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Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids. - Highlights fundamental concepts with advanced exploration of phenolic acids - Provides in-depth coverage on the design and development of novel drugs from natural phenolic acids - Reviews the changing role of phenolic acids

Recovered in 1755 during excavations in the Villa dei Papiri in Herculaneum, the prosciutto sundial is the earliest known portable Roman sundial. Palm-sized and in the shape of an Italian cured ham, its silver-plated cast bronze form cleverly combines an accurate modelling of a prosciutto with a relatively sophisticated scientific device capable of capturing the seasonal hours of the zodiacal year by employing the pig's tail to cast the sun's shadow onto the dial. This book explores the significance of this curious object's discovery in the Villa dei Papiri and offers the first comprehensive survey of its reception and analysis by drawing on contemporary correspondence and manuscripts, travel journals, popular accounts, archaeological studies, and scientific and horological assessments. Christopher Parslow shows how the prosciutto sundial is a rare example of an ancient artifact that has attracted the attention of a very broad audience, from archaeologists, art historians, and philologists to astronomers, philosophers, and sundial aficionados. The backdrop to its history features bitter infighting in the Bourbon court, clandestine descriptions circulating on the international scholarly network, and jockeying for preeminence among scholars in the learned foreign academies. Despite this long history, no scholar has treated the prosciutto adequately in full or analyzed it correctly because they lacked crucial evidence available only by examining the actual object in detail. Parslow addresses that shortcoming by providing results obtained through a 3D model to offer the first empirical analysis since the initial assessment by the Bourbon court of the prosciutto's remarkably accurate capabilities as a timepiece.

Published in 1997 as the first single-authored book on critical care neurology, The Practice of Emergency and Critical Care Neurology serves as a comprehensive guide to managing all aspects of critically ill neurologic patients. Following patients from the moment they enter the emergency department, this textbook demonstrates how specialists in the neurosciences assume full responsibility for patient care. Edited succinctly for relevance, this book differs from conventional textbooks by following the time course of clinical complexities as they emerge and change, instead of focusing on just the theoretical aspects of the field. Great emphasis is placed on the management of unstable and deteriorating patients. As any patient presents a unique, complex problem, the book pays special care in describing the considerations behind the rapid-fire decisions that comprise the work environment of the neurointensivist. In this new third edition, all chapters have been revised with added information and, in some, new concepts and ideas. Key features of this new edition include: 1. Additional chapters on the basics of neuroimaging and its interpretation; basic pharmacology issues in the intensive care setting (e.g., drug interactions and side effects); intoxications; the principles of critical care ultrasound and its relevance in the NeuroICU and the principles of neuro palliation including neuroethics 2. Rich illustrations using color photos of patients and drawings of important basic concepts of mechanisms in diseases of neurocritical care 3. Fully updated and comprehensive reference list 4. Narrated instruction video of the coma FOUR score

This book provides a broader understanding of infectious diseases and hearing loss prevention and treatment in children. In addition to all the common infections, the book covers the prion diseases, the autoinflammatory syndromes, and diseases of unknown etiology. A specific chapter is dedicated to cochlear implant infections. The final part reviews the available therapeutic agents. Written by international experts, the book will appeal to a wide readership, from ENT and pediatrics trainees, to practitioners and researchers in these disciplines.

This book contains four chapters reviewing hydrazine and its applications. Chapter One overviews derivatives of hydrazine as massive sources of pharmaceutically bioactive drugs. Chapter Two looks to hydrazine derivatives such as pyrazole, pyridazine, etc as a source of pharmaceutically bioactive drugs. Chapter Three explores the use of carbon based nanomaterials for the electrochemical determination of hydrazine. Chapter Four reviews a nano-composite materials approach to hydrazine detection.

The recent progress in analytical methods, aided by bringing in a wide range of other disciplines, opens up the study to a broader field, which means that biogeography now goes far beyond a simple description of the distribution of living species on Earth.Originating with Alexander von Humboldt, biogeography is a discipline in which ecologists and evolutionists aim to understand the way that living species are organized in connection with their environments. Today, as we face major challenges such as global warming, massive species extinction and devastating pandemics, biogeography offers hypotheses and explanations that may help to provide solutions.This book presents as wide an overview as possible of the different fields that biogeography interacts with. Sixteen authors from all over the world offer different approaches based on their specific areas of knowledge and experience; thus, we intend to illustrate the vast number of diverse aspects covered by biogeography.

É possível afirmar que o jogo é indispensável ao desenvolvimento físico, psicológico, moral e até mesmo social da criança - como será cada vez mais necessário a uma existência equilibrada e otimista do adulto. Como formas do afeto das pessoas e do calor das coisas, o jogo e o brinquedo são tão necessários à criança quanto o ar ou o alimento. Cabe à família proporcioná-los. À escola ajudá-los. Esse imperativo imediato se reveste de uma obrigação de longo alcance, uma vez que a prática dos jogos infantis é a melhor preparação para que o homem de amanhã se consagre alegremente ao lazer.

Cave organisms are the ‘monsters'of the underground world and studying them invariably raises interesting questions about the ways evolution has equipped them to survive in permanent darkness and low-energy environments. Undertaking ecological studies in caves and other subterranean habitats is not only challenging because they are difficult to access, but also because the domain is so different from what we know from the surface, with no plants at the base of food chains and with a nearly constant microclimate year-round. The research presented here answers key questions such as how a constant environment can produce the enormous biodiversity seen below ground, what adaptations and peculiarities allow subterranean organisms to thrive, and how they are affected by the constraints of their environment. This book is divided into six main parts, which address: the habitats of cave animals; their complex diversity; the environmental factors that support that diversity; individual case studies of cave ecosystems; and of the conservation challenges they face; all of which culminate in proposals for future research directions. Given its breadth of coverage, it offers an essential reference guide for graduate students and established researchers alike.

Schrifttragende Artefakte sind einer Vielzahl von Praktiken ausgesetzt, durch die sie in der einen oder anderen Form beschädigt werden. Dabei können die Absichten, Hintergründe und Kontexte dieser Praktiken stark variieren, sodass durch die Zeiten hindurch in verschiedenen kulturellen Kontexten, Situationen und Diskursen vielfältige Ausprägungen zu beobachten sind. Solche Fälle sind keineswegs darauf beschränkt, Missbilligung gegenüber Inhalten oder Autoren auszudrücken oder das Andenken an Personen auszulöschen. Anhand von detailliert aufgearbeiteten Fallbeispielen, die vom antiken Ägypten, Mesopotamien und dem Mittelmeerraum über das alte China, das europäische Mittelalter und die Neuzeit sowie islamische Traditionen bis zum heutigen Bali reichen, werden verschiedene Facetten der unterschiedlichen Praktiken und ihrer Motivationen erarbeitet und eine übergreifende Systematik entwickelt. Ziel ist es, eine an praxeologischen Kriterien orientierte Phänomenologie von Schriftzerstörung aufzustellen. Das Hauptaugenmerk liegt auf Praktiken in non-typographischen Gesellschaften, also in Kulturen, in denen Schriftdokumente nicht mittels Buchdruck und vergleichbaren Verfahren fast beliebig vervielfältigt, sondern von Hand einzeln angefertigt wurden.

Encyclopedia of Caves, Third Edition, provides detailed background information to anyone with a serious interest in caves. This includes students, both undergraduate and graduate, in the earth, biological and environmental sciences, and consultants, environmental scientists, land managers and government agency staff whose work requires them to know something about caves and the biota that inhabit them. Caves touch on many scientific interests in geology, climate science, biology, hydrology, archaeology, and paleontology, as well as more popular interests in sport caving and cave exploration. Case studies and descriptions of specific caves selected for their special features and public interest are also included. This book will appeal to these audiences by providing in-depth essays written by expert authors chosen for their expertise in their assigned subject. - Features 14 new chapters and 13 completely rewritten chapters - Contains beautifully illustrated content, with more than 500 color images of cave life and features - Provides extensive bibliographies that allow readers to access their subject of interest in greater depth

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in surgical critical care. The book reviews up to date data regarding the management of common problems that arise in the Surgical Intensive Care Unit. The protocols, care bundles, guidelines and checklists that have been shown to improve process measures, and in certain circumstances, are discussed in detail. The text also discusses several well designed randomized prospective trials conducted recently that have altered the way we care for surgical patients with traumatic brain injury, hemorrhagic shock, acute respiratory distress syndrome, and sepsis. This book provides the practicing physician with a clinically oriented practical approach to handle basic and complex issues in the Surgical Intensive Care Unit. This text will serve as a very useful resource for physicians dealing with critically ill surgical patients. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. This text will become an invaluable resource for all graduating fellows and practicing physicians who are taking the surgical critical care board examinations.

Partez à la découverte de la facture instrumentale avec ce Grand Article Universalis!Les instruments actuels de la musique savante occidentale sont souvent considérés comme des archétypes de la facture. Pourtant, bien des particularités ne s'expliquent que par référence à des instruments appartenant à d'autres civilisations et à ceux du passé. Les aménagements importants qui ont...Un ouvrage spécialement conçu pour le numérique afin d'en savoir plus sur la facture instrumentaleÀ PROPOS DES GRANDS ARTICLES D'UNIVERSALISLa collection des Grands Articles d'Universalis rassemble, dans tous les domaines du savoir, des articles écrits par des spécialistes reconnus mondialement et édités selon les critères professionnels les plus exigeants.Une sélection thématique, effectuée parmi les nombreux articles qui composent l'Encyclopaedia Universalis, permet au lecteur curieux d'en savoir plus sur un sujet précis et d'en faire le tour grâce à des ouvrages conçus pour une lecture en numérique.À PROPOS DE L'ENCYCLOPAEDIA UNIVERSALISÉcrite par plus de 7 400 auteurs spécialistes de renommée internationale et riche de près de 30 000 médias (vidéos, photos, cartes, dessins…), Encyclopaedia Universalis offre des réponses d'une grande qualité dans toutes les disciplines et sur tous les grands domaines de la connaissance. Elle est la référence encyclopédique du monde francophone.

Le Dictionnaire des Musiques réunit plus de six cents articles empruntés au fonds de l'Encyclopaedia Universalis et aborde tous les aspects de la musique : les formes et les genres (sonate, rhapsodie, valse, madrigal…), l'écriture et la théorie (gamme, arrangement, tempérament, rubato...), les voix et l'art lyrique (baryton, contre-ténor, bel canto, Covent Garden, Scala de Milan…), les traditions musicales (Afrique noire, Moyen-Orient, Asie du Sud-Est...), la musique contemporaine (aléatoire, concrète, minimaliste, sérielle...), tous les instruments (arc musical, piano, célesta, tympanon, flûte...), les courants musicaux d'aujourd'hui (rock, raï, hip-hop...), le jazz, le blues, la world music, la musique de film, les festivals… Un inépuisable inventaire des musiques passées et présentes, avec un accent mis sur les musiques savantes, sous la conduite des guides les plus qualifiés. Un index facilite la consultation du Dictionnaire des Musiques, auquel ont collaboré plus de cent auteurs, parmi lesquels François Bayle, Philippe Beaussant, Gérard Condé, Alain Féron, Paul Méfano, Alain Pâris, Marc Vignal…

The Chronic EarThere are many different ways to treat complex chronic middle ear disease, with ongoing advancements being made globally. Diverse approaches are necessitated for variations in patient age, degree of infection, extent of middle ear remodeling, inflammation severity, and underlying mechanisms of Eustachian tube dysfunction. Addressing multinational and clinical nuances, the editors have compiled 48 chapters with eclectic perspectives from otology experts in 13 countries. The surgical anatomy of the middle ear cleft and mastoid and underlying pathophysiological mechanisms of chronic otitis media are clinically challenging. Articles cover anatomy, physiology, disease characterizations and manifestations, clinical evaluation, office management, surgical procedures, and new horizons. Traditional and newer hybrid techniques for systematic disease and inflammatory conditions are presented in roundtable format, for example, underlay fascia tympanoplasty as well as the use of cartilage and bioengineered materials.Selected Key Topics:Applied middle ear anatomy and physiologyPathologic mechanisms of chronic otitis media Office evaluation, management and surgical decision makingMastoid cavity obliteration and canal wall reconstructionChallenges in tympanoplasty and ossicular chain reconstructionTraditional and hybrid tympanomastoid surgeryHearing implants in the chronic earThis is an exceptional teaching tool for ear surgeons in training as well as a must-have clinical resource for practicing otolaryngologists.

Les méningites sont des maladies rares. Cependant, l'éventail du spectre de gravité est large, allant du redoutable purpura fulminans d'origine méningococcique à la méningite virale guérissant sans traitement. Tout médecin a connu ou connaîtra la crainte de manquer ce diagnostic. La meilleure défense est d'avoir une vision globale et pragmatique de cette pathologie. C'est ce que propose cet ouvrage en balayant l'ensemble de la thématique : quand suspecter une méningite, comment réaliser une ponction lombaire selon les bonnes pratiques, comment analyser les résultats du liquide cérébrospinal, quelles en sont les principales étiologies bactériennes, virales, mais aussi parasitaires et les particularités dans la population pédiatrique, quelle est la place des biomarqueurs, sans oublier la prise en charge des céphalées post-rachicentèse et la prophylaxie entourant un cas index d'infection invasive à méningocoque.Cet ouvrage de référence est destiné aux médecins urgentistes, généralistes, pédiatres mais également aux autres spécialistes et permet d'avoir une vue circulaire et réaliste de la question.Rédigé par une équipe pluridisciplinaire d'urgentistes, anesthésistes, réanimateurs, infectiologues, pédiatres, il s'inscrit dans la collection « Références en médecine d'urgence » comme une aide pratique au quotidien.

Research in the 20th and 21st centuries into historical performance practice has changed not just the way performers approach music of the 17th and 18th centuries but, eventually, the way audiences listen to it. This volume, beginning with a 1915 Saint-Sa lecture on the performance of old music, sets out to capture musicological discussion that has actually changed the way Baroque music can sound. The articles deal with historical instruments, pitch, tuning, temperament, the nexus between technique and style, vibrato, the performance implications of musical scores, and some of the vexed questions relating to rhythmic alteration. It closes with a section on the musicological challenges to the ideology of the early music movement mounted (principally) in the 1990s. Leading writers on historical performance practice are represented. Recognizing that significant developments in historically-inspired performance have been led by instrument makers and performers, the volume also contains representative essays by key practitioners.

This work has been devoted to the exploitation of the synthesis of transition metal hydrazine cinnamates using transition metals salts, hydrazine hydrate and cinnamic acid. The study includes a detailed presentation of coordination complexes, chemistry of hydrazine, cinnamic acid and transition metals, their applications, and various metal hydrazine carboxylates. The scope and objectives of the study are also discussed. The specifications of all the materials used in the study and the details of the different experimental techniques employed in this study are elaborated. The main part of the book illustrates the synthesis and characterization of the different metal hydrazine cinnamates and the methods used for this.

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. - Enhanced encyclopedic format with drug monographs now organized alphabetically - Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions - Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing - Extensive bibliography with over 40,000 references - A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

Extrait du Dictionnaire des Musiques, précédemment paru dans la même collection, le Dictionnaire des Instruments de musique est dédié à tous les instruments, passés ou présents, proches ou lointains, par lesquels s'exprime la musique. Le sommaire comprend quelque 200 articles, d'ACCORDÉON à YUEQIN (luth chinois), en passant par CASTAGNETTES, COR DES ALPES ou GAMELAN, mais aussi par ALTO, CLAVECIN ou VIOLONCELLE. Illustré et très documenté, ce dictionnaire vous invite à découvrir, ou à mieux comprendre, l'histoire de ces instruments si divers, leur facture, les modes de jeu, les styles musicaux et les répertoires qui leur sont associés. Un index facilite la consultation du Dictionnaire des Instruments de musique, auquel ont collaboré 28 auteurs parmi lesquels Juliette Garrigues, Eugène Lledo, Michel Philippot…

Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.

In the decades following World War Two, and in part in response to the Cold War, governments across Western Europe set out ambitious programmes for social welfare and the redistribution of wealth that aimed to improve the everyday lives of their citizens. Many of these welfare state programmes - housing, schools, new towns, cultural and leisure centres – involved not just construction but a new approach to architectural design, in which the welfare objectives of these state-funded programmes were delineated and debated. The impact on architects and architectural design was profound and far-reaching, with welfare state projects moving centre-stage in architectural discourse not just in Europe but worldwide.This is the first book to explore the architecture of the welfare state in Western Europe from an international perspective. With chapters covering Austria, Belgium, France, Germany, Italy, The Netherlands, Sweden and the UK, the book explores the complex role played by architecture in the formation and development of the welfare state in both theory and practice. Themes include: the role of the built environment in the welfare state as a political project the colonial dimension of European welfare state architecture and its ‘export'to Africa and Asia the role of welfare state projects in promoting consumer culture and economic growth the picture of the collective produced by welfare state architecture the role of architectural innovation in the welfare state the role of the architect, as opposed to construction companies and others, in determining what was built the relationship between architectural and social theory the role of internal institutional critique and the counterculture. Contributors include: Tom Avermaete, Eve Blau, Nicholas Bullock, Miles Glendinning, Janina Gosseye, Hilde Heynen, Caroline Maniaque-Benton, Helena Mattsson, Luca Molinari, Simon Pepper, Michelle Provoost, Lukasz Stanek, Mark Swenarton, Florian Urban and Dirk van den Heuvel.

As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes. This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.

Now in its 4th edition, Kirklin/Barratt-Boyes Cardiac Surgery remains your indispensable source for definitive, state-of-the-art answers on every aspect of adult and pediatric cardiac surgery. This dynamic medical reference thoroughly and systematically covers the full range of new and classic surgical procedures—including the latest alternate and minimally invasive surgical techniques—and presents the up-to-date clinical evidence you need to make effective management decisions. - Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, definitive text in the field! - Get comprehensive coverage of all areas of cardiac surgery, including ischemic, valvular, and congenital heart disease; cardiac tumors; constrictive pericarditis; thoracic aortic surgery; cardiac transplantation; coronary artery disease; aortic valve disease; cardiac rhythm disturbances; heart failure and transplantation; disease of the thoracic aorta; tetralogy of Fallot; anesthesia; and postoperative care. - Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! - Make the most well-informed decisions and achieve optimal outcomes by exploring each condition's natural history; diagnostic criteria; indications for surgery; operative techniques; and follow-up care. - Reference information quickly thanks to a new, streamlined format. - Visually grasp and better understand critical information with the aid of a new, full-color design that includes an abundance of detailed charts and graphs. - Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! - Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at www.expertconsult.com.

Selected, peer reviewed papers from the 2011 International Conference on Applied Mechanics, Materials and Manufacturing (ICAMMM 2011), November 18-20, 2011, Shenzhen, China

This book provides a framework for understanding the pathophysiology of diseases involving the vestibular system. The book is divided into four parts: I. Anatomy and physiology of the vestibular system; II. Evaluation of the dizzy patient; III. Diagnosis and management of common neurotologic disorders; and IV. Symptomatic treatment of vertigo. Part I reviews the anatomy and physiology of the vestibular system with emphasis on clinically relevant material. Part II outlines the important features in the patient's history, examination, and laboratory evaluation that determine the probable site of lesion. Part III covers the differential diagnostic points that help the clinician decide on the cause and treatment of the patient's problem. Part IV describes the commonly used antivertiginous and antiemetic drugs and the rationale for vestibular exercises. The recent breakthroughs in the vestibular sciences are reviewed. This book will helpful to all physicians who study and treat patients complaining of dizziness.

Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 23 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2010. As with previous volumes in the series, Volume 23 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format. - Covers the heterocyclic literature published in 2010 - Includes specialized reviews - Features contributions from leading researchers in their fields

Murray and Nadel's Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions.Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia.Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts.Apply the expertise and fresh ideas of three new editors-Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel.Review the latest developments in genetics with advice on how the data will affect patient care.

Fully updated and revised, the second edition of The Practice of Emergency and Critical Care Neurology puts a more modern approach on the practice of emergency neurological care. When most texts within the field focus on the theoretical aspects, this book concentrates on the management of neurologic conditions, recognition of deterioration of neurologic functions, neurosurgical procedures, and immediate interventions. This text also presents hard data to explain why we do what we do. Dr. Wijdicks condenses essential information into several sections comprising of the principles in recognizing critically ill neurologic patients in the emergency department, the evaluation of symptoms indicating critical emergency, general principles of managing critically ill patients, monitoring devices and diagnostic tests, complete management of specific disorders in the neurosciences intensive care unit, postoperative neurosurgical and neurointerventional complications, management of medical complications, and end of life care. Key Features of the New Edition include 1. Additional chapters on critical consults in surgical and medical ICUs, critical care management, and comprehensive monitoring and biomarkers to reflect new research; 2. Rich illustrations using color photos of patients and drawings of important basic concepts of mechanism of acute neurologic disease; 3. Fully updated and comprehensive reference list; 4. A pocket book of selected tables and figures covering all essential points for quick reference and as a survival guide for house staff. This is the go-to guide for every physician, staff neurologist, neurointensivist, resident, and fellow in training with managing acutely ill neurologic patients.

La résistance aux antibiotiques est apparue peu après la prescription de ces molécules. Cependant, dès l'aube du vingtième siècle, des médecins avaient mis en garde contre l'apparition de la résistance aux antibactériens de synthèse. Les bactéries pathogènes (pneumocoque, staphylocoque, entérocoque, colibacille…) mirent alors en œuvre des stratégies de résistance particulières. Cette histoire passionnante s'adresse aux étudiants, biologistes, vétérinaires, pharmaciens, médecins.

Le «Traité de pneumologie» dont la 1ère édition a été publiée sous la direction du professeur Aubier en 1997, a immédiatement été reconnu comme le traité de référence dans la discipline. La nouvelle édition qui parait toujours sous la direction du professeur Aubier, prend en compte toutes les nouvelles acquisitions depuis 10 ans. L'ouvrage reste divisé en 4 parties : dans la 1ère, les auteurs traitent en 16 chapitres de la physiologie et la physiopathologie de l'appareil respiratoire, cette partie a été enrichie de chapitres sur le développement pulmonaire, l'immunologie respiratoire, le contrôle de la ventilation, l'altitude. Dans la 2ème partie, consacrée aux techniques d'exploration, les auteurs ont largement pris en compte les progrès de l'imagerie et en particulier de la tomodensitométrie et de la TEP. La 3ème partie traite des symptômes et syndromes : toux, dyspnée, expectoration, hémophysie, douleurs thoraciques. La 4ème partie expose, en 60 chapitres, toute la pathologie broncho-pulmonaire depuis la broncho-pneumopathie jusqu'aux manifestations respiratoires des maladies systémiques, en passant par l'asthme, le cancer broncho-pulmonaire, l'embolie pulmonaire, etc.. Dans cette édition, une place toute particulière a été réservée aux pneumopathies émergentes, aux localisations pulmonaires de l'infection par le VIH, à l'HTAP primitive, à la pollution. Dans tous ces chapitres de pathologie, les auteurs abordent successivement les signes cliniques, la stratégie diagnostique aidée des examens paracliniques, les armes thérapeutiques, les prévisions pronostiques. La richesse des illustrations, tableaux, arbres de décision, références bibliographiques fait de cet ouvrage complet, actuel et pratique l'outil indispensable au médecin.

Market: Cardiologists, Vascular Specialists, Vascular Surgeons, Hematologists, Internists, Family Physicians, Rheumatologists More than 500 color charts and tables Includesw an entire section on diagnostic imaging modalities

There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Moreover, recent observations of community acquired infections have been reported, especially in patients with various risk factors such as immuno-deficiencies. Also, it is now becoming evident that Acinetobacter infections occur frequently in violent situations such as earthquake or war zones. The mechanisms of Acinetobacter virulence are becoming increasingly clear, providing new insights into their pathogenic role in community acquired infections. It is apparent the time is appropriate for detailed review of the increasing knowledge concerning important new information, both clinical and therapeutic, especially information concerning virulence, resistance mechanisms and typing of Acinetobacter spp. Many new findings are accumulating in almost an exponential manner since publication of previous books on this subject in 1991 and 1996.

Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety…recommendations for vaccine use, with rationales…data on the impact of vaccination programs on morbidity and mortality…and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most!Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues.Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage.Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies.Analyses the cost-benefit and cost-effectiveness of vaccines.Discusses the proper use of immune globulins and antitoxins.Illustrates concepts and objective data with approximately 600 tables and figures.Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.

The aim of the book is to provide a text which brings together the expertise from two separate disciplines applied to a shared problem; that of hearing impairment resulting from an infectious cause. The book has been written to be accessible to both disciplines. It begins with chapters describing the anatomy and function of the ear and its development to allow those unfamiliar with the ear to understand how the pathogen can affect hearing. The following chapters include background information on the relevant viruses, bacteria and other pathogens so that those less familiar with these organisms will be able to understand the context within which they may affect the ear. The book also considers current ways in which these infections may be diagnosed, treated, and the potential for prevention.

Questo manuale offre una descrizione esaustiva di tutte le urgenze che possono interessare il paziente pediatrico. L'esposizione pratica, arricchita dall'inserimento di numerose tabelle e da box “da ricordare”, lo rendono uno strumento di grande utilità non solo per il pediatra che lavora in strutture dedicate ma, e forse soprattutto, per il pediatra ospedaliero e il pediatra di famiglia. Il lettore potrà migliorare le proprie capacità di porre diagnosi corrette e, di conseguenza, prendere le giuste decisioni terapeutiche attraverso la lettura dei casi clinici posti alla fine di ogni argomento.

Title from e-book title screen (viewed on April 8, 2005)

The reference work is prized for its scholarly presentation of persons and subjects related to Catholicism and the humanities. Topics include abortion, divorce, cloning, and reproductive technologies. In addition to the hundreds of new, signed articles on a wide variety of topics, this edition also features biographies of contemporary religious figures, thousands of photos, maps, and illustrations, and completely updated bibliographical citations. The 15th volume is a cumulative index to the entire encyclopedia.

The vestibular system plays a crucial role in enabling a person to remain oriented and move through his environment successfully. Dysfunction of this complex system may leave a patient totally disabled.'Dizziness'is a complaint commonly heard by neurologists, otolaryngologists, and other health care providers, yet its origins are many and often difficult to pinpoint and to treat. Clinical Neurophysiology of the Vestibular System is a classic text that provides a framework for understanding the pathphysiology of diseases involving the vestibular system. Part I reviews the anatomy and physiology of the vestibular system, with emphasis on clinically relevant material. Part II outlines important features in the patient's history, examination, and laboratory evaluation. Part III presents differential diagnostic points that help the clinician decide on the cause and treatment of the patient's problem. Part IV is a new section on the symptomatic treatment of vertigo. The third edition is thoroughly revised and has been expanded, covering the rapid advances that have occurred in the field in the last ten years. There are new chapters on the laboratory diagnosis of vestibular dysfunction, migraine, immune-mediated disorders, inherited disorders, symptomatic treatment of vertigo, antiemetic and antivertigo drugs, and vestibular rehabilitation.

Das kompakte Nachschlagewerk zu allen Bereichen der Musik. Das griffige Lexikon gibt Auskunft über alle Sachfragen zur Musik. Es enthält über 2.500 Artikel zu Sachen und Begriffen aus allen Bereichen der Musik - Klassik, Moderne, Weltmusik, Jazz und Unterhaltungsmusik.

This book describes a colorful period in French social and cultural history, during which music and science combined to provide the intellectual and aesthetic spirit of the Age of Enlightenment with an enormous vitality. Investigating the place assigned to music in France's preeminent scientific institution, the Paris Academy, the author shows the role played by the scientific movement in the evolution of musical thought prior to the Revolution.Originally published in 1982.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.