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Comprehensive resource covering toxicology fundamentals, distribution of pollutants in the environment, and research methodologies for toxicological assessment of chemical mixtures Toxicological Assessment of Combined Chemicals in the Environment offers an in-depth exploration of various approaches and molecular mechanisms regarding how minor alterations in chemical mixtures can influence an organism's toxicity, along with discussion of the challenges associated with assessing mixtures. The first section of the book provides a concise introduction to the background and significance of combined toxicity. Section two delves into the primary sources and enrichment mechanisms of different chemical mixtures, elucidating the biological exposure pathways of these compounds. Section three introduces both classical and emerging toxicological research models in detail. Building on the descriptions of compound emission, migration, accumulation, and transformation processes, and the analysis of combined molecular toxicity in the preceding sections, section four introduces computer mathematical modeling methods for hazard assessment of compound mixtures. The final section details the challenges and future trends in this field. Written by a highly qualified author and seasoned research contributor in the field, Toxicological Assessment of Combined Chemicals in the Environment covers sample topics including: The degradation, oxidation, absorption, distribution, biotransformation, and excretion of various compounds in both the environment and in organisms A variety of cell models and in vivo research models of model organisms, supplemented with case studies Combined molecular toxicity mechanisms of heavy metals, pesticides, persistent organic pollutants (POPs), and pharmaceutical and personal care products (PPCPs) Principal sources, fate, and mechanism of chemical mixtures in the environment, as well as experimental designs and sampling strategies for combined toxicity studies based on concentrations Toxicological Assessment of Combined Chemicals in the Environment serves as a valuable reference for researchers, students, and policymakers involved in environmental management and protection. It is particularly relevant for toxicologists, risk assessors, and those engaged in the molecular modeling of toxic mixtures.

Hacker's Guide to Machine Learning Concepts is crafted for those eager to dive into the world of ethical hacking. This book demonstrates how ethical hacking can help companies identify and fix vulnerabilities efficiently. With the rise of data and the evolving IT industry, the scope of ethical hacking continues to expand. We cover various hacking techniques, identifying weak points in programs, and how to address them. The book is accessible even to beginners, offering chapters on machine learning and programming in Python. Written in an easy-to-understand manner, it allows learners to practice hacking steps independently on Linux or Windows systems using tools like Netsparker. This book equips you with fundamental and intermediate knowledge about hacking, making it an invaluable resource for learners.

International Conference on Contemporary Trends In Multidisciplinary Research& Innovation (ICCTMRI- 2023) was conducted by Birla Institute of Technology Mesra, Ranchi Off Campus Jaipur, Rajasthan, India. ICCTMRI– 2023 provided a unique opportunity to interact with researchers, academicians, scientists, and specialists in the various research and development fields of Biotechnology and Bioengineering, Management, Animation, Science and Technology across the globe. ICCTMRI– 2023 offered a platform for global experts to gather and interact intensively on the topics of Animation, Biotechnology, Computer Science, Electronics Engineering, Electrical Engineering, Environmental Engineering, Management Practices, and Multimedia and Sciences.

This book constitutes the refereed proceedings of the 50th International Workshop on Graph-Theoretic Concepts in Computer Science, WG 2024, held in Gozd Martuljek, Slovenia in June 2024, The 31 papers presented in this volume were carefully reviewed and selected from 89 submissions. Additionally, this volume also contains a survey on approximation algorithms for tree-width, path-width, and tree-depth prepared by Hans Bodlander, who delivered the Test of Time Award talk at WG 2024. The WG 2024 workshop aims to merge theory and practice by demonstrating how concepts from graph theory can be applied to various areas in computer science or by extracting new graph-theoretic problems from applications.

Maritime infrastructures are fundamental to the working of societies and economies. They play a crucial role in supply, with 90% of commercial trade exchanges carried out worldwide handled by the maritime industry, in the functioning of the economy, the maintenance of mobility and the deployment of renewable energies. For the past decade, the attention of developed democratic nations has been focused on the protection of vital terrestrial objects, but less attention has been paid to critical maritime infrastructures and the need to increase their resilience. This book, Modern Technologies Enabling Innovative Methods for Maritime Monitoring and Strengthening Resilience in Maritime Critical Infrastructures, presents 23 papers delivered at the NATO Advanced Training Course (ATC) hosted in hybrid format from 15-20 January 2024 in Agadir, Morocco. The aim of the ATC was to cover the problem of monitoring critical maritime infrastructure in an interdisciplinary manner, and it was attended by researchers and students, security officers, stakeholders, and experts in tackling terrorism or other violent threats. The ATC was divided into 4 blocks: general aspects of strengthening the resilience of maritime critical infrastructure; unmanned systems (USs) and sensor network technology; monitoring, data analysis and structural modeling; and cybersecurity and protection of IT maritime infrastructures. There was also one practical session. The book covers many ways in which unmanned systems, sensor networks and other digital technologies can be used to monitor threats to maritime critical infrastructure, and will be of interest to all those working in the field.

This book provides an in-depth exploration of microbial biodiversity and its crucial role in diverse biotechnological and industrial sectors. It covers topics such as the integration of molecular approaches for identifying industrially significant strains, omics roles in the production of bioproducts, and modern genetic engineering techniques. It discusses biostatistical investigations and the impact of microbial biotechnology on healthcare and emerging contaminants. It highlights the significance of food microbiology, fermentation, and the latest technologies in improving human health. Additionally, the book delves into emerging trends in oligosaccharide production, biobased approaches for a sustainable future, and the importance of microbial biomolecules and secondary metabolites. It also explores the identification and production of industrially significant biocatalysts/enzymes, the valorization of agro-industrial waste using microorganisms for green energy generation, and the development of bioreactor systems for the biobased economy. The book covers advancements in solid-gaseous biofuels production, impact assessment of synthetic microfiber pollution, sustainable management strategies for waste management, and the impact of emerging technologies in medical microbiology. The book also discusses the development of healthcare products using nano-biotechnological advancements, the impact of novel remediation technology, and the utilization of microbial products in biomaterial development. It further explores microbial regulatory systems, gene expression studies, and the significance of mutations in microbial technology. This book serves as a great reference for researchers, environmentalists, microbiologists, biotechnologists, and graduate, post-graduate students, and doctoral students working on microbial biotechnology and industrial microbiology.

Herbal nutraceuticals demonstrate a variety of therapeutic benefits and have been found to prevent, treat, and even cure a range of diseases. This new book provides insight into nutraceuticals and their function in human health, highlighting their antimicrobial and immune-inflammatory properties. It describes the nutraceutical properties of various medicinal herbs and details the role of nutraceuticals in treating diseases such as Alzheimer's, Parkinson's, obesity, diabetes, cancer, cardiovascular diseases, skincare issues, and more.

Smart cities are experiencing a rapid evolution. The integration of technologies such as 5G, Internet of Things (IoT), Artificial Intelligence (AI), and blockchain has ushered in transformative applications, enhancing the quality of urban life. However, this evolution comes with its own challenges, most notably in security and privacy. Secure and Intelligent IoT-Enabled Smart Cities addresses these concerns, exploring theoretical frameworks and empirical research findings. The book embarks on the foundational elements of the Internet of Things, delving into the convergence of IoT and smart city applications, elucidating the layered architecture of IoT, and highlighting the security issues inherent in IoT-enabled Smart Cities. This book pinpoints the challenges smart city infrastructures face and offers innovative and pragmatic solutions to fortify their security. This book targets professionals and researchers immersed in the dynamic field of secure and intelligent environments within IoT-enabled smart city applications. It is a valuable resource for executives grappling with the strategic implications of emerging technologies in smart healthcare, smart parking, smart manufacturing, smart transportation, and beyond. By offering insights into the paradigms of intelligent privacy preservation and the fusion of technologies like blockchain, artificial intelligence, and deep learning, the book equips its readers to navigate the complexities of ensuring a secure and intelligent future for IoT-enabled smart cities beyond 5G.

This two-volume set LNCS 14465-14466 constitutes the proceedings of the 31st International Symposium on Graph Drawing and Network Visualization, GD 2023, held in Isola delle Femmine, Palermo, Italy, in September 2023. The 31 full papers, 7 short papers, presented together with 2 invited talks, and one contest report, were thoroughly reviewed and selected from the 100 submissions. The abstracts of 11 posters presented at the conference can be found in the back matter of the volume. The contributions were organized in topical sections as follows: beyond planarity; crossing numbers; linear layouts; geometric aspects; visualization challenges; graph representations; graph decompositions; topological aspects; parameterized complexity for drawings; planar graphs; frameworks; algorithmics.

Defense-related Proteins in Plants presents detailed information on the identification, characterization, mechanism of action, and application in crop improvement programs of these mechanisms in a single, cohesive volume. It includes foundational information to enable the understanding of these proteins and their applications in crop improvement programs.Defense-related proteins have drawn the attention of various plant and agricultural scientists and industries because they provide generalized direct stress tolerance in crop plants. These proteins, including lectins, chitinases, thaumatin, and osmotin among others, have been used for the development of transgenic plants to provide protection against various abiotic and biotic stresses. While there is a breadth of research and application information available, it has not previously been compiled into a single volume for the ease of comparison and translational work. This book is a complete guide to defense-related proteins in plants for various categories of readers. Also, it will inspire future research into the unexplored areas of the molecular aspects of these proteins to understand their role and action mechanism in plants and living organisms as a whole. Additionally agricultural scientists and industry professionals will find the application part of this book helpful in future crop design strategies. - Presents comprehensive information on defense-related proteins in plants - Highlights practical application of defense-related proteins in crops - Structured for ease of comparison and translational work

Advances in Heterocyclic Chemistry, Volume 142, the latest release in this definitive series, combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include Recent advances in the Synthesis of Benzo[b]furans, Recent Advances in the Synthesis of 6-Membered Heterocycles via Domino and Multicomponent Reactions (from 2017-2022), Multi-component synthesis of isatin based bioactive heterocycles, Recent advances in the chemistry of pyrazolo[1,5-a]pyrimidines, The Literature of Heterocyclic Chemistry, Part XXI, 2021, and much more.Additional sections present the latest Advances in applications of dihydropyridines in organic chemistry and Strategies for the annulation of five-membered sulfur-nitrogen rings to benzene and heterocycles. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

This two-volume set LNCS 15179-15180 constitutes the refereed proceedings of the 18th International Conference on Algorithmic Aspects in Information and Management, AAIM 2024, which took place virtually during September 21-23, 2024. The 45 full papers presented in these two volumes were carefully reviewed and selected from 76 submissions. The papers are organized in the following topical sections: Part I: Optimization and applications; submodularity, management and others, Part II: Graphs and networks; quantum and others.

Brooks'Theorem (1941) is one of the most famous and fundamental theorems in graph theory – it is mentioned/treated in all general monographs on graph theory. It has sparked research in several directions. This book presents a comprehensive overview of this development and see it in context. It describes results, both early and recent, and explains relations: the various proofs, the many extensions and similar results for other graph parameters. It serves as a valuable reference to a wealth of information, now scattered in journals, proceedings and dissertations. The reader gets easy access to this wealth of information in comprehensive form, including best known proofs of the results described. Each chapter ends in a note section with historical remarks, comments and further results. The book is also suitable for graduate courses in graph theory and includes exercises. The book is intended for readers wanting to dig deeper into graph coloring theory than what is possible in the existing book literature. There is a comprehensive list of references to original sources.

The Traveling Salesman Problem (TSP) is a central topic in discrete mathematics and theoretical computer science. It has been one of the driving forces in combinatorial optimization. The design and analysis of better and better approximation algorithms for the TSP has proved challenging but very fruitful. This is the first book on approximation algorithms for the TSP, featuring a comprehensive collection of all major results and an overview of the most intriguing open problems. Many of the presented results have been discovered only recently, and some are published here for the first time, including better approximation algorithms for the asymmetric TSP and its path version. This book constitutes and advances the state of the art and makes it accessible to a wider audience. Featuring detailed proofs, over 170 exercises, and 100 color figures, this book is an excellent resource for teaching, self-study, and further research.

This book integrates the research progress of Tryptophan (Trp) and its metabolites in animal nutrition and human health. It recapitulates the effects of Trp nutrition on the regulation of various physiological functions in farmed animals as well as the clinical connections between Trp metabolism and human diseases. Furthermore, this book includes detailed information about the manufacturing process of industrial Trp production and methodologies to study Trp metabolism. This book not only brings numerous benefits to academic communities worldwide but also provides practical values for industrial professionals/companies. Both of these two aspects will expand our understanding of how amino acid metabolism contributes to the maintenance of host health.

This new volume addresses the global concern of environmental pollution mediated by a variety of organic, inorganic, persistent, and nonpersistent pollutants, which have a substantial detrimental impact on the structural and functional aspects of ecosystems. The book presents some important and recent nanotechnological advances that provide significant potential for decontamination of many polluted sites. It first provides the introductory background of nanoremediation and then delves into applications for the restoration of environmental sites that have been contaminated with a diverse range of pollutants, such as heavy metal, pesticides, and dyes in soil and water. This volume improves our knowledge of nanotechnology-based remediation to make it less hazardous and reusable. It provides valuable information on the decontamination of the soil and water resources.

Advances in Microbial Physiology, Volume 84 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include Mycobacterial Efflux systems, New insights in bacterial organophosphorus cycling: from human pathogens to environmental bacteria, Link between gut sulfidogenic bacteria and disease, The Formate-H2 Axis and its Importance for Microbial Physiology, Physiology of diazotrophs, Antibiotic efficacy, and Microbial metabolites as modulators of host physiology. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Microbial Physiology serial - Covers Mycobacterial efflux systems, New insights in bacterial organophosphorus, The link between gut sulfidogenic bacteria and disease, and much more

This Festschrift is dedicated to Joost-Pieter Katoen in recognition of his outstanding research, teaching, and organizational successes. Joost-Pieter received his Master's and later his Ph.D. from the University of Twente, and his Professional Doctorate in Engineering from Eindhoven University of Technology. He had research positions at the University of Erlangen-Nuremberg and Philips Research, and visiting professorships in France, Australia, and the UK. Since 2004 he has been a professor at RWTH Aachen University and is part-time associated with the University of Twente. Joost-Pieter's main areas of research are formal methods, computer-aided verification, concurrency theory, probabilistic computation, and semantics. Among many recognitions for this work, he is an ACM Fellow; he was elected as a member of the Academia Europaea, the Royal Holland Society of Science and Humanities, the North Rhine-Westphalian Academy of Science, Humanities and the Arts, and the Leopoldina, the German National Academy of Sciences; he received an honorary doctorate from Aalborg University. He was awarded an ERC Advanced Grant; he has won best paper, distinguished paper, or test-of-time awards at key conferences such as ETAPS, IEEE SRDS, POPL, CONCUR, and LOPSTR; and he has given keynotes at dozens of major events. He has chaired the Steering Committee of the European Joint Conferences on Theory and Practice of Software (ETAPS) and the TACAS conference; he has been Program Chair, General Chair, or Program Committee member of hundreds of major conferences and workshops, and a board member of key journals; he has served on research boards (such as the EPSRC), doctoral committees, school and university committees, and IFIP working groups; and he coauthored Principles of Model Checking, a highly influential textbook. Throughout his career Joost-Pieter has been a remarkably successful teacher and mentor, supervising students and hosting postdoctoral researchers, many of whom have won awards for their research and advanced to senior positions, and he has collaborated in research and publications with a wide range of scientists. These successes are reflected in the papers contributed to this volume.

MATRIX is Australia's international and residential mathematical research institute. It facilitates new collaborations and mathematical advances through intensive residential research programs, each 1-2 weeks in duration. This book is a scientific record of the 24 programs held at MATRIX in 2021-2022, including tandem workshops with Mathematisches Forschungsinstitut Oberwolfach (MFO), with Research Institute for Mathematical Sciences Kyoto University (RIMS), and with Sydney Mathematical Research Institute (SMRI).

This book reports on innovative research and developments in the broad field of transportation. It covers innovative solutions relating to intelligent vehicles and infrastructure, energy and combustion management, vehicle dynamics and engineering. It also reports on advances in railway transport, air transportation, as well as transportation safety and logistics. Chapters are based on peer-reviewed papers presented at the 14th international scientific conference'Transbaltica: Transportation Science and Technology', held on September 14-15, 2023, at Vilnius Gediminas Technical University, in Vilnius, Lithuania. All in all, this book offers extensive and timely information to both researchers and practitioners in the field of transportation, logistics and related interdisciplinary areas.

This book contains proceedings of the international conference Santini and Italy, held in Rome in June 2023. In his contribution, Augusto Roca de Amicis describes the nature of the structural relations of Santini's work to Italian architecture. Pavel Kalina discusses the development of Santini scholarship in the art historical literature of the 20th and early 21st centuries. Richard Biegel shows in his contribution that the sources of Santini's work can be found not only in Italian but also in French architecture. Michael Young's text points to the connection between Santini's architecture and contemporary literary theory and practice, which blended different languages and styles. In his article, Ulrich Fürst stresses the importance of a sense of originality for the design of the Benedictine monastery church at Rajhrad, whose construction demonstrated its independence from the monastery of Břevnov, for which the Dientzenhofers worked. Johana Bronková explores the relationship between Santini's architecture and the work of the great Italian architect Francesco Borromini. Marisa Tabarrini presents a completely new discovery - the unknown plans of Santini's church of St. Peter and Paul in Prague's Zderaz. Important for understanding the functioning of Baroque buildings is the article by Jakub Řehak, who analyses the water and ventilation system of the monastery in Plasy. On the other hand, Madleine Riedenklau's text is devoted to the literature on the monastery and church in Sedlec. Irena Bukačová introduces the reader to the past and present of the pilgrimage site in Mariánská Týnice.

In academic research, qualitative analysis is a pillar for understanding complex phenomena in science and management. However, researchers and practitioners often face challenges navigating the ever-evolving landscape of qualitative methodologies and their integration into empirical projects. This knowledge gap can hinder the practical application of qualitative approaches, leading to suboptimal research outcomes and missed opportunities for insightful discoveries. Applying Qualitative Research Methods to Management Science serves as a beacon for researchers, practitioners, and students, providing a detailed roadmap to navigate the intricacies of qualitative analysis. Each chapter, authored by esteemed experts in the field, delves into specific qualitative themes and methodologies, offering practical insights and theoretical foundations based on the latest academic research. This book empowers readers to conduct rigorous and impactful qualitative research in diverse contexts by bridging the gap between theory and application. By offering a holistic view of qualitative research, this book equips readers with the tools and knowledge needed to excel in their academic and professional endeavors. From understanding the fundamental principles of qualitative analysis to implementing advanced methodologies, this book is a definitive guide for anyone seeking to master qualitative research in science and management. With its pedagogical approach and practical insights, this book is not just a reference but a companion for researchers and practitioners alike, ushering them into a realm of deeper understanding and impactful research.

The world we live in today is highly interconnected and has seen a significant rise in the use of the Internet of Things (IoT) and Industrial Internet of Things (IIoT). This digital transformation, while beneficial, has also created new cybersecurity challenges. Cyber threats are becoming more sophisticated and frequent, and individuals and organizations alike must adopt intelligent and agile cybersecurity solutions to safeguard their digital assets. Smart and Agile Cybersecurity for IoT and IIoT Environments addresses this pressing challenge by providing a comprehensive guide to securing IoT and IIoT environments. The book offers insights into the latest cybersecurity strategies and technologies, from intelligent threat detection to agile security approaches. By delving into data privacy, network security, and incident response, readers can gain the knowledge and skills to fortify their cybersecurity posture and mitigate risks effectively. Tailored for cybersecurity professionals, IT practitioners, and business leaders, Smart and Agile Cybersecurity for IoT and IIoT Environments equips readers with actionable insights and best practices to navigate the complexities of securing connected devices. Whether you're looking to enhance your cybersecurity knowledge or seeking practical implementation guides, this book is a valuable resource for anyone looking to secure their digital future in the evolving technological landscape.

Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This'sequential'strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the'druggability'of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term'Safety Pharmacology'was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. &nb

Książka jest autorskim, bardzo interesującym naukowym studium pedagogiczno-filozoficznym, opartym z jednej strony na własnych doświadczeniach i wynikających z nich perspektywach poznawczych, ale niepozbawionych prób obiektywizowania, z drugiej – na w pełni zobiektywizowanych analizach o charakterze naukowym zarówno materiałów źródłowych, jak i osobowych wątków twórców czechosłowackiej i czeskiej pedagogiki, a szerzej ujmując, obecnego czeskiego systemu edukacji i wychowania. Poruszane w monografii wątki wykraczają poza granice geograficzne oraz ukazują uniwersalność i tradycje myśli pedagogicznych w tej części Europy w ostatnich okresach historyczno-politycznych. Książkę czyta się z dużym zainteresowaniem i lekkością, co nieczęsto ma miejsce w przypadku naukowych publikacji pedagogicznych. Autor znakomicie operuje piórem, a przyjęta przez niego koncepcja pracy, jej styl narracji i charakter treści temu wyraźnie sprzyjają. Z recenzji prof. dr. hab. Marka Konopczyńskiego

Impact of Engineered Nanomaterials in Genomics and Epigenomics Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field. Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.

This book constitutes the proceedings of the 9th International Conference on Algorithms and Discrete Applied Mathematics, CALDAM 2023, which was held in Gandhinagar, India, during February 9-11, 2023.The 32 papers presented in this volume were carefully reviewed and selected from 67 submissions. The papers were organized in topical sections named: algorithms and optimization; computational geometry; game theory; graph coloring; graph connectivity; graph domination; graph matching; graph partition and graph covering.

A comprehensive explanation of drug metabolism concepts and applications in drug development and cancer treatment In the newly revised second edition of Drug Metabolism Handbook: Concepts and Applications in Cancer Research, a distinguished team of researchers delivers an incisive and robust exploration of the drug metabolism system and a well-illustrated and detailed explanation of the latest tools and techniques used in the research, pharmacology, and medicine. The book discusses the creation of new molecular entities, drug development, troubleshooting, and other highly relevant concepts, guiding readers through new applications in pharmaceutical research, development, and assessment. The latest edition offers updated content on metabolism basics and the application of a variety of new techniques to cancer treatment, including mass spectrometry, imaging, metabolomics, and immunotherapy. It also offers in-depth case studies highlighting the role of metabolism in drug development. Readers will also benefit from: A thorough introduction to drug metabolism, including a historical perspective, factors affecting metabolism, and biotransformations in drug metabolism Comprehensive discussions of technologies for in vitro and in vivo studies, including mass spectrometry and accelerating metabolite identification with mass spectrometry In-depth explorations of drug interactions, including discussions of enzyme inhibition and the characterization of cytochrome P450 mechanism-based inhibition Fulsome treatments of drug toxicity, including the role of drug metabolism in toxicity, and allergic reactions to drugsPerfect for medicinal chemists, pharmaceutical scientists, and toxicologists, Drug Metabolism Handbook: Concepts and Applications in Cancer Research, Second Edition will also earn a place in the libraries of analytical chemists and drug discovery professionals.

Industrial Application of Functional Foods, Ingredients and Nutraceuticals: Extraction, Processing and Formulation of Bioactive Compounds explains the fundamental concepts and underlying scientific principles of nutrient delivery, nutraceutical processing technologies and potential opportunities in the field of new product development. The book also includes sections on the extraction and purification of functional ingredients, effective delivery of nutrients, health benefits, safety and regulatory aspects. Divided in four sections this book provides an up-to-date, highly applicative work that highlights the mechanistic aspects related to the challenges and opportunities associated with developing, delivering and marketing functional foods and nutraceuticals. - Explains the fundamental concepts of nutrient delivery and nutraceutical processing technologies - Provides an understanding of pharmacokinetics, oral bioavailability and different delivery techniques - Features case studies to illustrate practical applications and commercialization

This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature. - Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view - Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures - Features a large number of color figures which give information in a clear-and-concise way - Includes extensive references to review articles and primary literature - Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer

The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.

The attention of many developed countries has increasingly focused on the security and protection of critical infrastructure. The use of Unmanned Systems (USs) for this purpose has been growing rapidly in recent years, as advances in technology, increased versatility and smaller size, together with the reduced risks and costs associated with removing the need for a pilot or operator on board, have all made these systems more attractive. This book, Monitoring and Protection of Critical Infrastructure by Unmanned Systems, presents 15 papers delivered at the NATO Advanced Training Course (ATC) of the same name hosted in Chisinau, the Republic of Moldova, from 30 May to 5 June 2022. This event was held in a hybrid format, and was attended in-person by 12 of the 31 speakers and the majority of the 92 attendees. The aim of the ATC was to explore the monitoring and protection of critical infrastructure using USs. Various USs, including ground control stations (GCS), data communication links, and a range of unmanned aerial (UAV), ground (UGV) and underwater (UUV) vehicles are covered, and the papers included here also deal with topics such as the use of drones for buildings inspection and the new technologies which can help with the recognition and monitoring of anthropogenic threats and natural hazards. There is also a focus on data analysis and modeling. Providing an overview of the use of unmanned vehicle systems and sensor-network technology for monitoring and protection, the book will be of interest to all those working to protect critical infrastructure.

This book reports on innovative research and developments in the broad field of transportation. It covers solutions relating to intelligent vehicles and infrastructure, energy and combustion management, vehicle dynamics and engineering, as well as research on railway transport, aerospace technologies, logistics and security. Contributions are based on peer-reviewed papers presented at the 13th international scientific conference'Transbaltica: Transportation Science and Technology', held on September 15-16, 2022, at Vilnius Gediminas Technical University, in Vilnius, Lithuania. All in all, this book offers extensive information on modern transport systems, with a good balance of theory and practice.

For the last 30 years, polyphenols were in the centre of research work worldwide. Silymarin, an extract from a medicinal plant Silybum marianum, also known as milk thistle, has a special place in this group, having been used in human medicine for the management of liver diseases since ancient times. Accumulating scientific evidence indicates that silymarin is characterised by a wide range of protective pharmacological activities and this topic has received tremendous attention in recent years. However, until now there has been no single monograph addressing major questions related to silymarin chemistry, biochemistry and practical applications. The goal of this book is to provide up to date information about silymarin chemistry, biochemistry and molecular mechanisms of protective actions of this phytochemical with a special emphasis to its vitagene- and transcription factor-modulating properties. Silymarin applications in human diseases, including hepatoprotection, neuroprotection, anti-diabetic, anti-arthritis and other protective activities are reviewed. Immunomodulating, anti-inflammatory, anti-toxic protective activities of silymarin are characterised in detail. Practical applications of silymarin in poultry and animal industry with a special emphasis on its protective roles in gut health maintenance are also presented. This book will be of practical importance to medical and pharmaceutical scientists, including medical doctors, pharmacists, consultants, etc. as well as to poultry/animal scientists, poultry producers, nutritionists and vets, as well as to students of medical, biological and agricultural backgrounds. It can also be of interest for researchers in areas related to physiology, biochemistry, nutrition and veterinary medicine.

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest.In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures.This volume:· Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. · Presents ethnopharmacological applications of various species of the 56 genera included in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world.· Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities.· Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis.· Provides a complete overview of each species of 56 genera and complete information up to 2022.Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, and biological and pharmacological activities of plants.

The use of different foods, herbs, and spices to treat or prevent disease has been recorded for thousands of years. Egyptian papyrus, hieroglyphics and ancient texts from the Middle East have described the cultivation and preparations of herbs and botanicals to'cure the sick'. There are even older records from China and India. Some ancient scripts describe the use of medicinal plants which have never been seen within European cultures. Indeed, all ancient civilizations have pictorial records of different foods, herbs, and spices being used for medical purposes. However, there are fundamental issues pertaining to the scientific evidence for the use of these agents or their extracts in modern medicine. There have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. For example, plants which have been used for “digestion” or “medical ills” since time immemorial are now being investigated for anti-cancer properties or their toxicity, using high throughput screening. Techniques also include molecular biology, cellular biochemistry, physiology, endocrinology and even medical imaging. However, much of the material relating to the scientific basis or applications of traditional foods, herbs, spices and botanicals is scattered among various sources. The widespread applicability of foods or botanicals are rarely described and cautionary notes on toxicity are often ignored. These issues are explored in Ancient and Traditional Foods, Plants, Herbs and Spices used in Cardiovascular Health and Disease.Features: Investigates alternative healthcare paradigms that use traditional dietary foods, plant-derived materials, and extracts to treat cardiovascular diseases Provides information on diets, specific agents, and extracts Many chapters focus on plant-derived material, providing a historical background, uses, toxicity and cautionary notes and summary points With contributions from leading international experts, this book is useful for cardiologists, nutritionists, physicians, healthcare workers, food scientists and those working in the food industry, pharmacologists, and research scientists.

Bacterial Secondary Metabolites: Synthesis and Applications in Agroecosystem presents the structure, properties, and biotechnological applications of bacterial metabolites and their upcoming industrial, pharmaceutical, antimicrobial, and anticancer applications. Chapters cover topics such as the use of lactic acid bacteria as an antifungal and antibacterial agent, bacterial siderophores structure and potential applications, and the role of cyanobacteria metabolites in disease management, among others. Plant and agri-food environmental scientists and researchers, graduate and post-graduate students in related fields will benefit from this reference book which is published as part of the series Nanobiotechnology for Plant Protection. - Explores how research might lead to the production of new bio-based commercial solutions to tackle global agricultural and human diseases - Contains extensive information to understand the intricate processes of cryptic genes and their relationship to the synthesis of bioactive chemicals - Provides in-depth insights into microbial biotechnology, namely secondary metabolites

QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide professional level technical summarizations but also cover introductory descriptions for all aspects of QSAR for safety evaluation and risk assessment. - Provides comprehensive content about the QSAR techniques and models in facilitating the safety evaluation of drugs and consumer products and risk assesment of environmental chemicals - Includes some of the most cutting-edge methodologies such as deep learning and machine learning for QSAR - Offers detailed procedures of modeling and provides examples of each model's application in real practice

The main aim of the book is to familiarize readers with the concepts of convergence of different connected and smart domains that are assisted by Cloud Computing, core technologies behind Cloud Computing, driving factors towards Cloud Computing, and security challenges and proposed solutions in Cloud Computing. The book covers not only the cloud, but also other pertinent topics such as Machine Learning, Deep Learning, IoT and Fog/Edge Computing. The last section of the book mainly focuses on the security aspects of connected technologies.The highpoints of the book is that it reviews the relation and combination of the mentioned topics, which together creates a better understanding about almost every aspect of Cloud Computing & related technologies.

Online user privacy is a delicate issue that has been unfortunately overlooked by technology corporations and especially the public since the birth of the internet. Many online businesses and services such as web search engines, retailers, and social network sites exploit user data for profit. There is a misconception among people about the term “privacy.” Usually, people think that privacy is the ability of an individual to isolate themselves or that it is a person's right to control access to their personal information. However, privacy is not just about revealing secret information; it also includes exploiting user personal data, as the exploitation of personal data may lead to disastrous consequences. Protecting User Privacy in Web Search Utilization presents both multidisciplinary and interdisciplinary works on questions related to experiences and phenomena that can or could be covered by concepts regarding the protection and privacy of web service users. It further highlights the importance of web search privacy to the readers and educates them about recent developments in the field. Covering topics such as AI-based intrusion detection, desktop search engines, and privacy risks, this premier reference source is an essential resource for students and educators of higher education, data experts, privacy professionals and engineers, IT managers, software developers, government officials, archivists and librarians, privacy rights activists, researchers, and academicians.

This book presents a comprehensive overview of all available surgical techniques for complex perineal reconstruction. Divided into 17 chapters and employing a multi-disciplinary approach, it provides valuable insights into the re- sectional aspects of this field, considerations in multiple organ removal (bladder, anus/colon, stomach), and the inclusion of radiology in preoperative planning for complex reconstructions, as well as anaesthetic aspects in perioperative patient care. Written by leading experts in the field, the respective chapters offer step-by-step descriptions of all available reconstructive options and detailed information on perineal and pelvic defects, together with valuable insights into surgical execution, indications, and common complications and pitfalls encountered when dealing with this challenging defect. Given its breadth of coverage, the book provides a practical and comprehensive guide for Consultant Plastic and Reconstructive Surgeons, and for surgeons of allied specialties involved in re-sectional aspects of perineal and pelvic surgery.

The presented publication is intended for future teachers of natural history at primary schools and it is supplementary study material for teaching the basics of geology. In an understandable form, it presents gemology – a science dealing with natural and artificial precious stones. The publication provides basic information about the properties of natural precious stones, their distribution in nature and methods of their processing. It is supplemented with many pictures documenting the beauty of precious stones. The intention is to introduce the issuce to readers who are not involved in geological sciences.

The intricate interplay between business, law, and societal expectations presents an unprecedented challenge in the field of commerce. Beyond the pursuit of profit, businesses navigate a complex ecosystem shaped by legal principles, government regulations, and evolving societal values. The Research Anthology on Business Law, Policy, and Social Responsibility tackles this complexity head-on, offering a comprehensive exploration of critical issues in a four-volume collection. As societal expectations for responsible and ethical business practices continue to rise, the need for up-to-date research becomes paramount, making this anthology a timely and indispensable resource. This anthology is a carefully curated selection of chapters shedding light on the latest trends, techniques, and applications in the realm of business law and policy. It covers a spectrum of topics, from the transformation of business ethics in the digital era to the examination of multi-national corporations'role in enforcing competition laws at a transnational level. By providing both broad and detailed perspectives on cutting-edge theories and developments, this anthology acts as a single reference source for academics, lawyers, policymakers, and business professionals seeking a nuanced understanding of the intricate web of laws and regulations governing commercial activities. Libraries aiming to provide their patrons with expansive and diverse research materials will find this anthology to be an exceptional solution. The anthology's multi-faceted approach, covering business ethics, corporate governance, social responsibility, and more, ensures that it caters to a wide range of academic interests. As a comprehensive and up-to-date resource, the anthology not only enriches the academic environment but also serves as an invaluable tool for researchers, educators, and students looking to delve into the complexities of contemporary business challenges. This makes the Research Anthology on Business Law, Policy, and Social Responsibility an indispensable addition to any institution's collection, meeting the diverse needs of those seeking insights into the intricate landscape of business law and policy.

Essential oils This exciting new volume, written and edited by some of the world's foremost experts in the field, provides up-to-date information about the chemical structure of essential oils, as well as their therapeutic and biological actions. It defines their functional uses while evaluating the advantages and disadvantages of their application in various sectors. Essential oils have been used by global communities for centuries, for different purposes such as medicinal, flavoring, preservatives, perfumery, aromatherapy, dentistry, cosmetics, insecticide, fungicide, and bactericide, among others. Essential oils are natural and biodegradable substances, usually non-toxic or with low toxicity to humans. Essential oils are botanical products that have volatile nature, known for their special odor, and found to be effective in the treatment of oxidative stress, cancer, epilepsy, skin allergies, indigestion, headache, insomnia, muscular pain, respiratory problems, etc. Essential oils principally enhance resistance to abiotic stress and protection against aquatic herbivores. They possess antimicrobial, antifungal, antitumor, and antioxidant properties. Essential oils are known to be volatile and susceptible to degradation from various ambient conditions, including temperature, air, light, and humidity, which limits their applications. Encapsulation is a proven technique that can protect essential oils and enable their use in various applications. This book aims to provide current knowledge on the chemical structure, therapeutic, and biological activities of essential oils, as well as to describe their functional uses and assess the benefits and drawbacks of their usage in various fields. By exploring the latest research on essential oils and their encapsulation, this book offers valuable insights and practical guidance for anyone interested in the science and application of these fascinating compounds.

This in-depth exploration of all aspects of physical transition is an accessible and supportive guide for transgender men, transmasculine people, and nonbinary people. Drawing on their personal experience and extensive research, Sage Buch walks you through a wide array of safe transition options. Inside, you'll learn about non-medical interventions like chest binding and packing, explore the varieties and effects of hormone replacement therapy, and get a comprehensive primer on choosing, preparing for, and recovering from top and bottom surgery. Medical research and jargon is made accessible, side effects and pros and cons are clearly spelled out, and empowering perspectives help you consider what transition path is right for you. Everything always comes back to checking in with yourself at every step of the way so that you can enjoy the unique self-expression that comes with finding yourself and who you are meant to be. Reading can be enhanced by working through The Transmasculine Guide to Physical Transition Workbook as you read.

This volume constitutes the thoroughly refereed proceedings of the 49th International Workshop on Graph-Theoretic Concepts in Computer Science, WG 2023. The 33 full papers presented in this volume were carefully reviewed and selected from a total of 116 submissions. The WG 2022 workshop aims to merge theory and practice by demonstrating how concepts from graph theory can be applied to various areas in computer science, or by extracting new graph theoretic problems from applications.

This book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.

This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues.Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented.Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.