological images to aid clinicopathological correlation 4. Up-to-date management details for all major dermatological disorders including emerging infections 5. All chapters fully referenced together with highlighted key references 6. Quick reference to essential facts, treatment ladders and management algorithms 7. Chapter dedicated to global skin health and inequalities 8. Description of the spectrum of presentations in dermatoses in skin of colour 9. Thorough review of surgical and aesthetic dermatology 10. On-line videos of practical procedures Rook's Textbook of Dermatology, 10th Edition is universally recognised as the most complete reference work for dermatologists of all experience levels and dermatology students worldwide.

Neuro-oncology broadly encompasses life-threatening brain and spinal cord malignancies, including primary lesions and lesions metastasizing to the central nervous system. It is well suited for diagnosis, classification, and prognosis as well as assessing treatment response. Radiomics and Radiogenomics (R-n-R) have become two central pillars in precision medicine for neuro-oncology.Radiomics is an approach to medical imaging used to extract many quantitative imaging features using different data characterization algorithms, while Radiogenomics, which has recently emerged as a novel mechanism in neuro-oncology research, focuses on the relationship of imaging phenotype and genetics of cancer. Due to the exponential progress of different computational algorithms, AI methods are composed to advance the precision of diagnostic and therapeutic approaches in neuro-oncology.The field of radiomics has been and definitely will remain at the lead of this emerging discipline due to its efficiency in the field of neuro-oncology. Several AI approaches applied to conventional and advanced medical imaging data from the perspective of radiomics are very efficient for tasks such as survival prediction, heterogeneity analysis of cancer, pseudo progression analysis, and infiltrating tumors. Radiogenomics advances our understanding and knowledge of cancer biology, letting noninvasive sampling of the molecular atmosphere with high spatial resolution along with a systems-level understanding of causal heterogeneous molecular and cellular processes. These AI-based R-n-R tools have the potential to stratify patients into more precise initial diagnostic and therapeutic pathways and permit better dynamic treatment monitoring in this period of personalized medicine. While extremely promising, the clinical acceptance of R-n-R methods and approaches will primarily hinge on their resilience to non-standardization across imaging protocols and their capability to show reproducibility across large multi-institutional cohorts.Radiomics and Radiogenomics in Neuro-Oncology: An Artificial Intelligence Paradigm provides readers with a broad and detailed framework for R-n-R approaches with AI in neuro-oncology, the description of cancer biology and genomics study of cancer, and the methods usually implemented for analyzing. Readers will also learn about the current solutions R-n-R can offer for personalized treatments of patients, limitations, and prospects. There is comprehensive coverage of information based on radiomics, radiogenomics, cancer biology, and medical image analysis viewpoints on neuro-oncology, so this in-depth coverage is divided into two Volumes.Volume 1: Radiogenomics Flow Using Artificial Intelligence provides coverage of genomics and molecular study of brain cancer, medical imaging modalities and analysis in neuro-oncology, and prognostic and predictive models using radiomics.Volume 2: Genetics and Clinical Applications provides coverage of imaging signatures for brain cancer molecular characteristics, clinical applications of R-n-R in neuro-oncology, and Machine Learning and Deep Learning AI approaches for R-n-R in neuro-oncology. - Includes coverage on the foundational concepts of the emerging fields of radiomics and radiogenomics - Covers neural engineering modeling and AI algorithms for the imaging, diagnosis, and predictive modeling of neuro-oncology - Presents crucial technologies and software platforms, along with advanced brain imaging techniques such as quantitative imaging using CT, PET, and MRI - Provides in-depth technical coverage of computational modeling techniques and applied mathematics for brain tumor segmentation and radiomics features such as extraction and selection

Schachner and Hansen's Pediatric Dermatology has been the gold-standard reference in pediatric dermatology for more than 33 years. The new edition is a comprehensive textbook covering all the skin conditions of children and adolescents in a two-volume masterwork that will meet the expectations of pediatric dermatologists, dermatologists, pediatricians and all who provide pediatric healthcare.

'ESAP 2023 features a wide range of topics relevant to the clinical practice of endocrinology, including Adrenal, Bone, and Mineral Metabolism, Diabetes and Glucose Metabolism, Female Reproduction, Male Reproduction, Obesity, Pituitary, Neuroendocrinology, and Thyroid'--

This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also features an update on the clinical management of these diseases, including new diagnostic and therapeutic tools. Written by a combination of recognized and emerging experts in the field, this book is intended as a major reference work, not only for endocrinologists and nephrologists, but also for pediatricians, neonatologists, cardiologists, and emergency medicine and intensive care specialists, who can be faced with the management of endocrine diseases responsible of salt and water imbalance. The book is part of the SpringerReference program, which provides access to ‘living editions'that are constantly updated using a dynamic, peer-review publishing process.

The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.

This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.

Renowned experts in the neuro-oncological field bring their expertise together for Neuro-Oncology Compendium for the Boards and Clinical Practice. This volume reviews the core topics of neuro-oncology including adult and pediatric neuro-oncology, management, central nervous system tumor complications, genetic considerations, and more. With a focus on updated treatments and terminology, this volume is designed to comprehensively review all major facets of neuro-oncology so that physicians-in-training may prepare for the board review and practicing specialists can stay up to date in their treatment of patients. This essential text includes hundreds of figures and tables, succinct review flashcards, end-of-chapter questions and answers, as well as end-of-volume exams so readers can review and test their own comprehension. Each chapter has been reviewed by the editors to ensure cohesive board-level verbiage, emphasizing practical clinical knowledge. Neuro-Oncology Compendium for the Boards and Clinical Practice is up-to-date and comprehensive, eliminating the need for multiple sources of study. Key features of this volume include: -End of chapter flashcards to summarize key content -End of chapter Questions and Answers for review -Practice exams to simulate board questions -Updated terminology and practices -Complimentary images and tables to support learning

Providing foundational knowledge and expert guidance on the complete spectrum of childhood eye disorders and strabismus, Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 6th Edition, remains the #1 reference of choice for practicing and trainee pediatric ophthalmologists. Edited by global leaders in the field, Drs. Christopher J. Lyons and Scott R. Lambert, this newly revised volume offers authoritative coverage of all the pediatric ophthalmic conditions you're likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Comprehensive updates, as well as new chapters, images, and video clips, make this well-regarded title the most current and complete reference available in this evolving field. - Offers state-of-the-art coverage of key areas such as OCT and current imaging techniques for the eye, orbit and visual pathways; anti-VEGF treatment for retinopathy of prematurity; pediatric cataracts; childhood glaucoma; and minimally invasive strabismus surgery. - Contains five new chapters covering Imaging the Child's Eye, Aniridia Syndromes, Mitochondrial Disorders, Neurofibromatosis Type 1 and 2, and Myasthenia Gravis. - Includes a unique'practical problems'section designed to help you handle difficult patient situations and a'how to'perform strabismus surgery chapter with extensive step-by-step illustrations for complete visual guidance. - Features more than 1,800 high-quality images and illustrations, including 600 new to this edition, that provide visual guidance in diagnosis and management. - Provides access to more than 50 narrated instructional video clips (nine are new!) depicting multiple diagnostic and surgical techniques, including the insertion of prosthetic eyes, lensectomy, pediatric cataract extraction, complications during strabismus surgery, goniotomy, the removal of conjunctival tumors, and more. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Offering a step-by-step, practical approach to this challenging area of dermatology, Procedures in Cosmetic Dermatology: Lasers, Lights, and Energy Devices, 5th Edition, enables you to master the up-to-date cosmetic techniques that produce the superior results your patients expect. Edited by expert clinicians Drs. Elizabeth L. Tanzi, Jeffrey S. Dover, and Leah K. Spring, it provides an overview of the underlying scientific principles of lasers and lights in dermatology, as well as the latest treatment options—all abundantly illustrated and evidence based. A substantial video library demonstrating applications and technical aspects helps you successfully incorporate the latest procedures into your practice. - Provides current, authoritative guidance on popular procedures including laser hair removal, tattoo removal, vascular lesions, pigmented lesions, non-ablative fractional laser rejuvenation, ablative laser resurfacing, tissue tightening, and body contouring. - Contains five new chapters: Treatment of Skin with Intense Pulsed Light Sources, Radiofrequency Microneedling, Photodynamic Therapy, Muscle Toning and Contouring, and Treatment of Acne with Light and Energy-Based Devices. - Features a greatly expanded video library with more than three dozen new videos, demonstrating modalities such as photodynamic therapy, IPL, radiofrequency microneedling, a wide range of lasers, and cryolipolysis. - Covers special considerations when treating skin of color, as well as complications and legal considerations of laser, light, and energy-based treatments. - Includes procedural how-to's, step-by-step advice on proper techniques, case studies, and pearls and pitfalls. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The field of oral pathology is challenging for even the most highly trained pathologists. Comprehensive and richly illustrated, Oral Pathology, 3rd Edition, covers the full histologic range of presentation of oral disease, serving as a handy bench manual for the practicing pathologist signing out cases in the oral mucosa, salivary glands, and jawbones. Dr. Sook-Bin Woo, board certified in both oral pathology and oral medicine, draws on her extensive clinical experience to help you achieve diagnostic certainty for even the most complex lesions. - Features 1,600 high-quality, full-color illustrations that capture the characteristic presentation of all types of neoplastic, dysplastic, and benign mucosal disease. - Provides the information you need to understand the clinical implications of the disease as it relates to prognosis and treatment. - Contains extensive details of pathologic features, with descriptions of the macroscopic features, microscopic findings, and as needed, ancillary studies. - Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. - Includes relevant data from ancillary techniques (cytogenetics and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. - Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout.