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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

As the subject of a popular web reality series, Suzanne Barston and her husband Steve became a romantic, ethereal model for new parenthood. Called'A Parent is Born,'the program's tagline was'The journey to parenthood... from pregnancy to delivery and beyond.'Barston valiantly surmounted the problems of pregnancy and delivery. It was the'beyond'that threw her for a loop when she found that, despite every effort, she couldn't breastfeed her son, Leo. This difficult encounter with nursing—combined with the overwhelming public attitude that breast is not only best, it is the yardstick by which parenting prowess is measured—drove Barston to explore the silenced, minority position that breastfeeding is not always the right choice for every mother and every child. Part memoir, part popular science, and part social commentary, Bottled Up probes breastfeeding politics through the lens of Barston's own experiences as well as those of the women she has met through her popular blog, The Fearless Formula Feeder. Incorporating expert opinions, medical literature, and popular media into a pithy, often wry narrative, Barston offers a corrective to our infatuation with the breast. Impassioned, well-reasoned, and thoroughly researched, Bottled Up asks us to think with more nuance and compassion about whether breastfeeding should remain the holy grail of good parenthood.